ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Ornoy A , Ergaz Z , 2017. Parvovirus B19 infection during pregnancy and risks to the fetus. Birth Defects Res 109: 311–323.
-
2.
De Jong E , Walther F , Kroes A , Oepkes D , 2011. Parvovirus B19 infection in pregnancy: new insights and management. Prenat Diagn 31: 419–425.
-
3.
Seetha D , Pillai HR , Nori SRC , Kalpathodi SG , Thulasi VP , Nair RR , 2021. Molecular-genetic characterization of human parvovirus B19 prevalent in Kerala State, India. Virol J 18: 96.
-
4.
Mühlemann B et al.2018. Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. Proc Natl Acad Sci USA 115: 7557–7562.
-
5.
Lamont RF , Sobel JD , Vaisbuch E , Kusanovic JP , Mazaki-Tovi S , Kim SK , Uldbjerg N , Romero R , 2010. Parvovirus B19 infection in human pregnancy. Int J Obtest Gynaecol 118: 175–186.
-
6.
Ros C , Bieri J , Leisi R , 2020. The VP1u of human parvovirus B19: a multifunctional capsid protein with biotechnological applications. Viruses 12: 1463.
-
7.
Macri A , Crane JS , 2021. Parvoviruses. Treasure Island, FL: StatPearls.
-
8.
Mirambo MM , Maliki F , Majigo M , Mushi MF , Moremi N , Seni J , Matovelo D , Mshana SE , 2017. The magnitude and correlates of parvovirus B19 infection among pregnant women attending antenatal clinics in Mwanza, Tanzania. BMC Pregnancy Childbirth 17: 1–7.
-
9.
Taherkhani R , Farshadpour F , Makvandi M , Hamidifard M , Esmailizadeh M , Ahmadi B , Heidari H , 2015. Determination of cytomegalovirus prevalence and glycoprotein B genotypes among ulcerative colitis patients in Ahvaz, Iran. Jundishapur J Microbiol 8: e17458.
-
10.
Servant A , Laperche S , Lallemand F , Marinho V , De Saint Maur G , Meritet JF , Garbarg-Chenon A , 2002. Genetic diversity within human erythroviruses: identification of three genotypes. J Virol 76: 9124–9134.
-
11.
Corcoran C , Hardie D , Yeats J , Smuts H , 2009. Genetic variants of human parvovirus B19 in South Africa: cocirculation of three genotypes and identification of a novel subtype of genotype 1. J Clin Microbiol 48: 137–142.
-
12.
Karami A , Hoseini SL , Ramazani A , Emadi P , Gholami H , Hoseini SM , 2019. Prevalence of parvovirus B19 infection by serology and PCR in pregnant women referring to obstetrics and gynecology clinic. J Natl Med Assoc 112: 91–96.
-
13.
Ziyaeyan M , Rasouli M , Alborzi A , 2005. The seroprevalence of parvovirus B19 infection among to-be-married girls, pregnant women, and their neonates in Shiraz, Iran. Jpn J Infect Dis 58: 95–97.
-
14.
Maksheed M , Pacsa AS , Essa SS , Ahmed MA , Monem RA , Surkouh M , 1999. The prevalence of antibody to human parvovirus B19 in pregnant women in Kuwait. Acta Trop 73: 225–229.
-
15.
Enders M , Weidner A , Enders G , 2006. Current epidemiological aspects of human parvovirus B19 infection during pregnancy and childhood in the western part of Germany. Epidemiol Infect 135: 563–569.
-
16.
Safiyanu MB , Akande AO , Babayo A , Umar J , Abdullahi IN , 2021. Serological detection of human parvovirus B19 infection and associated risk factors among pregnant women in Jigawa State, Nigeria. J Immunoassay Immunochem 42: 380–392.
-
17.
Buhtori M , 2015. Seroprevalence of parvovirus B19 among pregnant women in Damascus Syria. Int J Pharm Sci Rev Res 30: 227–229.
-
18.
Ahga N , Alharmni K , Alkhayat Z , 2020. Seroepidemiology of human parvovirus B19 among pregnant women in Erbil, Iraq. Med J Babylon 17: 64–68.
-
19.
Habibzadeh S , Peeri-Doghaheh H , Mohammad-Shahi J , Mobini E , Shahbazzadegan S , 2016. The prevalence of parvovirus B19 infection among pregnant women of Ardabil in 2013. Iran J Microbiol 8: 214–218.
-
20.
Khameneh ZR , Hanifian H , Barzegari R , Sepehrvand N , 2014. Human parvovirus B19 in Iranian pregnant women: a serologic survey. Indian J Pathol Microbiol 57: 442–444.
