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Reference Manager
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-
1.
Molton JS et al.2020. Oral vs intravenous antibiotics for patients with Klebsiella pneumoniae liver abscess: a randomized, controlled noninferiority study. Clin Infect Dis 71: 952–959.
-
2.
Chung DR et al.2007. Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea. J Infect 54: 578–583.
-
3.
Tan YM, Chee SP, Soo KC, Chow P , 2004. Ocular manifestations and complications of pyogenic liver abscess. World J Surg 28: 38–42.
-
4.
Okano H et al.2002. Clinicopathological analysis of liver abscess in Japan. Int J Mol Med 10: 627–630.
-
5.
Lee SS, Chen YS, Tsai HC, Wann SR, Lin HH, Huang CK, Liu YC , 2008. Predictors of septic metastatic infection and mortality among patients with Klebsiella pneumoniae liver abscess. Clin Infect Dis 47: 642–650.
-
6.
Cheng DL, Liu YC, Yen MY, Liu CY, Wang RS , 1991. Septic metastatic lesions of pyogenic liver abscess: their association with Klebsiella pneumoniae bacteremia in diabetic patients. Arch Intern Med 151: 1557–1559.
-
7.
Wang JH, Liu YC, Lee SS, Yen MY, Chen YS, Wang JH, Wann SR, Lin HH , 1998. Primary liver abscess due to Klebsiella pneumoniae in Taiwan. Clin Infect Dis 26: 1434–1438.
-
8.
Hui JY, Yang MK, Cho DH, Li A, Loke TK, Chan JC, Woo PC , 2007. Pyogenic liver abscesses caused by Klebsiella pneumoniae: US appearance and aspiration findings. Radiology 242: 769–776.
-
9.
Yang PW, Lin HD, Wang LM , 2008. Pyogenic liver abscess associated with septic pulmonary embolism. J Chin Med Assoc 71: 442–447.
-
10.
Yoon JH, Kim YJ, Jun YH, Kim SI, Kang JY, Suk KT, Kim DJ , 2014. Liver abscess due to Klebsiella pneumoniae: risk factors for metastatic infection. Scand J Infect Dis 46: 21–26.
-
11.
Chen SC, Lee YT, Lai KC, Cheng KS, Jeng LB, Wu WY, Chen CC, Lee MC , 2006. Risk factors for developing metastatic infection from pyogenic liver abscesses. Swiss Med Wkly 136: 119–126.
-
12.
Lin YT, Wang FD, Wu PF, Fung CP , 2013. Klebsiella pneumoniae liver abscess in diabetic patients: association of glycemic control with the clinical characteristics. BMC Infect Dis 13: 56.
-
13.
Han SH , 1995. Review of hepatic abscess from Klebsiella pneumoniae: an association with diabetes mellitus and septic endophthalmitis. West J Med 162: 220–224.
-
14.
Wang HH et al.2014. The association of haemoglobin A(1)C levels with the clinical and CT characteristics of Klebsiella pneumoniae liver abscesses in patients with diabetes mellitus. Eur Radiol 24: 980–989.
-
15.
Shin SU, Park CM, Lee Y, Kim EC, Kim SJ, Goo JM , 2013. Clinical and radiological features of invasive Klebsiella pneumoniae liver abscess syndrome. Acta Radiol 54: 557–563.
-
16.
Horan TC, Andrus M, Dudeck MA , 2008. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 36: 309–332.
-
17.
Tan YM, Chong CK, Chow PK , 2001. Pyogenic liver abscess complicated by endogenous endophthalmitis. ANZ J Surg 71: 744–746.
-
18.
Chang Z, Zheng J, Ma Y, Liu Z , 2015. Analysis of clinical and CT characteristics of patients with Klebsiella pneumoniae liver abscesses: an insight into risk factors of metastatic infection. Int J Infect Dis 33: 50–54.
-
19.
