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High Prevalence of Intestinal Capillariasis in Chronic Diarrhea Patients in Thailand: Serological Screening Using a Rapid Lateral-Flow Immunochromatographic Assay

Thidarat K. PrasongdeeDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;

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Krongkaew SeesuiNamphong Hospital, Khon Kaen, Thailand;

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Phuangphaka SadeeClinical Immunology Unit, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;

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Lakkhana SadaowDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand;

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Wattana SukeepaisarnjaroenDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;

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Ratthaphol KraiklangDepartment of Public Health Administration, Health Promotion, Nutrition, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand

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Oranuch SanpoolDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand;

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Wanchai MaleewongDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand;

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Pewpan M. IntapanDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;
Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand;

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ABSTRACT.

Intestinal capillariasis is an emerging fish-borne helminthic disease caused by the round worm Capillaria philippinensis. Chronic infection may lead to death if the disease is misdiagnosed and inappropriate treatment is given. We used a rapid lateral-flow immunochromatographic test for screening of intestinal capillariasis in patients with chronic diarrhea. We screened 292 chronic diarrhea patients who had visited hospitals in Thailand. Sixty-six (22.6%) cases were positive according to the kit. All positive patients received mebendazole at 200 mg twice per day for 30 consecutive days or albendazole at 200 mg twice per day for 10 consecutive days. Later, stool concentration techniques, used to examine stool samples from all serologically positive individuals on three consecutive days, revealed C. philippinensis eggs, larvae, and/or adults. The kit is useful for screening and rapid diagnosis of intestinal capillariasis in chronic diarrhea patients in an endemic area for prevention of serious disease and facilitates treatment.

Author Notes

Address correspondence to Pewpan M. Intapan, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. E-mail: pewpan@kku.ac.th

Financial support: This study was supported by a Distinguished Research Professor Grant from the Thailand Research Fund (Grant no. DPG6280002) and grants from the Khon Kaen University: Research and Graduate studies (Research Program grant) and Faculty of Medicine (WM, PMI, and OS, Grant no. RG63301). The fund providers had no role in study design, data collection/interpretation, or the decision to submit the work for publication.

Authors’ addresses: Thidarat K. Prasongdee, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mail: thidpr@kku.ac.th. Krongkaew Seesui, Namphong Hospital, Khon Kaen, Thailand, E-mail: jeem.mee66@gmail.com. Phuangphaka Sadee, Clinical Immunology Unit, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mail: sphuan@kku.ac.th. Lakkhana Sadaow, Oranuch Sanpool, Wanchai Maleewong, and Pewpan M. Intapan, Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, and Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand, E-mails: sadaow1986@gmail.com, sanpoolor@yahoo.com, wanch_ma@kku.ac.th, and pewpan@kku.ac.th. Wattana Sukeepaisarnjaroen, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, E-mail: swatta@kku.ac.th. Ratthaphol Kraiklang, Department of Public Health Administration, Health Promotion, Nutrition, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand, E-mail: ratthaphol.bc@gmail.com.

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