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-
1.
UNICEF, World Health Organization, International Bank for Reconstruction and Development/The World Bank , 2021. Levels and Trends in Child Malnutrition: Key Findings of the 2021 Edition of the Joint Child Malnutrition Estimates. Geneva, Switzerland: World Health Organization.
-
2.
Dewey KG, Begum K, 2011. Long-term consequences of stunting in early life. Matern Child Nutr 7 (Suppl 3 ):5–18.
-
3.
Lunn PG, Northrop-Clewes CA, Downes RM, 1991. Intestinal permeability, mucosal injury, and growth faltering in Gambian infants. Lancet 338: 907–910.
-
4.
Campbell DI, Elia M, Lunn PG, 2003. Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation. J Nutr 133: 1332–1338.
-
5.
Humphrey JH, 2009. Child undernutrition, tropical enteropathy, toilets, and handwashing. Lancet 374: 1032–1035.
-
6.
Cook GC, Kajubi SK, Lee FD, 1969. Jejunal morphology of the African in Uganda. J Pathol 98: 157–169.
-
7.
Kelly P et al., 2004. Responses of small intestinal architecture and function over time to environmental factors in a tropical population. Am J Trop Med Hyg 70: 412–419.
-
8.
Syed S, Ali A, Duggan C, 2016. Environmental enteric dysfunction in children. J Pediatr Gastroenterol Nutr 63: 6–14.
-
9.
Liu TC et al., 2020. A novel histological index for evaluation of environmental enteric dysfunction identifies geographic-specific features of enteropathy among children with suboptimal growth. PLoS Negl Trop Dis 14: e0007975.
-
10.
Campbell DI, Murch SH, Elia M, Sullivan PB, Sanyang MS, Jobarteh B, Lunn PG, 2003. Chronic T cell-mediated enteropathy in rural West African children: relationship with nutritional status and small bowel function. Pediatr Res 54: 306–311.
-
11.
Prendergast A, Kelly P, 2012. Enteropathies in the developing world: neglected effects on global health. Am J Trop Med Hyg 86: 756–763.
-
12.
Yu J, Ordiz MI, Stauber J, Shaikh N, Trehan I, Barnell E, Head RD, Maleta K, Tarr PI, Manary MJ, 2016. Environmental enteric dysfunction includes a broad spectrum of inflammatory responses and epithelial repair processes. Cell Mol Gastroenterol Hepatol 2: 158–174.e1.
-
13.
Rhoades NS, Hendrickson SM, Prongay K, Haertel A, Gill L, Edwards RA, Garzel L, Slifka MK, Messaoudi I, 2021. Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen. Mucosal Immunol 14: 1113–1126.
-
14.
McCormick BJJ et al., 2019. Intestinal permeability and inflammation mediate the association between nutrient density of complementary foods and biochemical measures of micronutrient status in young children: results from the MAL-ED study. Am J Clin Nutr 110: 1015–1025.
-
15.
Harper KM, Mutasa M, Prendergast AJ, Humphrey J, Manges AR, 2018. Environmental enteric dysfunction pathways and child stunting: a systematic review. PLoS Negl Trop Dis 12: e0006205.
-
16.
Peterson KM et al., 2013. REG1B as a predictor of childhood stunting in Bangladesh and Peru. Am J Clin Nutr 97: 1129–1133.
-
17.
Kosek M et al., 2013. Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants. Am J Trop Med Hyg 88: 390–396.
-
18.
Arndt MB, Richardson BA, Ahmed T, Mahfuz M, Haque R, John-Stewart GC, Denno DM, Petri WA Jr., Kosek M, Walson JL; in coordination with the MAL-ED Network Project , 2016. Fecal markers of environmental enteropathy and subsequent growth in Bangladeshi children. Am J Trop Med Hyg 95: 694–701.
-
19.
Guerrant RL et al., 2016. Biomarkers of environmental enteropathy, inflammation, stunting, and impaired growth in children in Northeast Brazil. PLoS One 11: e0158772.
-
20.
Kosek MN et al., 2016. Plasma tryptophan and the kynurenine-tryptophan ratio are associated with the acquisition of statural growth deficits and oral vaccine underperformance in populations with environmental enteropathy. Am J Trop Med Hyg 95: 928–937.
-
21.
Prata MM, Havt A, Bolick DT, Pinkerton R, Lima A, Guerrant RL, 2016. Comparisons between myeloperoxidase, lactoferrin, calprotectin and lipocalin-2, as fecal biomarkers of intestinal inflammation in malnourished children. J Transl Sci 2: 134–139.
-
22.
Kosek MN, MAL-ED Network Investigators , 2017. Causal pathways from enteropathogens to environmental enteropathy: findings from the MAL-ED birth cohort study. EBioMedicine 18: 109–117.
-
23.
Iqbal NT et al., 2018. Promising biomarkers of environmental enteric dysfunction: a prospective cohort study in Pakistani children. Sci Rep 8: 2966.
