Wroblewski KJ , Hidayat AA , Neafie RC , Rao NA , Zapor M , 2011. Ocular tuberculosis: a clinicopathologic and molecular study. Ophthalmology 118: 772ā777.
Standardization of Uveitis Nomenclature (SUN) Working Group , 2021. Classification criteria for tubercular uveitis. Am J Ophthalmol 228: 142ā151.
Kee AR et al., 2016. Anti-tubercular therapy for intraocular tuberculosis: a systematic review and meta-analysis. Surv Ophthalmol 61: 628ā653.
Agarwal A , Marchese A , Aggarwal K , Arora A , Thattaruthody F , Sharma K , Sharma S , Sharma A , Gupta V , Basu S , 2022. Diagnostic and therapeutic challenges. Retina 42: 216ā223.
Bansal R et al., 2015. Detection of Mycobacterium tuberculosis genome in vitreous fluid of eyes with multifocal serpiginoid choroiditis. Ophthalmology 122: 840ā850.
Central TB Division , 2021. Guidelines for Programmatic Management of Drug-Resistant Tuberculosis in India. Available at: https://www.tbcindia.nic.in/WriteReadData/l892s/8368587497Guidelines%20for%20PMDT%20in%20India.pdf. Accessed October 2, 2022.
Gilpin C , Korobitsyn A , Weyer K , 2016. Current tools available for the diagnosis of drug-resistant tuberculosis. Ther Adv Infect Dis 3: 145ā151.
World Health Organization , 2021. WHO Announces Updated Definitions of Extensively Drug-Resistant Tuberculosis. Available at: www.who.int/news/item/27-01-2021-who-announces-updated-definitions-of-extensively-drug-resistant-tuberculosis. Accessed July 17, 2022.
World Health Organization , 2021. Global Tuberculosis Report 2021. Available at: https://www.who.int/publications/i/item/9789240037021. Accessed July 17, 2022.
Alagna R , Cabibbe AM , Miotto P , Saluzzo F , Kƶser CU , Niemann S , Gagneux S , Rodrigues C , Rancoita PVM , Cirillo DM , 2021. Is the new WHO definition of extensively drug-resistant tuberculosis easy to apply in practice? Eur Respir J 58: 2100959.
Viney K , Linh NN , Gegia M , Zignol M , Glaziou P , Ismail N , Kasaeva T , Mirzayev F , 2021. New definitions of pre-extensively and extensively drug-resistant tuberculosis: update from the World Health Organization. Eur Respir J 57: 2100361.
Norbis L , Alagna R , Tortoli E , Codecasa LR , Migliori GB , Cirillo DM , 2014. Challenges and perspectives in the diagnosis of extrapulmonary tuberculosis. Expert Rev Anti Infect Ther 12: 633ā647.
Desai U , Joshi JM , 2019. Extrapulmonary drug-resistant tuberculosis at a drug-resistant tuberculosis center, Mumbai: our experience: hope in the midst of despair! Lung India 36: 3ā7.
Diriba G , Tola HH , Alemu A , Yenew B , Gamtesa DF , Kebede A , 2021. Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: a systematic review and meta-analysis. PLoS One 16: e0258295.
Biswas J , Madhavan HN , Gopal L , Badrinath SS , 1995. Intraocular tuberculosis: clinicopathologic study of five cases. Retina 15: 461ā468.
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We describe a patient with concurrent ocular and pulmonary tuberculosis (TB) in whom the diagnosis of extensively drug-resistant TB was made through phenotypic drug-sensitivity testing of an ocular fluid sample after sputum testing yielded incomplete results. Our results are remarkable, because culture-based diagnosis of TB in ocular fluid is unusual. We not only overcame this limitation, but also were able to create a complete drug-sensitivity testing profile from ocular samples, which led to effecting appropriate therapy for the patient.
