Case Report: Giant Oral Ulcers Attributed to Cytomegalovirus Infection in a Patient with AIDS

Jinli Liu Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;

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Yuting Tan Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;

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Shihui Song Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;

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Jie Liu Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;

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Shi Zou Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;

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Mingqi Luo Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;

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Wei Guo Department of Pathology, Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, China;
Pathology Department, Zhongnan Hospital of Wuhan University, Wuhan, China;

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Ke Liang Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;
Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;
Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;
Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, China

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ABSTRACT.

Oral ulcers are often neglected in patients with AIDS. However, giant oral ulcers are uncommon and are usually suspected to be malignant lesions. Our study presents a case of giant ulcers in an AIDS patient that were initially suspected to be oral cancer. To assist with diagnosis, conventional microbiological tests, metagenomic next-generation sequencing, and a pathological examination were conducted on oral lesion biopsy specimens. The case was finally confirmed via hematoxylin-eosin staining and immunohistochemical staining to be a cytomegalovirus infection.

Author Notes

Financial support: The work was supported by funding from the non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences (Grant no. 2020-PT320-004).

Authors’ addresses: Jinli Liu, Yuting Tan, Jie Liu, and Shi Zou, Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China, Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China, and Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China, E-mails: jliliu@yeah.net, 13122191353@163.com, liujiecarpediem@163.com, and zoushi321@163.com. Shihui Song and Mingqi Luo, Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China, E-mails: shsong2013@163.com and mingqiluo@163.com. Wei Guo, Department of Pathology, Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, China, and Pathology Department, Zhongnan Hospital of Wuhan University, Wuhan, China, E-mail: guowei@whu.edu.cn. Ke Liang, Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China, Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China, Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China, and Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, China, E-mail: keliang@whu.edu.cn.

Address correspondence to Wei Guo, Department of Pathology, Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan 430071, China, E-mail: guowei@whu.edu.cn or Ke Liang, Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan 430071, China, E-mail: keliang@whu.edu.cn
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