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Perinatal Transmission of Dengue Infection among Dengue Hemorrhagic Fever Outbreaks in Southern Vietnam: The First Case Managed at Tu Du Hospital and Review of Literature

Thanh Hai PhamTu Du Clinical Research Unit (TD-CRU), Tu Du Hospital, Ho Chi Minh City, Vietnam;

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Phuc Nhon NguyenTu Du Clinical Research Unit (TD-CRU), Tu Du Hospital, Ho Chi Minh City, Vietnam;
Department of High-Risk Pregnancy, Tu Du Hospital, Ho Chi Minh City, Vietnam;

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Quang Nhat HoDepartment of Postoperative Care, Tu Du Hospital, Ho Chi Minh City, Vietnam

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ABSTRACT.

Dengue hemorrhagic fever is a high-risk pathology in pregnancy, leading to an increased mortality rate for both the mother and baby. Perinatal transmission of dengue infection may occur during the labor stage of the febrile phase, despite its extreme rarity. In the present case, a young female patient with pregnancy at 39 weeks 3 days of gestational age was hospitalized because of dengue hemorrhagic fever. Upon monitoring, her platelet count gradually decreased to a very low of 13,000 mm3 on the third day of fever. However, her platelet count increased soon afterwards. On the eighth day of admission, she was delivered by emergency cesarean section due to acute fetal distress. The female neonate was promptly assessed by the pediatric team upon cesarean surgery. The neonate was diagnosed with vertical transmission of dengue infection based on positive dengue virus nonstructural protein 1 antigen, and low platelet count was found on the first day postpartum. When there is a high suspicion of perinatal transmission, closely monitoring the newborn helps to avoid the adverse outcomes and mortality for the infant. Herein, we thoroughly report an unusual case of maternal–fetal transmission of dengue during pregnancy at our maternity hospital.

Author Notes

Address correspondence to Phuc Nhon Nguyen, Department of High-Risk Pregnancy, Tu Du Hospital, 284 Cong Quynh, Pham Ngu Lao Ward, District 1, Ho Chi Minh City 730000, Vietnam. E-mail: docternhon@gmail.com

These authors contributed equally to this work.

Authors’ addresses: Thanh Hai Pham and Phuc Nhon Nguyen, Tu Du Clinical Research Unit (TD-CRU), Tu Du Hospital, Ho Chi Minh City, Vietnam, E-mails: haiphamtd@gmail.com and docternhon@gmail.com. Quang Nhat Ho, Department of Postoperative Care, Tu Du Hospital, Ho Chi Minh City, Vietnam, E-mail drnhattudu@gmail.com.

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