Clinical Characteristics and Follow-up of Cases of Streptococcus suis Meningitis in Patients of Liuzhou, China

Shan Deng Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers’ Hospital, Liuzhou, China

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Baoquan Lin Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers’ Hospital, Liuzhou, China

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Baohui Weng Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers’ Hospital, Liuzhou, China

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Hong Yang Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers’ Hospital, Liuzhou, China

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Kejian Zhou Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers’ Hospital, Liuzhou, China

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Liya Wu Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers’ Hospital, Liuzhou, China

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Lu Qin Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers’ Hospital, Liuzhou, China

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Liya Pan Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers’ Hospital, Liuzhou, China

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ABSTRACT.

We analyzed the clinical characteristics and outcomes of patients with Streptococcus suis meningitis in Liuzhou, China, to improve diagnostic accuracy and lower the chances of misdiagnosis. The major clinical manifestations, auxiliary examination results, treatment strategies, treatment efficacy, and follow-up results of 17 consecutively admitted patients with S. suis meningitis were evaluated. The most common clinical manifestations were fever (15/17), sensorineural hearing loss (13/17), headache (11/17), and altered mental status (8/17). In addition, 64.71% of the patients had residual symptoms of sensorineural hearing loss at discharge, and moderate disabilities occurred in 68.75% of the patients in the form of sensorineural deafness (11/17) and hemiparesis (1/17). The cerebrospinal fluid (CSF) of nine patients was used for metagenomic analysis with next-generation sequencing. The metagenomic analysis of CSF of four patients was positive, whereas blood and CSF cultures were negative. The average modified Rankin Scale (mRS) and Activities of Daily Living (ADL) scores improved significantly at the 6-month follow-up compared with those at admission (P < 0.05). There was no correlation between altered mRS and ADL scores and the CSF findings (P > 0.05). Early administration of antibiotics can prevent sensorineural hearing loss. Early CSF metagenomic analysis may be superior to blood and CSF culture.

Author Notes

Address correspondence to Lu Qin or Liya Pan, Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers’ Hospital, No. 156 Heping Rd., Liuzhou 545005, China. E-mails: 334053842@qq.com or panlya@126.com

These authors contributed equally to this work.

Financial support: This work was supported by Guangxi Zhuang Autonomous Region Health and Family Planning Commission Projects (Z2016197, Z20170891, Z20180471, Z20180477, Z20200017, Z20210561, Z20210903, Z20170189) and Liuzhou Science and Technology Plan Projects (2021CBC0121, 2021CBC0128).

Authors’ addresses: Shan Deng, Baoquan Lin, Baohui Weng, Hong Yang, Kejian Zhou, Liya Wu, Lu Qin, and Liya Pan, Department of Neurology, The Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Workers’ Hospital, Liuzhou, China, E-mails: dengshan399@sina.com, linbaoquan2008@163.com, wengbaohui2021@163.com, 13768341368@139.com, 380400625@qq.com, 31742858@qq.com, 334053842@qq.com, and panlya@126.com.

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