ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Ribas R , Lima AASd , 2017. Oral ulcers induced by cytomegalovirus infection: report on two cases. J Dent Indones 24: 50–54.
-
2.
Mary EO , Abiola OA , Titilola G , Mojirayo OO , Sulaimon AA , 2018. Prevalence of HIV related oral lesions in people living with HIV and on combined antiretroviral therapy: a Nigerian experience. Pan Afr Med J 31: 180.
-
3.
Felix DH , Luker J , Scully C , 2012. Oral medicine: 1. Ulcers: aphthous and other common ulcers. Dent Update 39: 513–519.
-
4.
Ozaki T , Yamashita H , Kaneko S , Yorifuji H , Takahashi H , Ueda Y , Takahashi Y , Kaneko H , Kano T , Mimori A , 2013. Cytomegalovirus disease of the upper gastrointestinal tract in patients with rheumatic diseases: a case series and literature review. Clin Rheumatol 32: 1683–1690.
-
5.
Jacobson MA , Mills J , 1988. Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS). Clinical findings, diagnosis, and treatment. Ann Intern Med 108: 585–594.
-
6.
Xiao J , Gao G , Li Y , Zhang W , Tian Y , Huang Y , Su W , Han N , Yang D , Zhao H , 2013. Spectrums of opportunistic infections and malignancies in HIV-infected patients in tertiary care hospital, China. PLoS One 8: e75915.
-
7.
Gerna G , Baldanti F , Revello MG , 2004. Pathogenesis of human cytomegalovirus infection and cellular targets. Hum Immunol 65: 381–386.
-
8.
Jordan MC , 1983. Latent infection and the elusive cytomegalovirus. Rev Infect Dis 5: 205–215.
-
9.
Jabs DA , Van Natta ML , Kempen JH , Reed Pavan P , Lim JI , Murphy RL , Hubbard LD , 2002. Characteristics of patients with cytomegalovirus retinitis in the era of highly active antiretroviral therapy. Am J Ophthalmol 133: 48–61.
-
10.
Clinicalinfo , 2021. Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV. Available at: https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/cytomegalovirus?view=full. Accessed July 4, 2022.
-
11.
Sato S , Takahashi M , Takahashi T , 2020. A case of cytomegalovirus-induced oral ulcer in an older adult patient with nephrotic syndrome due to membranous nephropathy. Case Rep Dent 2020: 8843816.
-
12.
Dodd CL , Winkler JR , Heinic GS , Daniels TE , Yee K , Greenspan D , 1993. Cytomegalovirus infection presenting as acute periodontal infection in a patient infected with the human immunodeficiency virus. J Clin Periodontol 20: 282–285.
-
13.
Reichart PA , 1997. Oral ulcerations in HIV infection. Oral Dis 3 (Suppl 1):S180–S182.
-
14.
Tognetti L , Cinotti E , Tripodi S , Garosi G , Rubegni P , 2017. Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis and muco-cutaneous lesions. Int J STD AIDS 29: 410–413.
-
15.
Zhao M , Zhuo C , Li Q , Liu L , 2020. Cytomegalovirus (CMV) infection in HIV/AIDS patients and diagnostic values of CMV-DNA detection across different sample types. Ann Palliat Med 9: 2710–2715.
-
16.
Theise ND , Conn M , Thung SN , 1993. Localization of cytomegalovirus antigens in liver allografts over time. Hum Pathol 24: 103–108.
-
17.
Schubert MM , Epstein JB , Lloid ME , Cooney E , 1993. Oral infections due to cytomegalovirus in immunocompromised patients. J Oral Pathol Med 22: 268–273.
-
18.
Heinic GS , Greenspan D , Greenspan JS , 1993. Oral CMV lesions and the HIV infected: early recognition can help prevent morbidity. J Am Dent Assoc 124: 99–105.
-
19.
Langford A , Kunze R , Timm H , Ruf B , Reichart P , 1990. Cytomegalovirus associated oral ulcerations in HIV-infected patients. J Oral Pathol Med 19: 71–76.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 3237 | 1463 | 32 |
| Full Text Views | 103 | 50 | 16 |
| PDF Downloads | 107 | 64 | 8 |
Case Report: Giant Oral Ulcers Attributed to Cytomegalovirus Infection in a Patient with AIDS
Jinli Liu
Jinli Liu
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;
Search for other papers by Jinli Liu in
Current site
Google Scholar
PubMed
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;
Search for other papers by Jinli Liu in
Current site
Google Scholar
PubMed
Yuting Tan
Yuting Tan
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;
Search for other papers by Yuting Tan in
Current site
Google Scholar
PubMed
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;
Search for other papers by Yuting Tan in
Current site
Google Scholar
PubMed
Shihui Song
Shihui Song
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Search for other papers by Shihui Song in
Current site
Google Scholar
PubMed
Search for other papers by Shihui Song in
Current site
Google Scholar
PubMed
Jie Liu
Jie Liu
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;
Search for other papers by Jie Liu in
Current site
Google Scholar
PubMed
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;
Search for other papers by Jie Liu in
Current site
Google Scholar
PubMed
Shi Zou
Shi Zou
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;
Search for other papers by Shi Zou in
Current site
Google Scholar
PubMed
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;
Search for other papers by Shi Zou in
Current site
Google Scholar
PubMed
Mingqi Luo
Mingqi Luo
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Search for other papers by Mingqi Luo in
Current site
Google Scholar
PubMed
Search for other papers by Mingqi Luo in
Current site
Google Scholar
PubMed
Wei Guo
Wei Guo
Department of Pathology, Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, China;
Pathology Department, Zhongnan Hospital of Wuhan University, Wuhan, China;
Search for other papers by Wei Guo in
Current site
Google Scholar
PubMed
Pathology Department, Zhongnan Hospital of Wuhan University, Wuhan, China;
Search for other papers by Wei Guo in
Current site
Google Scholar
PubMed
Ke Liang
Ke Liang
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;
Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, China
Search for other papers by Ke Liang in
Current site
Google Scholar
PubMed
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;
Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, China
Search for other papers by Ke Liang in
Current site
Google Scholar
PubMed
ABSTRACT.
