• 1.

    D’Suze G , Castillo C , Sevcik C , Brazón J , Malave C , Hernandez D , Zerpa N , 2015. Scorpionism and dangerous scorpion species in Venezuela. Scorpion Venoms. Gopalakrishnakone P, Possani LD, Schwartz EF, Rodríguez de la Vega RC, eds. Switzerland AG: Springer Nature, 273–298.

  • 2.

    Gopalakrishnakone P , Possani LD , Schwartz E , Rodríguez de la Vega RC , 2015. Scorpion Venoms. Dordrecht, The Netherlands: Springer.

  • 3.

    Miranda R et al.2021. Guía Práctica de Artrópodos Venenosos y/o Causantes de Alergia de Panamá: Alacranes, Arañas y Ácaros, 1st edition. Panama, Panama: Instituto Conmemorativo Gorgas de la Salud.

    • Search Google Scholar
    • Export Citation
  • 4.

    D’Suze G , Moncada S , González C , Sevcik C , Alagón A , 2007. Antigenic cross-reactivity between sixteen venoms from scorpions belonging to six genera. Clin Toxicol 45: 158163.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Kshirsagar V , Ahmed M , Colaco SM , 2012. Motor aphasia: a rare complication of scorpion sting. J Pediatr Neurosci. 3: 231--233.

  • 6.

     Mazzei de Dàvila CA, Dàvila DF, Donis JH, de Bellabarba GA, Villarreal V, Barboza JS, 2020. Sympathetic nervous system activation, antivenin administration and cardiovascular manifestations of scorpion envenomation. Toxicon 40: 1339--1346.

  • 7.

     Bonilha L, Cendes F, Ghizoni E, Vieira RJ, Li LM, 2004. Epilepsy due to a destructive brain lesion caused by a scorpion sting. Arch Neurol 61: 1294--1296.

  • 8.

     S?ğırcı A, Öztürk M, Yakıncı C, 2014. Cerebral atrophy and subdural haemorrhage after cerebellar and cerebral infarcts in an 8-month-old child after having been stung by a scorpion. BMJ Case Reports 2014: bcr2014205091. Available at: https://doi.org/10.1136/bcr-2014-205091.

  • 9.

    Romero NO , Hernández TJM , 2005. Cerebral edema associated to scorpion sting: a two case sting report. J Venom Anim Toxins Incl Trop Dis 11: 594--600.

    • Search Google Scholar
    • Export Citation
  • 10.

    D’Suze G , Moncada S , González C , Sevcik C , Aguilara V , Alagón A , 2003. Relationship between plasmatic levels of various cytokines, tumor necrosis factor, enzymes, glucose and venom concentration following Tityus scorpion sting. Toxicon 41: 367375.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

     Velasco-Benitez CA, 2011. Pancreatitis in children. Rev Col Gastroenterol 261: 58--64.

  • 12.

     Benmosbah M, Guegueniat P, Mayence C, Egmann G, Narcisse E, Gonon S, Hommel D, Kallel H, 2013. Epidemiological and clinical study on scorpionism in French Guiana. Toxicon 73: 56--62.

  • 13.

     Brazón J, Hughes CE, Mori J, Sevcik C, D’suze G, Watson SP, 2011. Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway. Platelets 22: 165--172.

  • 14.

     Nencioni ALA, Neto EB, de Freitas LA, Dorce VAC, 2018. Effects of Brazilian scorpion venoms on the central nervous system. J Venom Anim Toxins Incl Trop Dis 24: 3.

  • 15.

     Prasad R, Suri S, Shambhavi, Mishra OP, 2014. Ischemic infarction of cerebral cortex in a child with scorpion sting envenomation. Indian J Pediatr 81: 705--706.

    • PubMed
    • Export Citation
  • 16.

     De Sousa L, Kiriakos D, Jimenez J, Michieli D, Rodriguez C, Mirabal J, Quiroga M, 1995. Accidente cerebrovascular isquémico por emponzoñamiento escorpiónico: observación cl譩ca. SABER Rev Cons Invest Univ Oriente 7: 7--14.

  • 17.

     Sevcik C, D’Suze G, Díaz P, Salazar V, Hidalgo C, Azpúrua H, Bracho N, 2004. Modelling Tityus scorpion venom and antivenom pharmacokinetics. Evidence of active immunoglobulin G’s F(ab’)2 extrusion mechanism from blood to tissues. Toxicon 44: 731--741.

  • 18.