Chou DW, Wu SL, Chung KM, Han SC , 2015. Septic pulmonary embolism caused by a Klebsiella pneumoniae liver abscess: clinical characteristics, imaging findings, and clinical courses. Clinics (São Paulo) 70: 400–407.
-
20.
Lee CH, Leu HS, Wu TS, Su LH, Liu JW , 2005. Risk factors for spontaneous rupture of liver abscess caused by Klebsiella pneumoniae. Diagn Microbiol Infect Dis 52: 79–84.
-
21.
Chan DS, Archuleta S, Llorin RM, Lye DC, Fisher D , 2013. Standardized outpatient management of Klebsiella pneumoniae liver abscesses. Int J Infect Dis 17: e185–e188.
-
22.
Fang CT, Lai SY, Yi WC, Hsueh PR, Liu KL, Chang SC , 2007. Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Clin Infect Dis 45: 284–293.
-
23.
Lee IR et al.2016. Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population. Sci Rep 6: 29316.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 4087 | 1041 | 440 |
| Full Text Views | 253 | 150 | 1 |
| PDF Downloads | 127 | 20 | 2 |
Risk Factors of Septic Metastatic Infection among Patients with Klebsiella pneumoniae Liver Abscess in Singapore: A Case–Control Study
Shilpa Mukherjee
Shilpa Mukherjee
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore;
Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore;
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Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore;
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Sophia Archuleta
Sophia Archuleta
Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore;
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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Junxiong Pang
Junxiong Pang
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore;
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Search for other papers by Junxiong Pang in
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ABSTRACT.
Metastatic infection resulting from Klebsiella pneumoniae liver abscess (KPLA) results in high mortality and morbidity. This study aimed to determine the risk factors associated with metastatic infection among patients with KPLA in Singapore. A retrospective case–control analysis among adult patients admitted to the National University Hospital with KPLA between 2013 and 2017 was conducted. Univariate and multivariate regression analysis was conducted. Of the 116 KPLA patients, 38.8% had pulmonary metastatic infection. Length of hospital stay (P = 0.001) and intensive care unit admissions (P = 0.044) were significantly longer and greater, respectively, among the patients with metastatic infection. Sepsis-induced hypotension (adjusted odds ratio [AOR], 4.88; 95% CI, 1.1–21.69), breathlessness (AOR, 5.10; 95% CI, 1.42–18.27), and abscess size (AOR, 1.02; 95% CI, 1.01–1.03) were associated independently with septic metastatic infection. Patients with KPLA who had breathlessness and larger abscess size are at a greater risk of septic metastatic infection.
Author Notes
Authors’ addresses: Shilpa Mukherjee, Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, and Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore, E-mail: shilpa_mukherjee@nuhs.edu.sg. Sophia Archuleta, Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore, and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, E-mail: sophia@nus.edu.sg. Junxiong Pang, Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, E-mail: pangv@hotmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Molton JS et al.2020. Oral vs intravenous antibiotics for patients with Klebsiella pneumoniae liver abscess: a randomized, controlled noninferiority study. Clin Infect Dis 71: 952–959.
-
2.
Chung DR et al.2007. Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea. J Infect 54: 578–583.
-
3.
Tan YM, Chee SP, Soo KC, Chow P , 2004. Ocular manifestations and complications of pyogenic liver abscess. World J Surg 28: 38–42.
-
4.
Okano H et al.2002. Clinicopathological analysis of liver abscess in Japan. Int J Mol Med 10: 627–630.
-
5.
Lee SS, Chen YS, Tsai HC, Wann SR, Lin HH, Huang CK, Liu YC , 2008. Predictors of septic metastatic infection and mortality among patients with Klebsiella pneumoniae liver abscess. Clin Infect Dis 47: 642–650.
-
6.
Cheng DL, Liu YC, Yen MY, Liu CY, Wang RS , 1991. Septic metastatic lesions of pyogenic liver abscess: their association with Klebsiella pneumoniae bacteremia in diabetic patients. Arch Intern Med 151: 1557–1559.
