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A 39-year-old man presented with a history of fatigue, malaise, and rash with varied morphology on his perianal region. Polymerase chain reaction testing of the lesions confirmed coinfection with monkeypox and herpes simplex virus type 2. We emphasize the difficulty in distinguishing between monkeypox virus and herpes simplex virus type 2 based on history and examination alone.
Address correspondence to Kavitha K. Prabaker, Department of Clinical Epidemiology and Infection Prevention, UCLA David Geffen School of Medicine, 1260 15th St., Ste. 1119, Santa Monica, CA 90404. E-mail: email@example.com
Financial support: This study was funded by the UCLA Department of Pathology and Laboratory Medicine.