-
21.
Salimi V , Gouya MM , Esteghamati A , Safaie A , Heshmat R , Saadatmand Z , Mokhtari-Azad T , 2008. Seroepidemiology of human parvovirus B19 in 5–25 year old age people in Iran. Iran J Public Health 37: 19–25.
-
22.
Karimnia A , Elikaei A , Sharifi Z , 2020. Human parvovirus B19 infection among blood donors in north-east of Iran. Arch Clin Infect Dis 15: e97856.
-
23.
Adam O , Makkawi T , Reber U , Kirberg H , Eis-Hubinger AM , 2014. The seroprevalence of parvovirus B19 infection in pregnant women in Sudan. Epidemiol Infect 143: 242–248.
-
24.
van Gessel PH , Gaytant MA , Vossen AC , Galama JM , Ursem NT , Steegers EA , Wildschut HI , 2006. Incidence of parvovirus B19 infection among an unselected population of pregnant women in The Netherlands: a prospective study. Eur J Obstet Gynecol Reprod Biol 128: 46–49.
-
25.
Odland JO , Sergejeva IV , Ivaneev MD , Jensen IP , Stray-Pedersen B , 2001. Seropositivity of cytomegalovirus, parvovirus and rubella in pregnant women and recurrent aborters in Leningrad County, Russia. Acta Obstet Gynecol Scand 80: 1025–1029.
-
26.
Akyala I , Amuta E , Azua A , Agieni A , 2012. Parvovirus B19: evaluation of incidence, prevalence and risk factors among pregnant women attending ante-natal clinic in Nassarawa State, north central of Nigeria. Clin Med Diagn 2: 54–59.
-
27.
Kostolansky S , Waymack JR , 2021. Erythema Infectiosum. Treasure Island, FL: StatPearls.
-
28.
Marhamati N , Shirvani F , Azimi L , Hashemieh M , Hosseini A , Shahmirzadi SA , Dodangeh F , 2021. Molecular detection of human parvovirus B19 in umbilical cord blood: case study of Tehran, Iran. Gene Rep 23: 101183.
-
29.
Zadsar M , Aghakhani A , Banifazl M , Kazemimanesh M , Tabatabaei Yazdi SM , Mamishi S , Bavand A , Sadat Larijani M , Ramezani A , 2018. Seroprevalence, molecular epidemiology and quantitation of parvovirus B19 DNA levels in Iranian blood donors. J Med Virol 90: 1318–1322.
-
30.
Molenaar-de Backer MW , Lukashov VV , van Binnendijk RS , Boot HJ , Zaaijer HL , 2012. Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions. PLoS One 7: e43206.
-
31.
Abdelrahman D et al.2021. Prevalence and phylogenetic analysis of parvovirus (B19V) among blood donors with different nationalities residing in Qatar. Viruses 13: 540.
-
32.
Jia J , Ma Y , Zhao X , Huangfu C , Zhong Y , Fang C , Fan R , Lv M , Zhang J , 2016. Existence of various human parvovirus B19 genotypes in Chinese plasma pools: genotype 1, genotype 3, putative intergenotypic recombinant variants and new genotypes. Virol J 13: 1–10.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1209 | 488 | 22 |
| Full Text Views | 122 | 8 | 0 |
| PDF Downloads | 67 | 10 | 0 |
Molecular Evaluation of Human Parvovirus B19 Infection and Associated Risk Factors among Pregnant Women in Bushehr Province, Southern Iran
Reza Taherkhani
Reza Taherkhani
Department of Virology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
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Fatemeh Farshadpour
Fatemeh Farshadpour
Department of Virology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
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Masomeh Norozi
Masomeh Norozi
Department of Virology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
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Search for other papers by Masomeh Norozi in
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ABSTRACT.
Given the importance of human parvovirus B19 infection during pregnancy and the potential risks to the fetus, this study was designed to determine the prevalence, genotypic pattern, and risk factors of parvovirus B19 infection among a population-based sample of pregnant women in Bushehr Province, southern Iran. A total of 824 pregnant women were enrolled in this study. Serum samples were screened for the detection of anti-parvovirus B19 IgM and IgG by ELISA. The molecular evaluation was performed by nested polymerase chain reaction, targeting the non-structural protein 1–viral protein 1 unique region of the genome, and sequencing. Of 824 pregnant women, 330 (40.1%) were positive for anti-parvovirus B19 IgG and 50 women (6.1%) had anti-parvovirus B19 IgM. A greater rate of anti-parvovirus B19 IgG seroprevalence was observed in women older than 39 years, in Afghan immigrants, and in those women with more parities. Anti-parvovirus B19 IgM seroprevalence decreased with increasing gestational age and was significantly greater among women in the first trimester of pregnancy and among residents of the city of Borazjan. Moreover, 0.73% of the pregnant women had parvovirus B19 viremia with genotype 1 and subtype 1a. Parvovirus B19 DNA was detected in the samples collected in late autumn and winter, which is a rainy season associated with temperate climes in southern Iran. According to the results of this study, approximately 60% of pregnant women in this region are serologically negative and susceptible to parvovirus B19 infection. Therefore, assessment for maternal parvovirus B19 infection is important and should be considered as part of the fetal–maternal health policy in Iran.
