ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Costa F , Hagan JE , Calcagno J , Kane M , Torgerson P , Martinez-Silveira MS , Stein C , Abela-Ridder B , Ko AI , 2015. Global morbidity and mortality of leptospirosis: a systematic review. PLoS Negl Trop Dis 9: e0003898.
-
2.
Smith S , Kennedy BJ , Dermedgoglou A , Poulgrain SS , Paavola MP , Minto TL , Luc M , Liu YH , Hanson J , 2019. A simple score to predict severe leptospirosis. PLoS Negl Trop Dis 13: e0007205.
-
3.
Smith S , Liu YH , Carter A , Kennedy BJ , Dermedgoglou A , Poulgrain SS , Paavola MP , Minto TL , Luc M , Hanson J , 2019. Severe leptospirosis in tropical Australia: optimising intensive care unit management to reduce mortality. PLoS Negl Trop Dis 13: e0007929.
-
4.
Mathew T , Satishchandra P , Mahadevan A , Nagarathna S , Yasha TC , Chandramukhi A , Subbakrishna DK , Shankar SK , 2006. Neuroleptospirosis – revisited: experience from a tertiary care neurological centre from south India. Indian J Med Res 124: 155–162.
-
5.
Panicker JN , Mammachan R , Jayakumar RV , 2001. Primary neuroleptospirosis. Postgrad Med J 77: 589–590.
-
6.
Fairhead LJ , Smith S , Sim BZ , Stewart AGA , Stewart JD , Binotto E , Law M , Hanson J , 2022. The seasonality of infections in tropical Far North Queensland, Australia: a 21-year retrospective evaluation of the seasonal patterns of six endemic pathogens. PLOS Glob Public Health 2: e0000506.
-
7.
Gora H , Smith S , Wilson I , Preston-Thomas A , Ramsamy N , Hanson J , 2022. The epidemiology and outcomes of central nervous system infections in Far North Queensland, tropical Australia; 2000–2019. PLoS One 17: e0265410.
-
8.
Australian Government, Department of Health and Aged Care. 2007. Leptospirosis – Laboratory Case Definition. Available at: https://www.health.gov.au/resources/publications/leptospirosis-laboratory-case-definition. Accessed June 22, 2023.
-
9.
Samrot AV , Sean TC , Bhavya KS , Sahithya CS , Chan-Drasekaran S , Palanisamy R , Robinson ER , Subbiah SK , Mok PL , 2021. Leptospiral infection, pathogenesis and its diagnosis – a review. Pathogens 10: 145.
-
10.
Adler B, ed., 2015. Current topics in microbiology and immunology. Leptospira and Leptospirosis. Berlin/Heidelberg, Germany: Springer.
-
11.
Salaveria K , Smith S , Liu YH , Bagshaw R , Ott M , Stewart A , Law M , Carter A , Hanson J , 2021. The applicability of commonly used severity of illness scores to tropical infections in Australia. Am J Trop Med Hyg 106: 257–267.
-
12.
Chiappe-Gonzalez AJ , Ticona-Huaroto C , Hoerster V , Coral-Gonzales C , Sihuincha-Maldonado M , 2017. Primary neuroleptospirosis: a case report and literature review. Infect Dis Clin Pract 77: 589–590.
-
13.
Saeed N , Khoo CS , Remli R , Law ZK , Periyasamy P , Osman SS , Tan HJ , 2018. First reported case of neuroleptospirosis complicated with Anton’s syndrome. Front Neurol 9: 966.
-
14.
Singh R , Khurana D , Mehta S , Choudhary A , Petluri G , Lal V , 2016. Cerebellar ataxia due to Leptospirosis – a case report. BMC Infect Dis 16: 748.
-
15.
Cadavid D , 2010. Spirochetal infections. Handb Clin Neurol 96: 179–219.
-
16.
Mahesh MMM , Shivanagappa MMM , Venkatesh CRMM , 2015. Bilateral abducent palsy in leptospirosis – an eye opener to a rare neuro ocular manifestation: a case report. Iran J Med Sci 40: 544–547.
-
17.
El Bouazzaoui A , Houari N , Arika A , Belhoucine I , Boukatta B , Sbai H , El Alami N , Kanjaa N , 2011. Facial palsy associated with leptospirosis. Eur Ann Otorhinolaryngol Head Neck Dis 128: 275–277.
-
18.
Silva AA , Ducroquet M , Pedrozo JC Jr. , 2009. Bilateral facial palsy associated with leptospirosis. Braz J Infect Dis 13: 319–321.
-
19.
