• 1.

    Patterson MC , 2020. Neurological complications of measles (rubeola). Curr Neurol Neurosci Rep 20: 2.

  • 2.

    Jabbour JT, Garcia JH, Lemmi H, Ragland J, Duenas DA, Sever JL , 1969. Subacute sclerosing panencephalitis. a multidisciplinary study of eight cases. JAMA 207: 22482254.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 3.

    Kalita J, Kumar V, Misra UK, Kumar S , 2021. Movement disorder in Wilson disease: correlation with MRI and biomarkers of cell injury. J Mol Neurosci 71: 338346.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4.

    Anlar B, Yalaz K, Ustacelebi S , 1988. Symptômes et signes cliniques, données du laboratoire dans 80 cas de panencéphalite sclérosante subaiguë. Rev Neurol (Paris) 144: 829832.

    • Search Google Scholar
    • Export Citation
  • 5.

    Praveen-kumar S et al.2007. Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: a correlative study. Clin Neurophysiol 118: 19471954.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 6.

    Alkan A, Korkmaz L, Sigirci A, Kutlu R, Yakinci C, Erdem G, Yologlu S , 2006. Subacute sclerosing panencephalitis: relationship between clinical stage and diffusion-weighted imaging findings. J Magn Reson Imaging 23: 267272.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 7.

    Yuksel D, Diren B, Ulubay H, Altunbasak S, Anlar B , 2014. Neuronal loss is an early component of subacute sclerosing panencephalitis. Neurology 83: 938944.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 8.

    Yilmaz K, Yilmaz M, Mete A, Celen Z , 2010. A correlative study of FDG PET, MRI/CT, electroencephalography, and clinical features in subacute sclerosing panencephalitis. Clin Nucl Med 35: 675681.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 9.

    Nester M , 1996. Use of a brief assessment exam in a study involving isoprinosine and alpha interferon treatment of SSPE. J Child Neurol 11: 173180.

    • Search Google Scholar
    • Export Citation
  • 10.

    Aydin OF, Senbil N, Kuyucu N, Gürer YK , 2003. Combined treatment with subcutaneous interferon-alpha, oral isoprinosine, and lamivudine for subacute sclerosing panencephalitis. J Child Neurol 18: 104108.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 11.

    Gascon GG , 2003. International Consortium on Subacute Sclerosing Panencephalitis. Randomized treatment study of inosiplex versus combined inosiplex and intraventricular interferon-alpha in subacute sclerosing panencephalitis (SSPE): international multicenter study. J Child Neurol 18: 819827.

    • Crossref
    • Search Google Scholar
    • Export Citation
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

 

Case Report: Focal Myoclonus with a Striatal Lesion as a Presentation of Subacute Sclerosing Panencephalitis

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  • 1 Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;
  • | 2 Department of Neurology, Adhikari Neurocentre, Patna, India
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ABSTRACT.

Adult-onset subacute sclerosing panencephalitis (SSPE) is rare, and focal myoclonus as a presenting feature poses a diagnostic dilemma. We report an adult SSPE patient with unusual clinical and radiological features. A 20-year-old girl had jerky neck movement 9 months earlier, which progressed to left hemimyoclonus in 2 months and generalized frequent myoclonus and fall at 4 months. By 6 months, she was bedbound. On examination, her Mini-Mental State Examination score was 10, and patchy retinitis was observed around the macula. Magnetic resonance imaging revealed corpus striatal involvement and electroencephalography showed periodic discharges. Measles cerebrospinal fluid/serum immunoglobulin G index was 3.3 (normal < 1.3), confirming the diagnosis of SSPE. SSPE should also be considered in adults having focal myoclonus with corpus striatal lesion. EEG is helpful in the diagnosis.

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Author Notes

Address correspondence to Jayantee Kalita, Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical sciences, Lucknow, India. E-mails: jkalita@sgpgi.ac.in or jayanteek@yahoo.com

Disclosure: This study was approved by the institutional ethical committee of SGPGIMS, Lucknow, Uttar Pradesh, India.

Authors’ addresses: Jayantee Kalita, Sarvesh K. Chaudhury, and Mahesh Jadhav, Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; E-mails: jkalita@sgpgi.ac.in, skc087a@gmail.com, and drmaheshjadhav25@gmail.com. Bishwanath Kumar, Department of Neurology, Adhikari Neurocentre, Patna, India, E-mail: bishusgpgi@gmail.com.

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