-
24.
Richard SA et al., 2019. Enteric dysfunction and other factors associated with attained size at 5 years: MAL-ED birth cohort study findings. Am J Clin Nutr 110: 131–138.
-
25.
Sinharoy SS, Reese HE, Praharaj I, Chang HH, Clasen T, 2021. Effects of a combined water and sanitation intervention on biomarkers of child environmental enteric dysfunction and associations with height-for-age z-score: a matched cohort study in rural Odisha, India. PLoS Negl Trop Dis 15: e0009198.
-
26.
Lin A et al., 2013. Household environmental conditions are associated with enteropathy and impaired growth in rural Bangladesh. Am J Trop Med Hyg 89: 130–137.
-
27.
George CM et al., 2015. Geophagy is associated with environmental enteropathy and stunting in children in rural Bangladesh. Am J Trop Med Hyg 92: 1117–1124.
-
28.
George CM et al., 2015. Fecal markers of environmental enteropathy are associated with animal exposure and caregiver hygiene in Bangladesh. Am J Trop Med Hyg 93: 269–275.
-
29.
George CM et al., 2016. Unsafe child feces disposal is associated with environmental enteropathy and impaired growth. J Pediatr 176: 43–49.
-
30.
Lauer JM, Duggan CP, Ausman LM, Griffiths JK, Webb P, Bashaasha B, Agaba E, Turyashemererwa FM, Ghosh S, 2018. Unsafe drinking water is associated with environmental enteric dysfunction and poor growth outcomes in young children in rural southwestern Uganda. Am J Trop Med Hyg 99: 1606–1612.
-
31.
Morseth MS, Strand TA, Torheim LE, Chandyo RK, Ulak M, Shrestha SK, Shrestha B, Henjum S, 2018. Nutrient intake and environmental enteric dysfunction among Nepalese children 9–24 months old: the MAL-ED birth cohort study. Pediatr Res 84: 509–515.
-
32.
Ziegler TR, Evans ME, Fernández-Estívariz C, Jones DP, 2003. Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function. Annu Rev Nutr 23: 229–261.
-
33.
Lin A et al., 2020. Effects of water, sanitation, handwashing, and nutritional interventions on environmental enteric dysfunction in young children: a cluster-randomized, controlled trial in rural Bangladesh. Clin Infect Dis 70: 738–747.
-
34.
Gough EK et al., 2020. Effects of improved water, sanitation, and hygiene and improved complementary feeding on environmental enteric dysfunction in children in rural Zimbabwe: a cluster-randomized controlled trial. PLoS Negl Trop Dis 14: e0007963.
-
35.
Islam MA, Ahmed T, Faruque AS, Rahman S, Das SK, Ahmed D, Fattori V, Clarke R, Endtz HP, Cravioto A, 2012. Microbiological quality of complementary foods and its association with diarrhoeal morbidity and nutritional status of Bangladeshi children. Eur J Clin Nutr 66: 1242–1246.
-
36.
Kirk MD, Angulo FJ, Havelaar AH, Black RE, 2017. Diarrhoeal disease in children due to contaminated food. Bull World Health Organ 95: 233–234.
-
37.
Kung’u JK, Boor KJ, Ame SM, Ali NS, Jackson AE, Stoltzfus RJ, 2009. Bacterial populations in complementary foods and drinking-water in households with children aged 10–15 months in Zanzibar, Tanzania. J Health Popul Nutr 27: 41–52.
-
38.
Motarjemi Y, Käferstein F, Moy G, Quevedo F, 1993. Contaminated weaning food: a major risk factor for diarrhoea and associated malnutrition. Bull World Health Organ 71: 79–92.
-
39.
Parvez SM, Kwong L, Rahman MJ, Ercumen A, Pickering AJ, Ghosh PK, Rahman MZ, Das KK, Luby SP, Unicomb L, 2017. Escherichia coli contamination of child complementary foods and association with domestic hygiene in rural Bangladesh. Trop Med Int Health 22: 547–557.
-
40.
Ehiri JE, Azubuike MC, Ubbaonu CN, Anyanwu EC, Ibe KM, Ogbonna MO, 2001. Critical control points of complementary food preparation and handling in eastern Nigeria. Bull World Health Organ 79: 423–433.
-
41.
Islam MS et al., 2013. Hygiene intervention reduces contamination of weaning food in Bangladesh. Trop Med Int Health 18: 250–258.
-
42.
Chidziwisano K, Tilley E, Malolo R, Kumwenda S, Musaya J, Morse T, 2019. Risk factors associated with feeding children under 2 years in rural Malawi: a formative study. Int J Environ Res Public Health 16: 2146.
-
43.
Touré O, Coulibaly S, Arby A, Maiga F, Cairncross S, 2011. Improving microbiological food safety in peri-urban Mali: an experimental study. Food Control 22: 1565–1572.
-
44.
