ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
  Cheng AC , Currie BJ , 2005. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 18: 383–416.
-
2.
  Wiersinga WJ , Currie BJ , Peacock SJ , 2012. Melioidosis. N Engl J Med 367: 1035–1044.
-
3.
  Wiersinga WJ , Virk HS , Torres AG , Currie BJ , Peacock SJ , Dance DAB , Limmathurotsakul D , 2018. Melioidosis. Nat Rev Dis Primers 4: 17107.
-
4.
  Limmathurotsakul D , Wongratanacheewin S , Teerawattanasook N , Wongsuvan G , Chaisuksant S , Chetchotisakd P , Chaowagul W , Day NP , Peacock SJ , 2010. Increasing incidence of human melioidosis in northeast Thailand. Am J Trop Med Hyg 82: 1113–1117.
-
5.
  Currie BJ , Jacups SP , Cheng AC , Fisher DA , Anstey NM , Huffam SE , Krause VL , 2004. Melioidosis epidemiology and risk factors from a prospective whole-population study in northern Australia. Trop Med Int Health 9: 1167–1174.
-
6.
  Currie BJ , Ward L , Cheng AC , 2010. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.
-
7.
  Limmathurotsakul D et al.2016. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol 1: 15008.
-
8.
  Birnie E , Virk HS , Savelkoel J , Spijker R , Bertherat E , Dance DAB , Limmathurotsakul D , Devleesschauwer B , Haagsma JA , Wiersinga WJ , 2019. Global burden of melioidosis in 2015: a systematic review and data synthesis. Lancet Infect Dis 19: 892–902.
-
9.
  van Crevel R , van de Vijver S , Moore DAJ , 2017. The global diabetes epidemic: what does it mean for infectious diseases in tropical countries? Lancet Diabetes Endocrinol 5: 457–468.
-
10.
  Dunachie S , Chamnan P , 2019. The double burden of diabetes and global infection in low and middle-income countries. Trans R Soc Trop Med Hyg 113: 56–64.
-
11.
  Dance DA , Limmathurotsakul D , 2018. Global burden and challenges of melioidosis. Trop Med Infect Dis 3: 13.
-
12.
  Wiersinga WJ , 2018. Melioidosis: Time to Recognize a Deadly but Neglected Tropical Disease. Available at: https://naturemicrobiologycommunity.nature.com/posts/37031-melioidosis-time-to-recognize-a-deadly-but-neglected-tropical-disease. Accessed November 2020.
-
13.
  Wiersinga WJ et al.2015. Clinical, environmental, and serologic surveillance studies of melioidosis in Gabon, 2012– 2013. Emerg Infect Dis 21: 40–47.
-
14.
  Martin de Frémont G , Gominet M , Bousquet A , Gervaise A , Andriamanantena D , Ficko C , 2019. Burkholderia pseudomallei: prostatic abscesses in an AIDS patient back from Cameroon. AIDS 33: 1403–1404.
-
15.
  Morelli F , Smeets L , Hobijn M , Boom H , 2015. Melioidosis and renal failure in a Dutch man after a trip to Gambia. Neth J Med 73: 296–298.
-
16.
  Muthumbi EM et al.2019. Population-based estimate of Melioidosis, Kenya. Emerg Infect Dis 25: 984–987.
-
17.
  Katangwe T et al.2013. Human melioidosis, Malawi, 2011. Emerg Infect Dis 19: 981–984.
-
18.
  Borgherini G , Poubeau P , Paganin F , Picot S , Michault A , Thibault F , Berod CA , 2006. Melioidosis: an imported case from Madagascar. J Travel Med 13: 318–320.
-
19.
  Almog Y , Yagel Y , Geffen Y , Yagupsky P , 2016. A Burkholderia pseudomallei infection imported from Eritrea to Israel. Am J Trop Med Hyg 95: 997–998.
-
20.
