Multidrug resistance as a cause of steroid nonresponsive downgrading type 1 reaction in Hansen’s disease. Int J Mycobacteriol 8: 305–308.10.4103/ijmy.ijmy_121_19)| false
Leprosy reactions show increased Th17 cell activity and reduced FoxP3+ Tregs with concomitant decrease in TGF-β and increase in IL-6. PLoS Negl Trop Dis 10: e0004592.10.1371/journal.pntd.0004592)| false
Type 1 lepra reaction (T1R) is a major complication seen in nonpolar forms of leprosy and leads to significant morbidity. The classification of T1R as up and downgrading, based on previously defined histopathological criteria (by Ridley), has therapeutic and prognostic implications. The trigger factors for these reactions are poorly described, especially in case of downgrading T1R and we describe a case of leprosy reaction that was possibly triggered by chemoradiation and elucidate the possible mechanism.
Address correspondence to Kabir Sardana, Department of Dermatology, Dr. Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi 110001, India. E-mail: email@example.com
Data availability statement: Data sharing is not applicable to this article as no new data were created or analyzed in this study.
Ethics statement: We declare that the research was conducted in compliance with the declaration of Helsinki.