Muller-Hauser AA, Sobhan S, Huda TMN, Waid JL, Wendt AS, Islam MA, Rahman M, Gabrysch S, 2022. Key food hygiene behaviors to reduce microbial contamination of complementary foods in rural Bangladesh. Am J Trop Med Hyg 107: 709–719.
-
45.
Gautam OP, Schmidt WP, Cairncross S, Cavill S, Curtis V, 2017. Trial of a novel intervention to improve multiple food hygiene behaviors in Nepal. Am J Trop Med Hyg 96: 1415–1426.
-
46.
Manaseki-Holland S et al., 2021. Effects on childhood infections of promoting safe and hygienic complementary-food handling practices through a community-based programme: a cluster randomised controlled trial in a rural area of The Gambia. PLoS Med 18: e1003260.
-
47.
Chidziwisano K, Slekiene J, Mosler HJ, Morse T, 2020. Improving complementary food hygiene behaviors using the risk, attitude, norms, ability, and self-regulation approach in rural Malawi. Am J Trop Med Hyg 102: 1104–1115.
-
48.
Wendt AS, Sparling TM, Waid JL, Mueller AA, Gabrysch S, 2019. Food and Agricultural Approaches to Reducing Malnutrition (FAARM): protocol for a cluster-randomised controlled trial to evaluate the impact of a homestead food production programme on undernutrition in rural Bangladesh. BMJ Open 9: e031037.
-
49.
Sobhan S, Muller-Hauser AA, Huda TMN, Waid JL, Gautam OP, Gon G, Wendt AS, Gabrysch S, 2022. Design, delivery, and determinants of uptake: findings from a food hygiene behavior change intervention in rural Bangladesh. BMC Public Health 22: 887.
-
50.
National Institute of Population Research and Training (NIPORT), Mitra and Associates, and ICF International 2016. Bangladesh Demographic and Health Survey 2014. Dhaka, Bangladesh, and Rockville, Maryland, USA: NIPORT, Mitra and Associates, and ICF International.
-
51.
World Health Organization, UNICEF , 2017. JMP Methodology: 2017 Update & SDG Baselines. Geneva, Switzerland: World Health Organization.
-
52.
Hartung C, Lerer A, Anokwa Y, Tseng C, Brunette W, Borriello G, 2010. Open data kit: tools to build information services for developing regions. Proceedings of the 4th ACM/IEEE International Conference on Information and Communication Technologies and Development, December, 2010, London, UK.
-
53.
Erhardt JG, Estes JE, Pfeiffer CM, Biesalski HK, Craft NE, 2004. Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique. J Nutr 134: 3127–3132.
-
54.
Zambrano LD, Levy K, Menezes NP, Freeman MC, 2014. Human diarrhea infections associated with domestic animal husbandry: a systematic review and meta-analysis. Trans R Soc Trop Med Hyg 108: 313–325.
-
55.
Vasco K, Graham JP, Trueba G, 2016. Detection of zoonotic enteropathogens in children and domestic animals in a semirural community in Ecuador. Appl Environ Microbiol 82: 4218–4224.
-
56.
Hedman HD et al., 2020. Spatial exposure of agricultural antimicrobial resistance in relation to free-ranging domestic chicken movement patterns among agricultural communities in Ecuador. Am J Trop Med Hyg 103: 1803–1809.
-
57.
Raiten DJ, Ashour FAS, Ross AC, Meydani SN, Dawson HD, Stephensen CB, Brabin BJ, Suchdev PS, van Ommen B, INSPIRE Consultative Group , 2015. Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE). J Nutr 145: 1039S–1108S.
-
58.
McCormick BJJ et al., 2017. Dynamics and trends in fecal biomarkers of gut function in children from 1–24 months in the MAL-ED study. Am J Trop Med Hyg 96: 465–472.
-
59.
Vaz Nery S, Bennett I, Clarke NE, Lin A, Rahman Z, Rahman M, Clements ACA, 2018. Characterisation of environmental enteropathy biomarkers and associated risk factors in children in the context of a WASH trial in Timor-Leste. Int J Hyg Environ Health 221: 901–906.
-
60.
White H, Raitzer DA, 2017. Impact Evaluation of Development Interventions: A Practical Guide. Mandaluyong City, Philippines: Asian Development Bank.
-
61.
Lambrecht NJ, Müller-Hauser AA, Sobhan S, Schmidt W-P, Huda TMN, Waid JL, Wendt AS, Kader A, Gabrysch S, 2023. Effect of a Homestead Food Production Program on the Prevalence of Diarrhea and Acute Respiratory Infection in Children in Sylhet, Bangladesh: A Cluster-Randomized Controlled Trial. Am J Trop Med Hyg 109: 945–956.
-
62.
Ercumen A et al., 2017. Animal feces contribute to domestic fecal contamination: evidence from E. coli measured in water, hands, food, flies, and soil in Bangladesh. Environ Sci Technol 51: 8725–8734.
-
63.