-
7.
Wang JH, Liu YC, Lee SS, Yen MY, Chen YS, Wang JH, Wann SR, Lin HH , 1998. Primary liver abscess due to Klebsiella pneumoniae in Taiwan. Clin Infect Dis 26: 1434–1438.
-
8.
Hui JY, Yang MK, Cho DH, Li A, Loke TK, Chan JC, Woo PC , 2007. Pyogenic liver abscesses caused by Klebsiella pneumoniae: US appearance and aspiration findings. Radiology 242: 769–776.
-
9.
Yang PW, Lin HD, Wang LM , 2008. Pyogenic liver abscess associated with septic pulmonary embolism. J Chin Med Assoc 71: 442–447.
-
10.
Yoon JH, Kim YJ, Jun YH, Kim SI, Kang JY, Suk KT, Kim DJ , 2014. Liver abscess due to Klebsiella pneumoniae: risk factors for metastatic infection. Scand J Infect Dis 46: 21–26.
-
11.
Chen SC, Lee YT, Lai KC, Cheng KS, Jeng LB, Wu WY, Chen CC, Lee MC , 2006. Risk factors for developing metastatic infection from pyogenic liver abscesses. Swiss Med Wkly 136: 119–126.
-
12.
Lin YT, Wang FD, Wu PF, Fung CP , 2013. Klebsiella pneumoniae liver abscess in diabetic patients: association of glycemic control with the clinical characteristics. BMC Infect Dis 13: 56.
-
13.
Han SH , 1995. Review of hepatic abscess from Klebsiella pneumoniae: an association with diabetes mellitus and septic endophthalmitis. West J Med 162: 220–224.
-
14.
Wang HH et al.2014. The association of haemoglobin A(1)C levels with the clinical and CT characteristics of Klebsiella pneumoniae liver abscesses in patients with diabetes mellitus. Eur Radiol 24: 980–989.
-
15.
Shin SU, Park CM, Lee Y, Kim EC, Kim SJ, Goo JM , 2013. Clinical and radiological features of invasive Klebsiella pneumoniae liver abscess syndrome. Acta Radiol 54: 557–563.
-
16.
Horan TC, Andrus M, Dudeck MA , 2008. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 36: 309–332.
-
17.
Tan YM, Chong CK, Chow PK , 2001. Pyogenic liver abscess complicated by endogenous endophthalmitis. ANZ J Surg 71: 744–746.
-
18.
Chang Z, Zheng J, Ma Y, Liu Z , 2015. Analysis of clinical and CT characteristics of patients with Klebsiella pneumoniae liver abscesses: an insight into risk factors of metastatic infection. Int J Infect Dis 33: 50–54.
-
19.
Chou DW, Wu SL, Chung KM, Han SC , 2015. Septic pulmonary embolism caused by a Klebsiella pneumoniae liver abscess: clinical characteristics, imaging findings, and clinical courses. Clinics (São Paulo) 70: 400–407.
-
20.
Lee CH, Leu HS, Wu TS, Su LH, Liu JW , 2005. Risk factors for spontaneous rupture of liver abscess caused by Klebsiella pneumoniae. Diagn Microbiol Infect Dis 52: 79–84.
-
21.
Chan DS, Archuleta S, Llorin RM, Lye DC, Fisher D , 2013. Standardized outpatient management of Klebsiella pneumoniae liver abscesses. Int J Infect Dis 17: e185–e188.
-
22.
Fang CT, Lai SY, Yi WC, Hsueh PR, Liu KL, Chang SC , 2007. Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Clin Infect Dis 45: 284–293.
-
23.
Lee IR et al.2016. Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population. Sci Rep 6: 29316.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 4087 | 1041 | 440 |
| Full Text Views | 253 | 150 | 1 |
| PDF Downloads | 127 | 20 | 2 |