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RefWorks
Reference Manager
BibTeX
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-
1.
Rajshekhar V, 2018. Evolution of concepts in the management of cysticercosis of the brain: then (1970) and now (2018). Neurol India 66: 919–927.
-
2.
Abraham A et al., 2021. The effectiveness of anti-inflammatory and anti-seizure medication for individuals with single enhancing lesion neurocysticercosis: a meta-analysis and expert group-based consensus recommendations. PLoS Negl Trop Dis 15: e0009193.
-
3.
Garg RK, Malhotra HS, 2012. Solitary cysticercus granuloma. Expert Rev Anti Infect Ther 10: 597–612.
-
4.
Rajshekhar V, Chandy MJ, 1997. Validation of diagnostic criteria for solitary cerebral cysticercus granuloma in patients presenting with seizures. Acta Neurol Scand 96: 76–81.
-
5.
Carpio A et al., 2016. New diagnostic criteria for neurocysticercosis: reliability and validity. Ann Neurol 80: 434–442.
-
6.
Del Brutto OH, Nash TE, White AC Jr, Rajshekhar V, Wilkins PP, Singh G, Vasquez CM, Salgado P, Gilman RH, Garcia HH, 2017. Revised diagnostic criteria for neurocysticercosis. J Neurol Sci 372: 202–210.
-
7.
Rajshekhar V, 2001. Rate of spontaneous resolution of a solitary cysticercus granuloma in patients with seizures. Neurology 57: 2315–2317.
-
8.
Garcia HH, Nash TE, Del Brutto OH, 2014. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 13: 1202–1215.
-
9.
Lalla RS, Garg RK, Malhotra HS, Jain A, Verma R, Pandey CM, Singh GP, Sharma PK, 2015. Cytokines, MMP-2, and MMP-9 levels in patients with a solitary cysticercus granuloma. Neurol India 63: 190–196.
-
10.
Rajshekhar V, Chacko G, Haran RP, Chandy MJ, Chandi SM, 1995. Clinicoradiological and pathological correlations in patients with solitary cysticercus granuloma and epilepsy: focus on presence of the parasite and oedema formation. J Neurol Neurosurg Psychiatry 59: 284–286.
-
11.
Prabhakaran V, Drevets DA, Ramajayam G, Manoj JJ, Anderson MP, Hanas JS, Rajshekhar V, Oommen A, Carabin H, 2017. Comparison of monocyte gene expression among patients with neurocysticercosis-associated epilepsy, idiopathic epilepsy and idiopathic headaches in India. PLoS Negl Trop Dis 11: e0005664.
-
12.
Pamela BE et al., 2021. Monocyte gene expression distinguishes enhancing brain parenchymal cysticercal granulomas from tuberculomas. Open Forum Infect Dis 8: ofab427.
-
13.
Rajshekhar V, Chandy MJ, 1996. Comparative study of CT and MRI in patients with seizures and a solitary cerebral cysticercus granuloma. Neuroradiology 38: 542–546.
-
14.
Schmittgen TD, Livak KJ, 2008. Analyzing real-time PCR data by the comparative C T method. Nat Protoc 3: 1101–1108.
-
15.
Fleury A, Hernández M, Fragoso G, Parkhouse RM, Harrison LJ, Sciutto E, 2003. Detection of secreted cysticercal antigen: a useful tool in the diagnosis of inflammatory neurocysticercosis. Trans R Soc Trop Med Hyg 97: 542–546.
-
16.
Nash TE, Bustos JA, Garcia HH, for The Cysticercosis Working Group in Perú , 2017. Disease centered around calcified Taenia solium granuloma. Trends Parasitol 33: 65–73.
-
17.
Herrick JA et al., 2018. Inflammation is a key risk factor for persistent seizures in neurocysticercosis. Ann Clin Transl Neurol 5: 630–639.
-
18.
Shembade N, Harhaj NS, Liebl DJ, Harhaj EW, 2007. Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. EMBO J 26: 3910–3922.
-
19.
Waidmann O et al., 2020. Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis. Sci Rep 10: 16264.
-
20.
Kapoor T, Corrado M, Pearce EL, Grosschedl R, 2020. MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells. Sci Rep 10: 21626.
-
21.
Xiong E et al., 2019. MZB1 promotes the secretion of J-chain-containing dimeric IgA and is critical for the suppression of gut inflammation. Proc Natl Acad Sci USA 116: 13480–13489.
-
22.
