Case Report: Ocular Tissue Diagnosis of Previously Undiagnosed, Extensively Drug-Resistant Pulmonary Tuberculosis

Soumyava Basu Uveitis Service, LV Prasad Eye Institute, Hyderabad, India;

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Somasheila I. Murthy Uveitis Service, LV Prasad Eye Institute, Hyderabad, India;
The Cornea Institute, LV Prasad Eye Institute, Hyderabad, India;

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Sanchita Mitra Jhaveri Microbiology Laboratory, LV Prasad Eye Institute, Hyderabad, India;

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Sumalatha Chittiboyina State TB Training and Demonstration Centre, Hyderabad, India;

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Sivakumar Shanmugham Bacteriology Division, National Institute of Research in Tuberculosis, Chennai, India

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ABSTRACT.

We describe a patient with concurrent ocular and pulmonary tuberculosis (TB) in whom the diagnosis of extensively drug-resistant TB was made through phenotypic drug-sensitivity testing of an ocular fluid sample after sputum testing yielded incomplete results. Our results are remarkable, because culture-based diagnosis of TB in ocular fluid is unusual. We not only overcame this limitation, but also were able to create a complete drug-sensitivity testing profile from ocular samples, which led to effecting appropriate therapy for the patient.

Author Notes

Address correspondence to Soumyava Basu, Prof Brien Holden Eye Research Center, LV Prasad Eye Institute, Kalam Anji Reddy Campus, Hyderabad, India. E-mail: basu@lvpei.org

Financial support: This work was supported by the Hyderabad Eye Research Foundation.

Authors’ addresses: Soumyava Basu, Uveitis Service, LV Prasad Eye Institute, Hyderabad, India, E-mail: basu@lvpei.org. Somasheila I. Murthy, Uveitis Service, LV Prasad Eye Institute, Hyderabad, India, and The Cornea Institute, LV Prasad Eye Institute, Hyderabad, India, E-mail: smurthy@lvpei.org. Sanchita Mitra, Jhaveri Microbiology Laboratory, LV Prasad Eye Institute, Hyderabad, India, E-mail: sanchita.mitra@lvpei.org. Sumalatha Chittiboyina, State TB Training and Demonstration Centre, Hyderabad, India, E-mail: stdcepidemiologist@gmail.com. Sivakumar Shanmugham, Bacteriology Division, National Institute of Research in Tuberculosis, Chennai, India, E-mail: shanmugamsiva27@gmail.com.

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