Barrera L, Alvarez J, Tapias M, Idrovo V, Lopez R, 2013. Granulomatous hepatitis secondary to histoplasma infection after treatment with infliximab. Case Rep Hepatol 2013: 807537.
Rihana NA, Kandula M, Velez A, Dahal K, O’Neill EB, 2014. Histoplasmosis Presenting as granulomatous hepatitis: case report and review of the literature. Case Rep Med2014: 879535.
Wheat J, Freifeld AG, Kleiman MB, Baddley JW, McKinsey DS, Loyd JE, Kauffman CA, 2007. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Disease Society of America. Clin Infect Dis 45: 807–825.
Washburn L, Galvan NT, Dhingra S, Rana A, Goss JA, 2017. Histoplasmosis hepatitis after orthoptic liver transplantation. J Surg Case Rep 12: 1–3.
Park S, Cheong J, Kyi K, Aranez J, Abu-Farsakh S, Whitney-Miller C, Al-Judaibi B, Laryea M, 2020. Cholestasis and disseminated histoplasmosis in a psoriatic patient on infliximab: case report and review of literature. BMC Gastroenterol 20: 141.
Heninger E, Hogan LH, Karman J, Macvilay S, Hill B, Woods JP, Sandor M , 2006. Characterization of the Histoplasma capsulatum–induced granuloma. J Immunol 177: 3303–3313.
Koo S, Marty FM, Baden LR, 2010. Infectious complications associated with immunomodulating biologic agents. Infect Dis Clin North Am 24: 285–305.
Jain N, Doyon J, Lazarus J, Schaefer I-M, Johncilla M, Agoston AT, Dalal AK, Velasquez GE, 2018. A case of disseminated histoplasmosis in a patient with rheumatoid arthritis on abatacept. J Gen Intern Med 33: 769–772.
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Histoplasma capsulatum is the most common endemic mycosis in the United States and can cause disseminated histoplasmosis in immunocompromised patients.1 Although hepatic involvement is common with histoplasmosis, it can be challenging to diagnose. We report a case of a 50-year-old woman receiving adalimumab for rheumatoid arthritis who presented with right upper quadrant pain, fever, jaundice, and dyspnea. The initial working diagnosis was biliary obstruction with potential COVID-19 infection. Endoscopic retrograde cholangiopancreatography suggested Mirizzi syndrome, but successful sphincterotomy failed to improve jaundice over subsequent days. Bronchoscopy and liver biopsy were performed, with the first revealing budding yeast and the later growing H. capsulatum. The patient improved with the initiation of itraconazole therapy.
Authors’ addresses: Brittany Hjermstad, Department of Medicine, Hennepin Healthcare, Minneapolis, MN, E-mail: behjermstad@gmail.com. Dale Snover, Department of Pathology, University of Minnesota System, Minneapolis, MN, E-mail: snoverd@umn.edu. Jose Daniel Debes, Department of Infectious Disease and Gastroenterology, University of Minnesota, Minneapolis, MN, E-mail: debes003@umn.edu
Barrera L, Alvarez J, Tapias M, Idrovo V, Lopez R, 2013. Granulomatous hepatitis secondary to histoplasma infection after treatment with infliximab. Case Rep Hepatol 2013: 807537.
Rihana NA, Kandula M, Velez A, Dahal K, O’Neill EB, 2014. Histoplasmosis Presenting as granulomatous hepatitis: case report and review of the literature. Case Rep Med2014: 879535.
Wheat J, Freifeld AG, Kleiman MB, Baddley JW, McKinsey DS, Loyd JE, Kauffman CA, 2007. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Disease Society of America. Clin Infect Dis 45: 807–825.
Washburn L, Galvan NT, Dhingra S, Rana A, Goss JA, 2017. Histoplasmosis hepatitis after orthoptic liver transplantation. J Surg Case Rep 12: 1–3.
Park S, Cheong J, Kyi K, Aranez J, Abu-Farsakh S, Whitney-Miller C, Al-Judaibi B, Laryea M, 2020. Cholestasis and disseminated histoplasmosis in a psoriatic patient on infliximab: case report and review of literature. BMC Gastroenterol 20: 141.
Heninger E, Hogan LH, Karman J, Macvilay S, Hill B, Woods JP, Sandor M , 2006. Characterization of the Histoplasma capsulatum–induced granuloma. J Immunol 177: 3303–3313.
Koo S, Marty FM, Baden LR, 2010. Infectious complications associated with immunomodulating biologic agents. Infect Dis Clin North Am 24: 285–305.
Jain N, Doyon J, Lazarus J, Schaefer I-M, Johncilla M, Agoston AT, Dalal AK, Velasquez GE, 2018. A case of disseminated histoplasmosis in a patient with rheumatoid arthritis on abatacept. J Gen Intern Med 33: 769–772.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 7394 | 861 | 30 |
Full Text Views | 250 | 8 | 0 |
PDF Downloads | 89 | 9 | 0 |