    Ghersy de Nieto MT et al.2000. Emponzoñamiento escorpiónico: concentración de veneno en plasma y su efecto desencadenante de la respuesta inflamatoria sistémica. Arch Venez Pueri Pediatr. 64: 150--158.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 5000 5000 157
Full Text Views 33 33 8
PDF Downloads 37 37 7
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

 

Ischemic Stroke in a Child after a Probable Scorpion Sting

Laura NaranjoPoliclínica Metropolitana, Caracas, Venezuela;

Search for other papers by Laura Naranjo in
Current site
Google Scholar
PubMed
Close
,
Fernando Carrillo-VillaseñorTecnológico de Monterrey, Ciencias de la Salud y Escuela de Medicina, Guadalajara, Mexico;

Search for other papers by Fernando Carrillo-Villaseñor in
Current site
Google Scholar
PubMed
Close
,
Gina D’SuzeInstituto Venezolano de Investigaciones Científicas, CBB, Caracas, Venezuela;

Search for other papers by Gina D’Suze in
Current site
Google Scholar
PubMed
Close
,
Carlos SevcikInstituto Venezolano de Investigaciones Científicas, CBB, Caracas, Venezuela;

Search for other papers by Carlos Sevcik in
Current site
Google Scholar
PubMed
Close
,
Nathan GundackerMedical College of Wisconsin, Milwaukee, Wisconsin;

Search for other papers by Nathan Gundacker in
Current site
Google Scholar
PubMed
Close
,
Amy RaoUniversity of Colorado, Anschutz Medical Center, Aurora, Colorado;

Search for other papers by Amy Rao in
Current site
Google Scholar
PubMed
Close
,
Carlos Franco-ParedesUniversity of Colorado, Anschutz Medical Center, Aurora, Colorado;
Hospital Infantil de México, Federico Gomez, Mexico City, Mexico;

Search for other papers by Carlos Franco-Paredes in
Current site
Google Scholar
PubMed
Close
, and
José Antonio SuárezInstituto Conmemorativo Gorgas de Estudios de la Salud, Investigador SNI-SENACYT, Ciudad de Panama, Panama

Search for other papers by José Antonio Suárez in
Current site
Google Scholar
PubMed
Close
Restricted access

ABSTRACT.

Scorpion stings are common emergencies in the tropics. Species-specific antivenom therapies are available. However, fatalities resulting from scorpion stings remain a public health concern in many settings. Children residing in rural towns and peri-urban areas represent the most vulnerable populations. Delays in the diagnosis of scorpion stings often occur as a result of the non-specific clinical presentations, which then lead to life-threatening complications. We report a 2-year-old Venezuelan boy presenting with acute pancreatitis and pulmonary edema without an identifiable cause 48 hours after his initial symptoms. We administered antivenom therapy when an undetected scorpion sting was suspected. Despite some initial clinical improvement with respect to his acute pancreatitis, pulmonary edema, and coagulation abnormalities, our patient experienced an ischemic stroke. Fortunately, our patient did demonstrate some neurological improvement. Although acute pancreatitis and pulmonary edema are known end-organ damage manifestations of the sting of Tityus in the Americas, our particular case illustrates the risk of ischemic stroke.

Author Notes

Address correspondence to Carlos Franco-Paredes, Division of Infectious Diseases, University of Colorado Denver School of Medicine, Anschutz Medical Campus, 12700 East 19th Ave., 11C01, Aurora, CO 80045, E-mail: carlos.franco-paredes@cuanschutz.edu or José Antonio Suárez, Instituto Conmemorativo Gorgas. Avenida Justo Arosemena, Panama, E-mail: jasuarez05@gmail.com.

Disclosure: L. N. has been a GSK employee since 2010. G. D’Suze has been the chief operating officer of SciMeDAn since 2018. C. Sevcik is the chief executive officer of SciMeDAn.

Authors’ addresses: Laura Naranjo, Policlínica Metropolitana, Caracas, Venezuela, E-mail: naranjo.laura1@gmail.com. Fernando Carrillo-Villaseñor, Tecnológico de Monterrey, Ciencias de la Salud y Escuela de Medicina, Guadalajara, Mexico, E-mail: carrillo_888@hotmail.com. Gina D’Suze and Carlos Sevcik, Instituto Venezolano de Investigaciones Científicas, CBB, Caracas, Venezuela, E-mails: gina.dsuze@gmail.com and csevcik@ivic.ve. Nathan Gundacker, Medical College of Wisconsin, Milwaukee, WI, E-mail: nathan.gundacker@va.gov. Amy Rao, University of Colorado, Anschutz Medical Center, Aurora, CO, E-mail: amy.rao@cuanschutz.edu. Carlos Franco-Paredes, University of Colorado, Anschutz Medical Center, Aurora, CO, and Hospital Infantil de México, Federico Gomez, Mexico City, Mexico, E-mail: carlos.franco-paredes@cuanschutz.edu. José Antonio Suárez, Instituto Conmemorativo Gorgas de Estudios de la Salud, Investigador SNI-SENACYT, Ciudad de Panama, Panama, E-mail: jasuarez05@gmail.com.

Save