  Shongo MY-P , Yav MM , Mukuku O , Kankolongo G , Kumelundu KK , Kasongo ANW , Mutombo AM , Mutombo AK , Bunga PM , Tshilolo LM , 2021. Melioidosis and sickle cell disease: description of a rare association. Theory Clin Pract Pediatr 3: 57–62.
-
21.
  O’Connor C , Kenna D , Walsh A , Zamarreño DV , Dance D , 2020. Imported melioidosis in the United Kingdom: increasing incidence but continued under-reporting. Clin Infect Pract 7: 100051.
-
22.
  Salam AP , Khan N , Malnick H , Kenna DT , Dance DA , Klein JL , 2011. Melioidosis acquired by traveler to Nigeria. Emerg Infect Dis 17: 1296–1298.
-
23.
  Adeyemi F , Akinde S , 2021. ESßL, AmpC and carbapenemase co-production in multi-drug resistant gram-negative bacteria from HIV-infected patients in southwestern Nigeria. Afr J Clin Exp Microbiol 22: 38–51.
-
24.
  Ferry R , Poutrel B , Bruneau F , 1973. Isolation of Whitmore’s bacillus from lesions found in pigs from the Niamey slaughterhouse in Niger. Bull Soc Pathol Exot 66: 42–45.
-
25.
  Dodin A , Ferry R , 1974. Epidemiological studies of the bacillus of Whitmore in Africa. Bull Soc Pathol Exot 67: 121–126.
-
26.
  Provost A , Vigier M , 1960. Isolation in Tchad (Central Africa) of 2 strains of Malleomyces pseudomallei. Ann Inst Pasteur (Paris) 98: 461–463.
-
27.
  Van der Lugt JJ , Henton MM , 1995. Melioidosis in a goat. J S Afr Vet Assoc 66: 71–73.
-
28.
  Birnie E , Wiersinga WJ , Limmathurotsakul D , Grobusch MP , 2015. Melioidosis in Africa: should we be looking more closely? Future Microbiol 10: 273–281.
-
29.
  Steinmetz I et al.2018. Melioidosis in Africa: time to uncover the true disease load. Trop Med Infect Dis 3: 62.
-
30.
  Kohler C , Dunachie SJ , Müller E , Kohler A , Jenjaroen K , Teparrukkul P , Baier V , Ehricht R , Steinmetz I , 2016. Rapid and sensitive multiplex detection of Burkholderia pseudomallei-specific antibodies in melioidosis patients based on a protein microarray approach. PLoS Negl Trop Dis 10: e0004847.
-
31.
  Birnie E , van't Hof S , Bijnsdorp A , Mansaray Y , Huizenga E , van der Ende A , Hugenholtz F , Grobusch MP , Wiersinga WJ , 2019. Identification of Burkholderia thailandensis with novel genotypes in the soil of central Sierra Leone. PLoS Negl Trop Dis 13: e0007402.
-
32.
  Trinh TT et al.2018. Melioidosis in Vietnam: recently improved recognition but still an uncertain disease burden after almost a century of reporting. Trop Med Infect Dis 3: 39.
-
33.
  Trinh TT et al.2018. A simple laboratory algorithm for diagnosis of melioidosis in resource-constrained areas: a study from north-central Vietnam. Clin Microbiol Infect 24: 84.e1–84.e4.
-
34.
