ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Bustos J , Gonzales I , Saavedra H , Handali S , Garcia HH , 2021. Neurocysticercosis. A frequent cause of seizures, epilepsy, and other neurological morbidity in most of the world. J Neurol Sci 427: 117527.
-
2.
Fleury A , Carrillo-Mezo R , Flisser A , Sciutto E , Corona T , 2011. Subarachnoid basal neurocysticercosis: a focus on the most severe form of the disease. Expert Rev Anti Infect Ther 9: 123–133.
-
3.
Abanto J , Blanco D , Saavedra H , Gonzales I , Siu D , Pretell EJ , Bustos JA , Garcia HH , 2021. Mortality in parenchymal and subarachnoid neurocysticercosis. Am J Trop Med Hyg 105: 176–180.
-
4.
Marcin-Sierra M et al., 2017. Extraparenchymal neurocysticercosis: demographic, clinicoradiological, and inflammatory features. PLoS Negl Trop Dis 11: e0005646.
-
5.
Fleury A , Dessein A , Preux P , Dumas M , Tapia G , Larralde C , Sciutto E , 2004. Symptomatic human neurocysticercosis: age, sex and exposure factors relating with disease heterogeneity. J Neurol 251: 830–837.
-
6.
Monteiro L , Almeida-Pinto J , Stocker A , Sampaio-Silva M , 1993. Active neurocysticercosis, parenchymal and extraparenchymal: a study of 38 patients. J Neurol 241: 15–21.
-
7.
Bazan R , Hamamoto Filho PT , Luvizutto GJ , Nunes HR , Odashima NS , Dos Santos AC , Elias Júnior J , Zanini MA , Fleury A , Takayanagui OM , 2016. Clinical symptoms, imaging features and cyst distribution in the cerebrospinal fluid compartments in patients with extraparenchymal neurocysticercosis. PLoS Negl Trop Dis 10: e0005115.
-
8.
Nash TE , O’Connell EM , 2020. Subarachnoid neurocysticercosis: emerging concepts and treatment. Curr Opin Infect Dis 33: 339–346.
-
9.
Rodriguez S , Dorny P , Tsang VCW , Pretell EJ , Brandt J , Lescano AG , Gonzalez AE , Gilman RH , Garcia HH ; Cysticercosis Working Group in Peru , 2009. Detection of Taenia solium antigens and anti–T. solium antibodies in paired serum and cerebrospinal fluid samples from patients with intraparenchymal or extraparenchymal neurocysticercosis. J Infect Dis 199: 1345–1352.
-
10.
Arroyo G et al.; Cysticercosis Working Group in Peru , 2018. Antibody banding patterns of the enzyme-linked immunoelectrotransfer blot and brain imaging findings in patients with neurocysticercosis. Clin Infect Dis 66: 282–288.
-
11.
Serpa JA , Graviss EA , Kass JS , White AC , 2011. Neurocysticercosis in Houston, Texas: an update. Medicine (Baltimore) 90: 81–86.
-
12.
Dixon HB , Lipscomb FM , 1961. Cysticercosis: an analysis and follow-up of 450 cases. London, UK: H.M. Stationery Office.
-
13.
Del Brutto OH , 2012. Neurocysticercosis among international travelers to disease‐endemic areas. J Travel Med 19: 112–117.
-
14.
Murrieta I , Flores X , Osorio R , Kuschick Feher J , Carrillo-Mezo R , Fleury A , 2021. Natural history of extraparenchymal neurocysticercosis. Trans R Soc Trop Med Hyg 115: 1218–1225.
-
15.