Vila-Guilera J, Parikh P, Chaturvedi H, Ciric L, Lakhanpaul M, 2021. Towards transformative WASH: an integrated case study exploring environmental, sociocultural, economic and institutional risk factors contributing to infant enteric infections in rural tribal India. BMC Public Health 21: 1331.
-
64.
Cumming O et al., 2019. The implications of three major new trials for the effect of water, sanitation and hygiene on childhood diarrhea and stunting: a consensus statement. BMC Med 17: 173.
-
65.
Pickering AJ et al., 2019. The WASH Benefits and SHINE trials: interpretation of WASH intervention effects on linear growth and diarrhoea. Lancet Glob Health 7: e1139–e1146.
-
66.
Harvey SA, Winch PJ, Leontsini E, Torres Gayoso C, López Romero S, Gilman RH, Oberhelman RA, 2003. Domestic poultry-raising practices in a Peruvian shantytown: implications for control of Campylobacter jejuni–associated diarrhea. Acta Trop 86: 41–54.
-
67.
Amour C et al., 2016. Epidemiology and impact of Campylobacter infection in children in 8 low-resource settings: results from the MAL-ED study. Clin Infect Dis 63: 1171–1179.
-
68.
Headey D, Hirvonen K, 2016. Is exposure to poultry harmful to child nutrition? An observational analysis for rural Ethiopia. PLoS One 11: e0160590.
-
69.
Ercumen A, Prottas C, Harris A, Dioguardi A, Dowd G, Guiteras R, 2020. Poultry ownership associated with increased risk of child diarrhea: cross-sectional evidence from Uganda. Am J Trop Med Hyg 102: 526–533.
-
70.
Lambrecht NJ, Wilson ML, Bridges D, Eisenberg JNS, Adu B, Baylin A, Folson G, Jones AD, 2021. Ruminant-related risk factors are associated with Shiga toxin–producing Escherichia coli infection in children in southern Ghana. Am J Trop Med Hyg 106: 513–522.
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Effect of a Homestead Food Production and Food Hygiene Intervention on Biomarkers of Environmental Enteric Dysfunction in Children Younger Than 24 Months in Rural Bangladesh: A Cluster-Randomized Controlled Trial
Anna A. Müller-Hauser
Anna A. Müller-Hauser
Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Public Health, Berlin, Germany;
Research Department 2, Potsdam Institute for Climate Impact Research, (PIK), Member of the Leibniz Association, Potsdam, Germany;
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Research Department 2, Potsdam Institute for Climate Impact Research, (PIK), Member of the Leibniz Association, Potsdam, Germany;
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Tarique Md. Nurul Huda
Tarique Md. Nurul Huda
Department of Public Health, College of Public Health and Health Informatics, Qassim University, Al Bukairiyah, Saudi Arabia;
Environmental Interventions Unit, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh;
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Environmental Interventions Unit, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh;
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Shafinaz Sobhan
Shafinaz Sobhan
Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Public Health, Berlin, Germany;
Research Department 2, Potsdam Institute for Climate Impact Research, (PIK), Member of the Leibniz Association, Potsdam, Germany;
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Research Department 2, Potsdam Institute for Climate Impact Research, (PIK), Member of the Leibniz Association, Potsdam, Germany;
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Nathalie J. Lambrecht
Nathalie J. Lambrecht
Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Public Health, Berlin, Germany;
Research Department 2, Potsdam Institute for Climate Impact Research, (PIK), Member of the Leibniz Association, Potsdam, Germany;
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Research Department 2, Potsdam Institute for Climate Impact Research, (PIK), Member of the Leibniz Association, Potsdam, Germany;
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Jillian L. Waid
Jillian L. Waid
Research Department 2, Potsdam Institute for Climate Impact Research, (PIK), Member of the Leibniz Association, Potsdam, Germany;
Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany;
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Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany;
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Amanda S. Wendt
Amanda S. Wendt
Research Department 2, Potsdam Institute for Climate Impact Research, (PIK), Member of the Leibniz Association, Potsdam, Germany;
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Shahjahan Ali
Shahjahan Ali
Infectious Diseases Division, icddr,b, Dhaka, Bangladesh;
Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado
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Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado
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Mahbubur Rahman
Mahbubur Rahman
Environmental Interventions Unit, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh;
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Sabine Gabrysch
Sabine Gabrysch
Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Public Health, Berlin, Germany;
Research Department 2, Potsdam Institute for Climate Impact Research, (PIK), Member of the Leibniz Association, Potsdam, Germany;
Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany;
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Research Department 2, Potsdam Institute for Climate Impact Research, (PIK), Member of the Leibniz Association, Potsdam, Germany;
Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany;
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ABSTRACT.
