ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Rogerson SJ , Desai M , Mayor A , Sicuri E , Taylor SM , van Eijk AM , 2018. Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem. Lancet Infect Dis 18: e107–e118.
-
2.
Guyatt HL , Snow RW , 2004. Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa. Clin Microbiol Rev 17: 760–769.
-
3.
De Beaudrap P et al.2013. Impact of malaria during pregnancy on pregnancy outcomes in a Ugandan prospective cohort with intensive malaria screening and prompt treatment. Malar J 12: 139.
-
4.
Akum AE , Kuoh AJ , Minang JT , Achimbom BM , Ahmadou MJ , Troye-Blomberg M , 2005. The effect of maternal, umbilical cord and placental malaria parasitaemia on the birthweight of newborns from south-western Cameroon. Acta Paediatr 94: 917–923.
-
5.
Blencowe H et al.2013. Preterm birth-associated neurodevelopmental impairment estimates at regional and global levels for 2010. Pediatr Res 74 (Suppl 1): 17–34.
-
6.
Villar J et al.2015. Postnatal growth standards for preterm infants: the Preterm Postnatal Follow-up Study of the INTERGROWTH-21(st) Project. Lancet Glob Health 3: e681–e691.
-
7.
Upadhyay RP , Naik G , Choudhary TS , Chowdhury R , Taneja S , Bhandari N , Martines JC , Bahl R , Bhan MK , 2019. Cognitive and motor outcomes in children born low birth weight: a systematic review and meta-analysis of studies from South Asia. BMC Pediatr 19: 1–15.
-
8.
Weckman AM et al.2021. Neurocognitive outcomes in Malawian children exposed to malaria during pregnancy: an observational birth cohort study. PLoS Med 18: e1003701.
-
9.
Rudolph MD et al.2018. Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring. Nat Neurosci 21: 765–772.
-
10.
Ghassabian A , Albert PS , Hornig M , Yeung E , Cherkerzian S , Goldstein RB , Buka SL , Goldstein JM , Gilman SE , 2018. Gestational cytokine concentrations and neurocognitive development at 7 years. Transl Psychiatry 8: 1–8.
-
11.
Fried M et al.2017. Systemic inflammatory response to malaria during pregnancy is associated with pregnancy loss and preterm delivery. Nephrol Dial Transplant 65: 1729–1735.
-
12.
McDonald CR et al.2015. Experimental malaria in pregnancy induces neurocognitive injury in uninfected offspring via a C5a–C5a receptor dependent pathway. PLoS Pathog 11: e1005140.
-
13.
Conroy AL et al.2019. Case report: birth outcome and neurodevelopment in placental malaria discordant twins. Am J Trop Med Hyg 100: 552–555.
-
14.
Garrison A , Boivin MJ , Fiévet N , Zoumenou R , Alao JM , Massougbodji A , Cot M , Bodeau-Livinec F , 2022. The effects of malaria in pregnancy on neurocognitive development in children at 1 and 6 years of age in Benin: a prospective mother–child cohort. Clin Infect Dis 74: 766–775.
-
15.
Lawford HL et al.2021. Associations between malaria in pregnancy and neonatal neurological outcomes. Int J Infect Dis 112: 144–151.
-
16.
Divala TH et al.2018. Chloroquine as weekly chemoprophylaxis or intermittent treatment to prevent malaria in pregnancy in Malawi: a randomised controlled trial. Lancet Infect Dis 18: 1097–1107.
-
17.
Boudova S , Divala T , Mungwira R , Mawindo P , Tomoka T , Laufer MK , 2017. Placental but not peripheral Plasmodium falciparum infection during pregnancy is associated with increased risk of malaria in infancy. J Infect Dis 216: 732–735.
-
18.
Gladstone M , Lancaster GA , Umar E , Nyirenda M , Kayira E , van den Broek NR , Smyth RL , 2010. The Malawi Developmental Assessment Tool (MDAT): the creation, validation, and reliability of a tool to assess child development in rural African settings. PLoS Med 7: e1000273.
-
19.
Gomez LA et al.2018. Improved neurodevelopment after initiation of antiretroviral therapy in human immunodeficiency virus-infected children. Pediatr Infect Dis J 37: 916–922.
-
20.
Uwemedimo OT , Howlader A , Pierret G , 2017. Parenting practices and associations with development delays among young children in Dominican Republic. Ann Glob Health 83: 568–576.
-
21.
Gladstone MJ et al.2019. Independent and combined effects of improved water, sanitation, and hygiene (WASH) and improved complementary feeding on early neurodevelopment among children born to HIV-negative mothers in rural Zimbabwe: substudy of a cluster-randomized trial. PLoS Med 16: e1002766.
-
22.
