ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Tayyebi M , Darchini-Maragheh E , Layegh P , Kiafar B , Goyonlo VM , 2021. The effect of oral miltefosine in treatment of antimoniate resistant anthroponotic cutaneous leishmaniasis: an uncontrolled clinical trial. PLoS Negl Trop Dis 15: e0009241.
-
2.
Martinez S , Marr JJ , 1992. Allopurinol in the treatment of American cutaneous leishmaniasis. N Engl J Med 326: 741–744.
-
3.
Husein‐ElAhmed H , Gieler U , Steinhoff M , 2020. Evidence supporting the enhanced efficacy of pentavalent antimonials with adjuvant therapy for cutaneous leishmaniasis: a systematic review and meta‐analysis. J Eur Acad Dermatol Venereol 34: 2216–2228.
-
4.
Esfandiarpour I , Alavi A , 2002. Evaluating the efficacy of allopurinol and meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. Int J Dermatol 41: 521–524.
-
5.
Momeni AZ , Reiszadae MR , Aminjavaheri M , 2002. Treatment of cutaneous leishmaniasis with a combination of allopurinol and low‐dose meglumine antimoniate. Int J Dermatol 41: 441–443.
-
6.
Pinart M , Rueda JR , Romero GA , Pinzón-Flórez CE , Osorio-Arango K , Silveira Maia-Elkhoury AN , Reveiz L , Elias VM , Tweed JA , 2020. Interventions for American cutaneous and mucocutaneous leishmaniasis. Cochrane Database Syst Rev 8: CD004834.
-
7.
Momeni AZ , Jalayer T , Emamjomeh M , Bashardost N , Ghassemi R , Meghdadi M , Javadi A , Aminjavaheri M , 1996. Treatment of cutaneous leishmaniasis with itraconazole. Randomized double-blind study. Arch Dermatol 132: 784–786.
-
8.
Yaich S , Charfeddine K , Masmoudi A , Masmoudi M , Zaghdhane S , Turki H , Hachicha J , 2013. Atypical presentation of cutaneous leishmaniasis in a renal transplant recipient successfully treated with allopurinol and fluconazole. Ann Saudi Med 33: 187–191.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1849 | 1434 | 197 |
| Full Text Views | 1198 | 167 | 0 |
| PDF Downloads | 209 | 22 | 0 |
Treatment of Cutaneous Leishmaniasis with Allopurinol Plus Itraconazole in Iran
Vahid Mashayekhi Goyonlo
Vahid Mashayekhi Goyonlo
Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Search for other papers by Vahid Mashayekhi Goyonlo in
Current site
Google Scholar
PubMed
Search for other papers by Vahid Mashayekhi Goyonlo in
Current site
Google Scholar
PubMed
Zahra Derakhshan
Zahra Derakhshan
Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Search for other papers by Zahra Derakhshan in
Current site
Google Scholar
PubMed
Search for other papers by Zahra Derakhshan in
Current site
Google Scholar
PubMed
Emadodin Darchini-Maragheh
Emadodin Darchini-Maragheh
Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Search for other papers by Emadodin Darchini-Maragheh in
Current site
Google Scholar
PubMed
Search for other papers by Emadodin Darchini-Maragheh in
Current site
Google Scholar
PubMed
ABSTRACT.
Cutaneous leishmaniasis (CL) is a serious tropical disease and a neglected health challenge in Iran. Although limited data are available regarding anthroponotic CL, cases resistant to meglumine antimoniate (Glucantime) are increasingly being reported. Via an open-label noncontrolled case series, allopurinol (10 mg/kg/day) plus itraconazole (3–4 mg/kg/day) were orally administered for 1 month to 27 patients (56 lesions) with anthroponotic CL, most of whom were resistant to Glucantime. A mean lesion size of 3.5 ± 1.9 cm at baseline was reduced to 0.6 ± 1.0 after 1 month of treatment. Excellent treatment response was observed in 85.7% of lesions after 1 month. Recurrence only occurred in one patient in the 3-month follow-up session. This study presents preliminary evidence that oral allopurinol plus itraconazole could be an effective treatment in patients with anthroponotic CL.
Author Notes
Financial support: The study was supported by the Vice Chancellor for Research,
Authors’ addresses: Vahid Mashayekhi Goyonlo, Zahra Derakhshan, and Emadodin Darchini-Maragheh, Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, E-mails: mashayekhiv@mums.ac.ir, taraderakhshan93@gmail.com, and darchinime971@mums.ac.ir.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Tayyebi M , Darchini-Maragheh E , Layegh P , Kiafar B , Goyonlo VM , 2021. The effect of oral miltefosine in treatment of antimoniate resistant anthroponotic cutaneous leishmaniasis: an uncontrolled clinical trial. PLoS Negl Trop Dis 15: e0009241.
-
2.
Martinez S , Marr JJ , 1992. Allopurinol in the treatment of American cutaneous leishmaniasis. N Engl J Med 326: 741–744.
-
3.
Husein‐ElAhmed H , Gieler U , Steinhoff M , 2020. Evidence supporting the enhanced efficacy of pentavalent antimonials with adjuvant therapy for cutaneous leishmaniasis: a systematic review and meta‐analysis. J Eur Acad Dermatol Venereol 34: 2216–2228.
-
4.
Esfandiarpour I , Alavi A , 2002. Evaluating the efficacy of allopurinol and meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. Int J Dermatol 41: 521–524.
-
5.
Momeni AZ , Reiszadae MR , Aminjavaheri M , 2002. Treatment of cutaneous leishmaniasis with a combination of allopurinol and low‐dose meglumine antimoniate. Int J Dermatol 41: 441–443.
-
6.
Pinart M , Rueda JR , Romero GA , Pinzón-Flórez CE , Osorio-Arango K , Silveira Maia-Elkhoury AN , Reveiz L , Elias VM , Tweed JA , 2020. Interventions for American cutaneous and mucocutaneous leishmaniasis. Cochrane Database Syst Rev 8: CD004834.
-
7.
Momeni AZ , Jalayer T , Emamjomeh M , Bashardost N , Ghassemi R , Meghdadi M , Javadi A , Aminjavaheri M , 1996. Treatment of cutaneous leishmaniasis with itraconazole. Randomized double-blind study. Arch Dermatol 132: 784–786.
-
8.
Yaich S , Charfeddine K , Masmoudi A , Masmoudi M , Zaghdhane S , Turki H , Hachicha J , 2013. Atypical presentation of cutaneous leishmaniasis in a renal transplant recipient successfully treated with allopurinol and fluconazole. Ann Saudi Med 33: 187–191.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1849 | 1434 | 197 |
| Full Text Views | 1198 | 167 | 0 |
| PDF Downloads | 209 | 22 | 0 |