Article Category:
Case Report

Case Report: Upper Thoracic Esophageal Paralysis Accompanying a Type 1 Leprosy Reaction

Jianyu Zhu Department of Leprosy, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China;

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Chao Shi Department of Leprosy, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China;

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Huaibo Zhao Department of Leprosy, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China;

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Rongli He Department of Infectious Disease, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Zhichun Jing Department of Leprosy, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China;

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Degang Yang Department of Leprosy, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China;

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DOI:
https://doi.org/10.4269/ajtmh.22-0799
Volume/Issue:
Volume 109: Issue 2
Page(s):
343–344
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ABSTRACT.

Type 1 leprosy reactions (T1LRs) occur mainly in patients with borderline leprosy and an unstable immune status. The main symptoms of T1LRs include aggravated skin lesions and nerve damage. Nerve damage involving the glossopharyngeal and vagus nerves causes dysfunction of the nose, pharynx, larynx, and even the esophagus, which are innervated by these nerves. Here, we report a case of upper thoracic esophageal paralysis caused by vagus nerve involvement in a patient with T1LRs. Although infrequent, this serious emergency merits attention.

Author Notes

Address correspondence to Degang Yang, Department of Leprosy, Shanghai Skin Disease Hospital, Tongji University School of Medicine, 1278 Bao De Rd., Shanghai 200443, People’s Republic of China. E-mail: ydg007@gmail.com

These authors contributed equally to this work.

Financial support: This work was supported by the National Natural Science Foundation of China (Grant no. 81872537).

Authors’ addresses: Jianyu Zhu, Chao Shi, Huaibo Zhao, Zhichun Jing, and Degang Yang, Department of Leprosy, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China, E-mails: 35476451@qq.com, sc_mac@163.com, 1025849046@qq.com, 743835016@qq.com, and ydg007@gmail.com. Rongli He, Department of Infectious Disease, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China, E-mail: 155284114@qq.com.

Copyright:
© American Society of Tropical Medicine and Hygiene 2023
Received:
24 Dec 2022
|
Accepted:
17 Apr 2023
|
Published Online:
05 Jun 2023
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
  • 1.

    Naafs B, van Hees CL, 2016. Leprosy type 1 reaction (formerly reversal reaction). Clin Dermatol 34: 37–50.

  • 2.

    Walker S, Lockwood D, 2008. Leprosy type 1 (reversal) reactions and their management. Lepr Rev 1: 372–386.

  • 3.

    Lockwood DN, Saunderson P, 2012. Nerve damage in leprosy: a continuing challenge for scientists, clinicians and service providers. Int Health 4: 77–85.

    • Search Google Scholar
    • Export Citation
  • 4.

    Scollard DM, Adams LB, Gillis TP, Krahenbuhl JL, Truman RW, Williams DL, 2006. The continuing challenges of leprosy. Clin Microbiol Rev 19: 338–381.

    • Search Google Scholar
    • Export Citation
  • 5.

    Nery JA, Bernardes Filho F, Quintanilha J, Machado AM, Oliveira SdS, Sales AM, 2013. Understanding the type 1 reactional state for early diagnosis and treatment: a way to avoid disability in leprosy. An Bras Dermatol 88: 787–792.

    • Search Google Scholar
    • Export Citation
  • 6.

    Agrawal A, Pandit L, Dalal M, Shetty JP, 2005. Neurological manifestations of Hansen’s disease and their management. Clin Neurol Neurosurg 107: 445–454.

    • Search Google Scholar
    • Export Citation
  • 7.

    Gopinath DV, Thappa DM, Jaishankar TJ, 2004. A clinical study of the involvement of cranial nerves in leprosy. Indian J Lepr 76: 1–9.

  • 8.

    Canleblebici M, Yildirim H, Balbaba M, Aydemir O, 2022. A rare cause of acquired esotropia: leprosy. Indian J Ophthalmol 70: 2752–2754.

  • 9.

    Subbarao NT, Jaiswal AK, 2011. A case of leprosy with multiple cranial neuropathy mimicking Melkerson Rosenthal syndrome. Indian J Lepr 83: 101–102.

    • Search Google Scholar
    • Export Citation
  • 10.

    Kumar S, Alexander M, Gnanamuthu C, 2006. Cranial nerve involvement in patients with leprous neuropathy. Neurol India 54: 283–285.

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