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RefWorks
Reference Manager
BibTeX
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-
1.
Syed S, Ali A, Duggan C , 2016. Environmental enteric dysfunction in children. J Pediatr Gastroenterol Nutr 63: 6–14.
-
2.
MAL-ED Network Investigators, 2014. The MAL-ED study: a multinational and multidisciplinary approach to understand the relationship between enteric pathogens, malnutrition, gut physiology, physical growth, cognitive development, and immune responses in infants and children up to 2 years of age in resource-poor environments. Clin Infect Dis 59 (Suppl 4): S193--S206.
-
3.
Kosek MN , 2017. Causal pathways from enteropathogens to environmental enteropathy: findings from the MAL-ED Birth Cohort Study. E Bio Medicine 18: 109–117.
-
4.
Kosek M et al.2013. Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants. Am J Trop Med Hyg 88: 390–396.
-
5.
Stoll BJ et al.2002. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 110: 285–291.
-
6.
Christian P et al.2013. Risk of childhood undernutrition related to small-for-gestational age and preterm birth in low- and middle-income countries. Int J Epidemiol 42: 1340–1355.
-
7.
Liu E, Manji KP, McDonald CM, Gosselin K, Kisenge R, Fawzi WW, Gewirtz AT, Duggan CP, 2018. Preterm birth and biomarkers of environmental enteric dysfunction among infants in Tanzania. The FASEB Journal 31: 649.7.
-
8.
Gough EK et al.2020. Effects of improved water, sanitation, and hygiene and improved complementary feeding on environmental enteric dysfunction in children in rural Zimbabwe: a cluster-randomized controlled trial. PLoS Negl Trop Dis 14: e0007963.
-
9.
Galpin L, Manary MJ, Fleming K, Ou CN, Ashorn P, Shulman RJ , 2005. Effect of Lactobacillus GG on intestinal integrity in Malawian children at risk of tropical enteropathy. Am J Clin Nutr 82: 1040–1045.
-
10.
Trehan I, Shulman RJ, Ou CN, Maleta K, Manary MJ , 2009. A randomized, double-blind, placebo-controlled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathy. Am J Gastroenterol 104: 2326–2333.
-
11.
Wessells KR, Hinnouho GM, Barffour MA, Arnold CD, Kounnavong S, Kewcharoenwong C, Lertmemongkolchai G, Schuster GU, Stephensen CB, Hess SY , 2020. Impact of daily preventive zinc or therapeutic zinc supplementation for diarrhea on plasma biomarkers of environmental enteric dysfunction among rural Laotian children: a randomized controlled trial. Am J Trop Med Hyg 102: 415–426.
-
12.
Conde-Agudelo A, Diaz-Rossello JL , 2016. Kangaroo mother care to reduce morbidity and mortality in low birthweight infants. Cochrane Database Syst Rev Cd002771.
-
13.
WHO , 2003. Kangaroo Mother Care: A Practical Guide. Geneva, Switzerland: World Health Organization.
-
14.
Sep GOI , 2014. Kangaroo Mother Care and Optimal Feeding of Low Birth Weight Infants. Operational Guidelines. New Delhi, India: Ministry of Health and Family Welfare, Government of India.
-
15.
Mazumder S et al.2019. Effect of community-initiated kangaroo mother care on survival of infants with low birthweight: a randomised controlled trial. Lancet 394: 1724–1736.
-
16.
Mazumder S et al.2017. Impact of community-initiated Kangaroo Mother Care on survival of low birth weight infants: study protocol for a randomized controlled trial. Trials 18: 262.
-
17.
MOHFW , 2014. National rural health mission: about Accredited Social Health Activist. Ministry of Health and Family Welfare GoI, ed. New Delhi, India: Ministry of Health and Family Welfare Government of India.
-
18.
National health Mission, 2014. Guidelines on Accredited Social Health Activist (ASHA). In: Ministry of Health and Family Welfare GoI, editor. New Delhi, India: Ministry of Health and Family Welfare Government of India.
-
19.
Arndt MB, Richardson BA, Ahmed T, Mahfuz M, Haque R, John-Stewart GC, Denno DM, Petri WA Jr, Kosek M, Walson JL , 2016. Fecal markers of environmental enteropathy and subsequent growth in Bangladeshi children. Am J Trop Med Hyg 95: 694–701.
