Author:
ProCite
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Reference Manager
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-
1.
Moro P , Schantz PM , 2009. Echinococcosis: A review. Int J Infect Dis 13: 125–133.
-
2.
Brunetti E , Kern P , Vuitton DA , Writing Panel for the WHO-IWGE , 2010. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop 114: 1–16.
-
3.
Kadry Z , Renner EC , Bachmann LM , Attigah N , Renner EL , Ammann RW , Clavien PA , 2005. Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis. Br J Surg 92: 1110–1116.
-
4.
Wen H , Vuitton L , Tuxun T , Li J , Vuitton DA , Zhang W , McManus DP , 2019. Echinococcosis: Advances in the 21st century. Clin Microbiol Rev 32: e00075-18.
-
5.
Torgerson PR , Schweiger A , Deplazes P , Pohar M , Reichen J , Ammann RW , Tarr PE , Halkic N , Mullhaupt B , 2008. Alveolar echinococcosis: from a deadly disease to a well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35 years. J Hepatol 49: 72–77.
-
6.
Siles-Lucas M , Casulli A , Cirilli R , Carmena D , 2018. Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets. PLoS Negl Trop Dis 12: e0006422.
-
7.
Dusek D , Vince A , Kurelac I , Papic N , Viskovic K , Deplazes P , Beck R , 2020. Human alveolar echinococcosis, Croatia. Emerg Infect Dis 26: 364–366.
-
8.
Hemphill A , Stadelmann B , Rufener R , Spiliotis M , Boubaker G , Muller J , Muller N , Gorgas D , Gottstein B , 2014. Treatment of echinococcosis: Albendazole and mebendazole–what else? Parasite 21: 70.
-
9.
Lundstrom-Stadelmann B , Rufener R , Hemphill A , 2020. Drug repurposing applied: activity of the anti-malarial mefloquine against Echinococcus multilocularis. Int J Parasitol Drugs Drug Resist 13: 121–129.
-
10.
Reuter S , Buck A , Grebe O , Nussle-Kugele K , Kern P , Manfras BJ , 2003. Salvage treatment with amphotericin B in progressive human alveolar echinococcosis. Antimicrob Agents Chemother 47: 3586–3591.
-
11.
Tappe D , Muller A , Frosch M , Stich A , 2009. Limitations of amphotericin B and nitazoxanide in the treatment of alveolar echinococcosis. Ann Trop Med Parasitol 103: 177–181.
-
12.
Reuter S , Merkle M , Brehm K , Kern P , Manfras B , 2003. Effect of amphotericin B on larval growth of Echinococcus multilocularis. Antimicrob Agents Chemother 47: 620–625.
-
13.
Burkert S , Peters L , Bloehdorn J , Grüner B , 2022. Salvage therapy for alveolar echinococcosis – A case series. Pathogens 11: 333.
-
14.
Reuter S , Buck A , Manfras B , Kratzer W , Seitz HM , Darge K , Reske SN , Kern P , 2004. Structured treatment interruption in patients with alveolar echinococcosis. Hepatology 39: 509–517.
-
15.
Deibel A , Stocker D , Meyer Zu Schwabedissen C , Husmann L , Kronenberg PA , Grimm F , Deplazes P , Reiner CS , Mullhaupt B , 2022. Evaluation of a structured treatment discontinuation in patients with inoperable alveolar echinococcosis on long-term benzimidazole therapy: A retrospective cohort study. PLoS Negl Trop Dis 16: e0010146.
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Case Report: Amphotericin B and Mefloquine as a Salvage Treatment of Alveolar Echinococcosis
Karlo Jelicic
Karlo Jelicic
University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia;
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Neven Papic
Neven Papic
University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia;
School of Medicine, University of Zagreb, Zagreb, Croatia;
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School of Medicine, University of Zagreb, Zagreb, Croatia;
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Klaudija Viskovic
Klaudija Viskovic
University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia;
Faculty of Health Studies, University of Rijeka, Rijeka, Croatia
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Faculty of Health Studies, University of Rijeka, Rijeka, Croatia
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Adriana Vince
Adriana Vince
University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia;
School of Medicine, University of Zagreb, Zagreb, Croatia;
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School of Medicine, University of Zagreb, Zagreb, Croatia;
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ABSTRACT.
