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Detection of Enterotoxigenic Escherichia coli in Rotavirus-Infected Ghanaian Children Diagnosed with Acute Gastroenteritis
ABSTRACT.
Diarrhea is a notable global health problem in several developing countries, especially in children. Prior to the introduction of the rotavirus vaccination program in Ghana, a surveillance study was conducted to investigate the prevalence of the disease caused by rotavirus in children. In this report, we re-used archival stool samples from the pre-vaccine surveillance study to provide information on prevalence of enterotoxigenic Escherichia coli in Ghanaian children. Re-analysis of the stool samples revealed co-infection of enterotoxigenic E. coli and rotavirus in 2% of the children whose samples were selected for this study. As Ghana is approaching 10 years post-implementation of the rotavirus vaccination program, the preliminary data presented in this report are a vital reference for subsequent studies aimed at ascertaining the effect of the vaccine on both rotavirus and enterotoxigenic E. coli.
Author Notes
Authors’ addresses: Bartholomew Dzudzor, Albert Amenyedor, and Vincent Amarh, Department of Medical Biochemistry, University of Ghana Medical School, Korle-Bu, Ghana, E-mails: bdzudzor@ug.edu.gh, albertamenyedor@yahoo.com, and vamarh@ug.edu.gh. George E. Armah, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana, E-mail: garmah@noguchi.ug.edu.gh.