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Case Report: Amphotericin B and Mefloquine as a Salvage Treatment of Alveolar Echinococcosis

Karlo JelicicUniversity Hospital for Infectious Diseases Zagreb, Zagreb, Croatia;

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Neven PapicUniversity Hospital for Infectious Diseases Zagreb, Zagreb, Croatia;
School of Medicine, University of Zagreb, Zagreb, Croatia;

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Klaudija ViskovicUniversity Hospital for Infectious Diseases Zagreb, Zagreb, Croatia;
Faculty of Health Studies, University of Rijeka, Rijeka, Croatia

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Adriana VinceUniversity Hospital for Infectious Diseases Zagreb, Zagreb, Croatia;
School of Medicine, University of Zagreb, Zagreb, Croatia;

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ABSTRACT.

Alveolar echinococcosis is an emerging zoonotic disease caused by the parasite Echinococcus multilocularis. Most patients are diagnosed at a late stage, when lifelong treatment with benzimidazoles is required to stop disease progression. However, for patients who do not tolerate benzimidazole therapy, there are no alternatives. Here, we present a patient with advanced alveolar echinococcosis who was successfully treated with amphotericin B deoxycholate and mefloquine as a rescue therapy after he developed albendazole intolerance.

Author Notes

Address correspondence to Neven Papic, University Hospital for Infectious Diseases Zagreb, Mirogojska 8, 10000 Zagreb, Croatia. E-mail: npapic@bfm.hr

Authors’ Addresses: Karlo Jelicic, University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia, E-mail: kjelicic@bfm.hr. Neven Papic and Adriana Vince, University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia, and School of Medicine, University of Zagreb, Zagreb, Croatia, E-mails: npapic@bfm.hr and avince@bfm.hr. Klaudija Viskovic, University Hospital for Infectious Diseases Zagreb, Zagreb, Croatia, and Faculty of Health Studies, University of Rijeka, Rijeka, Croatia, E-mail: kviskovic@bfm.hr.

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