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Necrotizing Skin and Soft Tissue Infections Admitted to Intensive Care Unit in Reunion Island: A Retrospective Cohort Study

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  • 1 UMR 1094 Neuroépidémiologie Tropicale, University of Limoges, Limoges, France;
  • | 2 Cardio-Surgical Intensive Care Unit, CHU Limoges, Limoges, France;
  • | 3 René Labusquière Centre of Tropical Medicine, University of Bordeaux, Bordeaux, France;
  • | 4 Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion, Reunion Island, France

ABSTRACT.

This retrospective and single-center study in Reunion Island (Indian Ocean) assessed frequency, mortality, causative pathogens of severe necrotizing skin, and necrotizing skin and soft tissue infections (NSSTIs) admitted in intensive care unit (ICU). Sixty-seven consecutive patients were included from January 2012 to December 2018. Necrotizing skin and soft tissue infection represented 1.06% of total ICU admissions. We estimate the incidence of NSSTI requiring ICU at 1.21/100,000 person/years in Reunion Island. Twenty (30%) patients were receiving nonsteroidal anti-inflammatory drugs (NSAIDs) prior to admission in ICU and 40 (60%) were diagnosed patients with diabetes. Sites of infection were the lower limb in 52 (78%) patients, upper limb in 4 (6%), and perineum in 10 (15%). The surgical treatment was debridement for 40 patients, whereas 11 patients required an amputation. The most commonly isolated microorganisms were Streptococci (42%) and Gram-negative bacteria (22%).The mortality rate was 25.4%. NSAIDs did not influence mortality when interrupted upon admission to ICU.

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Author Notes

Address correspondence to David Vandroux, Cardiosurgical Intensive Care Unit, CHU Dupuytren, 2 Ave. Martin Luther King, 87042 Limoges Cedex, France. E-mail: vandroux.david@gmail.com

Disclaimer: The authors declare no conflict of interest and thank Ms. Jessica Vanderwall for her translation skills.

Authors’ addresses: David Vandroux, UMR 1094 Neuroépidémiologie Tropicale, University of Limoges, Limoges, France, Cardio-Surgical Intensive Care Unit, CHU Limoges, Limoges, France, and René Labusquière Centre of Tropical Medicine, University of Bordeaux, Bordeaux, France, E-mail: vandroux.david@gmail.com. Alexia Mubuanga Nkusu, UMR 1094 Neuroépidémiologie Tropicale, University of Limoges, Limoges, France, E-mail: alexiamubs@gmail.com. Bernard-Alex Gauzere, René Labusquière Centre of Tropical Medicine, University of Bordeaux, Bordeaux, France, E-mail: bagauzere@gmail.com. Olivier Martinet, Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion, Reunion Island, France, E-mail: olivier.martinet@chu-reunion.fr.

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