Gassiep I, Armstrong M, Norton R, 2020. Human melioidosis. Clin Microbiol Rev 33: e00006–e00019.
Chakravorty A, Heath C, 2019. Melioidosis: an updated review. Aust J Gen Pract 48: 327–332.
Karunanayake P, 2022. Melioidosis: clinical aspects. Clin Med (Lond) 22: 6–8.
Yaisawang S, Asawaphureekorn S, Chetchotisakd P, Wongratanacheewin S, Pakdee P, 2018. Ocular involvement in melioidosis: a 23-year retrospective review. J Ophthalmic Inflamm Infect 8: 5.
Siripanthong S, Teerapantuwat S, Prugsanusak W, Suputtamongkol Y, Viriyasithavat P, Chaowagul W, Dance DA, White NJ, 1991. Corneal ulcer caused by Pseudomonas pseudomallei: report of three cases. Rev Infect Dis 13: 335–337.
Lau SKP, Sridhar S, Ho CC, Chow WN, Lee KC, Lam CW, Yuen KY, Woo PC, 2015. Laboratory diagnosis of melioidosis: past, present and future. Exp Biol Med (Maywood) 240: 742–751.
Birnie E, Biemond JJ, Wiersinga WJ, 2022. Drivers of melioidosis endemicity: epidemiological transition, zoonosis, and climate change. Curr Opin Infect Dis 35: 196–204.
Ting DSJ, Ho CS, Deshmukh R, Said DG, Dua HS, 2021. Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance. Eye (Lond) 35: 1084–1101.
Limmathurotsakul D, Wongratanacheewin S, Teerawattanasook N, Wongsuvan G, Chaisuksant S, Chetchotisakd P, Chaowagul W, Day NP, Peacock SJ, 2010. Increasing incidence of human melioidosis in Northeast Thailand. Am J Trop Med Hyg 82: 1113–1117.
Cabrera-Aguas M, Khoo P, Watson SL, 2022. Infectious keratitis: a review. Clin Exp Ophthalmol 50: 543–562.
Karkhur S, Soni D, Sharma B, 2022. A novel technique of full-thickness scleral debridement in fulminant necrotising infectious scleritis and its outcomes: a consecutive case series. Int Ophthalmol 42: 581–592.
Pradhan ZS, Jacob P, 2013. Infectious scleritis: clinical spectrum and management outcomes in India. Indian J Ophthalmol 61: 590–593.
|Past two years||Past Year||Past 30 Days|
|Full Text Views||52||52||23|
This report is on a 45-year-old male patient without underlying disease who presented with a Burkholderia pseudomallei–caused keratoscleritis in his right eye. Slit-lamp examination revealed multiple, indistinct corneal infiltrations with subconjunctival/scleral abscesses. Corneal tissue culture was positive for B. pseudomallei and confirmed by mass spectrometry. The patient was treated with fortified ceftazidime, fortified gentamicin eyedrops, and intravenous ceftazidime injection. Penetrating keratoplasty, including intracameral ceftazidime injections, was undertaken due to corneal lesion worsening. Scleral debridement with subconjunctival ceftazidime injections were undertaken due to the progression of the scleral abscess. After 2 months, the corneal and scleral lesions were inactive, and the systemic and topical antibiotics were tapered. This is the first case report of B. pseudomallei–caused keratoscleritis with photography. The patient was seen in an endemic geographical area with multiple corneal infiltrations and subconjunctival/scleral abscess. Systemic and topical antibiotics accompanied with surgery should be considered.
Authors’ addresses: Onsiri Thanathanee, Korawin Charoensuk, Yuwarat Uthairat, Suparat Laohapitakvorn, Orapin Anutarapongpan, and Olan Suwan-apichon, Department of Ophthalmology, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand, E-mails: firstname.lastname@example.org, email@example.com, firstname.lastname@example.org, email@example.com, firstname.lastname@example.org, and email@example.com.