ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Ord RL , Lobo CA , 2015. Human babesiosis: pathogens, prevalence, diagnosis and treatment. Curr Clin Microbiol Rep 4: 173–181.
-
2.
Krause PJ , 2020. Human babesiosis. Int J Parasitol 49: 165–174.
-
3.
Yabsley MJ , Shock BC , 2013. Natural history of zoonotic Babesia: role of wildlife reservoirs. Int J Parasitol 2: 28–31.
-
4.
Swei A et al.2019. Evidence for transmission of the zoonotic apicomplexan parasite Babesia duncani by the tick Dermacentor albipictus. Int J Parasitol 49: 95–103.
-
5.
Kim JY et al.2007. First case of human babesiosis in Korea: detection and characterization of a novel type of Babesia sp. (KO1) similar to ovine Babesia. J Clin Microbiol 45: 2084–2087.
-
6.
Marathe A , Tripathi J , Handa V , Date V , 2005. Human babesiosis—a case report. Int J Med Microbiol 23: 267–269.
-
7.
Medlin L , Elwood HJ , Stickel S , Sogin ML , 1988. The characterization of enzymatically amplified eukaryotic 16S-like rRNA-coding regions. Gene 71: 491–499.
-
8.
Wei Q , Tsuji M , Zamoto A , Kohsaki M , Matsui T , Shiota T , Telford SR , Ishihara C , 2001. Human babesiosis in Japan: isolation of Babesia microti like parasites from an asymptomatic transfusion donor and from a rodent from an area where babesiosis is endemic. J Clin Microbiol 39: 2178–2183.
-
9.
Kumar S , Stecher G , Tamura K , 2016. MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets. Mol Biol Evol 33: 1870–1874.
-
10.
Thompson JD , Higgins DG , Gibson TJ , 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673–4680.
-
11.
Tamura K , Nei M , 1993. Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. Mol Biol Evol 10: 512–552.
-
12.
Vannier EG , Diuk-Wasser MA , Mamoun CB , Krause PJ , 2015. Babesiosis. Infect Dis Clin North Am 29: 357–370.
-
13.
Vannier EG , Krause MD , 2012. Human babesiosis. N Engl J Med 366: 2397–2407.
-
14.
Akel T , Mobarakai N , 2017. Haematologic manifestations of babesiosis. Ann Clin Microbiol Antimicrob 16: 6.
-
15.
Krause PJ , Daily J , Telford SR , Vannier E , Lantos P , Spielman A , 2007. Shared features in the pathobiology of babesiosis and malaria. Trends Parasitol 23: 605–610.
-
16.
Zhou X , Xia S , Huang JL , Tamblo E , Zhuge HX , Zhou XN , 2014. Human babesiosis, an emerging tick-borne disease in People’s Republic of China. Parasit Vectors 7: 509.
-
17.
Ghosh S , Bansal GC , Gupta SC , Ray D , Khan MQ , Irshad H , Shahiduzzaman M , Seitzer U , Ahmed JS , 2007. Status of tick distribution in Bangladesh, India and Pakistan. Parasitol Res 101: S207–S216.
-
18.
Oz S , Westlund KH , 2012. “Human babesiosis”: an emerging transfusion dilemma. Int J Hepatol. https://doi.org/10.1155/2012/431761.
-
19.
Sanchez E , Vannier E , Wormser GP , Hu LT , 2016. Diagnosis, treatment and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: a review. JAMA 315: 1767.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 6987 | 612 | 28 |
| Full Text Views | 233 | 10 | 0 |
| PDF Downloads | 112 | 15 | 0 |
Case Report: A Fatal Case of Babesiosis in a Splenectomized Male Patient from Western India
Ravi Godbole
Ravi Godbole
Department of Pathology, King Edward Memorial Hospital, Pune, India;
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Avantika Gaur
Avantika Gaur
Department of Pathology, King Edward Memorial Hospital, Pune, India;
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Priyanka Nayar
Priyanka Nayar
Department of Pathology, King Edward Memorial Hospital, Pune, India;
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Kala Gnanasekaran Kiruthiga
Kala Gnanasekaran Kiruthiga
Department of Pathology, King Edward Memorial Hospital, Pune, India;
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Pradeep D’Costa
Pradeep D’Costa
Department of Pathology, King Edward Memorial Hospital, Pune, India;
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Rumma Manchanda
Rumma Manchanda
Department of Pathology, King Edward Memorial Hospital, Pune, India;
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Ajinkya Khilari
Ajinkya Khilari
Biochemical Sciences Division, National Chemical Laboratory, Pune, India;
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India;
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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India;
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Dhanasekaran Shanmugam
Dhanasekaran Shanmugam
Biochemical Sciences Division, National Chemical Laboratory, Pune, India;
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India;
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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India;
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Kalpana D. Muglikar
Kalpana D. Muglikar
Western Regional Disease Diagnostic Laboratory, Pune, India;
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Krishnendu Kundu
Krishnendu Kundu
Department of Veterinary Parasitology, Faculty of Veterinary and Animal Science, Rajiv Gandhi South Campus, Banaras Hindu University, Barkachha, Mirzapur, India
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ABSTRACT.
