• 1.

    Vidal JE, 2019. HIV-related cerebral toxoplasmosis revisited: current concepts and controversies of an old disease. J Int Assoc Provid AIDS Care 18: 2325958219867315.

    • Search Google Scholar
    • Export Citation
  • 2.

    Serpa JA , Moran A , Goodman JC , Giordano TP , White AC Jr , 2007. Neurocysticercosis in the HIV era: a case report and review of the literature. Am J Trop Med Hyg 77: 113117.

    • Search Google Scholar
    • Export Citation
  • 3.

    Nash TE , Bustos JA , Garcia HH ; Cysticercosis Working Group in Perú, 2017. Disease centered around calcified Taenia solium granuloma. Trends Parasitol 33: 6573.

    • Search Google Scholar
    • Export Citation
  • 4.

    Del Brutto OH , Nash TE , White AC , Jr, Rajshekhar V , Wilkins PP , Singh G , Vasquez CM , Salgado P , Gilman RH , Garcia HH , 2017. Revised diagnostic criteria for neurocysticercosis. J Neurol Sci 372: 202210.

    • Search Google Scholar
    • Export Citation
  • 5.

    Thakur KT , Boubour A , Saylor D , Das M , Bearden DR , Birbeck GL , 2019. Global HIV neurology: a comprehensive review. AIDS 33: 163184.

  • 6.

    Celzo FG , 2013. Brain stones revisited-between a rock and a hard place. Insights Imaging 4: 625635.

  • 7.

    Nash TE , Ware JM , Mahanty S , 2017. Natural history of patients with perilesional edema around Taenia solium calcified granulomas. J Infect Dis 215: 11411147.

    • Search Google Scholar
    • Export Citation
  • 8.

    Del Brutto OH , Santibañez R , Noboa CA , Aguirre R , Díaz E , Alarcón TA , 1992. Epilepsy due to neurocysticercosis: analysis of 203 patients. Neurology 42: 389392.

    • Search Google Scholar
    • Export Citation
  • 9.

    Telles JP et al.2021. Neurological manifestations in people living with HIV/AIDS in the late cART era: a prospective observational study at a tertiary healthcare center in São Paulo, Brazil. HIV Res Clin Pract 22: 8795.

    • Search Google Scholar
    • Export Citation
  • 10.

    Jewell PD et al.2021. Neurocysticercosis and HIV/AIDS co-infection: a scoping review. Trop Med Int Health 26: 11401152.

  • 11.

    Nash T , 2012. Edema surrounding calcified calcified intracranial cysticerci: clinical manifestations, natural history, and treatment. Pathog Glob Health 106: 275279.

    • Search Google Scholar
    • Export Citation
  • 12.

    Pradhan S , Kathuria MK , Gupta RK , 2000. Perilesional gliosis and seizure outcome: a study based on magnetization transfer magnetic resonance imaging in patients with neurocysticercosis. Ann Neurol 48: 181187.

    • Search Google Scholar
    • Export Citation
  • 13.

    de Souza A , Nalini A , Kovoor JM , Yeshraj G , Siddalingaiah HS , Thennarasu K , 2011. Perilesional gliosis around solitary cerebral parenchymal cysticerci and long-term seizure outcome: a prospective study using serial magnetization transfer imaging. Epilepsia 52: 19181927.

    • Search Google Scholar
    • Export Citation
  • 14.

    Bustos JA , Coyle CM , 2020. Brain calcification because of neurocysticercosis: a vast field to be explored. Curr Opin Infect Dis 33: 334338.

    • Search Google Scholar
    • Export Citation
  • 15.

    Laissy JP et al.1994. Persistent enhancement after treatment for cerebral toxoplasmosis in patients with AIDS: predictive value for subsequent recurrence. AJNR Am J Neuroradiol 15: 17731778.

    • Search Google Scholar
    • Export Citation
  • 16.

    Martin-Blondel G , Alvarez M , Delobel P , Uro-Coste E , Cuzin L , Cuvinciuc V , Fillaux J , Massip P , Marchou B , 2011. Toxoplasmic encephalitis IRIS in HIV-infected patients: a case series and review of the literature. J Neurol Neurosurg Psychiatry 82: 691693.

    • Search Google Scholar
    • Export Citation
  • 17.

    van Bilsen WPH , van den Berg CHSB , Rijnders BJA , Brinkman K , Mulder JW , Gelinck LBS , Hoepelman AIM , Wit FWNM , van de Beek D , Prins JM , 2017. Immune reconstitution inflammatory syndrome associated with toxoplasmic encephalitis in HIV-infected patients. AIDS 31: 14151424.