Oral ulcers are often neglected in patients with AIDS. However, giant oral ulcers are uncommon and are usually suspected to be malignant lesions. Our study presents a case of giant ulcers in an AIDS patient that were initially suspected to be oral cancer. To assist with diagnosis, conventional microbiological tests, metagenomic next-generation sequencing, and a pathological examination were conducted on oral lesion biopsy specimens. The case was finally confirmed via hematoxylin-eosin staining and immunohistochemical staining to be a cytomegalovirus infection.
Author Notes
Financial support: The work was supported by funding from the
Authors’ addresses: Jinli Liu, Yuting Tan, Jie Liu, and Shi Zou, Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China, Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China, and Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China, E-mails: jliliu@yeah.net, 13122191353@163.com, liujiecarpediem@163.com, and zoushi321@163.com. Shihui Song and Mingqi Luo, Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China, E-mails: shsong2013@163.com and mingqiluo@163.com. Wei Guo, Department of Pathology, Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, China, and Pathology Department, Zhongnan Hospital of Wuhan University, Wuhan, China, E-mail: guowei@whu.edu.cn. Ke Liang, Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China, Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China, Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China, and Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, China, E-mail: keliang@whu.edu.cn.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Ribas R , Lima AASd , 2017. Oral ulcers induced by cytomegalovirus infection: report on two cases. J Dent Indones 24: 50–54.
-
2.
Mary EO , Abiola OA , Titilola G , Mojirayo OO , Sulaimon AA , 2018. Prevalence of HIV related oral lesions in people living with HIV and on combined antiretroviral therapy: a Nigerian experience. Pan Afr Med J 31: 180.
-
3.
Felix DH , Luker J , Scully C , 2012. Oral medicine: 1. Ulcers: aphthous and other common ulcers. Dent Update 39: 513–519.
-
4.
Ozaki T , Yamashita H , Kaneko S , Yorifuji H , Takahashi H , Ueda Y , Takahashi Y , Kaneko H , Kano T , Mimori A , 2013. Cytomegalovirus disease of the upper gastrointestinal tract in patients with rheumatic diseases: a case series and literature review. Clin Rheumatol 32: 1683–1690.
-
5.
Jacobson MA , Mills J , 1988. Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS). Clinical findings, diagnosis, and treatment. Ann Intern Med 108: 585–594.
-
6.
Xiao J , Gao G , Li Y , Zhang W , Tian Y , Huang Y , Su W , Han N , Yang D , Zhao H , 2013. Spectrums of opportunistic infections and malignancies in HIV-infected patients in tertiary care hospital, China. PLoS One 8: e75915.
-
7.
Gerna G , Baldanti F , Revello MG , 2004. Pathogenesis of human cytomegalovirus infection and cellular targets. Hum Immunol 65: 381–386.
-
8.
Jordan MC , 1983. Latent infection and the elusive cytomegalovirus. Rev Infect Dis 5: 205–215.
-
9.
Jabs DA , Van Natta ML , Kempen JH , Reed Pavan P , Lim JI , Murphy RL , Hubbard LD , 2002. Characteristics of patients with cytomegalovirus retinitis in the era of highly active antiretroviral therapy. Am J Ophthalmol 133: 48–61.
-
10.
Clinicalinfo , 2021. Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV. Available at: https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/cytomegalovirus?view=full. Accessed July 4, 2022.
-
11.
Sato S , Takahashi M , Takahashi T , 2020. A case of cytomegalovirus-induced oral ulcer in an older adult patient with nephrotic syndrome due to membranous nephropathy. Case Rep Dent 2020: 8843816.
-
12.
Dodd CL , Winkler JR , Heinic GS , Daniels TE , Yee K , Greenspan D , 1993. Cytomegalovirus infection presenting as acute periodontal infection in a patient infected with the human immunodeficiency virus. J Clin Periodontol 20: 282–285.
-
13.
Reichart PA , 1997. Oral ulcerations in HIV infection. Oral Dis 3 (Suppl 1):S180–S182.
-
14.
Tognetti L , Cinotti E , Tripodi S , Garosi G , Rubegni P , 2017. Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis and muco-cutaneous lesions. Int J STD AIDS 29: 410–413.
-
15.
Zhao M , Zhuo C , Li Q , Liu L , 2020. Cytomegalovirus (CMV) infection in HIV/AIDS patients and diagnostic values of CMV-DNA detection across different sample types. Ann Palliat Med 9: 2710–2715.
-
16.
Theise ND , Conn M , Thung SN , 1993. Localization of cytomegalovirus antigens in liver allografts over time. Hum Pathol 24: 103–108.
-
17.
Schubert MM , Epstein JB , Lloid ME , Cooney E , 1993. Oral infections due to cytomegalovirus in immunocompromised patients. J Oral Pathol Med 22: 268–273.
-
18.
Heinic GS , Greenspan D , Greenspan JS , 1993. Oral CMV lesions and the HIV infected: early recognition can help prevent morbidity. J Am Dent Assoc 124: 99–105.
-
19.
Langford A , Kunze R , Timm H , Ruf B , Reichart P , 1990. Cytomegalovirus associated oral ulcerations in HIV-infected patients. J Oral Pathol Med 19: 71–76.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 3237 | 1463 | 32 |
| Full Text Views | 103 | 50 | 16 |
| PDF Downloads | 107 | 64 | 8 |