Human babesiosis is a rare disease, caused by Babesia species and commonly transmitted by tick bite. Although human babesiosis is known to be asymptomatic in immunocompetent hosts, clinical cases of severe babesiosis have been reported from splenectomized or immunocompromised individuals. To our knowledge, only one case of human babesiosis in India has been previously reported. Here, we report a case of severe babesiosis with high parasitemia (∼70%) in a 30-year-old asplenic farmer. The patient presented with fever, yellowish discoloration of skin, oliguria, and anemia; he eventually developed multiorgan failure syndrome and died. Peripheral blood films were prepared and used to confirm the presence of piroplasms by microscopy. Total DNA isolated from blood was used for 18S ribosomal RNA gene fragment amplification by polymerase chain reaction, which was subjected to Sanger sequencing. Although 18S sequence indicated that the Babesia species infecting the patient was similar to that of other Babesia species originating from wild mammals, species identification could not be done. Phylogenetic analysis revealed that the patient-derived pathogen is distinct because it forms a separate clade in the cladogram.
Author Notes
Authors’ addresses: Ravi Godbole, Avantika Gaur, Priyanka Nayar, Kala Gnanasekaran Kiruthiga, Rumma Manchanda, Department of Pathology, King Edward Memorial Hospital, Pune, India, E-mails: docravigod@yahoo.com, avgaur1787@gmail.com, priyankanayar@hotmail.com, gnanasekarankiruthiga@gmail.com, and rman93@gmail.com. Pradeep D’Costa, Department of Medicine, King Edward Memorial Hospital, Pune, India, E-mail: pradeepdcosta@yahoo.co.in. Ajinkya Khilari, Biochemical Sciences Division, National Chemical Laboratory, Pune, India, E-mail: aa.khilari@ncl.res.in. Dhanasekaran Shanmugam, Biochemical Sciences Division, National Chemical Laboratory, Pune, India, E-mail: d.shanmugam@ncl.res.in. Kalpana D. Muglikar, Western Regional Disease Diagnostic Laboratory, Pune, India, E-mail: kdmuglikar@gmail.com. Krishnendu Kundu, Department of Veterinary Parasitology, Faculty of Veterinary and Animal Science, Rajiv Gandhi South Campus, Banaras Hindu University, Mirzapur, India, E-mail: krishkundu03@bhu.ac.in.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Ord RL , Lobo CA , 2015. Human babesiosis: pathogens, prevalence, diagnosis and treatment. Curr Clin Microbiol Rep 4: 173–181.
-
2.
Krause PJ , 2020. Human babesiosis. Int J Parasitol 49: 165–174.
-
3.
Yabsley MJ , Shock BC , 2013. Natural history of zoonotic Babesia: role of wildlife reservoirs. Int J Parasitol 2: 28–31.
-
4.
Swei A et al.2019. Evidence for transmission of the zoonotic apicomplexan parasite Babesia duncani by the tick Dermacentor albipictus. Int J Parasitol 49: 95–103.
-
5.
Kim JY et al.2007. First case of human babesiosis in Korea: detection and characterization of a novel type of Babesia sp. (KO1) similar to ovine Babesia. J Clin Microbiol 45: 2084–2087.
-
6.
Marathe A , Tripathi J , Handa V , Date V , 2005. Human babesiosis—a case report. Int J Med Microbiol 23: 267–269.
-
7.
Medlin L , Elwood HJ , Stickel S , Sogin ML , 1988. The characterization of enzymatically amplified eukaryotic 16S-like rRNA-coding regions. Gene 71: 491–499.
-
8.
Wei Q , Tsuji M , Zamoto A , Kohsaki M , Matsui T , Shiota T , Telford SR , Ishihara C , 2001. Human babesiosis in Japan: isolation of Babesia microti like parasites from an asymptomatic transfusion donor and from a rodent from an area where babesiosis is endemic. J Clin Microbiol 39: 2178–2183.
-
9.
Kumar S , Stecher G , Tamura K , 2016. MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets. Mol Biol Evol 33: 1870–1874.
-
10.
Thompson JD , Higgins DG , Gibson TJ , 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673–4680.
-
11.
Tamura K , Nei M , 1993. Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. Mol Biol Evol 10: 512–552.
-
12.
Vannier EG , Diuk-Wasser MA , Mamoun CB , Krause PJ , 2015. Babesiosis. Infect Dis Clin North Am 29: 357–370.
-
13.
Vannier EG , Krause MD , 2012. Human babesiosis. N Engl J Med 366: 2397–2407.
-
14.
Akel T , Mobarakai N , 2017. Haematologic manifestations of babesiosis. Ann Clin Microbiol Antimicrob 16: 6.
-
15.
Krause PJ , Daily J , Telford SR , Vannier E , Lantos P , Spielman A , 2007. Shared features in the pathobiology of babesiosis and malaria. Trends Parasitol 23: 605–610.
-
16.
Zhou X , Xia S , Huang JL , Tamblo E , Zhuge HX , Zhou XN , 2014. Human babesiosis, an emerging tick-borne disease in People’s Republic of China. Parasit Vectors 7: 509.
-
17.
Ghosh S , Bansal GC , Gupta SC , Ray D , Khan MQ , Irshad H , Shahiduzzaman M , Seitzer U , Ahmed JS , 2007. Status of tick distribution in Bangladesh, India and Pakistan. Parasitol Res 101: S207–S216.
-
18.
Oz S , Westlund KH , 2012. “Human babesiosis”: an emerging transfusion dilemma. Int J Hepatol. https://doi.org/10.1155/2012/431761.
-
19.
Sanchez E , Vannier E , Wormser GP , Hu LT , 2016. Diagnosis, treatment and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: a review. JAMA 315: 1767.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 6987 | 612 | 28 |
| Full Text Views | 233 | 10 | 0 |
| PDF Downloads | 112 | 15 | 0 |