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Arbovirus Antibody Seroprevalence in the Human Population from Cauca, Colombia
ABSTRACT.
Several arboviruses have emerged or reemerged into the New World during the past several decades, causing outbreaks of significant proportion. In particular, the outbreaks of Dengue virus (DENV), Zika virus, and Chikungunya virus (CHIKV) have been explosive and unpredictable, and have led to significant adverse health effects. These viruses are considered the leading cause of acute undifferentiated febrile illnesses in Colombia. However, Venezuelan equine encephalitis virus (VEEV) is endemic in Colombia, and arboviruses such as the Mayaro virus (MAYV) and the Oropouche virus (OROV) cause febrile illnesses in neighboring countries. Yet, evidence of human exposure to MAYV and OROV in Colombia is scarce. In this study, we conducted a serosurvey study in healthy individuals from the Cauca Department in Colombia. We assessed the seroprevalence of antibodies against multiple arboviruses, including DENV serotype 2, CHIKV, VEEV, MAYV, and OROV. Based on serological analyses, we found that the overall seroprevalence for DENV serotype 2 was 30%, 1% for MAYV, 2.6% for CHIKV, 4.4% for VEEV, and 2% for OROV. This study provides evidence about the circulation of MAYV and OROV in Colombia, and suggests that they—along with VEEV and CHIKV—might be responsible for cases of acute undifferentiated febrile illnesses that remain undiagnosed in the region. The study results also highlight the need to strengthen surveillance programs to identify outbreaks caused by these and other vector-borne pathogens.
Author Notes
Financial support: This research was supported by COLCIENCIAS (code 120374455209) and by the Fogarty International Center and the National Institute of Allergy and Infectious Diseases, NIH (award no. D43 TW010331). J. G. was supported by a Young Investigator Award provided by COLCIENCIAS.
Disclosure: This cross-sectional study was approved by the institutional review board from the Pontificia Universidad Javeriana. The procedures performed in the enrolled participants included a general survey containing demographics, clinical, and personal information followed by venipuncture to acquire a blood sample at only one point in the study. These procedures were considered minimal risk by the review board.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Authors’ addresses: Juliana Gil-Mora, Paola L. Betancourt-Ruiz, Heidy C. Martínez-Diaz, and Marylin Hidalgo, Pontificia Universidad Javeriana, Bogota, Colombia, E-mails: juliana.gil@javeriana.edu.co, betancourtp@javeriana.edu.co, h-martinez@javeriana.edu.co, and hidalgo.m@javeriana.edu.co. L. Yoana Acevedo-Gutiérrez, Diana Fernández, and Nathen E. Bopp, Department of Pathology, University of Texas Medical Branch, Galveston, TX, E-mails: leidy.acevedo@udea.edu.co, dpfernan@utmb.edu, and nebopp@utmb.edu. Luz A. Olaya-Másmela, Universidad Libre, Cali, Colombia, E-mail: adrianaolaya26@gmail.com. Eliana Bolaños, Secretaria de Salud Departamental, Popayán, Colombia, E-mail: eliana.bolanos@cauca.gov.co. Efraín Benavides, Universidad de la Salle, Bogota, Colombia, E-mail: efbenavides@unisalle.edu.co. Alejandro Villasante-Tezanos, Department of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, TX, E-mail: alvillas@utmb.edu. Patricia V. Aguilar, Department of Pathology, University of Texas Medical Branch, Galveston, TX, and Center for Tropical Diseases, Galveston, TX, E-mail: pvaguila@utmb.edu.