Author Notes
Financial support: This study was funded by the Deputy of Research and Affairs, Bushehr University of Medical Sciences, Bushehr, Iran (grant no. 358).
Authors’ addresses: Reza Taherkhani, Fatemeh Farshadpour, and Masomeh Norozi, Department of Virology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran, E-mails: r.taherkhani@bpums.ac.ir, f.farshadpour@bpums.ac.ir, and mn91123@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Ornoy A , Ergaz Z , 2017. Parvovirus B19 infection during pregnancy and risks to the fetus. Birth Defects Res 109: 311–323.
-
2.
De Jong E , Walther F , Kroes A , Oepkes D , 2011. Parvovirus B19 infection in pregnancy: new insights and management. Prenat Diagn 31: 419–425.
-
3.
Seetha D , Pillai HR , Nori SRC , Kalpathodi SG , Thulasi VP , Nair RR , 2021. Molecular-genetic characterization of human parvovirus B19 prevalent in Kerala State, India. Virol J 18: 96.
-
4.
Mühlemann B et al.2018. Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans. Proc Natl Acad Sci USA 115: 7557–7562.
-
5.
Lamont RF , Sobel JD , Vaisbuch E , Kusanovic JP , Mazaki-Tovi S , Kim SK , Uldbjerg N , Romero R , 2010. Parvovirus B19 infection in human pregnancy. Int J Obtest Gynaecol 118: 175–186.
-
6.
Ros C , Bieri J , Leisi R , 2020. The VP1u of human parvovirus B19: a multifunctional capsid protein with biotechnological applications. Viruses 12: 1463.
-
7.
Macri A , Crane JS , 2021. Parvoviruses. Treasure Island, FL: StatPearls.
-
8.
Mirambo MM , Maliki F , Majigo M , Mushi MF , Moremi N , Seni J , Matovelo D , Mshana SE , 2017. The magnitude and correlates of parvovirus B19 infection among pregnant women attending antenatal clinics in Mwanza, Tanzania. BMC Pregnancy Childbirth 17: 1–7.
-
9.
Taherkhani R , Farshadpour F , Makvandi M , Hamidifard M , Esmailizadeh M , Ahmadi B , Heidari H , 2015. Determination of cytomegalovirus prevalence and glycoprotein B genotypes among ulcerative colitis patients in Ahvaz, Iran. Jundishapur J Microbiol 8: e17458.
-
10.
Servant A , Laperche S , Lallemand F , Marinho V , De Saint Maur G , Meritet JF , Garbarg-Chenon A , 2002. Genetic diversity within human erythroviruses: identification of three genotypes. J Virol 76: 9124–9134.
-
11.
Corcoran C , Hardie D , Yeats J , Smuts H , 2009. Genetic variants of human parvovirus B19 in South Africa: cocirculation of three genotypes and identification of a novel subtype of genotype 1. J Clin Microbiol 48: 137–142.
-
12.
Karami A , Hoseini SL , Ramazani A , Emadi P , Gholami H , Hoseini SM , 2019. Prevalence of parvovirus B19 infection by serology and PCR in pregnant women referring to obstetrics and gynecology clinic. J Natl Med Assoc 112: 91–96.
-
13.
Ziyaeyan M , Rasouli M , Alborzi A , 2005. The seroprevalence of parvovirus B19 infection among to-be-married girls, pregnant women, and their neonates in Shiraz, Iran. Jpn J Infect Dis 58: 95–97.
-
14.
Maksheed M , Pacsa AS , Essa SS , Ahmed MA , Monem RA , Surkouh M , 1999. The prevalence of antibody to human parvovirus B19 in pregnant women in Kuwait. Acta Trop 73: 225–229.
-
15.
Enders M , Weidner A , Enders G , 2006. Current epidemiological aspects of human parvovirus B19 infection during pregnancy and childhood in the western part of Germany. Epidemiol Infect 135: 563–569.
