Murray CJ et al., 2022. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399: 629–655.
Cervino G , Cicciù M , Biondi A , Bocchieri S , Herford AS , Laino L , Fiorillo L , 2019. Antibiotic prophylaxis on third molar extraction: systematic review of recent data. Antibiotics (Basel) 8: 1–14.
Thompson W , Williams D , Pulcini C , 2020. The Essential Role of the Dental Team in Reducing Antibiotic Resistance. Geneva, Switzerland: FDI World Dental Federation. Available at: https://www.fdiworlddental.org/sites/default/files/2020-11/abr_white_paper_english.pdf. Accessed March 8, 2022.
Marra F , George D , Chong M , Sutherland S , Patrick DM , 2016. Antibiotic prescribing by dentists has increased: why? J Am Dent Assoc 147: 320–327.
Hubbard CC , Evans CT , Calip GS , Zhou J , Rowan SA , Suda KJ , 2022. Appropriateness of antibiotic prophylaxis before dental procedures, 2016–2018. Am J Prev Med 62: 943–948.
Osaiyuwu O , 2021. Occurrence of bacteraemia following oral and maxillofacial surgical procedures in Port Harcourt, Nigeria. Afr Health Sci 21: 1692–1700.
Ramos E , Santamaría J , Santamaría G , Barbier L , Arteagoitia I , 2016. Do systemic antibiotics prevent dry socket and infection after third molar extraction? A systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 122: 403–425.
Menon RK , Gopinath D , Li KY , Leung YY , Botelho MG , 2019. Does the use of amoxicillin/amoxicillin–clavulanic acid in third molar surgery reduce the risk of postoperative infection? A systematic review with meta-analysis. Int J Oral Maxillofac Surg 48: 263–273.
Wilson WR et al., 2021. Prevention of viridans group Streptococcal infective endocarditis: a scientific statement from the American Heart Association. Circulation 143: e963–e978.
Nishimura RA et al., 2017. 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 135: e1159–e1195.
Thornhill MH , Gibson TB , Durkin MJ , Dayer MJ , Lockhart PB , O’Gara PT , Baddour LM , 2020. Prescribing of antibiotic prophylaxis to prevent infective endocarditis. J Am Dent Assoc 151: 835–845.e31.
Buonavoglia A , Leone P , Solimando AG , Fasano R , Malerba E , Prete M , Corrente M , Prati C , Vacca A , Racanelli V , 2021. Antibiotics or no antibiotics, that is the question: an update on efficient and effective use of antibiotics in dental practice. Antibiotics (Basel) 10: 550.
Zar J , 2010. Biostatistical Analysis, 5th edition. Hoboken, NJ: Prentice Hall.
Angarita-Díaz M del P et al., 2020. Prescribing antibiotics by dentists in Colombia: toward a conscientious prescription. J Public Health Dent 81: 100–112.
Dar-Odeh NS , Abu-Hammad OA , Al-Omiri MK , Khraisat AS , Shehabi AA , 2010. Antibiotic prescribing practices by dentists: a review. Ther Clin Risk Manag 6: 301–306.
Segura-Egea JJ , Gould K , Şen BH , Jonasson P , Cotti E , Mazzoni A , Sunay H , Tjäderhane L , Dummer PMH , 2017. Antibiotics in endodontics: a review. Int Endod J 50: 1169–1184.
Stein K , Farmer J , Singhal S , Marra F , Sutherland S , Quiñonez C , 2018. The use and misuse of antibiotics in dentistry: a scoping review. J Am Dent Assoc 149: 869–884.e5.
Lockhart PB , Thornhill MH , Zhao J , Baddour LM , Davis J , McKnight PE , Gilbert GH , Mungia R , Mougeot JL ; National Dental PBRN Collaborative Group , 2020. Prophylactic antibiotic prescribing in dental practice: findings from a National Dental Practice-Based Research Network questionnaire. J Am Dent Assoc 151: 770–781.e6.
