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Reference Manager
BibTeX
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EndNote
-
1.
Campos M, Alonso DP, Conn JE, Vinetz JM, Emerson KJ, Ribolla PEM , 2019. Genetic diversity of Nyssorhynchus (Anopheles) darlingi related to biting behavior in western Amazon. Parasit Vectors 12: 242.
-
2.
Chu VM, Sallum MAM, Moore TE, Lainhart W, Schlichting CD, Conn JE , 2019. Regional variation in life history traits and plastic responses to temperature of the major malaria vector Nyssorhynchus darlingi in Brazil. Sci Rep 9: 5356.
-
3.
Girod R, Roux E, Berger F, Stefani A, Gaborit P, Carinci R, Issaly J, Carme B, Dusfour I , 2011. Unravelling the relationships between Anopheles darlingi (Diptera: Culicidae) densities, environmental factors and malaria incidence: understanding the variable patterns of malarial transmission in French Guiana (South America). Ann Trop Med Parasitol 105: 107–122.
-
4.
Orjuela LI et al.2018. Insecticide resistance and its intensity in populations of malaria vectors in Colombia. BioMed Res Int 2018: 9163543.
-
5.
Galardo AKR, Póvoa MM, Sucupira IMC, Galardo CD, Santos RLCD , 2015. Anopheles darlingi and Anopheles marajoara (Diptera: Culicidae) susceptibility to pyrethroids in an endemic area of the Brazilian Amazon. Rev Soc Bras Med Trop 48: 765–769.
-
6.
Pommier de Santi V et al.2016. Epidemiological and entomological studies of a malaria outbreak among French armed forces deployed at illegal gold mining sites reveal new aspects of the disease’s transmission in French Guiana. Malar J 15: 35.
-
7.
Pommier de Santi V et al.2016. Malaria in French Guiana linked to illegal gold mining. Emerg Infect Dis 22: 344–346.
-
8.
Pommier de Santi V et al.2016. Malaria hyperendemicity and risk for artemisinin resistance among illegal gold miners, French Guiana. Emerg Infect Dis 22: 903–906.
-
9.
Musset L, Pelleau S, Girod R, Ardillon V, Carvalho L, Dusfour I, Gomes MSM, Djossou F, Legrand E , 2014. Malaria on the Guiana Shield: a review of the situation in French Guiana. Mem Inst Oswaldo Cruz 109: 525–533.
-
10.
Mosnier E et al.2020. Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil. BMC Infect Dis 20: 373.
-
11.
Vezenegho SB, Adde A, Pommier de Santi V, Issaly J, Carinci R, Gaborit P, Dusfour I, Girod R, Briolant S , 2016. High malaria transmission in a forested malaria focus in French Guiana: how can exophagic Anopheles darlingi thwart vector control and prevention measures? Mem Inst Oswaldo Cruz 111: 561–569.
-
12.
WHO , 2016. Test Procedures for Insecticide Resistance Monitoring in Malaria Vector Mosquitoes, 2nd edition. Geneva, Switzerland: World Health Organization. Available at: http://www.who.int/malaria/publications/atoz/9789241511575/. Accessed September 18, 2018.
-
13.
Abbott WS , 1987. A method of computing the effectiveness of an insecticide. J Am Mosq Control Assoc 3: 302–303.
-
14.
Milese P, Pocquet N, Labbé P , 2013. BioRssay: A R Script for Bioassay Analyses. Available at: http://www.isem.univ-montp2.fr/recherche/equipes/genomique-deladaptation/personnel/labbe-pierrick/.
-
15.
Orjuela LI, Álvarez-Diaz DA, Morales JA, Grisales N, Ahumada ML, Venegas HJ, Quiñones ML, Yasnot MF , 2019. Absence of knockdown mutations in pyrethroid and DDT resistant populations of the main malaria vectors in Colombia. Malar J 18: 384.
-
16.
Migliani R, Pradines B, Michel R, Aoun O, Dia A, Deparis X, Rapp C , 2014. Malaria control strategies in French armed forces. Travel Med Infect Dis 12: 307–317, doi: 10.1016/j.tmaid.2014.05.008.
-
17.