  Rylance J , Nsutebu E , Mergani KO , Grobusch MP , Jacob ST , 2018. The African Sepsis Alliance: making a difference in the fight against sepsis in Africa. Infection 46: 733–734.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 448279 | 407385 | 75670 |
| Full Text Views | 6483 | 1782 | 691 |
| PDF Downloads | 389 | 79 | 8 |
Melioidosis in Africa: Time to Raise Awareness and Build Capacity for Its Detection, Diagnosis, and Treatment
Emma Birnie
Emma Birnie
Division of Infectious Diseases, Department of Medicine and Center for Experimental Molecular Medicine (CEMM), Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands;
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Ayorinde James
Ayorinde James
Department of Biochemistry, Nigerian Institute of Medical Research, Lagos, Nigeria;
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Folake Peters
Folake Peters
Department of Medical Microbiology and Parasitology, Lagos University Teaching Hospital, Lagos, Nigeria;
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Makinwa Olajumoke
Makinwa Olajumoke
Department of Medical Microbiology and Parasitology, Lagos University Teaching Hospital, Lagos, Nigeria;
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Tieble Traore
Tieble Traore
World Health Organization, Regional Office for Africa, Dhakar-Hub, Senegal;
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Eric Bertherat
Eric Bertherat
Department of Infectious Hazard Management, Health Emergency Programme, World Health Organization, Geneva, Switzerland;
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Trung T. Trinh
Trung T. Trinh
VNU Institute of Microbiology and Biotechnology, Vietnam National University, Hanoi, Vietnam;
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Dhamari Naidoo
Dhamari Naidoo
World Health Organization, Abuja, Nigeria;
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Ivo Steinmetz
Ivo Steinmetz
Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Austria;
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W. Joost Wiersinga
W. Joost Wiersinga
Division of Infectious Diseases, Department of Medicine and Center for Experimental Molecular Medicine (CEMM), Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands;
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Rita Oladele
Rita Oladele
Department of Medical Microbiology and Parasitology, Lagos University Teaching Hospital, Lagos, Nigeria;
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Alani S. Akanmu
Alani S. Akanmu
Department of Hematology and Blood Transfusion, Lagos University Teaching Hospital, Lagos, Nigeria
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ABSTRACT.
Melioidosis is a tropical infectious disease caused by the soil-dwelling bacterium Burkholderia pseudomallei with a mortality of up to 50% in low resource settings. Only a few cases have been reported from African countries. However, studies on the global burden of melioidosis showed that Africa holds a significant unrecognized disease burden, with Nigeria being at the top of the list. The first World Health Organization African Melioidosis Workshop was organized in Lagos, Nigeria, with representatives of health authorities, microbiology laboratories, and clinical centers from across the continent. Dedicated hands-on training was given on laboratory diagnostics of B. pseudomallei. This report summarises the meeting objectives, including raising awareness of melioidosis and building capacity for the detection, diagnosis, biosafety, treatment, and prevention across Africa. Further, collaboration with regional and international experts provided a platform for sharing ideas on best practices.
Author Notes
These authors contributed equally to this work.
Financial support: This workshop was made possible through the generous support of the WHO, together with the support of a Research Grant (2018) to E. B. by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Research Grant 2018.
Disclosure: The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of WHO or the authors’ affiliated institutions.
Authors’ addresses: Emma Birnie and W. Joost Wiersinga, Division of Infectious Diseases, Department of Medicine and Center for Experimental Molecular Medicine (CEMM), Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands, E-mails: e.birnie@amsterdamumc.nl and w.j.wiersinga@amsterdamumc.nl. Ayorinde James, Department of Biochemistry, Nigerian Institute of Medical Research, Lagos, Nigeria, E-mail: ayorindejames@gmail.com. Folake Peters, Makinwa Olajumoke, and Rita Oladele, Department of Medical Microbiology and Parasitology, Lagos University Teaching Hospital, Lagos, Nigeria, E-mails: ayotim3@gmail.com, jummywhales@yahoo.com, and oladelerita@gmail.com. Tieble Traore, World Health Organization, Regional Office for Africa, Dhakar-Hub, Senegal, E-mail: traoret@who.int. Eric Bertherat, Department of Infectious Hazard Management, Health Emergency Programme, World Health Organization, Geneva, Switzerland, E-mail: bertherate@who.int. Trung T. Trinh, VNU Institute of Microbiology and Biotechnology, Vietnam National University, Hanoi, Vietnam, E-mail: tttrung@vnu.edu.vn. Dhamari Naidoo, World Health Organization, Abuja, Nigeria, E-mail: naidood@who.int. Ivo Steinmetz, Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Austria, E-mail: ivo.steinmetz@medunigraz.at. Alani S. Akanmu, Department of Hematology and Blood Transfusion, Lagos University Teaching Hospital, Lagos, Nigeria, E-mail: asulaimona@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
  Cheng AC , Currie BJ , 2005. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 18: 383–416.