Poor sanitation and hygiene practices and inadequate diets can contribute to environmental enteric dysfunction (EED). We evaluated the impact of a combined homestead food production and food hygiene intervention on EED biomarkers in young children in rural Bangladesh. The analysis was conducted within the Food and Agricultural Approaches to Reducing Malnutrition (FAARM) cluster-randomized trial in Sylhet, Bangladesh. The FAARM trial enrolled 2,705 married women and their children younger than 3 years of age in 96 settlements (geographic clusters): 48 intervention and 48 control. The 3-year intervention (2015–2018) included training on gardening, poultry rearing, and improved nutrition practices and was supplemented by an 8-month food hygiene behavior change component, implemented from mid-2017. We analyzed data on 574 children age 0 to 24 months with multilevel linear regression. We assessed fecal myeloperoxidase (MPO), neopterin (NEO), and alpha-1-antitrypsin (AAT) as biomarkers of EED, and serum C-reactive protein (CRP) and alpha-1-acid glycoprotein (AGP) as biomarkers of systemic inflammation, using ELISA. There was no intervention effect on NEO, AAT, CRP, and AGP concentrations, but, surprisingly, MPO levels were increased in children of the intervention group (0.11 log ng/mL; 95% CI, 0.001–0.22). This increase was greater with increasing child age and among intervention households with poultry that were not kept in a shed. A combined homestead food production and food hygiene intervention did not decrease EED in children in our study setting. Small-scale poultry rearing promoted by the intervention might be a risk factor for EED.
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Author Notes
Financial support: The German Federal Ministry of Education and Research is the primary funder for the
Disclosure: The FAARM trial protocol was positively reviewed by Heidelberg University in Germany (Ref. S‐121/2014) and the James P. Grant School of Public Health, BRAC University in Bangladesh (Ref. 37A). The FHEED study protocol was positively reviewed by Heidelberg University (Ref. S‐606/2017) and icddr,b in Bangladesh (Ref. PR‐17126). All participants provided informed written consent by signature or thumbprint.
Authors‘ addresses: Anna A. Müller-Hauser, Shafinaz Sobhan, and Nathalie J. Lambrecht, Charité–Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany, and Research Department 2, Potsdam Institute for Climate Impact Research, Potsdam, Germany, E-mails: anna.mueller-hauser@charite.de, shafinaz.sobhan@charite.de, and nathalie.lambrecht@charite.de. Tarique Md. Nurul Huda, Department of Public Health, College of Public Health and Health Informatics, Qassim University, Al Bukairiyah, Saudi Arabia, and Environmental Interventions Unit, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh, E-mail: t.huda@qu.edu.sa. Jillian L. Waid, Research Department 2, Potsdam Institute for Climate Impact Research, Potsdam, Germany, and Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany, E-mail: waid@pik-potsdam.de. Amanda S. Wendt, Research Department 2, Potsdam Institute for Climate Impact Research, Potsdam, Germany, E-mail: wendt@pik-potsdam.de. Shahjahan Ali, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh, and Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, E-mail: shahjahanjohny@gmail.com. Mahbubur Rahman, Environmental Interventions Unit, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh, E-mail: mahbubr@icddrb.org. Sabine Gabrysch, Charité–Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany, Research Department 2, Potsdam Institute for Climate Impact Research, Potsdam, Germany, and Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany, E-mail: sabine.gabrysch@pik-potsdam.de.
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-
1.
UNICEF, World Health Organization, International Bank for Reconstruction and Development/The World Bank , 2021. Levels and Trends in Child Malnutrition: Key Findings of the 2021 Edition of the Joint Child Malnutrition Estimates. Geneva, Switzerland: World Health Organization.
-
2.
Dewey KG, Begum K, 2011. Long-term consequences of stunting in early life. Matern Child Nutr 7 (Suppl 3 ):5–18.
-
3.
Lunn PG, Northrop-Clewes CA, Downes RM, 1991. Intestinal permeability, mucosal injury, and growth faltering in Gambian infants. Lancet 338: 907–910.
-
4.
Campbell DI, Elia M, Lunn PG, 2003. Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation. J Nutr 133: 1332–1338.
-
5.
Humphrey JH, 2009. Child undernutrition, tropical enteropathy, toilets, and handwashing. Lancet 374: 1032–1035.
-
6.
Cook GC, Kajubi SK, Lee FD, 1969. Jejunal morphology of the African in Uganda. J Pathol 98: 157–169.
-
7.
Kelly P et al., 2004. Responses of small intestinal architecture and function over time to environmental factors in a tropical population. Am J Trop Med Hyg 70: 412–419.
-
8.
Syed S, Ali A, Duggan C, 2016. Environmental enteric dysfunction in children. J Pediatr Gastroenterol Nutr 63: 6–14.
-
9.
Liu TC et al., 2020. A novel histological index for evaluation of environmental enteric dysfunction identifies geographic-specific features of enteropathy among children with suboptimal growth. PLoS Negl Trop Dis 14: e0007975.
-
10.
Campbell DI, Murch SH, Elia M, Sullivan PB, Sanyang MS, Jobarteh B, Lunn PG, 2003. Chronic T cell-mediated enteropathy in rural West African children: relationship with nutritional status and small bowel function. Pediatr Res 54: 306–311.