De Brito T , Silva A , Abreu PAE , 2018. Pathology and pathogenesis of human leptospirosis: a commented review. Rev Inst Med Trop São Paulo 60: e23.
-
20.
Cagliero J , Villanueva S , Matsui M , 2018. Leptospirosis pathophysiology: into the storm of cytokines. Front Cell Infect Microbiol 8: 204.
-
21.
Yang B , de Vries SG , Ahmed A , Visser BJ , Nagel IM , Spijker R , Grobusch MP , Hartskeerl RA , Goris MG , Leeflang MM , 2019. Nucleic acid and antigen detection tests for leptospirosis. Cochrane Database Syst Rev 8: CD011871.
-
22.
Wilson MR et al., 2014. Actionable diagnosis of neuroleptospirosis by next-generation sequencing. N Engl J Med 370: 2408–2417.
-
23.
Saver JL , 2006. Time is brain – quantified. Stroke 37: 263–266.
-
24.
Nau R , Sorgel F , Eiffert H , 2010. Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Clin Microbiol Rev 23: 858–883.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 4327 | 1387 | 217 |
| Full Text Views | 85 | 38 | 1 |
| PDF Downloads | 106 | 37 | 0 |
Case Report: Leptospirosis Complicated by Persistent, Bilateral Sensorineural Hearing Loss
Stuart Campbell
Stuart Campbell
Division of Medicine, Cairns Hospital, Cairns, Australia;
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James Stewart
James Stewart
Division of Medicine, Cairns Hospital, Cairns, Australia;
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Gavin Quail
Gavin Quail
Department of Surgery, Cairns Hospital, Cairns, Australia;
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Grant Withey
Grant Withey
Department of Radiology, Cairns Hospital, Cairns, Australia;
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Simon Smith
Simon Smith
Division of Medicine, Cairns Hospital, Cairns, Australia;
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Josh Hanson
Josh Hanson
Division of Medicine, Cairns Hospital, Cairns, Australia;
The Kirby Institute, University of New South Wales, Sydney, Australia
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The Kirby Institute, University of New South Wales, Sydney, Australia
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ABSTRACT.
The clinical manifestations of leptospirosis range from mild to life-threatening and can impact on multiple organ systems. A wide array of neurological manifestations of leptospirosis have been reported, although the pathophysiology of neuroleptospirosis remains incompletely understood. We present a case of leptospirosis complicated by bilateral sensorineural deafness, with nodular meningitis demonstrated in the internal auditory meatus on magnetic resonance imaging. The patient was treated with doxycycline, ceftriaxone, systemic and topical steroids, and hyperbaric oxygen therapy, with modest, but incomplete, improvement.
Author Notes
Authors’ addresses: Stuart Campbell, James Stewart, and Simon Smith, Department of Medicine, Cairns Hospital, Cairns, Australia, E-mails: stuartc345@gmail.com, james.stewart7@health.qld.gov.au, and simon.smith2@health.qld.gov.au. Gavin Quail, Department of Surgery, Cairns Hospital, Cairns, Australia, E-mail: gavin.quail@health.qld.gov.au. Grant Withey, Department of Radiology, Cairns Hospital, Cairns, Australia, E-mail: grant.withey@health.qld.gov.au. Josh Hanson, Department of Medicine, Cairns Hospital, Cairns, Australia, and The Kirby Institute, University of New South Wales, Sydney, Australia, E-mail: jhanson@kirby.unsw.edu.au.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Costa F , Hagan JE , Calcagno J , Kane M , Torgerson P , Martinez-Silveira MS , Stein C , Abela-Ridder B , Ko AI , 2015. Global morbidity and mortality of leptospirosis: a systematic review. PLoS Negl Trop Dis 9: e0003898.
-
2.
Smith S , Kennedy BJ , Dermedgoglou A , Poulgrain SS , Paavola MP , Minto TL , Luc M , Liu YH , Hanson J , 2019. A simple score to predict severe leptospirosis. PLoS Negl Trop Dis 13: e0007205.
-
3.
Smith S , Liu YH , Carter A , Kennedy BJ , Dermedgoglou A , Poulgrain SS , Paavola MP , Minto TL , Luc M , Hanson J , 2019. Severe leptospirosis in tropical Australia: optimising intensive care unit management to reduce mortality. PLoS Negl Trop Dis 13: e0007929.
-
4.
Mathew T , Satishchandra P , Mahadevan A , Nagarathna S , Yasha TC , Chandramukhi A , Subbakrishna DK , Shankar SK , 2006. Neuroleptospirosis – revisited: experience from a tertiary care neurological centre from south India. Indian J Med Res 124: 155–162.