Suzuki K, Vogelzang A, Fagarasan S, 2019. MZB1 folding and unfolding the role of IgA. Proc Natl Acad Sci USA 116: 13163–13165.
-
23.
Prabhakaran V, Rajshekhar V, Murrell KD, Oommen A, 2004. Taenia solium metacestode glycoproteins as diagnostic antigens for solitary cysticercus granuloma in Indian patients. Trans R Soc Trop Med Hyg 98: 478–484.
-
24.
Garcia HH, O’Neal SE, Noh J, Handali S, for The Cysticercosis Working Group in Peru , 2018. Laboratory diagnosis of neurocysticercosis (Taenia solium). J Clin Microbiol 56: e00424–e18.
-
25.
Vasudevan P et al., 2022. Imaging correlates of serum enzyme-linked immunoelectrotransfer blot (EITB) positivity in patients with parenchymal neurocysticercosis: results from 521 patients. Trans R Soc Trop Med Hyg 116: 117–123.
-
26.
Garcia HH, Parkhouse RME, Gilman RH, Montenegro T, Bernal T, Martinez SM, Gonzalez AE, Tsang VCW, Harrison LJS, for The Cysticercosis Working Group in Peru , 2000. Serum antigen detection in the diagnosis, treatment, and follow-up of neurocysticercosis patients. Trans R Soc Trop Med Hyg 94: 673–676.
-
27.
Brandt JRA, Geerts S, De Deken R, Kumar V, Ceulemans F, Brijis L, Falla N, 1992. A monoclonal antibody-based ELISA for the detection of circulating excretory-secretory antigens in Taenia saginata cysticercosis. Int J Parasitol 22: 471–477.
-
28.
Rodriguez S, Wilkins P, Dorny P, 2012. Immunological and molecular diagnosis of cysticercosis. Pathog Glob Health 106: 286–298.
-
29.
Jin J, Yu Q, Han C, Hu X, Xu S, Wang Q, Wang J, Li N, Cao X, 2013. LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition. Nat Commun 4: 2075.
-
30.
Dai P, Jeong SY, Yu Y, Leng T, Wu X, Xie L, Chen X, 2009. Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. J Immunol 182: 3450–3460.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1984 | 919 | 305 |
| Full Text Views | 156 | 91 | 5 |
| PDF Downloads | 151 | 96 | 16 |
Correlation between Monocyte Gene Expression and Inflammation on Brain Imaging in Patients with Solitary Cerebral Cysticercus Granuloma
Betcy Evangeline Pamela
Betcy Evangeline Pamela
Department of Neurological Sciences, Christian Medical College, Vellore, India;
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Subashini Thamizhmaran
Subashini Thamizhmaran
Department of Neurological Sciences, Christian Medical College, Vellore, India;
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Josephin Manoj
Josephin Manoj
Department of Neurological Sciences, Christian Medical College, Vellore, India;
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Anupriya Thanigachalam
Anupriya Thanigachalam
Department of Neurological Sciences, Christian Medical College, Vellore, India;
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Hélène Carabin
Hélène Carabin
Department of Pathology and Microbiology, University of Montreal, Canada;
Department of Social and Preventive Medicine, University of Montreal, Canada;
Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;
Centre de Recherche en Santé Publique (CReSP), Montreal, Canada;
Groupe de Recherche en Épidémiologie des Zoonoses et Santé Publique (GREZOSP), Saint-Hyacinthe, Canada;
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Department of Social and Preventive Medicine, University of Montreal, Canada;
Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;
Centre de Recherche en Santé Publique (CReSP), Montreal, Canada;
Groupe de Recherche en Épidémiologie des Zoonoses et Santé Publique (GREZOSP), Saint-Hyacinthe, Canada;
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Vasudevan Prabhakaran
Vasudevan Prabhakaran
Department of Neurological Sciences, Christian Medical College, Vellore, India;
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Ranjith K. Moorthy
Ranjith K. Moorthy
Department of Neurological Sciences, Christian Medical College, Vellore, India;
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Anna Oommen
Anna Oommen
Gudalur Adivasi Hospital, Gudalur, India;
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Douglas A. Drevets
Douglas A. Drevets
Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
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Vedantam Rajshekhar
Vedantam Rajshekhar
Department of Neurological Sciences, Christian Medical College, Vellore, India;
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ABSTRACT.
