β-Blockers in Hepatosplenic Schistosomiasis: A Narrative Review

Fernanda Alves Gelape Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;

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Claudia Alves Couto Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;

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Guilherme Grossi Lopes Cançado Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;
Hospital da Polícia Militar de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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ABSTRACT.

Hepatosplenic schistosomiasis (HSS) is a serious complication of chronic schistosomiasis that can result in portal hypertension and variceal bleeding. β-blockers, a class of medications commonly used to treat hypertension and other cardiovascular conditions, have been investigated for their potential use in preventing variceal bleeding in HSS. Several studies have shown that β-blockers can reduce portal pressure and prevent variceal bleeding effectively in these patients. However, there are limited data on the long-term efficacy and safety of β-blockers in this setting, and further research is needed to determine the optimal use of these medications. This review summarizes the evidence supporting current recommendations of β-blocker use in patients with HSS.

Author Notes

Financial support: We acknowledge the financial support of the Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais.

Authors’ addresses: Fernanda Gelape, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, E-mail: fernandagelape@hotmail.com. Claudia Alves Couto, Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, E-mail: clalcouto@gmail.com. Guilherme Grossi Lopes Cançado, Hospital das Clínicas da Universidade Federal de Minas Gerais, and Hospital da Polícia Militar de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, E-mail: guilhermegrossi@terra.com.br.

Address correspondence to Fernanda Alves Gelape, Instituto Alfa de Gastroenterologia, Avenida Professor Alfredo Balena, 110, 2° andar, Belo Horizonte, Minas Gerais, Brazil. E-mail: fernandagelape@hotmail.com
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