-
11.
Prendergast A, Kelly P, 2012. Enteropathies in the developing world: neglected effects on global health. Am J Trop Med Hyg 86: 756–763.
-
12.
Yu J, Ordiz MI, Stauber J, Shaikh N, Trehan I, Barnell E, Head RD, Maleta K, Tarr PI, Manary MJ, 2016. Environmental enteric dysfunction includes a broad spectrum of inflammatory responses and epithelial repair processes. Cell Mol Gastroenterol Hepatol 2: 158–174.e1.
-
13.
Rhoades NS, Hendrickson SM, Prongay K, Haertel A, Gill L, Edwards RA, Garzel L, Slifka MK, Messaoudi I, 2021. Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen. Mucosal Immunol 14: 1113–1126.
-
14.
McCormick BJJ et al., 2019. Intestinal permeability and inflammation mediate the association between nutrient density of complementary foods and biochemical measures of micronutrient status in young children: results from the MAL-ED study. Am J Clin Nutr 110: 1015–1025.
-
15.
Harper KM, Mutasa M, Prendergast AJ, Humphrey J, Manges AR, 2018. Environmental enteric dysfunction pathways and child stunting: a systematic review. PLoS Negl Trop Dis 12: e0006205.
-
16.
Peterson KM et al., 2013. REG1B as a predictor of childhood stunting in Bangladesh and Peru. Am J Clin Nutr 97: 1129–1133.
-
17.
Kosek M et al., 2013. Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants. Am J Trop Med Hyg 88: 390–396.
-
18.
Arndt MB, Richardson BA, Ahmed T, Mahfuz M, Haque R, John-Stewart GC, Denno DM, Petri WA Jr., Kosek M, Walson JL; in coordination with the MAL-ED Network Project , 2016. Fecal markers of environmental enteropathy and subsequent growth in Bangladeshi children. Am J Trop Med Hyg 95: 694–701.
-
19.
Guerrant RL et al., 2016. Biomarkers of environmental enteropathy, inflammation, stunting, and impaired growth in children in Northeast Brazil. PLoS One 11: e0158772.
-
20.
Kosek MN et al., 2016. Plasma tryptophan and the kynurenine-tryptophan ratio are associated with the acquisition of statural growth deficits and oral vaccine underperformance in populations with environmental enteropathy. Am J Trop Med Hyg 95: 928–937.
-
21.
Prata MM, Havt A, Bolick DT, Pinkerton R, Lima A, Guerrant RL, 2016. Comparisons between myeloperoxidase, lactoferrin, calprotectin and lipocalin-2, as fecal biomarkers of intestinal inflammation in malnourished children. J Transl Sci 2: 134–139.
-
22.
Kosek MN, MAL-ED Network Investigators , 2017. Causal pathways from enteropathogens to environmental enteropathy: findings from the MAL-ED birth cohort study. EBioMedicine 18: 109–117.
-
23.
Iqbal NT et al., 2018. Promising biomarkers of environmental enteric dysfunction: a prospective cohort study in Pakistani children. Sci Rep 8: 2966.
-
24.
Richard SA et al., 2019. Enteric dysfunction and other factors associated with attained size at 5 years: MAL-ED birth cohort study findings. Am J Clin Nutr 110: 131–138.
-
25.
Sinharoy SS, Reese HE, Praharaj I, Chang HH, Clasen T, 2021. Effects of a combined water and sanitation intervention on biomarkers of child environmental enteric dysfunction and associations with height-for-age z-score: a matched cohort study in rural Odisha, India. PLoS Negl Trop Dis 15: e0009198.
-
26.
Lin A et al., 2013. Household environmental conditions are associated with enteropathy and impaired growth in rural Bangladesh. Am J Trop Med Hyg 89: 130–137.
-
27.
George CM et al., 2015. Geophagy is associated with environmental enteropathy and stunting in children in rural Bangladesh. Am J Trop Med Hyg 92: 1117–1124.
-
28.
George CM et al., 2015. Fecal markers of environmental enteropathy are associated with animal exposure and caregiver hygiene in Bangladesh. Am J Trop Med Hyg 93: 269–275.
-
29.
George CM et al., 2016. Unsafe child feces disposal is associated with environmental enteropathy and impaired growth. J Pediatr 176: 43–49.
-
30.
Lauer JM, Duggan CP, Ausman LM, Griffiths JK, Webb P, Bashaasha B, Agaba E, Turyashemererwa FM, Ghosh S, 2018. Unsafe drinking water is associated with environmental enteric dysfunction and poor growth outcomes in young children in rural southwestern Uganda. Am J Trop Med Hyg 99: 1606–1612.
-
31.
Morseth MS, Strand TA, Torheim LE, Chandyo RK, Ulak M, Shrestha SK, Shrestha B, Henjum S, 2018. Nutrient intake and environmental enteric dysfunction among Nepalese children 9–24 months old: the MAL-ED birth cohort study. Pediatr Res 84: 509–515.
