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RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Gérardin P et al.Encephalchik Study Group , 2016. Chikungunya virus-associated encephalitis: a cohort study on La Réunion Island, 2005–2009. Neurology 86: 94–102.
-
2.
Ledermann JP , Powers AM , 2016. Analysis of CHIKV in mosquitoes infected via artificial blood meal. Methods Mol Biol 1426: 129–142.
-
3.
Mawuntu AHP , Bernadus JBB , Dhenni R , Wiyatno A , Anggreani R , 2018. Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia. PLoS One 13: e0207440.
-
4.
Martin DA , Muth DA , Brown T , Johnson AJ , Karabatsos N , Roehrig JT , 2000. Standardization of immunoglobulin M capture enzyme-linked immunosorbent assays for routine diagnosis of arboviral infections. J Clin Microbiol 38: 1823–1826.
-
5.
Quick J et al., 2017. Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples. Nat Protoc 12: 1261–1276.
-
6.
Mehta R , Gerardin P , de Brito CAA , Soares CN , Ferreira MLB , Solomon T , 2018. The neurological complications of chikungunya virus: a systematic review. Rev Med Virol 28: e1978.
-
7.
Renault P et al., 2007. A major epidemic of Chikungunya virus infection on Réunion Island, France, 2005–2006. Am J Trop Med Hyg 77: 727–731.
-
8.
Chusri S , Siripaitoon P , Hirunpat S , Silpapojakul K , 2011. Case reports of neuro-Chikungunya in southern Thailand. Am J Trop Med Hyg 85: 386–389.
-
9.
Chandak N , Kashyap R , Kabra D , Karandikar P , Saha S , Morey S , Purohit H , Taori G , Daginawala H , 2009. Neurological complications of Chikungunya virus infection. Neurol India 57: 177.
-
10.
Brito Ferreira ML , 2020. Neurological disease in adults with Zika and Chikungunya virus infection in northeast Brazil: a prospective observational study. Lancet Neurol 19: 826–839.
-
11.
Duong V et al., 2012. Reemergence of chikungunya virus in Cambodia. Emerg Infect Dis 18: 2066–2069.
-
12.
Harapan H , Michie A , Mudatsir M , Nusa R , Yohan B , Wagner AL , Sasmono RT , Imrie A , 2019. Chikungunya virus infection in Indonesia: a systematic review and evolutionary analysis. BMC Infect Dis 19: 243.
-
13.
Kosasih H et al., 2013. Evidence for endemic Chikungunya virus infections in Bandung, Indonesia. PLoS Negl Trop Dis 7: e2483.
-
14.
Arif M et al., 2020. Chikungunya in Indonesia: epidemiology and diagnostic challenges. PLoS Negl Trop Dis 14: e0008355.
-
15.
Sasmono RT , Perkasa A , Yohan B , Haryanto S , Yudhaputri FA , Hayati RF , Ma’roef CN , Ledermann JP , Aye Myint KS , Powers AM , 2017. Chikungunya detection during dengue outbreak in Sumatra, Indonesia: clinical manifestations and virological profile. Am J Trop Med Hyg 97: 1393–1398.
-
16.
Capeding MR et al., 2013. Dengue and other common causes of acute febrile illness in Asia: an active surveillance study in children. PLoS Negl Trop Dis 7: e2331.
-
17.
Lewthwaite P et al., 2009. Chikungunya virus and central nervous system infections in children, India. Emerg Infect Dis 15: 329–331.
-
18.
Mahto SK , Gupta PK , Singh A , Meena RC , 2018. Atypical neurological manifestations of chikungunya fever: two case reports. Indian J Crit Care Med 22: 306–308.
-
19.
Staples JE , Breiman RF , Powers AM , 2009. Chikungunya fever: an epidemiological review of a re-emerging infectious disease. Clin Infect Dis 49: 942–948.
-
20.
Horwood PF et al., 2017. Aetiology of acute meningoencephalitis in Cambodian children, 2010–2013. Emerg Microbes Infect 6: 1–8.
-
21.