Dusfour I, Thalmensy V, Gaborit P, Issaly J, Carinci R, Girod R , 2011. Multiple insecticide resistance in Aedes aegypti (Diptera: Culicidae) populations compromises the effectiveness of dengue vector control in French Guiana. Mem Inst Oswaldo Cruz 106: 346–352.
-
18.
Angêlla AF, Salgueiro P, Gil LHS, Vicente JL, Pinto J, Ribolla PEM , 2014. Seasonal genetic partitioning in the neotropical malaria vector, Anopheles darlingi. Malar J 13: 203.
-
19.
Fonseca-González I, Quiñones ML, McAllister J, Brogdon WG , 2009. Mixed-function oxidases and esterases associated with cross-resistance between DDT and lambda-cyhalothrin in Anopheles darlingi Root 1926 populations from Colombia. Mem Inst Oswaldo Cruz 104: 18–26.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2726 | 1342 | 349 |
| Full Text Views | 413 | 27 | 0 |
| PDF Downloads | 175 | 28 | 0 |
Variation in Pyrethroid Resistance Phenotypes in Anopheles darlingi in an Area with Residual Malaria Transmission: Warning of Suspected Resistance in French Guiana
Samuel Vezenegho
Samuel Vezenegho
Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France;
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Romuald Carinci
Romuald Carinci
Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France;
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Jean Issaly
Jean Issaly
Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France;
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Christophe Nguyen
Christophe Nguyen
Unité de Parasitologie et Entomologie, Département de Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France;
Aix Marseille Université, IRD, AP-HM, SSA, UMR Vecteurs—Infections Tropicales et Méditerranéennes (VITROME), IHU—Méditerranée Infection, Marseille, France;
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Aix Marseille Université, IRD, AP-HM, SSA, UMR Vecteurs—Infections Tropicales et Méditerranéennes (VITROME), IHU—Méditerranée Infection, Marseille, France;
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Pascal Gaborit
Pascal Gaborit
Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France;
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Laetitia Ferraro
Laetitia Ferraro
Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France;
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Guillaume Lacour
Guillaume Lacour
Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France;
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Emilie Mosnier
Emilie Mosnier
Unité des Maladies Infectieuses et Tropicales, Centre Hospitalier Andrée Rosemon, rue des Flamboyants, Cayenne, French Guiana, France;
Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, Marseille, France;
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Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, Marseille, France;
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Vincent Pommier de Santi
Vincent Pommier de Santi
Aix Marseille Université, IRD, AP-HM, SSA, UMR Vecteurs—Infections Tropicales et Méditerranéennes (VITROME), IHU—Méditerranée Infection, Marseille, France;
Centre d’Epidémiologie et de Santé Publique des Armées, Marseille, France;
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Centre d’Epidémiologie et de Santé Publique des Armées, Marseille, France;
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Yanouk Epelboin
Yanouk Epelboin
Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France;
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Romain Girod
Romain Girod
Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France;
Unité d’Entomologie Médicale, Institut Pasteur de Madagascar, Antananarivo, Madagascar;
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Unité d’Entomologie Médicale, Institut Pasteur de Madagascar, Antananarivo, Madagascar;
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Sebastien Briolant
Sebastien Briolant
Unité de Parasitologie et Entomologie, Département de Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France;
Aix Marseille Université, IRD, AP-HM, SSA, UMR Vecteurs—Infections Tropicales et Méditerranéennes (VITROME), IHU—Méditerranée Infection, Marseille, France;
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Aix Marseille Université, IRD, AP-HM, SSA, UMR Vecteurs—Infections Tropicales et Méditerranéennes (VITROME), IHU—Méditerranée Infection, Marseille, France;
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Isabelle Dusfour
Isabelle Dusfour
Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France;
Département de Santé Globale, Institut Pasteur, Paris, France;
MIVEGEC, Univ Montpellier, CNRS, IRD, Montpellier, France
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Département de Santé Globale, Institut Pasteur, Paris, France;
MIVEGEC, Univ Montpellier, CNRS, IRD, Montpellier, France
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ABSTRACT.