Vyas S , Kumaranayake L , 2006. Constructing socio-economic status indices: how to use principal components analysis. Health Policy Plan 21: 459–468.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 9551 | 1534 | 96 |
| Full Text Views | 1006 | 27 | 0 |
| PDF Downloads | 287 | 25 | 0 |
The Association among Malaria in Pregnancy, Neonatal inflammation, and Neurocognitive Development in a Cohort of Malawian Infants
Andrea G. Buchwald
Andrea G. Buchwald
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland;
Search for other papers by Andrea G. Buchwald in
Current site
Google Scholar
PubMed
Search for other papers by Andrea G. Buchwald in
Current site
Google Scholar
PubMed
Sarah Boudova
Sarah Boudova
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland;
Search for other papers by Sarah Boudova in
Current site
Google Scholar
PubMed
Search for other papers by Sarah Boudova in
Current site
Google Scholar
PubMed
Ingrid Peterson
Ingrid Peterson
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland;
Search for other papers by Ingrid Peterson in
Current site
Google Scholar
PubMed
Search for other papers by Ingrid Peterson in
Current site
Google Scholar
PubMed
Titus Divala
Titus Divala
Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi;
Search for other papers by Titus Divala in
Current site
Google Scholar
PubMed
Search for other papers by Titus Divala in
Current site
Google Scholar
PubMed
Randy Mungwira
Randy Mungwira
Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi;
Search for other papers by Randy Mungwira in
Current site
Google Scholar
PubMed
Search for other papers by Randy Mungwira in
Current site
Google Scholar
PubMed
Patricia Mawindo
Patricia Mawindo
Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi;
Search for other papers by Patricia Mawindo in
Current site
Google Scholar
PubMed
Search for other papers by Patricia Mawindo in
Current site
Google Scholar
PubMed
Melissa Gladstone
Melissa Gladstone
Institute of Translational Research, University of Liverpool, Liverpool, United Kingdom;
Search for other papers by Melissa Gladstone in
Current site
Google Scholar
PubMed
Search for other papers by Melissa Gladstone in
Current site
Google Scholar
PubMed
Cristiana Cairo
Cristiana Cairo
Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland
Search for other papers by Cristiana Cairo in
Current site
Google Scholar
PubMed
Search for other papers by Cristiana Cairo in
Current site
Google Scholar
PubMed
Miriam K. Laufer
Miriam K. Laufer
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland;
Search for other papers by Miriam K. Laufer in
Current site
Google Scholar
PubMed
Search for other papers by Miriam K. Laufer in
Current site
Google Scholar
PubMed
ABSTRACT.
Malaria in pregnancy (MIP) causes poor birth outcomes, but its impact on neurocognitive development has not been well characterized. Between 2012 and 2014, we enrolled 307 mother–infant pairs and monitored 286 infants for neurocognitive development using the Malawi Developmental Assessment Tool at 6, 12, and 24 months of age. MIP was diagnosed from peripheral blood and placental specimens. Cord blood cytokine levels were assessed for a subset of neonates. Predictors of neurodevelopment were examined using mixed-effect logistic regression for developmental delay. Among the participants, 78 mothers (25.4%) had MIP, and 45 infants (15.7%) experienced severe neurocognitive delay. MIP was not associated with differences in cord blood cytokine levels or neurocognitive development. Preterm birth, low birthweight, increasing maternal education level, and increasing interleukin 6 levels were associated significantly with delay. The results highlight the prevalence of severe delay and a need for broad access to early childhood support in this setting.
- Supplemental Materials (PDF 1520 KB)
Author Notes
Financial support: This work was supported by the American Society of Tropical Medicine and Hygiene Benjamin H. Kean Travel Fellowship grant (to S. B.), the Infectious Diseases Society of America Medical Scholars Program (to S. B.), the National Institute of Allergy and Infectious Diseases (F30AI114195 to S.B., R01AI104702 to C. C., and U01AI087624 to M. K. L.), and the University of Maryland Baltimore, Institute for Clinical & Translational Research.
Authors’ addresses: Andrea Buchwald, Sarah Boudova, Ingrid Peterson, and Miriam K. Laufer, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, E-mails: andreabuchwald@umaryland.edu, sboudova@gmail.com, idpet2@gmail.com, and mlaufer@som.umaryland.edu. Titus Divala, Randy Mungwira, and Patricia Mawindo, Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi, E-mails: tdivala@kuhes.ac.mw, rmungwira@who.int, and patmawindo@gmail.com. Melissa Gladstone, Institute of Translational Research, University of Liverpool, Liverpool, UK, E-mail: melglad@liverpool.ac.uk. Cristiana Cairo, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, E-mail: ccairo@ihv.umaryland.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Rogerson SJ , Desai M , Mayor A , Sicuri E , Taylor SM , van Eijk AM , 2018. Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem. Lancet Infect Dis 18: e107–e118.
-
2.