-
16.
Safiyanu MB , Akande AO , Babayo A , Umar J , Abdullahi IN , 2021. Serological detection of human parvovirus B19 infection and associated risk factors among pregnant women in Jigawa State, Nigeria. J Immunoassay Immunochem 42: 380–392.
-
17.
Buhtori M , 2015. Seroprevalence of parvovirus B19 among pregnant women in Damascus Syria. Int J Pharm Sci Rev Res 30: 227–229.
-
18.
Ahga N , Alharmni K , Alkhayat Z , 2020. Seroepidemiology of human parvovirus B19 among pregnant women in Erbil, Iraq. Med J Babylon 17: 64–68.
-
19.
Habibzadeh S , Peeri-Doghaheh H , Mohammad-Shahi J , Mobini E , Shahbazzadegan S , 2016. The prevalence of parvovirus B19 infection among pregnant women of Ardabil in 2013. Iran J Microbiol 8: 214–218.
-
20.
Khameneh ZR , Hanifian H , Barzegari R , Sepehrvand N , 2014. Human parvovirus B19 in Iranian pregnant women: a serologic survey. Indian J Pathol Microbiol 57: 442–444.
-
21.
Salimi V , Gouya MM , Esteghamati A , Safaie A , Heshmat R , Saadatmand Z , Mokhtari-Azad T , 2008. Seroepidemiology of human parvovirus B19 in 5–25 year old age people in Iran. Iran J Public Health 37: 19–25.
-
22.
Karimnia A , Elikaei A , Sharifi Z , 2020. Human parvovirus B19 infection among blood donors in north-east of Iran. Arch Clin Infect Dis 15: e97856.
-
23.
Adam O , Makkawi T , Reber U , Kirberg H , Eis-Hubinger AM , 2014. The seroprevalence of parvovirus B19 infection in pregnant women in Sudan. Epidemiol Infect 143: 242–248.
-
24.
van Gessel PH , Gaytant MA , Vossen AC , Galama JM , Ursem NT , Steegers EA , Wildschut HI , 2006. Incidence of parvovirus B19 infection among an unselected population of pregnant women in The Netherlands: a prospective study. Eur J Obstet Gynecol Reprod Biol 128: 46–49.
-
25.
Odland JO , Sergejeva IV , Ivaneev MD , Jensen IP , Stray-Pedersen B , 2001. Seropositivity of cytomegalovirus, parvovirus and rubella in pregnant women and recurrent aborters in Leningrad County, Russia. Acta Obstet Gynecol Scand 80: 1025–1029.
-
26.
Akyala I , Amuta E , Azua A , Agieni A , 2012. Parvovirus B19: evaluation of incidence, prevalence and risk factors among pregnant women attending ante-natal clinic in Nassarawa State, north central of Nigeria. Clin Med Diagn 2: 54–59.
-
27.
Kostolansky S , Waymack JR , 2021. Erythema Infectiosum. Treasure Island, FL: StatPearls.
-
28.
Marhamati N , Shirvani F , Azimi L , Hashemieh M , Hosseini A , Shahmirzadi SA , Dodangeh F , 2021. Molecular detection of human parvovirus B19 in umbilical cord blood: case study of Tehran, Iran. Gene Rep 23: 101183.
-
29.
Zadsar M , Aghakhani A , Banifazl M , Kazemimanesh M , Tabatabaei Yazdi SM , Mamishi S , Bavand A , Sadat Larijani M , Ramezani A , 2018. Seroprevalence, molecular epidemiology and quantitation of parvovirus B19 DNA levels in Iranian blood donors. J Med Virol 90: 1318–1322.
-
30.
Molenaar-de Backer MW , Lukashov VV , van Binnendijk RS , Boot HJ , Zaaijer HL , 2012. Global co-existence of two evolutionary lineages of parvovirus B19 1a, different in genome-wide synonymous positions. PLoS One 7: e43206.
-
31.
Abdelrahman D et al.2021. Prevalence and phylogenetic analysis of parvovirus (B19V) among blood donors with different nationalities residing in Qatar. Viruses 13: 540.
-
32.
Jia J , Ma Y , Zhao X , Huangfu C , Zhong Y , Fang C , Fan R , Lv M , Zhang J , 2016. Existence of various human parvovirus B19 genotypes in Chinese plasma pools: genotype 1, genotype 3, putative intergenotypic recombinant variants and new genotypes. Virol J 13: 1–10.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1209 | 488 | 22 |
| Full Text Views | 122 | 8 | 0 |
| PDF Downloads | 67 | 10 | 0 |