-
5.
Panicker JN , Mammachan R , Jayakumar RV , 2001. Primary neuroleptospirosis. Postgrad Med J 77: 589–590.
-
6.
Fairhead LJ , Smith S , Sim BZ , Stewart AGA , Stewart JD , Binotto E , Law M , Hanson J , 2022. The seasonality of infections in tropical Far North Queensland, Australia: a 21-year retrospective evaluation of the seasonal patterns of six endemic pathogens. PLOS Glob Public Health 2: e0000506.
-
7.
Gora H , Smith S , Wilson I , Preston-Thomas A , Ramsamy N , Hanson J , 2022. The epidemiology and outcomes of central nervous system infections in Far North Queensland, tropical Australia; 2000–2019. PLoS One 17: e0265410.
-
8.
Australian Government, Department of Health and Aged Care. 2007. Leptospirosis – Laboratory Case Definition. Available at: https://www.health.gov.au/resources/publications/leptospirosis-laboratory-case-definition. Accessed June 22, 2023.
-
9.
Samrot AV , Sean TC , Bhavya KS , Sahithya CS , Chan-Drasekaran S , Palanisamy R , Robinson ER , Subbiah SK , Mok PL , 2021. Leptospiral infection, pathogenesis and its diagnosis – a review. Pathogens 10: 145.
-
10.
Adler B, ed., 2015. Current topics in microbiology and immunology. Leptospira and Leptospirosis. Berlin/Heidelberg, Germany: Springer.
-
11.
Salaveria K , Smith S , Liu YH , Bagshaw R , Ott M , Stewart A , Law M , Carter A , Hanson J , 2021. The applicability of commonly used severity of illness scores to tropical infections in Australia. Am J Trop Med Hyg 106: 257–267.
-
12.
Chiappe-Gonzalez AJ , Ticona-Huaroto C , Hoerster V , Coral-Gonzales C , Sihuincha-Maldonado M , 2017. Primary neuroleptospirosis: a case report and literature review. Infect Dis Clin Pract 77: 589–590.
-
13.
Saeed N , Khoo CS , Remli R , Law ZK , Periyasamy P , Osman SS , Tan HJ , 2018. First reported case of neuroleptospirosis complicated with Anton’s syndrome. Front Neurol 9: 966.
-
14.
Singh R , Khurana D , Mehta S , Choudhary A , Petluri G , Lal V , 2016. Cerebellar ataxia due to Leptospirosis – a case report. BMC Infect Dis 16: 748.
-
15.
Cadavid D , 2010. Spirochetal infections. Handb Clin Neurol 96: 179–219.
-
16.
Mahesh MMM , Shivanagappa MMM , Venkatesh CRMM , 2015. Bilateral abducent palsy in leptospirosis – an eye opener to a rare neuro ocular manifestation: a case report. Iran J Med Sci 40: 544–547.
-
17.
El Bouazzaoui A , Houari N , Arika A , Belhoucine I , Boukatta B , Sbai H , El Alami N , Kanjaa N , 2011. Facial palsy associated with leptospirosis. Eur Ann Otorhinolaryngol Head Neck Dis 128: 275–277.
-
18.
Silva AA , Ducroquet M , Pedrozo JC Jr. , 2009. Bilateral facial palsy associated with leptospirosis. Braz J Infect Dis 13: 319–321.
-
19.
De Brito T , Silva A , Abreu PAE , 2018. Pathology and pathogenesis of human leptospirosis: a commented review. Rev Inst Med Trop São Paulo 60: e23.
-
20.
Cagliero J , Villanueva S , Matsui M , 2018. Leptospirosis pathophysiology: into the storm of cytokines. Front Cell Infect Microbiol 8: 204.
-
21.
Yang B , de Vries SG , Ahmed A , Visser BJ , Nagel IM , Spijker R , Grobusch MP , Hartskeerl RA , Goris MG , Leeflang MM , 2019. Nucleic acid and antigen detection tests for leptospirosis. Cochrane Database Syst Rev 8: CD011871.
-
22.
Wilson MR et al., 2014. Actionable diagnosis of neuroleptospirosis by next-generation sequencing. N Engl J Med 370: 2408–2417.
-
23.
Saver JL , 2006. Time is brain – quantified. Stroke 37: 263–266.
-
24.
Nau R , Sorgel F , Eiffert H , 2010. Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Clin Microbiol Rev 23: 858–883.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 4327 | 1387 | 217 |
| Full Text Views | 85 | 38 | 1 |
| PDF Downloads | 106 | 37 | 0 |