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Pythium insidiosum is a parasitic oomycete that can cause keratitis and closely resembles fungus, both clinically and morphologically. It requires a trained microbiologist for its differentiation from fungal filaments and has poor response to antifungal therapy. We present a case of primary isolation of the organism from the vitreous cavity in a case of endophthalmitis. The infection spread quickly and involved all the ocular tissues. The eye had poor visual outcome despite a sequence of rapidly completed retinal and corneal surgeries along with initiation of anti-Pythium therapy.
Financial support: All authors were supported by the Hyderabad Eye Research Foundation, Hyderabad, India. B. T. was supported by a Department of Biotechnology Wellcome Trust India Alliance Clinical Research Centre grant awarded to the IHOPE Centre (grant number IA/CRC/19/1/610010).
Authors’ addresses: David Aggarwal, Anant Bajaj Retina Institute, L V Prasad Eye Institute (LVPEI), Hyderabad, India, E-mail: email@example.com. Sanchita Mitra, Jhaveri Microbiology Center, LVPEI, Hyderabad, India, E-mail: firstname.lastname@example.org. Paavan Kalra and Bhupesh Bagga, The Cornea Institute, LVPEI, Hyderabad, India, E-mails: email@example.com and firstname.lastname@example.org. Dilip Mishra, Department of Ophthalmic Pathology Laboratory, LVPEI, Hyderabad, India, E-mail: email@example.com. Brijesh Takkar, Anant Bajaj Retina Institute, LVPEI, Hyderabad, India, and Indian Health Outcomes, Public Health, and Economics Research Centre, LVPEI, Hyderabad, India, E-mail: firstname.lastname@example.org.