Nash TE , O’Connell EM , Hammoud DA , Wetzler L , Ware JM , Mahanty S , 2020. Natural history of treated subarachnoid neurocysticercosis. Am J Trop Med Hyg 102: 78–89.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1241 | 627 | 28 |
| Full Text Views | 467 | 49 | 3 |
| PDF Downloads | 145 | 34 | 5 |
Older Age in Subarachnoid Neurocysticercosis Reflects a Long Prepatent Period
Fernando Nateros
Fernando Nateros
Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Peru;
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
Search for other papers by Fernando Nateros in
Current site
Google Scholar
PubMed
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
Search for other papers by Fernando Nateros in
Current site
Google Scholar
PubMed
Edith Saenz
Edith Saenz
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
Search for other papers by Edith Saenz in
Current site
Google Scholar
PubMed
Search for other papers by Edith Saenz in
Current site
Google Scholar
PubMed
Herbert Saavedra
Herbert Saavedra
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
Search for other papers by Herbert Saavedra in
Current site
Google Scholar
PubMed
Search for other papers by Herbert Saavedra in
Current site
Google Scholar
PubMed
Isidro Gonzales
Isidro Gonzales
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
Unidad de Investigación, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
Search for other papers by Isidro Gonzales in
Current site
Google Scholar
PubMed
Unidad de Investigación, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
Search for other papers by Isidro Gonzales in
Current site
Google Scholar
PubMed
E. Javier Pretell
E. Javier Pretell
Hospital Nacional Alberto Sabogal, Callao, Peru;
Search for other papers by E. Javier Pretell in
Current site
Google Scholar
PubMed
Search for other papers by E. Javier Pretell in
Current site
Google Scholar
PubMed
Erika Perez
Erika Perez
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
Search for other papers by Erika Perez in
Current site
Google Scholar
PubMed
Search for other papers by Erika Perez in
Current site
Google Scholar
PubMed
Yesenia Castillo
Yesenia Castillo
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru
Search for other papers by Yesenia Castillo in
Current site
Google Scholar
PubMed
Search for other papers by Yesenia Castillo in
Current site
Google Scholar
PubMed
Javier A. Bustos
Javier A. Bustos
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru
Search for other papers by Javier A. Bustos in
Current site
Google Scholar
PubMed
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru
Search for other papers by Javier A. Bustos in
Current site
Google Scholar
PubMed
Hector H. Garcia
Hector H. Garcia
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru
Search for other papers by Hector H. Garcia in
Current site
Google Scholar
PubMed
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru
Search for other papers by Hector H. Garcia in
Current site
Google Scholar
PubMed
for the Cysticercosis Working Group in Peru
for the Cysticercosis Working Group in Peru
Search for other papers by for the Cysticercosis Working Group in Peru in
Current site
Google Scholar
PubMed
Search for other papers by for the Cysticercosis Working Group in Peru in
Current site
Google Scholar
PubMed
ABSTRACT.
Patients with subarachnoid neurocysticercosis (NCC) are usually older than those with parenchymal disease. Whether this difference reflects a prolonged presymptomatic period or a delay in diagnosis is not clear. From 408 eligible patients, we retrospectively compared the age at symptom onset in 140 patients diagnosed with parenchymal (pure viable or pure calcified) and subarachnoid NCC who had a confirmatory image available not more than 2 years after the beginning of symptoms. Patients with mixed (parenchymal and subarachnoid) NCC or those with parenchymal cysts at different stages (viable and/or degenerating and/or calcified) were not included. After controlling by sex and residence in rural endemic regions, the mean age at symptom onset in patients with subarachnoid disease was 13.69 years older than those with viable parenchymal disease. A long incubation period is a major contributing factor to older age at presentation in subarachnoid NCC, independent of delayed diagnosis or access to care.
- Supplemental Materials (PDF 350.57 KB)
Author Notes
Financial support: This study was partially supported by
Authors’ addresses: Fernando Nateros, Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Peru, and Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, E-mail: percy.nateros.b@upch.pe. Edith Saenz, Herbert Saavedra, and Erika Perez, Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, E-mails: edith.saenz.h@upch.pe, hsaavedrapastor@hotmail.com, and erika.perez.p@upch.pe. Isidro Gonzales, Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, and Unidad de Investigación, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, E-mail: isidrogonzalesq@hotmail.com. E. Javier Pretell, Hospital Nacional Alberto Sabogal, Callao, Peru, E-mail: ejpretell@hotmail.com. Yesenia Castillo, Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: yesenia.castillo.b@upch.pe. Javier A. Bustos and Hector H. Garcia, Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, and Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mails: javier.bustos.p@upch.pe and hgarcia@jhsph.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Bustos J , Gonzales I , Saavedra H , Handali S , Garcia HH , 2021. Neurocysticercosis. A frequent cause of seizures, epilepsy, and other neurological morbidity in most of the world. J Neurol Sci 427: 117527.
