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Reference Manager
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-
1.
Diallo M, Thonnon J, Traore-Lamizana M, Fontenille D, 1999. Vectors of Chikungunya virus in Senegal: current data and transmission cycles. Am J Trop Med Hyg 60: 281–286.
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2.
Horwood PF, Buchy P, 2015. Chikungunya. Rev Sci Tech 34: 479–489.
-
3.
Staikowsky F, Talarmin F, Grivard P, Souab A, Schuffenecker I, Le Roux K, Lecuit M, Michault A, 2009. Prospective study of Chikungunya virus acute infection in the island of La Réunion during the 2005–2006 outbreak. PLoS One 4: e7603.
-
4.
Thiberville SD, Boisson V, Gaudart J, Simon F, Flahault A, de Lamballerie X, 2013. Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, south-west Indian Ocean. PLoS Negl Trop Dis 7: e2004.
-
5.
Suhrbier A, Jaffar-Bandjee MC, Gasque P, 2012. Arthritogenic alphaviruses—an overview. Nat Rev Rheumatol 8: 420–429.
-
6.
Harapan H, Michie A, Mudatsir M, Nusa R, Yohan B, Wagner AL, Sasmono RT, Imrie A, 2019. Chikungunya virus infection in Indonesia: a systematic review and evolutionary analysis. BMC Infect Dis 19: 243.
-
7.
Appassakij H, Khuntikij P, Kemapunmanus M, Wutthanarungsan R, Silpapojakul K, 2013. Viremic profiles in asymptomatic and symptomatic chikungunya fever: a blood transfusion threat? Transfusion 53: 2567–2574.
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8.
Simmons G et al., 2016. High incidence of Chikungunya virus and frequency of viremic blood donations during epidemic, Puerto Rico, USA, 2014. Emerg Infect Dis 22: 1221–1228.
-
9.
Petersen LR, Epstein JS, 2014. Chikungunya virus: new risk to transfusion safety in the Americas. Transfusion 54: 1911–1915.
-
10.
Badan Pusat Statistik Indonesia , 2021. Peraturan Kepala Badan Pusat Statistik Nomor 120 Tahun 2020 Tentang Klasifikasi Desa Perkotaan Dan Perdesaan Di Indonesia 2020 Buku 3 Bali, Nusa Tenggara, Kalimantan, Sulawesi, Maluku, Dan Papua. https://www.bps.go.id/publication/2021/05/26/7eba842e1090fccf23f34e71/peraturan-kepala-badan-pusat-statistik-nomor-120-tahun-2020-tentang-klasifikasi-desa-perkotaan-dan-perdesaan-di-indonesia-2020-buku-3-bali–nusa-tenggara–kalimantan–sulawesi–maluku–dan-papua.html. Accessed August 30, 2022.
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11.
Kosasih H et al., 2013. Evidence for endemic chikungunya virus infections in Bandung, Indonesia. PLoS Negl Trop Dis 7: e2483.
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12.
Lanciotti RS, Kosoy OL, Laven JJ, Panella AJ, Velez JO, Lambert AJ, Campbell GL, 2007. Chikungunya virus in US travelers returning from India, 2006. Emerg Infect Dis 13: 764–767.
-
13.
Stubbs SCB et al., 2020. An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia. PLoS Negl Trop Dis 14: e0008934 [correction published June 1, 2022: In the title of this article, there is a typographical error in the word “investigation.” The correct title is: An investigation into the epidemiology of Chikungunya virus across neglected regions of Indonesia].
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14.
Azami NA, Salleh SA, Shah SA, Neoh HM, Othman Z, Zakaria SZ, Jamal R, 2013. Emergence of chikungunya seropositivity in healthy Malaysian adults residing in outbreak-free locations: chikungunya seroprevalence results from the Malaysian Cohort. BMC Infect Dis 13: 67.
-
15.
Ang LW et al., 2017. Seroprevalence of antibodies against chikungunya virus in Singapore resident adult population. PLoS Negl Trop Dis 11: e0006163.
-
16.
Luvai EAC, Kyaw AK, Sabin NS, Yu F, Hmone SW, Thant KZ, Inoue S, Morita K, Ngwe Tun MM, 2021. Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018. PLoS Negl Trop Dis 15: e0009961.
-
17.
Vongpunsawad S, Intharasongkroh D, Thongmee T, Poovorawan Y, 2017. Seroprevalence of antibodies to dengue and chikungunya viruses in Thailand. PLoS One 12: e0180560.