Guyatt HL , Snow RW , 2004. Impact of malaria during pregnancy on low birth weight in sub-Saharan Africa. Clin Microbiol Rev 17: 760–769.
-
3.
De Beaudrap P et al.2013. Impact of malaria during pregnancy on pregnancy outcomes in a Ugandan prospective cohort with intensive malaria screening and prompt treatment. Malar J 12: 139.
-
4.
Akum AE , Kuoh AJ , Minang JT , Achimbom BM , Ahmadou MJ , Troye-Blomberg M , 2005. The effect of maternal, umbilical cord and placental malaria parasitaemia on the birthweight of newborns from south-western Cameroon. Acta Paediatr 94: 917–923.
-
5.
Blencowe H et al.2013. Preterm birth-associated neurodevelopmental impairment estimates at regional and global levels for 2010. Pediatr Res 74 (Suppl 1): 17–34.
-
6.
Villar J et al.2015. Postnatal growth standards for preterm infants: the Preterm Postnatal Follow-up Study of the INTERGROWTH-21(st) Project. Lancet Glob Health 3: e681–e691.
-
7.
Upadhyay RP , Naik G , Choudhary TS , Chowdhury R , Taneja S , Bhandari N , Martines JC , Bahl R , Bhan MK , 2019. Cognitive and motor outcomes in children born low birth weight: a systematic review and meta-analysis of studies from South Asia. BMC Pediatr 19: 1–15.
-
8.
Weckman AM et al.2021. Neurocognitive outcomes in Malawian children exposed to malaria during pregnancy: an observational birth cohort study. PLoS Med 18: e1003701.
-
9.
Rudolph MD et al.2018. Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring. Nat Neurosci 21: 765–772.
-
10.
Ghassabian A , Albert PS , Hornig M , Yeung E , Cherkerzian S , Goldstein RB , Buka SL , Goldstein JM , Gilman SE , 2018. Gestational cytokine concentrations and neurocognitive development at 7 years. Transl Psychiatry 8: 1–8.
-
11.
Fried M et al.2017. Systemic inflammatory response to malaria during pregnancy is associated with pregnancy loss and preterm delivery. Nephrol Dial Transplant 65: 1729–1735.
-
12.
McDonald CR et al.2015. Experimental malaria in pregnancy induces neurocognitive injury in uninfected offspring via a C5a–C5a receptor dependent pathway. PLoS Pathog 11: e1005140.
-
13.
Conroy AL et al.2019. Case report: birth outcome and neurodevelopment in placental malaria discordant twins. Am J Trop Med Hyg 100: 552–555.
-
14.
Garrison A , Boivin MJ , Fiévet N , Zoumenou R , Alao JM , Massougbodji A , Cot M , Bodeau-Livinec F , 2022. The effects of malaria in pregnancy on neurocognitive development in children at 1 and 6 years of age in Benin: a prospective mother–child cohort. Clin Infect Dis 74: 766–775.
-
15.
Lawford HL et al.2021. Associations between malaria in pregnancy and neonatal neurological outcomes. Int J Infect Dis 112: 144–151.
-
16.
Divala TH et al.2018. Chloroquine as weekly chemoprophylaxis or intermittent treatment to prevent malaria in pregnancy in Malawi: a randomised controlled trial. Lancet Infect Dis 18: 1097–1107.
-
17.
Boudova S , Divala T , Mungwira R , Mawindo P , Tomoka T , Laufer MK , 2017. Placental but not peripheral Plasmodium falciparum infection during pregnancy is associated with increased risk of malaria in infancy. J Infect Dis 216: 732–735.
-
18.
Gladstone M , Lancaster GA , Umar E , Nyirenda M , Kayira E , van den Broek NR , Smyth RL , 2010. The Malawi Developmental Assessment Tool (MDAT): the creation, validation, and reliability of a tool to assess child development in rural African settings. PLoS Med 7: e1000273.
-
19.
Gomez LA et al.2018. Improved neurodevelopment after initiation of antiretroviral therapy in human immunodeficiency virus-infected children. Pediatr Infect Dis J 37: 916–922.
-
20.
Uwemedimo OT , Howlader A , Pierret G , 2017. Parenting practices and associations with development delays among young children in Dominican Republic. Ann Glob Health 83: 568–576.
-
21.
Gladstone MJ et al.2019. Independent and combined effects of improved water, sanitation, and hygiene (WASH) and improved complementary feeding on early neurodevelopment among children born to HIV-negative mothers in rural Zimbabwe: substudy of a cluster-randomized trial. PLoS Med 16: e1002766.
-
22.
Vyas S , Kumaranayake L , 2006. Constructing socio-economic status indices: how to use principal components analysis. Health Policy Plan 21: 459–468.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 9551 | 1534 | 96 |
| Full Text Views | 1006 | 27 | 0 |
| PDF Downloads | 287 | 25 | 0 |