-
20.
Campbell RK, Schulze KJ, Shaikh S, Raqib R, Wu LSF, Ali H, Mehra S, West KP, Christian P , 2018. Environmental enteric dysfunction and systemic inflammation predict reduced weight but not length gain in rural Bangladeshi children. Br J Nutr 119: 407–414.
-
21.
Lin A et al.2020. Effects of water, sanitation, handwashing, and nutritional interventions on environmental enteric dysfunction in young children: a cluster-randomized, controlled trial in rural Bangladesh. Nephrol Dial Transplant 70: 738–747.
-
22.
Sinha B, Sommerfelt H, Ashorn P, Mazumder S, Taneja S, More D, Bahl R, Bhandari N , 2021. Effect of community-initiated Kangaroo Mother Care on postpartum depressive symptoms and stress among mothers of low-birth-weight infants: a randomized clinical trial. JAMA Netw Open 4: e216040.
-
23.
McCormick BJJ et al.2017. Dynamics and trends in fecal biomarkers of gut function in children from 1–24 months in the MAL-ED study. Am J Trop Med Hyg 96: 465–472.
-
24.
Praharaj I, Revathy R, Bandyopadhyay R, Benny B, Azharuddin Ko M, Liu J, Houpt ER, Kang G , 2018. Enteropathogens and gut inflammation in asymptomatic infants and children in different environments in southern India. Am J Trop Med Hyg 98: 576–580.
-
25.
Vander Weele TJ, Knol MJ , 2011. Interpretation of subgroup analyses in randomized trials: heterogeneity versus secondary interventions. Ann Intern Med 154: 680–683.
-
26.
Harper KM, Mutasa M, Prendergast AJ, Humphrey J, Manges AR , 2018. Environmental enteric dysfunction pathways and child stunting: a systematic review. PLoS Negl Trop Dis 12: e0006205.
| Past two years | Past Year | Past 30 Days | |
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Effect of Community-Initiated Kangaroo Mother Care on Fecal Biomarkers of Gut Function in Low Birth Weight Infants in North India: A Randomized Clinical Trial
Bireshwar Sinha
Bireshwar Sinha
Centre for Health Research and Development, Society for Applied Studies, New Delhi, India;
Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, and Tampere University Hospital, Finland;
Clinical and Public health Fellow, DBT/Wellcome India Alliance, Hyderabad, India;
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Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, and Tampere University Hospital, Finland;
Clinical and Public health Fellow, DBT/Wellcome India Alliance, Hyderabad, India;
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Halvor Sommerfelt
Halvor Sommerfelt
Centre for Intervention Science in Maternal and Child Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway;
Cluster for Global Health, Division for Health Services, Norwegian Institute of Public Health, Oslo, Norway;
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Cluster for Global Health, Division for Health Services, Norwegian Institute of Public Health, Oslo, Norway;
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Per Ashorn
Per Ashorn
Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, and Tampere University Hospital, Finland;
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Sarmila Mazumder
Sarmila Mazumder
Centre for Health Research and Development, Society for Applied Studies, New Delhi, India;
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Deepak More
Deepak More
Clinical and Research Laboratories, Society for Applied Studies, New Delhi, India;
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Sunita Taneja
Sunita Taneja
Centre for Health Research and Development, Society for Applied Studies, New Delhi, India;
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Rajiv Bahl
Rajiv Bahl
Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland
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Nita Bhandari
Nita Bhandari
Centre for Health Research and Development, Society for Applied Studies, New Delhi, India;
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ABSTRACT.
