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Visceral leishmaniasis (VL) is a tropical disease endemic to Brazil. The clinical manifestations of the infection range from asymptomatic to severe. In VL, changes in lipid metabolism, such as hypocholesterolemia and hypertriglyceridemia, occur that are believed to be related to its progression and severity. This study investigated the associations between serum levels of cholesterol, triglycerides, and lipoproteins (high-density lipoprotein, low-density lipoprotein, and very low-density lipoprotein) with clinical and hematological parameters that predict severity in a case series of 83 VL patients. Severely ill patients had higher mean serum triglyceride levels than non-severely ill patients. There was a significant positive correlation between disease severity score and serum triglyceride levels, very low-density lipoprotein, international normalized ratio for prothrombin time test, total bilirubin, and age. An inverse correlation was detected between the disease severity score and mean platelet and neutrophil counts. Hypertriglyceridemia can be a prognostic indicator of severity in patients diagnosed with VL.
Authors’ addresses: Mariana Garcez Varela, Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil, Encrinology Service from the University Hospital/EBSERH, Federal University of Sergipe, Aracaju, Sergipe, Brazil, and Heath Science Graduate Program, Aracaju, Brazil, E-mail: firstname.lastname@example.org. Mariana de Oliveira Bezerra, Felipe Vieira Santana, Marcos Couto Gomes, and Fabricia Alvisi de Oliveira, Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil, E-mails: email@example.com, firstname.lastname@example.org, email@example.com, and firstname.lastname@example.org. Pedro Ribeiro de Jesus Almeida, Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Belo Horizonte, Minas Gerais, Brazil, E-mail: email@example.com. Geydson Silveira da Cruz, Heath Science Graduate Program, Aracaju, Brazil, and Hematology Service, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil, E-mail: firstname.lastname@example.org. Enaldo Vieira de Melo, Pediatric Clinic, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil, E-mail: email@example.com. Paulo Roberto de Oliveira Costa, Infectious Disease Clinic, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil, E-mail: firstname.lastname@example.org. Amélia Ribeiro de Jesus and Roque Pacheco de Almeida, Immunology and Molecular Biology Laboratory, University Hospital, Federal University of Sergipe (HU-UFS), Aracaju, Sergipe, Brazil, Heath Science Graduate Program, Aracaju, Brazil, and Immunology Investigative Institute, INCT, CNPq, E-mails: email@example.com and firstname.lastname@example.org.