Anopheles darlingi is the main vector of malaria in South America. In French Guiana, malaria transmission occurs inland and along the rivers with a regular reemergence in the lower Oyapock area. Control against malaria vectors includes indoor residual spraying of deltamethrin and the distribution of long-lasting impregnated bednets. In this context, the level of resistance to pyrethroids was monitored for 4 years using CDC bottle tests in An. darlingi populations. A loss of susceptibility to pyrethroids was recorded with 30-minute knock-down measured as low as 81%. However, no pyrethroid molecular resistance was found by sequencing a 170 base pair fragment of the S6 segment of domain II of the voltage-gated sodium channel gene. Fluctuation of resistance phenotypes may be influenced by the reintroduction of susceptible alleles from sylvatic populations or by other mechanisms of metabolic resistance.
Author Notes
These authors contributed equally to this work.
Financial support: This work was funded by the “Agence Régionale de Santé de la Guyane” through a yearly grant to support vector control and by the French Army (Grant LR607e). YE and GL salaries were funded by FEDER “CONTROLE,” project n° Synergie: GY0010695.
Authors’ addresses: Samuel Vezenegho, Romuald Carinci, and Jean Issaly, Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France, E-mails: vsambumuh@yahoo.com, rcarinci@pasteur-cayenne.fr, and jissaly@pasteur-cayenne.fr. Christophe Nguyen, Unité de Parasitologie et Entomologie, Département de Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France, and Aix Marseille Université, IRD, AP-HM, SSA, UMR Vecteurs—Infections Tropicales et Méditerranéennes (VITROME), IHU—Méditerranée Infection, Marseille, France, E-mail: christophenguyen2005@gmail.com. Pascal Gaborit, Laetitia Ferraro, and Guillaume Lacour, Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France, E-mails: pgaborit@pasteur-cayenne.fr, laetitia.ferraro@yahoo.fr, and glacour.84@gmail.com. Emilie Mosnier, Unité des Maladies Infectieuses et Tropicales, Centre Hospitalier Andrée Rosemon, rue des Flamboyants, Cayenne, French Guiana, France and Aix Marseille University, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, Marseille, France, E-mail: emilie.mosnier@gmail.com. Vincent Pommier de Santi, Aix Marseille Université, IRD, AP-HM, SSA, UMR Vecteurs—Infections Tropicales et Méditerranéennes (VITROME), IHU—Méditerranée Infection, Marseille, France, and Centre d’Epidémiologie et de Santé Publique des Armées, Marseille, France, E-mail: v.pommierdesanti@gmail.com. Yanouk Epelboin, Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France, E-mail: yanoukepelboin@hotmail.com. Romain Girod, Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France, and Unité d’Entomologie Médicale, Institut Pasteur de Madagascar, Antananarivo, Madagascar, E-mail: rgirod@pasteur.mg. Sebastien Briolant, Unité de Parasitologie et Entomologie, Département de Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France, and Aix Marseille Université, IRD, AP-HM, SSA, UMR Vecteurs—Infections Tropicales et Méditerranéennes (VITROME), IHU—Méditerranée Infection, Marseille, France, E-mail: sbriolant@wanadoo.fr. Isabelle Dusfour, Institut Pasteur de la Guyane, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana, France, Département de Santé Globale, Institut Pasteur, Paris, France, and MIVEGEC, Univ Montpellier, CNRS, IRD, Montpellier, France, E-mail: isabelle.dusfour@pasteur.fr.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Campos M, Alonso DP, Conn JE, Vinetz JM, Emerson KJ, Ribolla PEM , 2019. Genetic diversity of Nyssorhynchus (Anopheles) darlingi related to biting behavior in western Amazon. Parasit Vectors 12: 242.
-
2.
Chu VM, Sallum MAM, Moore TE, Lainhart W, Schlichting CD, Conn JE , 2019. Regional variation in life history traits and plastic responses to temperature of the major malaria vector Nyssorhynchus darlingi in Brazil. Sci Rep 9: 5356.
-
3.
Girod R, Roux E, Berger F, Stefani A, Gaborit P, Carinci R, Issaly J, Carme B, Dusfour I , 2011. Unravelling the relationships between Anopheles darlingi (Diptera: Culicidae) densities, environmental factors and malaria incidence: understanding the variable patterns of malarial transmission in French Guiana (South America). Ann Trop Med Parasitol 105: 107–122.
