• 1.

    Costa F, Wunder EA Jr, De Oliveira D, Bisht V, Rodrigues G, Reis MG, Ko AI, Begon M, Childs JE, 2015. Patterns in Leptospira shedding in Norway rats (Rattus norvegicus) from Brazilian slum communities at high risk of disease transmission. PLoS Negl Trop Dis 9: 6.

    • Search Google Scholar
    • Export Citation
  • 2.

    Donovan CM, Lee MJ, Byers KA, Bidulka J, Patrick DM, Himsworth CG, 2018. Leptospira spp. in the oral cavity of urban brown rats (Rattus norvegicus) from Vancouver, Canada-implications for rat-rat and rat-human transmission. J Wildl Dis 54: 635637.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Luzzi GA, Milne LM, Waitkins SA, 1987. Rat-bite acquired leptospirosis. J Infect 15: 5760.

  • 4.

    Faggion Vinholo T, Ribeiro GS, Silva NF, Cruz J, Reis MG, Ko AI, Costa F, 2020. Severe leptospirosis after rat bite: a case report. PLoS Negl Trop Dis 14: 7.

    • Search Google Scholar
    • Export Citation
  • 5.

    Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI, 2015. Global morbidity and mortality of leptospirosis: a systematic review. PLoS Negl Trop Dis 9: 9.

    • Search Google Scholar
    • Export Citation
  • 6.

    National Institute of Infectious Diseases and Tuberculosis and Infectious Diseases Control Division, Ministry of Health, Labour and Welfare, 2016. Leptospirosis in Japan. Infect Agents Surveil Rep 37: 103–105.

  • 7.

    Koizumi N, Muto M, Tanikawa T, Mizutani H, Sohmura Y, Hayashi E, Akao N, Hoshino M, Kawabata H, Watanabe H, 2009. Human leptospirosis cases and the prevalence of rats harbouring Leptospira interrogans in urban areas of Tokyo, Japan. J Med Microbiol 58: 12271230.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8.

    Mutoh Y, Koizumi N, Morino E, Hayakawa K, Kato Y, Ohmagari N, 2017. Leptospirosis cases in the Tokyo metropolitan area, Japan. Jpn J Infect Dis 70: 669671.

  • 9.

    Tubiana S, Mikulski M, Becam J, Lacassin F, Lefèvre P, Gourinat A-C, Goarant C, D’Ortenzio E, 2013. Risk factors and predictors of severe leptospirosis in New Caledonia. PLoS Negl Trop Dis 7: 1.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 6336 6336 36
Full Text Views 43 43 3
PDF Downloads 60 60 3
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

 

Case Report: Leptospirosis by Wild Rat Bite in Winter in Tokyo Metropolitan Area, Japan

View More View Less
  • 1 Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;
  • | 2 Emerging and Re-emerging Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Japan;
  • | 3 Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan;
  • | 4 Department of Infection Control, Graduate School of Medicine/Faculty of Medicine, Osaka University, Osaka, Japan
Restricted access

ABSTRACT.

We report a case of leptospirosis in Tokyo in winter due to a rat bite, an uncommon cause of Leptospira infection. In Japan, many cases due to exposure to fresh water have been reported from domestic southwest islands in summer. However, a previous report on leptospirosis in Tokyo documented several cases occurring in winter. The main route of infection in the Tokyo metropolitan area during winter was attributed to the increased chance of direct rat exposure. Rapid and feasible diagnostic methods are needed to elucidate its epidemiology and provide prompt treatment.

Author Notes

Address correspondence to Tetsuya Suzuki, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan. E-mail: tesuzuki@hosp.ncgm.go.jp

Financial support: K. Y. received research grants from Fujirebio, Inc., Mizuho Medy, Co., Ltd., and VisGene Inc., Sanyo Chemical Industries, Ltd., outside the submitted work.

Authors’ addresses: Tetsuya Suzuki, Shinichiro Morioka, Hidetoshi Nomoto, and Norio Ohmagari, Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan, and Emerging and Re-emerging Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Japan, E-mails: tesuzuki@hosp.ncgm.go.jp, shmorioka@hosp.ncgm.go.jp, hnomoto@hosp.ncgm.go.jp, and nohmagari@hosp.ncgm.go.jp. Tatsuya Kikuchi, Lubna Sato, Kei Yamamoto, and Kayoko Hayakawa, Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan, E-mails: tkikuchi@hosp.ncgm.go.jp, rsato@hosp.ncgm.go.jp, kyamamoto@hosp.ncgm.go.jp, and khayakawa@hosp.ncgm.go.jp. Nobuo Koizumi, Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan, E-mail: nkoizumi@niid.go.jp. Satoshi Kutsuna, Department of Infectious Diseases, Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan, and Department of Infection Control, Faculty of Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan, E-mail: kutsuna@hp-infect.med.osaka-u.ac.jp.

Save