-
2.
Fleury A , Carrillo-Mezo R , Flisser A , Sciutto E , Corona T , 2011. Subarachnoid basal neurocysticercosis: a focus on the most severe form of the disease. Expert Rev Anti Infect Ther 9: 123–133.
-
3.
Abanto J , Blanco D , Saavedra H , Gonzales I , Siu D , Pretell EJ , Bustos JA , Garcia HH , 2021. Mortality in parenchymal and subarachnoid neurocysticercosis. Am J Trop Med Hyg 105: 176–180.
-
4.
Marcin-Sierra M et al., 2017. Extraparenchymal neurocysticercosis: demographic, clinicoradiological, and inflammatory features. PLoS Negl Trop Dis 11: e0005646.
-
5.
Fleury A , Dessein A , Preux P , Dumas M , Tapia G , Larralde C , Sciutto E , 2004. Symptomatic human neurocysticercosis: age, sex and exposure factors relating with disease heterogeneity. J Neurol 251: 830–837.
-
6.
Monteiro L , Almeida-Pinto J , Stocker A , Sampaio-Silva M , 1993. Active neurocysticercosis, parenchymal and extraparenchymal: a study of 38 patients. J Neurol 241: 15–21.
-
7.
Bazan R , Hamamoto Filho PT , Luvizutto GJ , Nunes HR , Odashima NS , Dos Santos AC , Elias Júnior J , Zanini MA , Fleury A , Takayanagui OM , 2016. Clinical symptoms, imaging features and cyst distribution in the cerebrospinal fluid compartments in patients with extraparenchymal neurocysticercosis. PLoS Negl Trop Dis 10: e0005115.
-
8.
Nash TE , O’Connell EM , 2020. Subarachnoid neurocysticercosis: emerging concepts and treatment. Curr Opin Infect Dis 33: 339–346.
-
9.
Rodriguez S , Dorny P , Tsang VCW , Pretell EJ , Brandt J , Lescano AG , Gonzalez AE , Gilman RH , Garcia HH ; Cysticercosis Working Group in Peru , 2009. Detection of Taenia solium antigens and anti–T. solium antibodies in paired serum and cerebrospinal fluid samples from patients with intraparenchymal or extraparenchymal neurocysticercosis. J Infect Dis 199: 1345–1352.
-
10.
Arroyo G et al.; Cysticercosis Working Group in Peru , 2018. Antibody banding patterns of the enzyme-linked immunoelectrotransfer blot and brain imaging findings in patients with neurocysticercosis. Clin Infect Dis 66: 282–288.
-
11.
Serpa JA , Graviss EA , Kass JS , White AC , 2011. Neurocysticercosis in Houston, Texas: an update. Medicine (Baltimore) 90: 81–86.
-
12.
Dixon HB , Lipscomb FM , 1961. Cysticercosis: an analysis and follow-up of 450 cases. London, UK: H.M. Stationery Office.
-
13.
Del Brutto OH , 2012. Neurocysticercosis among international travelers to disease‐endemic areas. J Travel Med 19: 112–117.
-
14.
Murrieta I , Flores X , Osorio R , Kuschick Feher J , Carrillo-Mezo R , Fleury A , 2021. Natural history of extraparenchymal neurocysticercosis. Trans R Soc Trop Med Hyg 115: 1218–1225.
-
15.
Nash TE , O’Connell EM , Hammoud DA , Wetzler L , Ware JM , Mahanty S , 2020. Natural history of treated subarachnoid neurocysticercosis. Am J Trop Med Hyg 102: 78–89.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1241 | 627 | 28 |
| Full Text Views | 467 | 49 | 3 |
| PDF Downloads | 145 | 34 | 5 |