Lockhart PB , Brennan MT , Sasser HC , Fox PC , Paster BJ , Bahrani-Mougeot FK , 2008. Bacteremia associated with toothbrushing and dental extraction. Circulation 117: 3118–3125.
Kannan T , 2017. ASA grading: a step forward. J Perioper Pract 27: 54–58.
Limones A , Sáez-Alcaide LM , Díaz-Parreño SA , Helm A , Bornstein M-M , Molinero-Mourelle P , 2020. Medication-related osteonecrosis of the jaws (MRONJ) in cancer patients treated with denosumab vs. zoledronic acid: a systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal 25: e326–e336.
Lodi G , Sardella A , Salis A , Demarosi F , Tarozzi M , Carrassi A , 2010. Tooth extraction in patients taking intravenous bisphosphonates: a preventive protocol and case series. J Oral Maxillofac Surg 68: 107–110.
NICE , 2008. Prophylaxis against Infective Endocarditis: Antimicrobial Prophylaxis against Infective Endocarditis in Adults and Children. London, United Kingdom: National Institute for Health and Care Excellence.
Dayer MJ , Jones S , Prendergast B , Baddour LM , Lockhart PB , Thornhill MH , 2015. An increase in the incidence of infective endocarditis in England since 2008: a secular trend interrupted time series analysis HHS Public Access. Lancet 385: 1219–1228.
NICE , 2016. Prophylaxis against Infective Endocarditis: Antimicrobial Prophylaxis against Infective Endocarditis in Adults and Children Undergoing Interventional Procedures. Available at: https://www.nice.org.uk/guidance/cg64. Accessed January 7, 2022.
Milani BA , Bauer HC , Sampaio-Filho H , Horliana ACRT , Perez FEG , Tortamano IP , Jorge WA , 2015. Antibiotic therapy in fully impacted lower third molar surgery: randomized three-arm, double-blind, controlled trial. Oral Maxillofac Surg 19: 341–346.
Sidana S , Mistry Y , Gandevivala A , Motwani N , 2017. Evaluation of the need for antibiotic prophylaxis during routine intra-alveolar dental extractions in healthy patients: a randomized double-blind controlled trial. J Evid Based Dent Pract 17: 184–189.
Marghalani A , 2014. Antibiotic prophylaxis reduces infectious complications but increases adverse effects after third-molar extraction in healthy patients. J Am Dent Assoc 145: 476–478.
Kreutzer K , Storck K , Weitz J , 2014. Current evidence regarding prophylactic antibiotics in head and neck and maxillofacial surgery. BioMed Res Int 2014: 879437.
Taberner-Vallverdú M , Sánchez-Garcés MÁ , Gay-Escoda C , 2017. Efficacy of different methods used for dry socket prevention and risk factor analysis: a systematic review. Med Oral Patol Oral Cir Bucal 22: e750–e758.
Gill AS , Morrissey H , Rahman A , 2018. A systematic review and meta-analysis evaluating antibiotic prophylaxis in dental implants and extraction procedures. Medicina (Kaunas) 54: 1–27.
Taberner-Vallverdú M , Nazir M , Sánchez-Garcés MA , Gay-Escoda C , 2015. Efficacy of different methods used for dry socket management: a systematic review. Med Oral Patol Oral Cir Bucal 20: e633–e639.
Arteagoitia MI , Barbier L , Santamaría J , Santamaría G , Ramos E , 2016. Efficacy of amoxicillin and amoxicillin/clavulanic acid in the prevention of infection and dry socket after third molar extraction: a systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal 21: e494–e504.
Thornhill MH , Dayer M , Lockhart PB , Prendergast B , 2017. Antibiotic prophylaxis of infective endocarditis. Curr Infect Dis Rep 19: 9.
Chitnis AS et al., 2013. Epidemiology of community-associated Clostridium difficile infection, 2009 through 2011. JAMA Intern Med 173: 1359–1367.