-
2.
  Wiersinga WJ , Currie BJ , Peacock SJ , 2012. Melioidosis. N Engl J Med 367: 1035–1044.
-
3.
  Wiersinga WJ , Virk HS , Torres AG , Currie BJ , Peacock SJ , Dance DAB , Limmathurotsakul D , 2018. Melioidosis. Nat Rev Dis Primers 4: 17107.
-
4.
  Limmathurotsakul D , Wongratanacheewin S , Teerawattanasook N , Wongsuvan G , Chaisuksant S , Chetchotisakd P , Chaowagul W , Day NP , Peacock SJ , 2010. Increasing incidence of human melioidosis in northeast Thailand. Am J Trop Med Hyg 82: 1113–1117.
-
5.
  Currie BJ , Jacups SP , Cheng AC , Fisher DA , Anstey NM , Huffam SE , Krause VL , 2004. Melioidosis epidemiology and risk factors from a prospective whole-population study in northern Australia. Trop Med Int Health 9: 1167–1174.
-
6.
  Currie BJ , Ward L , Cheng AC , 2010. The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis 4: e900.
-
7.
  Limmathurotsakul D et al.2016. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol 1: 15008.
-
8.
  Birnie E , Virk HS , Savelkoel J , Spijker R , Bertherat E , Dance DAB , Limmathurotsakul D , Devleesschauwer B , Haagsma JA , Wiersinga WJ , 2019. Global burden of melioidosis in 2015: a systematic review and data synthesis. Lancet Infect Dis 19: 892–902.
-
9.
  van Crevel R , van de Vijver S , Moore DAJ , 2017. The global diabetes epidemic: what does it mean for infectious diseases in tropical countries? Lancet Diabetes Endocrinol 5: 457–468.
-
10.
  Dunachie S , Chamnan P , 2019. The double burden of diabetes and global infection in low and middle-income countries. Trans R Soc Trop Med Hyg 113: 56–64.
-
11.
  Dance DA , Limmathurotsakul D , 2018. Global burden and challenges of melioidosis. Trop Med Infect Dis 3: 13.
-
12.
  Wiersinga WJ , 2018. Melioidosis: Time to Recognize a Deadly but Neglected Tropical Disease. Available at: https://naturemicrobiologycommunity.nature.com/posts/37031-melioidosis-time-to-recognize-a-deadly-but-neglected-tropical-disease. Accessed November 2020.
-
13.
  Wiersinga WJ et al.2015. Clinical, environmental, and serologic surveillance studies of melioidosis in Gabon, 2012– 2013. Emerg Infect Dis 21: 40–47.
-
14.
  Martin de Frémont G , Gominet M , Bousquet A , Gervaise A , Andriamanantena D , Ficko C , 2019. Burkholderia pseudomallei: prostatic abscesses in an AIDS patient back from Cameroon. AIDS 33: 1403–1404.
-
15.
  Morelli F , Smeets L , Hobijn M , Boom H , 2015. Melioidosis and renal failure in a Dutch man after a trip to Gambia. Neth J Med 73: 296–298.
-
16.
  Muthumbi EM et al.2019. Population-based estimate of Melioidosis, Kenya. Emerg Infect Dis 25: 984–987.
-
17.
  Katangwe T et al.2013. Human melioidosis, Malawi, 2011. Emerg Infect Dis 19: 981–984.
-
18.
  Borgherini G , Poubeau P , Paganin F , Picot S , Michault A , Thibault F , Berod CA , 2006. Melioidosis: an imported case from Madagascar. J Travel Med 13: 318–320.