Alveolar echinococcosis is an emerging zoonotic disease caused by the parasite Echinococcus multilocularis. Most patients are diagnosed at a late stage, when lifelong treatment with benzimidazoles is required to stop disease progression. However, for patients who do not tolerate benzimidazole therapy, there are no alternatives. Here, we present a patient with advanced alveolar echinococcosis who was successfully treated with amphotericin B deoxycholate and mefloquine as a rescue therapy after he developed albendazole intolerance.
Author Notes
Authors’ Addresses: Karlo Jelicic, University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia, E-mail: kjelicic@bfm.hr. Neven Papic and Adriana Vince, University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia, and School of Medicine, University of Zagreb, Zagreb, Croatia, E-mails: npapic@bfm.hr and avince@bfm.hr. Klaudija Viskovic, University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia, and Faculty of Health Studies, University of Rijeka, Rijeka, Croatia, E-mail: kviskovic@bfm.hr.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Moro P , Schantz PM , 2009. Echinococcosis: A review. Int J Infect Dis 13: 125–133.
-
2.
Brunetti E , Kern P , Vuitton DA , Writing Panel for the WHO-IWGE , 2010. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop 114: 1–16.
-
3.
Kadry Z , Renner EC , Bachmann LM , Attigah N , Renner EL , Ammann RW , Clavien PA , 2005. Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis. Br J Surg 92: 1110–1116.
-
4.
Wen H , Vuitton L , Tuxun T , Li J , Vuitton DA , Zhang W , McManus DP , 2019. Echinococcosis: Advances in the 21st century. Clin Microbiol Rev 32: e00075-18.
-
5.
Torgerson PR , Schweiger A , Deplazes P , Pohar M , Reichen J , Ammann RW , Tarr PE , Halkic N , Mullhaupt B , 2008. Alveolar echinococcosis: from a deadly disease to a well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35 years. J Hepatol 49: 72–77.
-
6.
Siles-Lucas M , Casulli A , Cirilli R , Carmena D , 2018. Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets. PLoS Negl Trop Dis 12: e0006422.
-
7.
Dusek D , Vince A , Kurelac I , Papic N , Viskovic K , Deplazes P , Beck R , 2020. Human alveolar echinococcosis, Croatia. Emerg Infect Dis 26: 364–366.
-
8.
Hemphill A , Stadelmann B , Rufener R , Spiliotis M , Boubaker G , Muller J , Muller N , Gorgas D , Gottstein B , 2014. Treatment of echinococcosis: Albendazole and mebendazole–what else? Parasite 21: 70.
-
9.
Lundstrom-Stadelmann B , Rufener R , Hemphill A , 2020. Drug repurposing applied: activity of the anti-malarial mefloquine against Echinococcus multilocularis. Int J Parasitol Drugs Drug Resist 13: 121–129.
-
10.
Reuter S , Buck A , Grebe O , Nussle-Kugele K , Kern P , Manfras BJ , 2003. Salvage treatment with amphotericin B in progressive human alveolar echinococcosis. Antimicrob Agents Chemother 47: 3586–3591.
-
11.
Tappe D , Muller A , Frosch M , Stich A , 2009. Limitations of amphotericin B and nitazoxanide in the treatment of alveolar echinococcosis. Ann Trop Med Parasitol 103: 177–181.
-
12.
Reuter S , Merkle M , Brehm K , Kern P , Manfras B , 2003. Effect of amphotericin B on larval growth of Echinococcus multilocularis. Antimicrob Agents Chemother 47: 620–625.
-
13.
Burkert S , Peters L , Bloehdorn J , Grüner B , 2022. Salvage therapy for alveolar echinococcosis – A case series. Pathogens 11: 333.
-
14.
Reuter S , Buck A , Manfras B , Kratzer W , Seitz HM , Darge K , Reske SN , Kern P , 2004. Structured treatment interruption in patients with alveolar echinococcosis. Hepatology 39: 509–517.
-
15.
Deibel A , Stocker D , Meyer Zu Schwabedissen C , Husmann L , Kronenberg PA , Grimm F , Deplazes P , Reiner CS , Mullhaupt B , 2022. Evaluation of a structured treatment discontinuation in patients with inoperable alveolar echinococcosis on long-term benzimidazole therapy: A retrospective cohort study. PLoS Negl Trop Dis 16: e0010146.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 905 | 905 | 32 |
| Full Text Views | 159 | 159 | 1 |
| PDF Downloads | 178 | 178 | 2 |