Prior work has shown that 14 monocyte genes are upregulated in patients with different forms of parenchymal neurocysticercosis, including solitary cysticercus granuloma (SCG). The aim of this study was to investigate whether changes in inflammation associated with SCG seen on follow-up brain imaging are also reflected in changes in expression of these 14 genes. Peripheral blood CD14+ monocytes were isolated from 20 patients with SCG at initial diagnosis and at clinical and imaging follow-up of 6 months or more. Expressions of 14 target monocyte genes were determined by quantitative polymerase chain reaction at each visit. At a median follow-up of 14 months, the SCG had resolved in 11 patients, was persistent in four patients, and had calcified in five patients. Edema seen in the initial imaging in 17 patients had resolved in 15 patients and was markedly reduced in two patients. The expression levels of the monocyte genes LRRFIP2, TAXIBP1, and MZB1 were significantly lower at follow-up, regardless of the status of SCG on follow-up imaging. Our findings show that expression levels of monocyte genes involved with inflammatory processes decrease in patients with SCG concomitant with follow-up imaging that reveals a reduction in inflammation as revealed by complete or near-complete resolution of edema, as well as resolution or reduction in the enhancement of the granuloma.
Author Notes
Financial support: This study was supported by a grant from the
Authors’ addresses: Betcy Evangeline Pamela, Subashini Thamizhmaran, Josephin Manoj, Anupriya Thanigachalam, Vasudevan Prabhakaran, Ranjith K. Moorthy, and Vedantam Rajshekhar, Department of Neurological Sciences, Christian Medical College, Vellore, India, E-mails: betcyevangeline07@gmail.com, subatamil96@gmail.com, josephinjustinbabu86@gmail.com, anutc91@gmail.com, prabhakaran@cmcvellore.ac.in, ranjith@cmcvellore.ac.in, and rajshekhar@cmcvellore.ac.in. Hélène Carabin, Department of Pathology and Microbiology and Department of Social and Preventive Medicine, University of Montreal, Montreal, Canada, Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, Centre de Recherche en Santé Publique (CReSP), Montreal, Canada, and Groupe de Recherche en Épidémiologie des Zoonoses et Santé Publique (GREZOSP), Saint-Hyacinthe, Canada, E-mail: helene.carabin@umontreal.ca. Anna Oommen, Gudalur Adivasi Hospital, Gudalur, India, E-mail: annasoommen@gmail.com. Douglas A. Drevets, Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, E-mail: Douglas-Drevets@ouhsc.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Rajshekhar V, 2018. Evolution of concepts in the management of cysticercosis of the brain: then (1970) and now (2018). Neurol India 66: 919–927.
-
2.
Abraham A et al., 2021. The effectiveness of anti-inflammatory and anti-seizure medication for individuals with single enhancing lesion neurocysticercosis: a meta-analysis and expert group-based consensus recommendations. PLoS Negl Trop Dis 15: e0009193.
-
3.
Garg RK, Malhotra HS, 2012. Solitary cysticercus granuloma. Expert Rev Anti Infect Ther 10: 597–612.
-
4.
Rajshekhar V, Chandy MJ, 1997. Validation of diagnostic criteria for solitary cerebral cysticercus granuloma in patients presenting with seizures. Acta Neurol Scand 96: 76–81.
-
5.
Carpio A et al., 2016. New diagnostic criteria for neurocysticercosis: reliability and validity. Ann Neurol 80: 434–442.
-
6.
Del Brutto OH, Nash TE, White AC Jr, Rajshekhar V, Wilkins PP, Singh G, Vasquez CM, Salgado P, Gilman RH, Garcia HH, 2017. Revised diagnostic criteria for neurocysticercosis. J Neurol Sci 372: 202–210.
-
7.
Rajshekhar V, 2001. Rate of spontaneous resolution of a solitary cysticercus granuloma in patients with seizures. Neurology 57: 2315–2317.
-
8.
Garcia HH, Nash TE, Del Brutto OH, 2014. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 13: 1202–1215.
-
9.
Lalla RS, Garg RK, Malhotra HS, Jain A, Verma R, Pandey CM, Singh GP, Sharma PK, 2015. Cytokines, MMP-2, and MMP-9 levels in patients with a solitary cysticercus granuloma. Neurol India 63: 190–196.
-
10.
Rajshekhar V, Chacko G, Haran RP, Chandy MJ, Chandi SM, 1995. Clinicoradiological and pathological correlations in patients with solitary cysticercus granuloma and epilepsy: focus on presence of the parasite and oedema formation. J Neurol Neurosurg Psychiatry 59: 284–286.
-
11.