-
32.
Ziegler TR, Evans ME, Fernández-Estívariz C, Jones DP, 2003. Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function. Annu Rev Nutr 23: 229–261.
-
33.
Lin A et al., 2020. Effects of water, sanitation, handwashing, and nutritional interventions on environmental enteric dysfunction in young children: a cluster-randomized, controlled trial in rural Bangladesh. Clin Infect Dis 70: 738–747.
-
34.
Gough EK et al., 2020. Effects of improved water, sanitation, and hygiene and improved complementary feeding on environmental enteric dysfunction in children in rural Zimbabwe: a cluster-randomized controlled trial. PLoS Negl Trop Dis 14: e0007963.
-
35.
Islam MA, Ahmed T, Faruque AS, Rahman S, Das SK, Ahmed D, Fattori V, Clarke R, Endtz HP, Cravioto A, 2012. Microbiological quality of complementary foods and its association with diarrhoeal morbidity and nutritional status of Bangladeshi children. Eur J Clin Nutr 66: 1242–1246.
-
36.
Kirk MD, Angulo FJ, Havelaar AH, Black RE, 2017. Diarrhoeal disease in children due to contaminated food. Bull World Health Organ 95: 233–234.
-
37.
Kung’u JK, Boor KJ, Ame SM, Ali NS, Jackson AE, Stoltzfus RJ, 2009. Bacterial populations in complementary foods and drinking-water in households with children aged 10–15 months in Zanzibar, Tanzania. J Health Popul Nutr 27: 41–52.
-
38.
Motarjemi Y, Käferstein F, Moy G, Quevedo F, 1993. Contaminated weaning food: a major risk factor for diarrhoea and associated malnutrition. Bull World Health Organ 71: 79–92.
-
39.
Parvez SM, Kwong L, Rahman MJ, Ercumen A, Pickering AJ, Ghosh PK, Rahman MZ, Das KK, Luby SP, Unicomb L, 2017. Escherichia coli contamination of child complementary foods and association with domestic hygiene in rural Bangladesh. Trop Med Int Health 22: 547–557.
-
40.
Ehiri JE, Azubuike MC, Ubbaonu CN, Anyanwu EC, Ibe KM, Ogbonna MO, 2001. Critical control points of complementary food preparation and handling in eastern Nigeria. Bull World Health Organ 79: 423–433.
-
41.
Islam MS et al., 2013. Hygiene intervention reduces contamination of weaning food in Bangladesh. Trop Med Int Health 18: 250–258.
-
42.
Chidziwisano K, Tilley E, Malolo R, Kumwenda S, Musaya J, Morse T, 2019. Risk factors associated with feeding children under 2 years in rural Malawi: a formative study. Int J Environ Res Public Health 16: 2146.
-
43.
Touré O, Coulibaly S, Arby A, Maiga F, Cairncross S, 2011. Improving microbiological food safety in peri-urban Mali: an experimental study. Food Control 22: 1565–1572.
-
44.
Muller-Hauser AA, Sobhan S, Huda TMN, Waid JL, Wendt AS, Islam MA, Rahman M, Gabrysch S, 2022. Key food hygiene behaviors to reduce microbial contamination of complementary foods in rural Bangladesh. Am J Trop Med Hyg 107: 709–719.
-
45.
Gautam OP, Schmidt WP, Cairncross S, Cavill S, Curtis V, 2017. Trial of a novel intervention to improve multiple food hygiene behaviors in Nepal. Am J Trop Med Hyg 96: 1415–1426.
-
46.
Manaseki-Holland S et al., 2021. Effects on childhood infections of promoting safe and hygienic complementary-food handling practices through a community-based programme: a cluster randomised controlled trial in a rural area of The Gambia. PLoS Med 18: e1003260.
-
47.
Chidziwisano K, Slekiene J, Mosler HJ, Morse T, 2020. Improving complementary food hygiene behaviors using the risk, attitude, norms, ability, and self-regulation approach in rural Malawi. Am J Trop Med Hyg 102: 1104–1115.
-
48.
Wendt AS, Sparling TM, Waid JL, Mueller AA, Gabrysch S, 2019. Food and Agricultural Approaches to Reducing Malnutrition (FAARM): protocol for a cluster-randomised controlled trial to evaluate the impact of a homestead food production programme on undernutrition in rural Bangladesh. BMJ Open 9: e031037.
-
49.
Sobhan S, Muller-Hauser AA, Huda TMN, Waid JL, Gautam OP, Gon G, Wendt AS, Gabrysch S, 2022. Design, delivery, and determinants of uptake: findings from a food hygiene behavior change intervention in rural Bangladesh. BMC Public Health 22: 887.
-
50.
National Institute of Population Research and Training (NIPORT), Mitra and Associates, and ICF International 2016. Bangladesh Demographic and Health Survey 2014. Dhaka, Bangladesh, and Rockville, Maryland, USA: NIPORT, Mitra and Associates, and ICF International.
