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-
1.
Filipovich A, McClain K, Grom A, 2010. Histiocytic disorders: recent insights into pathophysiology and practical guidelines. Biol Blood Marrow Transplant 16: S82–S89.
-
2.
Rouphael NG, Talati NJ, Vaughan C, Cunningham K, Moreira R, Gould C, 2007. Infections associated with haemophagocytic syndrome. Lancet Infect Dis 7: 814–822.
-
3.
La Rosée P et al., 2019. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood 133: 2465–2477.
-
4.
Dass R, Barman H, Duwarah SG, Choudhury V, Jain P, Deka NM, Murari M, 2010. Macrophage activation syndrome in malaria. Rheumatol Int 30: 1099–1101.
-
5.
Retornaz F, Seux V, Arnoulet C, Durand JM, Sainty D, Soubeyrand J, 2000. Plasmodium falciparum malaria infection complicated by haemophagocytic syndrome in an old man. Acta Haematol 103: 224–225.
-
6.
Fuchs A, Orth HM, Germing U, Kondakci M, Holtfreter M, Feldt T, Jensen BE, Häussinger D, 2020. Falciparum malaria-induced secondary hemophagocytic lymphohistiocytosis successfully treated with ruxolitinib. Int J Infect Dis 100: 382–385.
-
7.
Rojo-Marcos G et al., 2018. Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections. Malar J 17: 399.
-
8.
Ullah W, Abdullah HM, Qadir S, Shahzad MA, 2016. Haemophagocytic lymphohistiocytosis (HLH): a rare but potentially fatal association with Plasmodium vivax malaria. BMJ Case Rep 2016: bcr2016215366.
-
9.
Groger M et al., 2018. Prospective clinical trial assessing species-specific efficacy of artemether-lumefantrine for the treatment of Plasmodium malariae, Plasmodium ovale, and mixed Plasmodium malaria in Gabon. Antimicrob Agents Chemother 62: e01758-17.
-
10.
Amireh S, Shaaban H, Guron G, 2018. Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline. Hematol Oncol Stem Cell Ther 11: 34–37.
-
11.
Cheikhrouhou F, Ammar R, Bellili S, Jdidi I, Bahloul M, Ayadi A, Bouaziz M, 2019. Macrophage activation syndrome in a patient affected by Plasmodium falciparum Aeroport malaria. Tunis Med 97: 379–382.
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12.
Hemmer CJ, Holst FG, Kern P, Chiwakata CB, Dietrich M, Reisinger EC, 2006. Stronger host response per parasitized erythrocyte in Plasmodium vivax or ovale than in Plasmodium falciparum malaria. Trop Med Int Health 11: 817–823.
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Case Report: Hemophagocytic Lymphohistiocytosis Secondary to Plasmodium ovale wallikeri Infection
María Novella-Mena
María Novella-Mena
Medicina Interna, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain;
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Purificación Cantudo-Muñoz
Purificación Cantudo-Muñoz
Microbiología y Parasitología Clínica, UGC Laboratorio Análisis Clínicos, Hospital Universitario San Agustín, Linares, Jaén, Spain;
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José David Tallón-Pérez
José David Tallón-Pérez
Hematología y Hemoterapia, UGC Hematología y Hemoterapia, Hospital Universitario San Agustín, Linares, Jaén, Spain;
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María del Mar Gómez-Rodríguez
María del Mar Gómez-Rodríguez
Medicina Interna, UGC Medicina Interna, Hospital Universitario San Agustín, Linares, Jaén, Spain;
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Gerardo Rojo-Marcos
Gerardo Rojo-Marcos
Medicina Interna, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain;
Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
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Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
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ABSTRACT.
We report the first known case of hemophagocytic lymphohistiocytosis (HLH) secondary to imported Plasmodium ovale wallikeri infection in a 58-year-old white woman. A delayed diagnosis of malaria and HLH was made after protracted fever and pancytopenia failed to respond adequately to antimalarial treatment, which required intravenous methylprednisolone and gamma-globulin therapy to resolve.