Prabhakaran V, Drevets DA, Ramajayam G, Manoj JJ, Anderson MP, Hanas JS, Rajshekhar V, Oommen A, Carabin H, 2017. Comparison of monocyte gene expression among patients with neurocysticercosis-associated epilepsy, idiopathic epilepsy and idiopathic headaches in India. PLoS Negl Trop Dis 11: e0005664.
-
12.
Pamela BE et al., 2021. Monocyte gene expression distinguishes enhancing brain parenchymal cysticercal granulomas from tuberculomas. Open Forum Infect Dis 8: ofab427.
-
13.
Rajshekhar V, Chandy MJ, 1996. Comparative study of CT and MRI in patients with seizures and a solitary cerebral cysticercus granuloma. Neuroradiology 38: 542–546.
-
14.
Schmittgen TD, Livak KJ, 2008. Analyzing real-time PCR data by the comparative C T method. Nat Protoc 3: 1101–1108.
-
15.
Fleury A, Hernández M, Fragoso G, Parkhouse RM, Harrison LJ, Sciutto E, 2003. Detection of secreted cysticercal antigen: a useful tool in the diagnosis of inflammatory neurocysticercosis. Trans R Soc Trop Med Hyg 97: 542–546.
-
16.
Nash TE, Bustos JA, Garcia HH, for The Cysticercosis Working Group in Perú , 2017. Disease centered around calcified Taenia solium granuloma. Trends Parasitol 33: 65–73.
-
17.
Herrick JA et al., 2018. Inflammation is a key risk factor for persistent seizures in neurocysticercosis. Ann Clin Transl Neurol 5: 630–639.
-
18.
Shembade N, Harhaj NS, Liebl DJ, Harhaj EW, 2007. Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. EMBO J 26: 3910–3922.
-
19.
Waidmann O et al., 2020. Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis. Sci Rep 10: 16264.
-
20.
Kapoor T, Corrado M, Pearce EL, Grosschedl R, 2020. MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells. Sci Rep 10: 21626.
-
21.
Xiong E et al., 2019. MZB1 promotes the secretion of J-chain-containing dimeric IgA and is critical for the suppression of gut inflammation. Proc Natl Acad Sci USA 116: 13480–13489.
-
22.
Suzuki K, Vogelzang A, Fagarasan S, 2019. MZB1 folding and unfolding the role of IgA. Proc Natl Acad Sci USA 116: 13163–13165.
-
23.
Prabhakaran V, Rajshekhar V, Murrell KD, Oommen A, 2004. Taenia solium metacestode glycoproteins as diagnostic antigens for solitary cysticercus granuloma in Indian patients. Trans R Soc Trop Med Hyg 98: 478–484.
-
24.
Garcia HH, O’Neal SE, Noh J, Handali S, for The Cysticercosis Working Group in Peru , 2018. Laboratory diagnosis of neurocysticercosis (Taenia solium). J Clin Microbiol 56: e00424–e18.
-
25.
Vasudevan P et al., 2022. Imaging correlates of serum enzyme-linked immunoelectrotransfer blot (EITB) positivity in patients with parenchymal neurocysticercosis: results from 521 patients. Trans R Soc Trop Med Hyg 116: 117–123.
-
26.
Garcia HH, Parkhouse RME, Gilman RH, Montenegro T, Bernal T, Martinez SM, Gonzalez AE, Tsang VCW, Harrison LJS, for The Cysticercosis Working Group in Peru , 2000. Serum antigen detection in the diagnosis, treatment, and follow-up of neurocysticercosis patients. Trans R Soc Trop Med Hyg 94: 673–676.
-
27.
Brandt JRA, Geerts S, De Deken R, Kumar V, Ceulemans F, Brijis L, Falla N, 1992. A monoclonal antibody-based ELISA for the detection of circulating excretory-secretory antigens in Taenia saginata cysticercosis. Int J Parasitol 22: 471–477.
-
28.
Rodriguez S, Wilkins P, Dorny P, 2012. Immunological and molecular diagnosis of cysticercosis. Pathog Glob Health 106: 286–298.
-
29.
Jin J, Yu Q, Han C, Hu X, Xu S, Wang Q, Wang J, Li N, Cao X, 2013. LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition. Nat Commun 4: 2075.
-
30.
Dai P, Jeong SY, Yu Y, Leng T, Wu X, Xie L, Chen X, 2009. Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. J Immunol 182: 3450–3460.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1984 | 919 | 305 |
| Full Text Views | 156 | 91 | 5 |
| PDF Downloads | 151 | 96 | 16 |