-
18.
Quan TM, Phuong HT, Vy NHT, Thanh NTL, Lien NTN, Hong TTK, Dung PN, Chau NVV, Boni MF, Clapham HE, 2018. Evidence of previous but not current transmission of chikungunya virus in southern and central Vietnam: results from a systematic review and a seroprevalence study in four locations. PLoS Negl Trop Dis 12: e0006246.
-
19.
Arif M et al., 2020. Chikungunya in Indonesia: epidemiology and diagnostic challenges. PLoS Negl Trop Dis 14: e0008355.
-
20.
Agarwal A, Dash PK, Singh AK, Sharma S, Gopalan N, Rao PVL, Parida MM, Reiter P, 2014. Evidence of experimental vertical transmission of emerging novel ECSA genotype of Chikungunya virus in Aedes aegypti. PLoS Negl Trop Dis 8: e2990.
-
21.
Ndenga BA, Mutuku FM, Ngugi HN, Mbakaya JO, Aswani P, Musunzaji PS, Vulule J, Mukoko D, Kitron U, LaBeaud AD, 2017. Characteristics of Aedes aegypti adult mosquitoes in rural and urban areas of western and coastal Kenya. PLoS One 12: e0189971.
-
22.
Salje H et al., 2016. Reconstruction of 60 years of chikungunya epidemiology in the Philippines demonstrates episodic and focal transmission. J Infect Dis 213: 604–610.
-
23.
Dom NC, Ahmad AH, Ismail R, 2013. Habitat characterization of Aedes sp. breeding in urban hotspot area. Procedia Soc Behav Sci 85: 100–109.
-
24.
Johnson BW, Goodman CH, Holloway K, de Salazar PM, Valadere AM, Drebot MA, 2016. Evaluation of commercially available chikungunya virus immunoglobulin M detection assays. Am J Trop Med Hyg 95: 182–192.
-
25.
Slavov SN, Otaguiri KK, Bianquini ML, Bitencourt HTO, Chagas MCM, Guerreiro DSS, Figueiredo LTM, Covas DT, Kashima S, 2018. Seroprevalence of Chikungunya virus in blood donors from northern and southeastern Brazil. Hematol Transfus Cell Ther 40: 358–362.
-
26.
Myint KSA et al., 2022. Neurological disease associated with Chikungunya in Indonesia. Am J Trop Med Hyg 107: 291–295.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2798 | 1377 | 53 |
| Full Text Views | 752 | 35 | 0 |
| PDF Downloads | 310 | 38 | 0 |
Seroprevalence of Chikungunya in an Asymptomatic Adult Population in North and South Sulawesi, Indonesia
Mohammed A. Jalloh
Mohammed A. Jalloh
Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Bogor, Indonesia;
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I Made Artika
I Made Artika
Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Bogor, Indonesia;
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Yora P. Dewi
Yora P. Dewi
Eijkman Institute for Molecular Biology, Jakarta, Indonesia;
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Din Syafruddin
Din Syafruddin
Eijkman Institute for Molecular Biology, Jakarta, Indonesia;
Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia;
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Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia;
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Irfan Idris
Irfan Idris
Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia;
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Janno B.B. Bernadus
Janno B.B. Bernadus
Department of Parasitology, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia;
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Agustevie Telew
Agustevie Telew
Indonesian Red Cross Society, Manado, Indonesia;
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Diana S. Purwanto
Diana S. Purwanto
Department of Biochemistry, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia;
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Yoeke D. Rosita
Yoeke D. Rosita
Health Laboratory Center (Balai Besar Laboratorium Kesehatan), Makassar, Indonesia;
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Ungke Antonjaya
Ungke Antonjaya
Eijkman Institute for Molecular Biology, Jakarta, Indonesia;
Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia
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Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia
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Khin S.A. Myint
Khin S.A. Myint
Eijkman Institute for Molecular Biology, Jakarta, Indonesia;
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ABSTRACT.