-
4.
Orjuela LI et al.2018. Insecticide resistance and its intensity in populations of malaria vectors in Colombia. BioMed Res Int 2018: 9163543.
-
5.
Galardo AKR, Póvoa MM, Sucupira IMC, Galardo CD, Santos RLCD , 2015. Anopheles darlingi and Anopheles marajoara (Diptera: Culicidae) susceptibility to pyrethroids in an endemic area of the Brazilian Amazon. Rev Soc Bras Med Trop 48: 765–769.
-
6.
Pommier de Santi V et al.2016. Epidemiological and entomological studies of a malaria outbreak among French armed forces deployed at illegal gold mining sites reveal new aspects of the disease’s transmission in French Guiana. Malar J 15: 35.
-
7.
Pommier de Santi V et al.2016. Malaria in French Guiana linked to illegal gold mining. Emerg Infect Dis 22: 344–346.
-
8.
Pommier de Santi V et al.2016. Malaria hyperendemicity and risk for artemisinin resistance among illegal gold miners, French Guiana. Emerg Infect Dis 22: 903–906.
-
9.
Musset L, Pelleau S, Girod R, Ardillon V, Carvalho L, Dusfour I, Gomes MSM, Djossou F, Legrand E , 2014. Malaria on the Guiana Shield: a review of the situation in French Guiana. Mem Inst Oswaldo Cruz 109: 525–533.
-
10.
Mosnier E et al.2020. Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil. BMC Infect Dis 20: 373.
-
11.
Vezenegho SB, Adde A, Pommier de Santi V, Issaly J, Carinci R, Gaborit P, Dusfour I, Girod R, Briolant S , 2016. High malaria transmission in a forested malaria focus in French Guiana: how can exophagic Anopheles darlingi thwart vector control and prevention measures? Mem Inst Oswaldo Cruz 111: 561–569.
-
12.
WHO , 2016. Test Procedures for Insecticide Resistance Monitoring in Malaria Vector Mosquitoes, 2nd edition. Geneva, Switzerland: World Health Organization. Available at: http://www.who.int/malaria/publications/atoz/9789241511575/. Accessed September 18, 2018.
-
13.
Abbott WS , 1987. A method of computing the effectiveness of an insecticide. J Am Mosq Control Assoc 3: 302–303.
-
14.
Milese P, Pocquet N, Labbé P , 2013. BioRssay: A R Script for Bioassay Analyses. Available at: http://www.isem.univ-montp2.fr/recherche/equipes/genomique-deladaptation/personnel/labbe-pierrick/.
-
15.
Orjuela LI, Álvarez-Diaz DA, Morales JA, Grisales N, Ahumada ML, Venegas HJ, Quiñones ML, Yasnot MF , 2019. Absence of knockdown mutations in pyrethroid and DDT resistant populations of the main malaria vectors in Colombia. Malar J 18: 384.
-
16.
Migliani R, Pradines B, Michel R, Aoun O, Dia A, Deparis X, Rapp C , 2014. Malaria control strategies in French armed forces. Travel Med Infect Dis 12: 307–317, doi: 10.1016/j.tmaid.2014.05.008.
-
17.
Dusfour I, Thalmensy V, Gaborit P, Issaly J, Carinci R, Girod R , 2011. Multiple insecticide resistance in Aedes aegypti (Diptera: Culicidae) populations compromises the effectiveness of dengue vector control in French Guiana. Mem Inst Oswaldo Cruz 106: 346–352.
-
18.
Angêlla AF, Salgueiro P, Gil LHS, Vicente JL, Pinto J, Ribolla PEM , 2014. Seasonal genetic partitioning in the neotropical malaria vector, Anopheles darlingi. Malar J 13: 203.
-
19.
Fonseca-González I, Quiñones ML, McAllister J, Brogdon WG , 2009. Mixed-function oxidases and esterases associated with cross-resistance between DDT and lambda-cyhalothrin in Anopheles darlingi Root 1926 populations from Colombia. Mem Inst Oswaldo Cruz 104: 18–26.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2726 | 1342 | 349 |
| Full Text Views | 413 | 27 | 0 |
| PDF Downloads | 175 | 28 | 0 |