This individually randomized trial was conducted to estimate the effect of promoting community-initiated Kangaroo Mother Care (ciKMC) in low birth weight (LBW) infants on gut inflammation and permeability. Participants included 200 stable LBW infants (weighing 1,500–2,250 g) in North India enrolled between May and October 2017. The ciKMC intervention included promotion and support of continuous skin-to-skin contact and exclusive breastfeeding through home visits. The mothers in the intervention arm were supported to practice ciKMC until 28 days after birth, i.e., the neonatal period, or till the baby wriggled out of KMC position, if earlier. Infant stool specimens were collected during the first week of birth, and within 1 week after end of the neonatal period. Concentrations of fecal neopterin (nmol/L), myeloperoxidase (ng/mL), and alpha-1-antitrypsin (μg/mL) were determined using ELISA, and composite enteric enteropathy (EE) score at the end of the neonatal period was calculated by principal component analysis. We did not find any substantial difference in means between the ciKMC and control arm infants in the log-transformed values of neopterin (0.03; 95% CI −0.15 to 0.21), myeloperoxidase (0.28; 95% CI −0.05 to 0.61) and alpha-1-antitrypsin (0.02; 95% CI −0.30 to 0.34). The mean (SD) composite EE score was 13.6 (7.5) in the ciKMC and 12.4 (8.3) in the control arm infants, and the adjusted difference in means was, 0.4 (95% CI −1.8 to 2.7). Our findings suggest that the promotion of ciKMC did not affect gut inflammation and permeability in our target population of LBW infants in North India.
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Author Notes
Financial support: This work was funded by the Science and Engineering Research Board (SERB), a statutory body of the Department of Science and Technology, Government of India (File No. EMR/2017/003414). The project is also supported by the Centre for Intervention Science in Maternal and Child Health (CISMAC; project number 223269), which is funded by the Research Council of Norway through its Centres of Excellence scheme and the University of Bergen (UiB), Norway. The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Authors’ addresses: Bireshwar Sinha, Sarmila Mazumder, Sunita Taneja, and Nita Bhandari, Centre for Health Research and Development, Society for Applied Studies, New Delhi, India, E-mails: bireshwar.sinha@sas.org.in, sarmila.mazumder@sas.org.in, sunita.taneja@sas.org.in, and nita.bhandari@sas.org.in. Halvor Sommerfelt, Centre for Intervention Science in Maternal and Child Health (www.cismac.org), Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway, E-mail: halvor.sommerfelt@uib.no. Per Ashorn, Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, and Tampere University Hospital, Finland, E-mail: per.ashorn@tuni.fi. Deepak More, Clinical and Research Laboratories, Society for Applied Studies, New Delhi, India, E-mail: drdeepak.more@yahoo.in. Rajiv Bahl, Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland, E-mail: bahlr@who.int.
ProCite
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Reference Manager
BibTeX
Zotero
EndNote
-
1.
Syed S, Ali A, Duggan C , 2016. Environmental enteric dysfunction in children. J Pediatr Gastroenterol Nutr 63: 6–14.
-
2.
MAL-ED Network Investigators, 2014. The MAL-ED study: a multinational and multidisciplinary approach to understand the relationship between enteric pathogens, malnutrition, gut physiology, physical growth, cognitive development, and immune responses in infants and children up to 2 years of age in resource-poor environments. Clin Infect Dis 59 (Suppl 4): S193--S206.
-
3.
Kosek MN , 2017. Causal pathways from enteropathogens to environmental enteropathy: findings from the MAL-ED Birth Cohort Study. E Bio Medicine 18: 109–117.
-
4.
Kosek M et al.2013. Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants. Am J Trop Med Hyg 88: 390–396.
-
5.
Stoll BJ et al.2002. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 110: 285–291.
-
6.
Christian P et al.2013. Risk of childhood undernutrition related to small-for-gestational age and preterm birth in low- and middle-income countries. Int J Epidemiol 42: 1340–1355.
-
7.
Liu E, Manji KP, McDonald CM, Gosselin K, Kisenge R, Fawzi WW, Gewirtz AT, Duggan CP, 2018. Preterm birth and biomarkers of environmental enteric dysfunction among infants in Tanzania. The FASEB Journal 31: 649.7.
-
8.
Gough EK et al.2020. Effects of improved water, sanitation, and hygiene and improved complementary feeding on environmental enteric dysfunction in children in rural Zimbabwe: a cluster-randomized controlled trial. PLoS Negl Trop Dis 14: e0007963.
-
9.
Galpin L, Manary MJ, Fleming K, Ou CN, Ashorn P, Shulman RJ , 2005. Effect of Lactobacillus GG on intestinal integrity in Malawian children at risk of tropical enteropathy. Am J Clin Nutr 82: 1040–1045.
-
10.
Trehan I, Shulman RJ, Ou CN, Maleta K, Manary MJ , 2009. A randomized, double-blind, placebo-controlled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathy. Am J Gastroenterol 104: 2326–2333.