Author Notes
Authors’ addresses: María Novella-Mena, Medicina Interna, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain, E-mail: mnovellam@gmail.com. Purificación Cantudo-Muñoz, Microbiología y Parasitología Clínica, UGC Laboratorio Análisis Clínicos, Hospital Universitario San Agustín, Linares, Jaén, Spain, E-mail: purificacion.cantudo.sspa@juntadeandalucia.es. José David Tallón-Pérez, Hematología y Hemoterapia, UGC Hematología y Hemoterapia, Hospital Universitario San Agustín, Linares, Jaén, Spain, E-mail: jd.tallon@gmx.es. María del Mar Gómez-Rodríguez, Medicina Interna, UGC Medicina Interna, Hospital Universitario San Agustín, Linares, Jaén, Spain, E-mail: margoro65@gmail.com. Gerardo Rojo-Marcos, Medicina Interna, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain, and Universidad de Alcalá, Alcalá de Henares, Madrid, Spain, E-mail: grojo.hupa@salud.madrid.org.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Filipovich A, McClain K, Grom A, 2010. Histiocytic disorders: recent insights into pathophysiology and practical guidelines. Biol Blood Marrow Transplant 16: S82–S89.
-
2.
Rouphael NG, Talati NJ, Vaughan C, Cunningham K, Moreira R, Gould C, 2007. Infections associated with haemophagocytic syndrome. Lancet Infect Dis 7: 814–822.
-
3.
La Rosée P et al., 2019. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood 133: 2465–2477.
-
4.
Dass R, Barman H, Duwarah SG, Choudhury V, Jain P, Deka NM, Murari M, 2010. Macrophage activation syndrome in malaria. Rheumatol Int 30: 1099–1101.
-
5.
Retornaz F, Seux V, Arnoulet C, Durand JM, Sainty D, Soubeyrand J, 2000. Plasmodium falciparum malaria infection complicated by haemophagocytic syndrome in an old man. Acta Haematol 103: 224–225.
-
6.
Fuchs A, Orth HM, Germing U, Kondakci M, Holtfreter M, Feldt T, Jensen BE, Häussinger D, 2020. Falciparum malaria-induced secondary hemophagocytic lymphohistiocytosis successfully treated with ruxolitinib. Int J Infect Dis 100: 382–385.
-
7.
Rojo-Marcos G et al., 2018. Prospective comparative multi-centre study on imported Plasmodium ovale wallikeri and Plasmodium ovale curtisi infections. Malar J 17: 399.
-
8.
Ullah W, Abdullah HM, Qadir S, Shahzad MA, 2016. Haemophagocytic lymphohistiocytosis (HLH): a rare but potentially fatal association with Plasmodium vivax malaria. BMJ Case Rep 2016: bcr2016215366.
-
9.
Groger M et al., 2018. Prospective clinical trial assessing species-specific efficacy of artemether-lumefantrine for the treatment of Plasmodium malariae, Plasmodium ovale, and mixed Plasmodium malaria in Gabon. Antimicrob Agents Chemother 62: e01758-17.
-
10.
Amireh S, Shaaban H, Guron G, 2018. Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline. Hematol Oncol Stem Cell Ther 11: 34–37.
-
11.
Cheikhrouhou F, Ammar R, Bellili S, Jdidi I, Bahloul M, Ayadi A, Bouaziz M, 2019. Macrophage activation syndrome in a patient affected by Plasmodium falciparum Aeroport malaria. Tunis Med 97: 379–382.
-
12.
Hemmer CJ, Holst FG, Kern P, Chiwakata CB, Dietrich M, Reisinger EC, 2006. Stronger host response per parasitized erythrocyte in Plasmodium vivax or ovale than in Plasmodium falciparum malaria. Trop Med Int Health 11: 817–823.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1944 | 453 | 63 |
| Full Text Views | 213 | 130 | 1 |
| PDF Downloads | 86 | 43 | 0 |