Financial support: This work was supported by the
Authorsā addresses: Soumyava Basu, Uveitis Service, LV Prasad Eye Institute, Hyderabad, India, E-mail: basu@lvpei.org. Somasheila I. Murthy, Uveitis Service, LV Prasad Eye Institute, Hyderabad, India, and The Cornea Institute, LV Prasad Eye Institute, Hyderabad, India, E-mail: smurthy@lvpei.org. Sanchita Mitra, Jhaveri Microbiology Laboratory, LV Prasad Eye Institute, Hyderabad, India, E-mail: sanchita.mitra@lvpei.org. Sumalatha Chittiboyina, State TB Training and Demonstration Centre, Hyderabad, India, E-mail: stdcepidemiologist@gmail.com. Sivakumar Shanmugham, Bacteriology Division, National Institute of Research in Tuberculosis, Chennai, India, E-mail: shanmugamsiva27@gmail.com.
Wroblewski KJ , Hidayat AA , Neafie RC , Rao NA , Zapor M , 2011. Ocular tuberculosis: a clinicopathologic and molecular study. Ophthalmology 118: 772ā777.
Standardization of Uveitis Nomenclature (SUN) Working Group , 2021. Classification criteria for tubercular uveitis. Am J Ophthalmol 228: 142ā151.
Kee AR et al., 2016. Anti-tubercular therapy for intraocular tuberculosis: a systematic review and meta-analysis. Surv Ophthalmol 61: 628ā653.
Agarwal A , Marchese A , Aggarwal K , Arora A , Thattaruthody F , Sharma K , Sharma S , Sharma A , Gupta V , Basu S , 2022. Diagnostic and therapeutic challenges. Retina 42: 216ā223.
Bansal R et al., 2015. Detection of Mycobacterium tuberculosis genome in vitreous fluid of eyes with multifocal serpiginoid choroiditis. Ophthalmology 122: 840ā850.
Central TB Division , 2021. Guidelines for Programmatic Management of Drug-Resistant Tuberculosis in India. Available at: https://www.tbcindia.nic.in/WriteReadData/l892s/8368587497Guidelines%20for%20PMDT%20in%20India.pdf. Accessed October 2, 2022.
Gilpin C , Korobitsyn A , Weyer K , 2016. Current tools available for the diagnosis of drug-resistant tuberculosis. Ther Adv Infect Dis 3: 145ā151.
World Health Organization , 2021. WHO Announces Updated Definitions of Extensively Drug-Resistant Tuberculosis. Available at: www.who.int/news/item/27-01-2021-who-announces-updated-definitions-of-extensively-drug-resistant-tuberculosis. Accessed July 17, 2022.
World Health Organization , 2021. Global Tuberculosis Report 2021. Available at: https://www.who.int/publications/i/item/9789240037021. Accessed July 17, 2022.
Alagna R , Cabibbe AM , Miotto P , Saluzzo F , Kƶser CU , Niemann S , Gagneux S , Rodrigues C , Rancoita PVM , Cirillo DM , 2021. Is the new WHO definition of extensively drug-resistant tuberculosis easy to apply in practice? Eur Respir J 58: 2100959.
Viney K , Linh NN , Gegia M , Zignol M , Glaziou P , Ismail N , Kasaeva T , Mirzayev F , 2021. New definitions of pre-extensively and extensively drug-resistant tuberculosis: update from the World Health Organization. Eur Respir J 57: 2100361.
Norbis L , Alagna R , Tortoli E , Codecasa LR , Migliori GB , Cirillo DM , 2014. Challenges and perspectives in the diagnosis of extrapulmonary tuberculosis. Expert Rev Anti Infect Ther 12: 633ā647.
Desai U , Joshi JM , 2019. Extrapulmonary drug-resistant tuberculosis at a drug-resistant tuberculosis center, Mumbai: our experience: hope in the midst of despair! Lung India 36: 3ā7.
Diriba G , Tola HH , Alemu A , Yenew B , Gamtesa DF , Kebede A , 2021. Drug resistance and its risk factors among extrapulmonary tuberculosis in Ethiopia: a systematic review and meta-analysis. PLoS One 16: e0258295.
Biswas J , Madhavan HN , Gopal L , Badrinath SS , 1995. Intraocular tuberculosis: clinicopathologic study of five cases. Retina 15: 461ā468.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 1113 | 1113 | 91 |
Full Text Views | 36 | 36 | 10 |
PDF Downloads | 47 | 47 | 16 |