-
11.
Wessells KR, Hinnouho GM, Barffour MA, Arnold CD, Kounnavong S, Kewcharoenwong C, Lertmemongkolchai G, Schuster GU, Stephensen CB, Hess SY , 2020. Impact of daily preventive zinc or therapeutic zinc supplementation for diarrhea on plasma biomarkers of environmental enteric dysfunction among rural Laotian children: a randomized controlled trial. Am J Trop Med Hyg 102: 415–426.
-
12.
Conde-Agudelo A, Diaz-Rossello JL , 2016. Kangaroo mother care to reduce morbidity and mortality in low birthweight infants. Cochrane Database Syst Rev Cd002771.
-
13.
WHO , 2003. Kangaroo Mother Care: A Practical Guide. Geneva, Switzerland: World Health Organization.
-
14.
Sep GOI , 2014. Kangaroo Mother Care and Optimal Feeding of Low Birth Weight Infants. Operational Guidelines. New Delhi, India: Ministry of Health and Family Welfare, Government of India.
-
15.
Mazumder S et al.2019. Effect of community-initiated kangaroo mother care on survival of infants with low birthweight: a randomised controlled trial. Lancet 394: 1724–1736.
-
16.
Mazumder S et al.2017. Impact of community-initiated Kangaroo Mother Care on survival of low birth weight infants: study protocol for a randomized controlled trial. Trials 18: 262.
-
17.
MOHFW , 2014. National rural health mission: about Accredited Social Health Activist. Ministry of Health and Family Welfare GoI, ed. New Delhi, India: Ministry of Health and Family Welfare Government of India.
-
18.
National health Mission, 2014. Guidelines on Accredited Social Health Activist (ASHA). In: Ministry of Health and Family Welfare GoI, editor. New Delhi, India: Ministry of Health and Family Welfare Government of India.
-
19.
Arndt MB, Richardson BA, Ahmed T, Mahfuz M, Haque R, John-Stewart GC, Denno DM, Petri WA Jr, Kosek M, Walson JL , 2016. Fecal markers of environmental enteropathy and subsequent growth in Bangladeshi children. Am J Trop Med Hyg 95: 694–701.
-
20.
Campbell RK, Schulze KJ, Shaikh S, Raqib R, Wu LSF, Ali H, Mehra S, West KP, Christian P , 2018. Environmental enteric dysfunction and systemic inflammation predict reduced weight but not length gain in rural Bangladeshi children. Br J Nutr 119: 407–414.
-
21.
Lin A et al.2020. Effects of water, sanitation, handwashing, and nutritional interventions on environmental enteric dysfunction in young children: a cluster-randomized, controlled trial in rural Bangladesh. Nephrol Dial Transplant 70: 738–747.
-
22.
Sinha B, Sommerfelt H, Ashorn P, Mazumder S, Taneja S, More D, Bahl R, Bhandari N , 2021. Effect of community-initiated Kangaroo Mother Care on postpartum depressive symptoms and stress among mothers of low-birth-weight infants: a randomized clinical trial. JAMA Netw Open 4: e216040.
-
23.
McCormick BJJ et al.2017. Dynamics and trends in fecal biomarkers of gut function in children from 1–24 months in the MAL-ED study. Am J Trop Med Hyg 96: 465–472.
-
24.
Praharaj I, Revathy R, Bandyopadhyay R, Benny B, Azharuddin Ko M, Liu J, Houpt ER, Kang G , 2018. Enteropathogens and gut inflammation in asymptomatic infants and children in different environments in southern India. Am J Trop Med Hyg 98: 576–580.
-
25.
Vander Weele TJ, Knol MJ , 2011. Interpretation of subgroup analyses in randomized trials: heterogeneity versus secondary interventions. Ann Intern Med 154: 680–683.
-
26.
Harper KM, Mutasa M, Prendergast AJ, Humphrey J, Manges AR , 2018. Environmental enteric dysfunction pathways and child stunting: a systematic review. PLoS Negl Trop Dis 12: e0006205.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 4669 | 479 | 46 |
| Full Text Views | 115 | 23 | 0 |
| PDF Downloads | 99 | 22 | 0 |