Johnson BW , Goodman CH , Holloway K , de Salazar PM , Valadere AM , Drebot MA , 2016. Evaluation of commercially available Chikungunya virus immunoglobulin M detection assays. Am J Trop Med Hyg 95: 182–192.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 4045 | 1670 | 387 |
| Full Text Views | 469 | 22 | 2 |
| PDF Downloads | 287 | 36 | 4 |
Neurological Disease Associated with Chikungunya in Indonesia
Khin S. A. Myint
Khin S. A. Myint
Eijkman Institute for Molecular Biology, Jakarta, Indonesia;
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Arthur H. P. Mawuntu
Arthur H. P. Mawuntu
Faculty of Medicine, Universitas Sam Ratulangi, R.D. Kandou Hospital, Manado, Indonesia;
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Sotianingsih Haryanto
Sotianingsih Haryanto
Raden Mattaher Hospital, Jambi, Indonesia;
Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;
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Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;
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Darma Imran
Darma Imran
Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia;
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Sofiati Dian
Sofiati Dian
Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia;
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Yora P. Dewi
Yora P. Dewi
Eijkman Institute for Molecular Biology, Jakarta, Indonesia;
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Ahmad R. Ganiem
Ahmad R. Ganiem
Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia;
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Riane Anggreani
Riane Anggreani
Faculty of Medicine, Universitas Sam Ratulangi, R.D. Kandou Hospital, Manado, Indonesia;
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Mirna M. Iskandar
Mirna M. Iskandar
Raden Mattaher Hospital, Jambi, Indonesia;
Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;
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Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;
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Janno B. B. Bernadus
Janno B. B. Bernadus
Faculty of Medicine, Universitas Sam Ratulangi, R.D. Kandou Hospital, Manado, Indonesia;
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Kartika Maharani
Kartika Maharani
Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia;
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David Susanto
David Susanto
Faculty of Medicine, Universitas Sam Ratulangi, R.D. Kandou Hospital, Manado, Indonesia;
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Riwanti Estiasari
Riwanti Estiasari
Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia;
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Hasna Dewi
Hasna Dewi
Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;
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Amanda Kristiani
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KS Prima Laboratory, Jambi, Indonesia;
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Lidia Gaghiwu
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Faculty of Medicine, Universitas Sam Ratulangi, R.D. Kandou Hospital, Manado, Indonesia;
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Edison Johar
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Eijkman Institute for Molecular Biology, Jakarta, Indonesia;
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Frilasita A. Yudhaputri
Frilasita A. Yudhaputri
Eijkman Institute for Molecular Biology, Jakarta, Indonesia;
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Ungke Antonjaya
Ungke Antonjaya
Eijkman Institute for Molecular Biology, Jakarta, Indonesia;
Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia;
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Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia;
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Jeremy P. Ledermann
Jeremy P. Ledermann
Centers for Disease Control and Prevention, Fort Collins, Colorado;
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Reinout van Crevel
Reinout van Crevel
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Raph L. Hamers
Raph L. Hamers
Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia;
Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom
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Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom
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Ann M. Powers
Ann M. Powers
Centers for Disease Control and Prevention, Fort Collins, Colorado;
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ABSTRACT.
Chikungunya virus (CHIKV) is recognized but rarely considered as a cause of central nervous system infection in endemic areas. A total of 244 patients with acute meningoencephalitis in Indonesia were retrospectively tested to identify whether any CHIKV infection was associated with neurological manifestations, especially in provinces known for CHIKV endemicity. Cerebrospinal fluid (CSF) and blood specimens were tested using CHIKV-specific real-time reverse transcription polymerase chain reaction and IgM ELISA, alongside a panel of neurotropic viruses. We report four cases of suspected or confirmed CHIKV-associated neurological disease, including CHIKV RNA detection in CSF of one patient and in acute serum of another, and CHIKV IgM in CSF of three patients and in serum of a fourth. In conclusion, CHIKV should be considered as a cause of neurologic disease in endemic areas and especially during outbreaks, in addition to the more common arboviral diseases such as dengue and Japanese encephalitis viruses.
Author Notes
Financial support: This work was supported by the Ministry of Research and Technology, Republic of Indonesia; Sam Ratulangi University Medical Faculty; Faculty of Medicine and Health Sciences, Universitas Jambi; and the U.S. Centers for Disease Control and Prevention. The Indonesia Brain Infection Study received support from the U.S. National Institutes of Health through the ULTIMATE project (Grant no. R01AI145781). RLH is supported by the Wellcome Trust.
Disclaimers: The funding institutions did not participate in study design, data collection or analysis, decision to publish, or preparation of the manuscript. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the Centers for Disease Control and Prevention.
Authors’ addresses: Khin S. A. Myint, Yora P. Dewi, Edison Johar, and Frilasita A. Yudhaputri, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, E-mails: khinsawying@hotmail.com, yoradewi@eijkman.go.id, edisonjohar@eijkman.go.id, and sisi@eijkman.go.id. Arthur H. P. Mawuntu, Riane Anggreani, Janno B. B. Bernadus, David Susanto, and Lidia Gaghiwu, Faculty of Medicine, Universitas Sam Ratulangi, R. D. Kandou Hospital, Manado, Indonesia, E-mails: arthur_mawuntu@yahoo.com, ririanggreani636@gmail.com, jannobernadusmd@gmail.com, david_susanto@outlook.com, and gaghiwulidia@gmail.com. Sotianingsih Haryanto and Mirna M. Iskandar, Raden Mattaher Hospital, Jambi, Indonesia, and Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia, E-mails: sotianingsih@yahoo.com and mirnamiskandar@gmail.com. Darma Imran, Kartika Maharani, and Riwanti Estiasari, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, E-mails: darma_imran@yahoo.com, tikamaharanimd@gmail.com, and estiasari@gmail.com. Sofiati Dian and Ahmad R. Ganiem, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia, E-mails: sofiatidian@gmail.com and rizalbdg@gmail.com. Hasna Dewi, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia, E-mail: hasnadewidr@gmail.com. Amanda Kristiani, KS Prima Laboratory, Jambi, Indonesia, E-mail: amandakristianii@gmail.com. Ungke Antonjaya, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, and Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, E-mail: ungkeajy@gmail.com. Jeremy P. Ledermann and Ann M. Powers, Centers for Disease Control and Prevention, Fort Collins, CO, E-mails: jledermann@cdc.gov and apowers@cdc.gov. Reinout van Crevel, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, E-mail: reinout.vancrevel@radboudumc.nl. Raph L. Hamers, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, and Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom, E-mail: rhamers@eocru.org.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Gérardin P et al.Encephalchik Study Group , 2016. Chikungunya virus-associated encephalitis: a cohort study on La Réunion Island, 2005–2009. Neurology 86: 94–102.