-
51.
World Health Organization, UNICEF , 2017. JMP Methodology: 2017 Update & SDG Baselines. Geneva, Switzerland: World Health Organization.
-
52.
Hartung C, Lerer A, Anokwa Y, Tseng C, Brunette W, Borriello G, 2010. Open data kit: tools to build information services for developing regions. Proceedings of the 4th ACM/IEEE International Conference on Information and Communication Technologies and Development, December, 2010, London, UK.
-
53.
Erhardt JG, Estes JE, Pfeiffer CM, Biesalski HK, Craft NE, 2004. Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique. J Nutr 134: 3127–3132.
-
54.
Zambrano LD, Levy K, Menezes NP, Freeman MC, 2014. Human diarrhea infections associated with domestic animal husbandry: a systematic review and meta-analysis. Trans R Soc Trop Med Hyg 108: 313–325.
-
55.
Vasco K, Graham JP, Trueba G, 2016. Detection of zoonotic enteropathogens in children and domestic animals in a semirural community in Ecuador. Appl Environ Microbiol 82: 4218–4224.
-
56.
Hedman HD et al., 2020. Spatial exposure of agricultural antimicrobial resistance in relation to free-ranging domestic chicken movement patterns among agricultural communities in Ecuador. Am J Trop Med Hyg 103: 1803–1809.
-
57.
Raiten DJ, Ashour FAS, Ross AC, Meydani SN, Dawson HD, Stephensen CB, Brabin BJ, Suchdev PS, van Ommen B, INSPIRE Consultative Group , 2015. Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE). J Nutr 145: 1039S–1108S.
-
58.
McCormick BJJ et al., 2017. Dynamics and trends in fecal biomarkers of gut function in children from 1–24 months in the MAL-ED study. Am J Trop Med Hyg 96: 465–472.
-
59.
Vaz Nery S, Bennett I, Clarke NE, Lin A, Rahman Z, Rahman M, Clements ACA, 2018. Characterisation of environmental enteropathy biomarkers and associated risk factors in children in the context of a WASH trial in Timor-Leste. Int J Hyg Environ Health 221: 901–906.
-
60.
White H, Raitzer DA, 2017. Impact Evaluation of Development Interventions: A Practical Guide. Mandaluyong City, Philippines: Asian Development Bank.
-
61.
Lambrecht NJ, Müller-Hauser AA, Sobhan S, Schmidt W-P, Huda TMN, Waid JL, Wendt AS, Kader A, Gabrysch S, 2023. Effect of a Homestead Food Production Program on the Prevalence of Diarrhea and Acute Respiratory Infection in Children in Sylhet, Bangladesh: A Cluster-Randomized Controlled Trial. Am J Trop Med Hyg 109: 945–956.
-
62.
Ercumen A et al., 2017. Animal feces contribute to domestic fecal contamination: evidence from E. coli measured in water, hands, food, flies, and soil in Bangladesh. Environ Sci Technol 51: 8725–8734.
-
63.
Vila-Guilera J, Parikh P, Chaturvedi H, Ciric L, Lakhanpaul M, 2021. Towards transformative WASH: an integrated case study exploring environmental, sociocultural, economic and institutional risk factors contributing to infant enteric infections in rural tribal India. BMC Public Health 21: 1331.
-
64.
Cumming O et al., 2019. The implications of three major new trials for the effect of water, sanitation and hygiene on childhood diarrhea and stunting: a consensus statement. BMC Med 17: 173.
-
65.
Pickering AJ et al., 2019. The WASH Benefits and SHINE trials: interpretation of WASH intervention effects on linear growth and diarrhoea. Lancet Glob Health 7: e1139–e1146.
-
66.
Harvey SA, Winch PJ, Leontsini E, Torres Gayoso C, López Romero S, Gilman RH, Oberhelman RA, 2003. Domestic poultry-raising practices in a Peruvian shantytown: implications for control of Campylobacter jejuni–associated diarrhea. Acta Trop 86: 41–54.
-
67.
Amour C et al., 2016. Epidemiology and impact of Campylobacter infection in children in 8 low-resource settings: results from the MAL-ED study. Clin Infect Dis 63: 1171–1179.
-
68.
Headey D, Hirvonen K, 2016. Is exposure to poultry harmful to child nutrition? An observational analysis for rural Ethiopia. PLoS One 11: e0160590.
-
69.
Ercumen A, Prottas C, Harris A, Dioguardi A, Dowd G, Guiteras R, 2020. Poultry ownership associated with increased risk of child diarrhea: cross-sectional evidence from Uganda. Am J Trop Med Hyg 102: 526–533.
-
70.
Lambrecht NJ, Wilson ML, Bridges D, Eisenberg JNS, Adu B, Baylin A, Folson G, Jones AD, 2021. Ruminant-related risk factors are associated with Shiga toxin–producing Escherichia coli infection in children in southern Ghana. Am J Trop Med Hyg 106: 513–522.
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