Case Report: Hemorrhagic Fever with Renal Syndrome Complicated by Bilateral Subdural Hematoma

Wei Xiao Department of Neurosurgical Care Unit, The First People’s Hospital of Changde City, Changde, China

Search for other papers by Wei Xiao in
Current site
Google Scholar
PubMed
Close
,
Yanli Tang Department of Neurosurgical Care Unit, The First People’s Hospital of Changde City, Changde, China

Search for other papers by Yanli Tang in
Current site
Google Scholar
PubMed
Close
,
Lie Chen Department of Neurosurgical Care Unit, The First People’s Hospital of Changde City, Changde, China

Search for other papers by Lie Chen in
Current site
Google Scholar
PubMed
Close
,
Zheyong Jia Department of Neurosurgical Care Unit, The First People’s Hospital of Changde City, Changde, China

Search for other papers by Zheyong Jia in
Current site
Google Scholar
PubMed
Close
, and
Tao Mei Department of Neurosurgical Care Unit, The First People’s Hospital of Changde City, Changde, China

Search for other papers by Tao Mei in
Current site
Google Scholar
PubMed
Close
Restricted access

ABSTRACT.

Hemorrhagic fever with renal syndrome (HFRS) is an acute, natural focal disease worldwide. Bilateral subdural hematoma (BSH) is a rare occurrence in patients with HFRS. A 51-year-old man was admitted with fever, headache, lower back pain, and reduced urine volume. The patient was diagnosed with HFRS accompanied by BSH, as evidenced by IgM and IgG antibodies for hantavirus that were positive, and abnormal blood test results and computed tomographic head scan. He recovered and was discharged after symptomatic treatment. Hemorrhagic fever with renal syndrome might present rare clinical manifestations with BSH. The early identification of this condition is crucial to an improved prognosis.

Author Notes

Financial support: This study was supported by the Foundation of Hunan Science and Technology Department, Clinical Medical Technology Demonstration Base for Neurosurgery in Hunan Province (2018SK4003). The funding bodies had no role in the design of the study; in data collection, analysis, and interpretation; and in writing the manuscript.

Disclosures: This study was approved by the Ethics Committees of The First People’s Hospital of Changde City (2022-076-01). Written informed consent was obtained from the patient for the publication of this report. The data sets used and/or analyzed during the study are available from the corresponding author upon reasonable request.

Authors’ addresses: Wei Xiao, Yanli Tang, Lie Chen, Zheyong Jia, and Tao Mei, Department of Neurosurgical Care Unit, The First People’s Hospital of Changde City, Changde, China, E-mails: xiaoweihn@163.com, yazixiangjiao@163.com, chenlie20062007@126.com, 19173605610m@sina.cn, and yilan1008@sina.com.

Address correspondence to Tao Mei, Department of Neurosurgical Care Unit, The First People’s Hospital of Changde City, 818 Renmin Road, Changde, Hunan Province 415003, China. E-mail: yilan1008@sina.com
  • 1.

    Fan X , Deng H , Sang J , Li N , Zhang X , Han Q , Liu Z , 2018. High serum procalcitonin concentrations in patients with hemorrhagic fever with renal syndrome caused by Hantaan virus. Front Cell Infect Microbiol 8: 129.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Li S , Zhu L , Zhang L , Zhang G , Ren H , Lu L , 2023. Urbanization-related environmental factors and hemorrhagic fever with renal syndrome: a review based on studies taken in China. Int J Environ Res Public Health 20: 3328.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Liu HN et al., 2014. Time-specific ecologic niche models forecast the risk of hemorrhagic fever with renal syndrome in Dongting Lake district, China, 2005–2010. PLoS One 9: e106839.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4.

    Romero MG , Anjum F , 2022. Hemorrhagic Fever Renal Syndrome. Available at: https://www.ncbi.nlm.nih.gov/books/NBK560660/. Accessed October 11, 2023.

    • PubMed
    • Export Citation
  • 5.

    Sun L , Zou LX , 2018. Spatiotemporal analysis and forecasting model of hemorrhagic fever with renal syndrome in mainland China. Epidemiol Infect 146: 16801688.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Liu J et al., 2012. Genetic analysis of hantaviruses and their rodent hosts in central-south China. Virus Res 163: 439447.

  • 7.

    Liang W et al., 2018. Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005–2016. Sci Rep 8: 749.

  • 8.

    Yang ZQ et al., 2004. Prevalence of hemorrhagic fever with renal syndrome virus in domestic pigs: an epidemiological investigation in Shandong province. J First Mil Med Univ 24: 12831286 [in Chinese].

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Jiang H , Zheng X , Wang L , Du H , Wang P , Bai X , 2017. Hantavirus infection: a global zoonotic challenge. Virol Sin 32: 3243.

  • 10.

    Wang X et al., 2020. A case-control study on the risk factors for hemorrhagic fever with renal syndrome. BMC Infect Dis 20: 103.

  • 11.

    Xie D , Xu W , Xian Y , Yuan X , Huang Z , You J , Bi X , 2021. Rare case of intracranial hemorrhage associated with seoul virus infection diagnosed by metagenomic next-generation sequencing. J Clin Lab Anal 35: e23616.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Jiang H , Du H , Wang LM , Wang PZ , Bai XF , 2016. Hemorrhagic fever with renal syndrome: pathogenesis and clinical picture. Front Cell Infect Microbiol 6: 1.

  • 13.

    Alexeyev OA, Morozov VG,1995. Neurological manifestations of hemorrhagic fever with renal syndrome caused by Puumala virus: review of 811 cases. Clin Infect Dis 20:255–8.

    • PubMed
    • Export Citation
  • 14.

    Hautala T et al., 2010. Central nervous system-related symptoms and findings are common in acute Puumala hantavirus infection. Ann Med 42: 344351.

  • 15.

    Cohen MS , Kwei HE , Chin CC , Ge HC , 1983. CNS manifestations of epidemic hemorrhagic fever: an advanced manifestation of disease associated with poor prognosis. Arch Intern Med 143: 20702072.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Avšič-Županc T , Saksida A , Korva M , 2019. Hantavirus infections. Clin Microbiol Infect 21S: e6e16.

Past two years Past Year Past 30 Days
Abstract Views 2537 2537 72
Full Text Views 50 50 1
PDF Downloads 48 48 1
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save