Chikungunya (CHIK) is an emerging and reemerging infectious disease of public health importance in Indonesia. Information on the asymptomatic and true burden of CHIK virus (CHIKV) infections is limited. We assayed 1,092 healthy population samples, collected in North and South Sulawesi between 2019 and 2020, for antibodies against CHIKV. Blood samples were screened by IgM and IgG ELISAs and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) assay. CHIKV IgG seroprevalence in North and South Sulawesi was 53.2% and 53.9%, respectively. The overall prevalence of anti-CHIKV IgM antibody was 12.9%. Molecular testing of blood donors revealed 0.66% (2/300) were positive for CHIKV qRT-PCR. Our study provides new insights into the CHIKV endemicity situation in the eastern part of Indonesia and warrants the need for further systematic surveillance considering there is no treatment or vaccine for CHIK infection.
Author Notes
Financial support: This work was supported by Bogor Agricultural University; the Ministry of Research and Technology, Republic of Indonesia; and the U.S. Centers for Disease Control and Prevention.
Authors’ addresses: Mohammed A. Jalloh and I Made Artika, Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Bogor, Indonesia, E-mails: moh_jalloh@outlook.com and imart@apps.ipb.ac.id. Yora P. Dewi and Khin S.A. Myint, Emerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, E-mails: yoradewi@eijkman.go.id and khinsawying@hotmail.com. Din Syafruddin, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, and Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, E-mail: din@eijkman.go.id. Irfan Idris, Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia, E-mail: irfanfaal@gmail.com. Janno B.B. Bernadus, Department of Parasitology, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia, E-mail: jannobernadusmd@gmail.com. Agustevie Telew, Indonesian Red Cross Society, Manado, Indonesia, E-mail: agusteivie@unima.ac.id. Diana S. Purwanto, Department of Biochemistry, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia, E-mail: dianashintapurwanto@unsrat.ac.id. Yoeke D. Rosita, Health Laboratory Center (Balai Besar Laboratorium Kesehatan), Makassar, Indonesia, E-mail: yoekedr@gmail.com. Ungke Antonjaya, Emerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, and Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, E-mail: ungkeajy@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Diallo M, Thonnon J, Traore-Lamizana M, Fontenille D, 1999. Vectors of Chikungunya virus in Senegal: current data and transmission cycles. Am J Trop Med Hyg 60: 281–286.
-
2.
Horwood PF, Buchy P, 2015. Chikungunya. Rev Sci Tech 34: 479–489.
-
3.
Staikowsky F, Talarmin F, Grivard P, Souab A, Schuffenecker I, Le Roux K, Lecuit M, Michault A, 2009. Prospective study of Chikungunya virus acute infection in the island of La Réunion during the 2005–2006 outbreak. PLoS One 4: e7603.
-
4.
Thiberville SD, Boisson V, Gaudart J, Simon F, Flahault A, de Lamballerie X, 2013. Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, south-west Indian Ocean. PLoS Negl Trop Dis 7: e2004.
-
5.
Suhrbier A, Jaffar-Bandjee MC, Gasque P, 2012. Arthritogenic alphaviruses—an overview. Nat Rev Rheumatol 8: 420–429.
-
6.
Harapan H, Michie A, Mudatsir M, Nusa R, Yohan B, Wagner AL, Sasmono RT, Imrie A, 2019. Chikungunya virus infection in Indonesia: a systematic review and evolutionary analysis. BMC Infect Dis 19: 243.
-
7.
Appassakij H, Khuntikij P, Kemapunmanus M, Wutthanarungsan R, Silpapojakul K, 2013. Viremic profiles in asymptomatic and symptomatic chikungunya fever: a blood transfusion threat? Transfusion 53: 2567–2574.
-
8.
Simmons G et al., 2016. High incidence of Chikungunya virus and frequency of viremic blood donations during epidemic, Puerto Rico, USA, 2014. Emerg Infect Dis 22: 1221–1228.
-
9.
Petersen LR, Epstein JS, 2014. Chikungunya virus: new risk to transfusion safety in the Americas. Transfusion 54: 1911–1915.
-
10.
Badan Pusat Statistik Indonesia , 2021. Peraturan Kepala Badan Pusat Statistik Nomor 120 Tahun 2020 Tentang Klasifikasi Desa Perkotaan Dan Perdesaan Di Indonesia 2020 Buku 3 Bali, Nusa Tenggara, Kalimantan, Sulawesi, Maluku, Dan Papua. https://www.bps.go.id/publication/2021/05/26/7eba842e1090fccf23f34e71/peraturan-kepala-badan-pusat-statistik-nomor-120-tahun-2020-tentang-klasifikasi-desa-perkotaan-dan-perdesaan-di-indonesia-2020-buku-3-bali–nusa-tenggara–kalimantan–sulawesi–maluku–dan-papua.html. Accessed August 30, 2022.