Jakobsson HE , Jernberg C , Andersson AF , Sjölund-Karlsson M , Jansson JK , Engstrand L , 2010. Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome. PLoS One 5: e9836.
Dureja C , Olaitan AO , Hurdle JG , 2022. Mechanisms and impact of antimicrobial resistance in Clostridioides difficile. Curr Opin Microbiol 66: 63–72.
Patangia DV , Anthony Ryan C , Dempsey E , Ross RP , Stanton C , 2022. Impact of antibiotics on the human microbiome and consequences for host health. MicrobiologyOpen 11: 1–23.
Hancox JC , Hasnain M , Vieweg WVR , Crouse ELB , Baranchuk A , 2013. Azithromycin, cardiovascular risks, QTc interval prolongation, torsade de pointes, and regulatory issues: a narrative review based on the study of case reports. Ther Adv Infect Dis 1: 155–165.
Pickering H , Hart JD , Burr S , Stabler R , Maleta K , Kalua K , Bailey RL , Holland MJ , 2022. Impact of azithromycin mass drug administration on the antibiotic-resistant gut microbiome in children: a randomized, controlled trial. Gut Pathog 14: 1–11.
Rodríguez Sánchez F , Rodríguez Andrés C , Arteagoitia Calvo I , 2017. Does chlorhexidine prevent alveolar osteitis after third molar extractions? Systematic review and meta-analysis. J Oral Maxillofac Surg 75: 901–914.
Hasheminia D , Moaddabi A , Moradi S , Soltani P , Moannaei M , Issazadeh M , 2018. The efficacy of 1% betadine mouthwash on the incidence of dry socket after mandibular third molar surgery. J Clin Exp Dent 10: e445–e449.
Requena-Calla S , Funes-Rumiche I , 2016. Effectiveness of intra-alveolar chlorhexidine gel in reducing dry socket following surgical extraction of lower third molars: a pilot study. J Clin Exp Dent 8: e160–e163.
Payer M et al., 2020. The effect of systemic antibiotics on clinical and patient-reported outcome measures of oral implant therapy with simultaneous guided bone regeneration. Clin Oral Implants Res 31: 442–451.
Lockhart PB , Brennan MT , Thornhill M , Michalowicz BS , Noll J , Bahrani-Mougeot FK , Sasser HC , 2009. Poor oral hygiene as a risk factor for infective endocarditis-related bacteremia. J Am Dent Assoc 140: 1238–1244.
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The irrational use of antimicrobial drugs has become a serious epidemiological problem due to the development of bacterial resistance, causing consequences for global health. In dentistry, antibiotics are the second most common pharmacological class prescribed. Thus, we evaluated the use of antimicrobial prophylaxis by dentists in Porto Alegre, Brazil, and the metropolitan region using an online questionnaire. Dentists were asked to complete an anonymous questionnaire concerning antimicrobial prescription. The questionnaire was prepared on the Microsoft Forms platform and shared with dentists through social media and was available for a period of 40 days. The questionnaire was answered by 82 dentists, and 85.3% of them reported prescribing antibiotic prophylaxis (AP). Many different protocols were observed, but the majority of dentists prescribe amoxicillin (2 g) 1 hour before a procedure. The greatest diversity was found in the prescriptions for post-procedure prophylaxis, but most professionals prescribe 500 mg of antibiotics every 8 hours for 7 days. An overwhelming 91.5% of participants think that guidelines for prescribing antibiotics in dentistry are necessary, and 62.2% believe that the use of AP can have some impact on bacterial resistance. There is a wide range of different prescriptions for antimicrobials, suggesting a need for better aligned guidelines and education of professionals on the proper use of antimicrobials and its consequences on bacterial resistance to antibiotics.
Authors’ addresses: Bethina S. Sinhorelli and Sílvia D. Oliveira, Laboratório de Imunologia e Microbiologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Porto Alegre, Brazil, and Programa de Pós-graduação em Odontologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Porto Alegre, Brazil, E-mails: firstname.lastname@example.org and email@example.com.