    • Search Google Scholar
    • Export Citation
  • 18.

    Del Brutto OH , 2013. Neurocysticercosis: new thoughts on controversial issues. Curr Opin Neurol 26: 289294.

  • 19.

    Nash T , Garcia HH , 2011. Diagnosis and treatment of neurocysticercosis. Nat Rev Neurol 7: 584594.

  • 20.

    White AC , Jr, Coyle CM , Rajshekhar V , Singh G , Hauser WA , Mohanty A , Garcia HH , Nash TE , 2018. Diagnosis and treatment of neurocysticercosis: 2017 Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Clin Infect Dis 66: e49e75.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 5216 5217 66
Full Text Views 47 47 7
PDF Downloads 62 62 7
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

 

Case Report: Calcified Cerebral Toxoplasmosis Associated with Perilesional Edema in People Living with HIV/AIDS: Case Series of a Presentation Mimicking Neurocysticercosis

José E. VidalDepartamento de Neurologia, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil;
Divisão de Moléstias Infecciosas, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil;
LIM 49, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil;

Search for other papers by José E. Vidal in
Current site
Google Scholar
PubMed
Close
,
René L. M. RiveroSetor de Radiologia, Divisão de Apoio ao Diagnóstico e Terapêutica, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil;

Search for other papers by René L. M. Rivero in
Current site
Google Scholar
PubMed
Close
,
Sigrid de Sousa dos SantosDepartamento de Medicina, Universidade Federal de São Carlos, São Carlos, Brazil;

Search for other papers by Sigrid de Sousa dos Santos in
Current site
Google Scholar
PubMed
Close
,
Bruno F. GuedesDepartmento de Neurologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil;

Search for other papers by Bruno F. Guedes in
Current site
Google Scholar
PubMed
Close
,
Hélio R. GomesDepartmento de Neurologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil;
LIM 14, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil;

Search for other papers by Hélio R. Gomes in
Current site
Google Scholar
PubMed
Close
,
Augusto C. Penalva de OliveiraDepartamento de Neurologia, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil;

Search for other papers by Augusto C. Penalva de Oliveira in
Current site
Google Scholar
PubMed
Close
, and
Hector H. GarciaCentro de Salud Global, Universidad Peruana Cayetano Herédia, Lima, Peru;
Unidad de Cisticercosis, Instituto de Ciencias Neurológicas, Lima, Peru

Search for other papers by Hector H. Garcia in
Current site
Google Scholar
PubMed
Close
Restricted access

ABSTRACT.

Perilesional edema, associated or not with neurological manifestations, is a well-characterized finding in cases of calcified neurocysticercosis. There are no previous reports of HIV-related calcified toxoplasmosis that mimics this presentation of neurocysticercosis. We report on five patients, four of them with new-onset neurological manifestations, who showed brain calcifications associated with perilesional edema. All cases had a history of HIV-related toxoplasmosis and current virological and immunological control of HIV infection. Similar to neurocysticercosis, brain calcified toxoplasmosis may cause perilesional edema and symptoms in people living with HIV/AIDS.

Author Notes

Address correspondence to José E. Vidal, LIM 49, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, Avenida Dr. Enéas de Carvalho de Aguiar, 470 - CEP 05403-000, São Paulo, Brazil. E-mail: josevibe@gmail.com

Authors’ addresses: José E. Vidal, Departamento de Neurologia, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil, Divisão de Moléstias Infecciosas, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, and LIM 49, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, E-mail: josevibe@gmail.com. René L. M. Rivero, Setor de Radiologia, Divisão de Apoio ao Diagnóstico e Terapêutica, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil, E-mail: reneleandro3@hotmail.com. Sigrid de Sousa dos Santos, Departamento de Medicina, Universidade Federal de São Carlos, São Carlos, Brazil, E-mail: sigridsantos@gmail.com. Bruno F. Guedes, Departmento de Neurologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, E-mail: bruno.guedes@hc.fm.usp.br. Hélio R. Gomes, Departmento de Neurologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, and LIM 14, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, E-mail: helio.gomes@hc.fm.usp.br. Augusto C. Penalva de Oliveira, Departamento de Neurologia, Instituto de Infectologia Emílio Ribas, São Paulo, Brazil, E-mail: rdcassia@uol.com.br. Hector H. Garcia, Centro de Salud Global, Universidad Peruana Cayetano Herédia, Lima, Peru, and Unidad de Cisticercosis, Instituto de Ciencias Neurológicas, Lima, Peru, E-mail: hhgarcia1@jhu.edu.

Save