-
2.
Ledermann JP , Powers AM , 2016. Analysis of CHIKV in mosquitoes infected via artificial blood meal. Methods Mol Biol 1426: 129–142.
-
3.
Mawuntu AHP , Bernadus JBB , Dhenni R , Wiyatno A , Anggreani R , 2018. Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia. PLoS One 13: e0207440.
-
4.
Martin DA , Muth DA , Brown T , Johnson AJ , Karabatsos N , Roehrig JT , 2000. Standardization of immunoglobulin M capture enzyme-linked immunosorbent assays for routine diagnosis of arboviral infections. J Clin Microbiol 38: 1823–1826.
-
5.
Quick J et al., 2017. Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples. Nat Protoc 12: 1261–1276.
-
6.
Mehta R , Gerardin P , de Brito CAA , Soares CN , Ferreira MLB , Solomon T , 2018. The neurological complications of chikungunya virus: a systematic review. Rev Med Virol 28: e1978.
-
7.
Renault P et al., 2007. A major epidemic of Chikungunya virus infection on Réunion Island, France, 2005–2006. Am J Trop Med Hyg 77: 727–731.
-
8.
Chusri S , Siripaitoon P , Hirunpat S , Silpapojakul K , 2011. Case reports of neuro-Chikungunya in southern Thailand. Am J Trop Med Hyg 85: 386–389.
-
9.
Chandak N , Kashyap R , Kabra D , Karandikar P , Saha S , Morey S , Purohit H , Taori G , Daginawala H , 2009. Neurological complications of Chikungunya virus infection. Neurol India 57: 177.
-
10.
Brito Ferreira ML , 2020. Neurological disease in adults with Zika and Chikungunya virus infection in northeast Brazil: a prospective observational study. Lancet Neurol 19: 826–839.
-
11.
Duong V et al., 2012. Reemergence of chikungunya virus in Cambodia. Emerg Infect Dis 18: 2066–2069.
-
12.
Harapan H , Michie A , Mudatsir M , Nusa R , Yohan B , Wagner AL , Sasmono RT , Imrie A , 2019. Chikungunya virus infection in Indonesia: a systematic review and evolutionary analysis. BMC Infect Dis 19: 243.
-
13.
Kosasih H et al., 2013. Evidence for endemic Chikungunya virus infections in Bandung, Indonesia. PLoS Negl Trop Dis 7: e2483.
-
14.
Arif M et al., 2020. Chikungunya in Indonesia: epidemiology and diagnostic challenges. PLoS Negl Trop Dis 14: e0008355.
-
15.
Sasmono RT , Perkasa A , Yohan B , Haryanto S , Yudhaputri FA , Hayati RF , Ma’roef CN , Ledermann JP , Aye Myint KS , Powers AM , 2017. Chikungunya detection during dengue outbreak in Sumatra, Indonesia: clinical manifestations and virological profile. Am J Trop Med Hyg 97: 1393–1398.
-
16.
Capeding MR et al., 2013. Dengue and other common causes of acute febrile illness in Asia: an active surveillance study in children. PLoS Negl Trop Dis 7: e2331.
-
17.
Lewthwaite P et al., 2009. Chikungunya virus and central nervous system infections in children, India. Emerg Infect Dis 15: 329–331.
-
18.
Mahto SK , Gupta PK , Singh A , Meena RC , 2018. Atypical neurological manifestations of chikungunya fever: two case reports. Indian J Crit Care Med 22: 306–308.
-
19.
Staples JE , Breiman RF , Powers AM , 2009. Chikungunya fever: an epidemiological review of a re-emerging infectious disease. Clin Infect Dis 49: 942–948.
-
20.
Horwood PF et al., 2017. Aetiology of acute meningoencephalitis in Cambodian children, 2010–2013. Emerg Microbes Infect 6: 1–8.
-
21.
Johnson BW , Goodman CH , Holloway K , de Salazar PM , Valadere AM , Drebot MA , 2016. Evaluation of commercially available Chikungunya virus immunoglobulin M detection assays. Am J Trop Med Hyg 95: 182–192.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 4045 | 1670 | 387 |
| Full Text Views | 469 | 22 | 2 |
| PDF Downloads | 287 | 36 | 4 |