-
19.
  Almog Y , Yagel Y , Geffen Y , Yagupsky P , 2016. A Burkholderia pseudomallei infection imported from Eritrea to Israel. Am J Trop Med Hyg 95: 997–998.
-
20.
  Shongo MY-P , Yav MM , Mukuku O , Kankolongo G , Kumelundu KK , Kasongo ANW , Mutombo AM , Mutombo AK , Bunga PM , Tshilolo LM , 2021. Melioidosis and sickle cell disease: description of a rare association. Theory Clin Pract Pediatr 3: 57–62.
-
21.
  O’Connor C , Kenna D , Walsh A , Zamarreño DV , Dance D , 2020. Imported melioidosis in the United Kingdom: increasing incidence but continued under-reporting. Clin Infect Pract 7: 100051.
-
22.
  Salam AP , Khan N , Malnick H , Kenna DT , Dance DA , Klein JL , 2011. Melioidosis acquired by traveler to Nigeria. Emerg Infect Dis 17: 1296–1298.
-
23.
  Adeyemi F , Akinde S , 2021. ESßL, AmpC and carbapenemase co-production in multi-drug resistant gram-negative bacteria from HIV-infected patients in southwestern Nigeria. Afr J Clin Exp Microbiol 22: 38–51.
-
24.
  Ferry R , Poutrel B , Bruneau F , 1973. Isolation of Whitmore’s bacillus from lesions found in pigs from the Niamey slaughterhouse in Niger. Bull Soc Pathol Exot 66: 42–45.
-
25.
  Dodin A , Ferry R , 1974. Epidemiological studies of the bacillus of Whitmore in Africa. Bull Soc Pathol Exot 67: 121–126.
-
26.
  Provost A , Vigier M , 1960. Isolation in Tchad (Central Africa) of 2 strains of Malleomyces pseudomallei. Ann Inst Pasteur (Paris) 98: 461–463.
-
27.
  Van der Lugt JJ , Henton MM , 1995. Melioidosis in a goat. J S Afr Vet Assoc 66: 71–73.
-
28.
  Birnie E , Wiersinga WJ , Limmathurotsakul D , Grobusch MP , 2015. Melioidosis in Africa: should we be looking more closely? Future Microbiol 10: 273–281.
-
29.
  Steinmetz I et al.2018. Melioidosis in Africa: time to uncover the true disease load. Trop Med Infect Dis 3: 62.
-
30.
  Kohler C , Dunachie SJ , Müller E , Kohler A , Jenjaroen K , Teparrukkul P , Baier V , Ehricht R , Steinmetz I , 2016. Rapid and sensitive multiplex detection of Burkholderia pseudomallei-specific antibodies in melioidosis patients based on a protein microarray approach. PLoS Negl Trop Dis 10: e0004847.
-
31.
  Birnie E , van't Hof S , Bijnsdorp A , Mansaray Y , Huizenga E , van der Ende A , Hugenholtz F , Grobusch MP , Wiersinga WJ , 2019. Identification of Burkholderia thailandensis with novel genotypes in the soil of central Sierra Leone. PLoS Negl Trop Dis 13: e0007402.
-
32.
  Trinh TT et al.2018. Melioidosis in Vietnam: recently improved recognition but still an uncertain disease burden after almost a century of reporting. Trop Med Infect Dis 3: 39.
-
33.
  Trinh TT et al.2018. A simple laboratory algorithm for diagnosis of melioidosis in resource-constrained areas: a study from north-central Vietnam. Clin Microbiol Infect 24: 84.e1–84.e4.
-
34.
  Rylance J , Nsutebu E , Mergani KO , Grobusch MP , Jacob ST , 2018. The African Sepsis Alliance: making a difference in the fight against sepsis in Africa. Infection 46: 733–734.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 448279 | 407385 | 75670 |
| Full Text Views | 6483 | 1782 | 691 |
| PDF Downloads | 389 | 79 | 8 |