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Seroprevalence of Dengue Infection Using IgG Capture ELISA in India, 2017–2018
ABSTRACT.
We conducted a nationally representative population-based survey in 60 districts from 15 Indian states covering all five geographic regions during 2017–2018 to estimate the age specific seroprevalence of dengue. Of the 12,300 sera collected, 4,955 were positive for IgG antibodies against dengue virus using IgG Indirect ELISA indicating past dengue infection. We tested 4,948 sera (seven had inadequate volume) positive for IgG antibodies on indirect ELISA using anti-dengue IgG capture ELISA to estimate the proportion of dengue infections with high antibody titers, suggestive of acute or recent secondary infection. Of the 4,948 sera tested, 529 (10.7%; 95% CI: 9.4–12.1) were seropositive on IgG capture ELISA. The proportions of dengue infections with high titers were 1.1% in the northeastern, 1.5% in the eastern, 6.2% in the western, 12.2% in the southern, and 16.7% in the northern region. The distribution of dengue infections varied across geographic regions, with a higher proportion of infections with high antibody titer in the northern and southern regions of India. The study findings could be useful for planning facilities for clinical management of dengue infections.
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Author Notes
These authors contributed equally to this work.
Financial support: This study was funded by Indian Council of Medical Research, New Delhi
Authors’ addresses: Muthusamy Santhosh Kumar, P. Kamaraj, C. P. Girish Kumar, R. Sabarinathan, V. Saravana Kumar, T. Karunakaran, Annamma Jose, and Manoj Murhekar, ICMR-National Institute of Epidemiology, Chennai, India, E-mails: drsanthosmph09@gmail.com, pkrajreddy@gmail.com, girishmicro@gmail.com, sabari@nieicmr.org.in, saravanan.biostat1985@gmail.com, thiyakaruna@gmail.com, and aanjose.9@gmail.com. Siraj Ahmed Khan, ICMR-Regional Medical Research Centre, Northeast Region, Dibrugarh, India, E-mail: sirajkhanicmr@gmail.com. Ramesh Reddy Allam, Science Health Allied Research Education India, Hyderabad, India, E-mail: rameshallam@sharefoundations.org. Pradip V. Barde, ICMR-National Institute of Research in Tribal Health, Jabalpur, India, E-mail: pradip_barde@hotmail.com. Bhagirathi Dwibedi, ICMR-Regional Medical Research Centre, Bhubaneswar, India, E-mail: bhagirathidwibedi@yahoo.com. Suman Kanungo, Provash Sadhukhan, and Shanta Dutta, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India, E-mails: sumankanungo@gmail.com, provash2000@gmail.com, and shanta1232001@gmail.com. Uday Mohan, King George’s Medical University, Lucknow, India, E-mail: drudaymohan@yahoo.co.in. Suman Sundar Mohanty and G. S. Toteja, ICMR, National Institute for Implementation Research on Non-Communicable Diseases, Jodhpur, India, E-mails: ssnimr@gmail.com and gstoteja@gmail.com. Subarna Roy, ICMR-National Institute of Traditional Medicine, Belagavi, India, E-mail: drsubarnaroy@gmail.com. Vivek Sagar, Postgraduate Institute of Medical Education and Research, Chandigarh, India, E-mail: vivekgenetics@gmail.com. Deepali Savargaonkar, ICMR-National Institute of Malaria Research, New Delhi, India, E-mail: dr.deepali27@gmail.com. Babasaheb V. Tandale, ICMR-National Institute of Virology, Pune, India, E-mail: drtandale@gmail.com. Roshan Kamal Topno, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Patna, India, E-mail: roshanktopno@yahoo.co.in.