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Traub R , Wisseman CL , Farhang-Azad A , 1978. The ecology of murine typhus-a critical review. Trop Dis Bull 75: 237–317.
Miller ES , Beeson PB , 1946. Murine typhus fever. Medicine (Baltimore) 25: 1–15.
Tsioutis C , Zafeiri M , Avramopoulos A , Prousali E , Miligkos M , Karageorgos SA , 2017. Clinical and laboratory characteristics, epidemiology, and outcomes of murine typhus: a systematic review. Acta Trop 166: 16–24.
Stuart BM , Pullen RL , 1945. Endemic (murine) typhus fever: clinical observations of 180 cases. Ann Intern Med 23: 17.
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Pieracci EG , Evert N , Drexler NA , Mayes B , Vilcins I , Huang P , Campbell J , Behravesh CB , Paddock CD , 2017. Fatal fleaborne typhus in Texas: a retrospective case series, 1985–2015. Am J Trop Med Hyg 96: 1088–1093.
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Silpapojakul K , Ukkachoke C , Krisanapan S , Silpapojakul K , 1991. Rickettsial meningitis and encephalitis. Arch Intern Med 151: 1753–1757.
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Newton PN et al., 2019. A prospective, open-label, randomized trial of doxycycline versus azithromycin for the treatment of uncomplicated murine typhus. Clin Infect Dis 68: 738–747.
Vohra RF , Walker DH , Blanton LS , 2018. Analysis of health-care charges in murine typhus: need for improved clinical recognition and diagnostics for acute disease. Am J Trop Med Hyg 98: 1594–1598.
Howard A , Fergie J , 2018. Murine typhus in south Texas children: an 18-year review. Pediatr Infect Dis J 37: 1071–1076.
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Murine typhus is an undifferentiated febrile illness. Historically recognized throughout Latin America, it has been seldom reported in recent decades. When clinicians and researchers are attuned, endemic foci have reemerged. The demonstrable seroprevalence in areas devoid of reported cases indicates murine typhus is an underappreciated infectious disease in Latin America.
Financial support: At the time of this work, Álvaro A. Faccini-Martínez was supported by the Fogarty International Center and the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health under Award Number D43 TW010331. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Disclaimer: The authors have no conflicts of interest to disclose.
Authors’ addresses: Álvaro A. Faccini-Martínez, Research Institute, Fundación Universitaria de Ciencias de la Salud - FUCS, Bogotá, Colombia, and Servicios y Asesorías en Infectología - SAI, Bogotá, Colombia. E-mails: afaccini@gmail.com and afaccini@fucsalud.edu.co. David H. Walker, Department of Pathology, University Boulevard, Galveston, TX, E-mail: dwalker@utmb.edu. Lucas S. Blanton, Department of Internal Medicine–Division of Infectious Diseases, University Boulevard, Galveston, TX, E-mail: lsblanto@utmb.edu.
Yu X-J , Walker DH , 2005. Family I. Rickettsiaceae. Brenner DJ , Kreig NR , Stanley JT , eds. Bergey’s Manual of Systematic Bacteriology. New York, NY: Springer, 96–116.
Blanton LS , Dumler JS , Walker DH , 2020. Rickettsia typhi (Murine Typhus). Bennett JE , Dolin R , Blaser MJ , eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Philadelphia, PA: Elsevier, 2372–2376.
Traub R , Wisseman CL , Farhang-Azad A , 1978. The ecology of murine typhus-a critical review. Trop Dis Bull 75: 237–317.
Miller ES , Beeson PB , 1946. Murine typhus fever. Medicine (Baltimore) 25: 1–15.
Tsioutis C , Zafeiri M , Avramopoulos A , Prousali E , Miligkos M , Karageorgos SA , 2017. Clinical and laboratory characteristics, epidemiology, and outcomes of murine typhus: a systematic review. Acta Trop 166: 16–24.
Stuart BM , Pullen RL , 1945. Endemic (murine) typhus fever: clinical observations of 180 cases. Ann Intern Med 23: 17.
Moreira J , Bressan CS , Brasil P , Siqueira AM , 2018. Epidemiology of acute febrile illness in Latin America. Clin Microbiol Infect 24: 827–835.
Pieracci EG , Evert N , Drexler NA , Mayes B , Vilcins I , Huang P , Campbell J , Behravesh CB , Paddock CD , 2017. Fatal fleaborne typhus in Texas: a retrospective case series, 1985–2015. Am J Trop Med Hyg 96: 1088–1093.
Dumler JS , Taylor JP , Walker DH , 1991. Clinical and laboratory features of murine typhus in south Texas, 1980 through 1987. JAMA 266: 1365–1370.
van der Vaart TW , van Thiel PP , Juffermans NP , van Vugt M , Geerlings SE , Grobusch MP , Goorhuis A , 2014. Severe murine typhus with pulmonary system involvement. Emerg Infect Dis 20: 1375–1377.
Shaked Y , Shpilberg O , Samra Y , 1994. Involvement of the kidneys in Mediterranean spotted fever and murine typhus. Q J Med 87: 103–107.
Hernandez Cabrera M , Angel-Moreno A , Santana E , Bolanos M , Frances A , Martin-Sanchez MS , Perez-Arellano JL , 2004. Murine typhus with renal involvement in Canary Islands, Spain. Emerg Infect Dis 10: 740–743.
Blanton LS , Berman MA , Afrouzian M , 2020. Case report: renal failure due to focal segmental glomerulosclerosis in a patient with murine typhus. Am J Trop Med Hyg 103: 1017–1019.
Silpapojakul K , Ukkachoke C , Krisanapan S , Silpapojakul K , 1991. Rickettsial meningitis and encephalitis. Arch Intern Med 151: 1753–1757.
Carr SB , Bergamo DF , Emmanuel PJ , Ferreira JA , 2014. Murine typhus as a cause of cognitive impairment: case report and a review of the literature. Pediatr Neurol 50: 265–268.
Lew HL , Lane B , Zeiner H , 2005. Neuroimaging and clinical manifestations of bilateral temporal encephalopathy secondary to murine typhus infection. Am J Phys Med Rehabil 84: 310–311.
Newton PN et al., 2019. A prospective, open-label, randomized trial of doxycycline versus azithromycin for the treatment of uncomplicated murine typhus. Clin Infect Dis 68: 738–747.
Vohra RF , Walker DH , Blanton LS , 2018. Analysis of health-care charges in murine typhus: need for improved clinical recognition and diagnostics for acute disease. Am J Trop Med Hyg 98: 1594–1598.
Howard A , Fergie J , 2018. Murine typhus in south Texas children: an 18-year review. Pediatr Infect Dis J 37: 1071–1076.
Ruiz-Castaneda M , Varela G , 1971. Hermann Mooser: in memoriam. Gac Med Mex 102: 667–668.
Mooser H , 1928. Experiments relating to the pathology and the etiology of Mexican typhus (tabardillo): 1. Clinical course and pathologic anatomy of trabardillo in guinea-pigs. J Infect Dis 43: 241–260.
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