-
11.
Kosasih H et al., 2013. Evidence for endemic chikungunya virus infections in Bandung, Indonesia. PLoS Negl Trop Dis 7: e2483.
-
12.
Lanciotti RS, Kosoy OL, Laven JJ, Panella AJ, Velez JO, Lambert AJ, Campbell GL, 2007. Chikungunya virus in US travelers returning from India, 2006. Emerg Infect Dis 13: 764–767.
-
13.
Stubbs SCB et al., 2020. An investig-ation into the epidemiology of chikungunya virus across neglected regions of Indonesia. PLoS Negl Trop Dis 14: e0008934 [correction published June 1, 2022: In the title of this article, there is a typographical error in the word “investigation.” The correct title is: An investigation into the epidemiology of Chikungunya virus across neglected regions of Indonesia].
-
14.
Azami NA, Salleh SA, Shah SA, Neoh HM, Othman Z, Zakaria SZ, Jamal R, 2013. Emergence of chikungunya seropositivity in healthy Malaysian adults residing in outbreak-free locations: chikungunya seroprevalence results from the Malaysian Cohort. BMC Infect Dis 13: 67.
-
15.
Ang LW et al., 2017. Seroprevalence of antibodies against chikungunya virus in Singapore resident adult population. PLoS Negl Trop Dis 11: e0006163.
-
16.
Luvai EAC, Kyaw AK, Sabin NS, Yu F, Hmone SW, Thant KZ, Inoue S, Morita K, Ngwe Tun MM, 2021. Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018. PLoS Negl Trop Dis 15: e0009961.
-
17.
Vongpunsawad S, Intharasongkroh D, Thongmee T, Poovorawan Y, 2017. Seroprevalence of antibodies to dengue and chikungunya viruses in Thailand. PLoS One 12: e0180560.
-
18.
Quan TM, Phuong HT, Vy NHT, Thanh NTL, Lien NTN, Hong TTK, Dung PN, Chau NVV, Boni MF, Clapham HE, 2018. Evidence of previous but not current transmission of chikungunya virus in southern and central Vietnam: results from a systematic review and a seroprevalence study in four locations. PLoS Negl Trop Dis 12: e0006246.
-
19.
Arif M et al., 2020. Chikungunya in Indonesia: epidemiology and diagnostic challenges. PLoS Negl Trop Dis 14: e0008355.
-
20.
Agarwal A, Dash PK, Singh AK, Sharma S, Gopalan N, Rao PVL, Parida MM, Reiter P, 2014. Evidence of experimental vertical transmission of emerging novel ECSA genotype of Chikungunya virus in Aedes aegypti. PLoS Negl Trop Dis 8: e2990.
-
21.
Ndenga BA, Mutuku FM, Ngugi HN, Mbakaya JO, Aswani P, Musunzaji PS, Vulule J, Mukoko D, Kitron U, LaBeaud AD, 2017. Characteristics of Aedes aegypti adult mosquitoes in rural and urban areas of western and coastal Kenya. PLoS One 12: e0189971.
-
22.
Salje H et al., 2016. Reconstruction of 60 years of chikungunya epidemiology in the Philippines demonstrates episodic and focal transmission. J Infect Dis 213: 604–610.
-
23.
Dom NC, Ahmad AH, Ismail R, 2013. Habitat characterization of Aedes sp. breeding in urban hotspot area. Procedia Soc Behav Sci 85: 100–109.
-
24.
Johnson BW, Goodman CH, Holloway K, de Salazar PM, Valadere AM, Drebot MA, 2016. Evaluation of commercially available chikungunya virus immunoglobulin M detection assays. Am J Trop Med Hyg 95: 182–192.
-
25.
Slavov SN, Otaguiri KK, Bianquini ML, Bitencourt HTO, Chagas MCM, Guerreiro DSS, Figueiredo LTM, Covas DT, Kashima S, 2018. Seroprevalence of Chikungunya virus in blood donors from northern and southeastern Brazil. Hematol Transfus Cell Ther 40: 358–362.
-
26.
Myint KSA et al., 2022. Neurological disease associated with Chikungunya in Indonesia. Am J Trop Med Hyg 107: 291–295.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2798 | 1377 | 53 |
| Full Text Views | 752 | 35 | 0 |
| PDF Downloads | 310 | 38 | 0 |