• 1.

    World Health Organization , 2011. Comprehensive Guidelines for Prevention and Control of Dengue and Dengue Haemorrhagic Fever. Revised and expanded edition. New Delhi, India: WHO, Regional Office for South-East Asia.

  • 2.

    Ebi KL , Nealon J , 2016. Dengue in a changing climate. Environ Res 151: 151115151123.

  • 3.

    Hadinegoro SR , 2012. The revised WHO dengue case classification: does the system need to be modified? Paediatr Int Child Health 32 (Suppl): 133–138.

    • Search Google Scholar
    • Export Citation
  • 4.

    World Health Organization , 2009. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. Geneva, Switzerland: WHO.

  • 5.

    Mallhi TH , Khan AH , Adnan AS , Sarriff A , Khan YH , Gan SH , 2018. Short-term renal outcomes following acute kidney injury among dengue patients: a follow-up analysis from large prospective cohort. PLoS One 13: e0192510.

    • Search Google Scholar
    • Export Citation
  • 6.

    Kuo MC , Lu PL , Chang JM , Lin MY , Tsai JJ , Chen YH , Chang K , Chen HC , Hwang SJ , 2008. Impact of renal failure on the outcome of dengue viral infection. Clin J Am Soc Nephrol 3: 13501356.

    • Search Google Scholar
    • Export Citation
  • 7.

    Laoprasopwattana K , Pruekprasert P , Dissaneewate P , Geater A , Vachvanichsanong P , 2010. Outcome of dengue hemorrhagic fever-caused acute kidney injury in Thai children. J Pediatr 157: 303309.

    • Search Google Scholar
    • Export Citation
  • 8.

    Mallhi TH , Khan AH , Adnan AS , Sarriff A , Khan YH , Jummaat F , 2015. Incidence, characteristics and risk factors of acute kidney injury among dengue patients: a retrospective analysis. PLoS One 10: e0138465.

    • Search Google Scholar
    • Export Citation
  • 9.

    Nair JJ , Bhat A , Prabhu MV , 2016. A clinical study of acute kidney injury in tropical acute febrile illness. J Clin Diagn Res 10: OC01OC05.

    • Search Google Scholar
    • Export Citation
  • 10.

    Mehta RL , Kellum JA , Shah SV , Molitoris BA , Ronco C , Warnock DG , Levin A , 2007. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11: R31.

    • Search Google Scholar
    • Export Citation
  • 11.

    Ostermann M , Joannidis M , 2016. Acute kidney injury 2016: diagnosis and diagnostic workup. Crit Care 20: 299.

  • 12.

    Selby NM , Fluck RJ , Kolhe NV , Taal MW , 2016. International criteria for acute kidney injury: advantages and remaining challenges. PLoS Med 13: e1002122.

    • Search Google Scholar
    • Export Citation
  • 13.

    KDIGO , 2012. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2: 1936.

  • 14.

    Lopes JA , Jorge S , 2013. The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review. Clin Kidney J 6: 814.

    • Search Google Scholar
    • Export Citation
  • 15.

    Niu HS , Li Y , Liu BY , Luo XL , Wang XD , 2017. Incidence and outcomes of acute kidney injury among patients attending intensive care unit in China. Int J Clin Exp Med 10: 35173525.

    • Search Google Scholar
    • Export Citation
  • 16.

    Nejat M , Pickering JW , Devarajan P , Bonventre JV , Edelstein CL , Walker RJ , Endre ZH , 2012. Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney Int 81: 12541262.

    • Search Google Scholar
    • Export Citation
  • 17.

    Lee IK , Liu JW , Yang KD , 2009. Clinical characteristics, risk factors, and outcomes in adults experiencing dengue hemorrhagic fever complicated with acute renal failure. Am J Trop Med Hyg 80: 651655.

    • Search Google Scholar
    • Export Citation
  • 18.

    Huang HS , Hsu CC , Ye JC , Su SB , Huang CC , Lin HJ , 2017. Predicting the mortality in geriatric patients with dengue fever. Medicine 96: e7878.

    • Search Google Scholar
    • Export Citation
  • 19.

    Basu G , Chrispal A , Boorugu H , Gopinath KG , Chandy S , Prakash JA , Thomas K , Abraham AM , John GT , 2011. Acute kidney injury in tropical acute febrile illness in a tertiary care centre: RIFLE criteria validation. Nephrol Dial Transplant 26: 524531.

    • Search Google Scholar
    • Export Citation
  • 20.

    Khalil MA , Sarwar S , Chaudry MA , Maqbool B , Khalil Z , Tan J , Yaqub S , Hussain SA , 2012. Acute kidney injury in dengue virus infection. Clin Kidney. 5: 390394.

    • Search Google Scholar
    • Export Citation
  • 21.

    Huang SY , Lee IK , Liu JW , Kung CT , Wang L , 2015. Clinical features of and risk factors for rhabdomyolysis among adult patients with dengue virus infection. Am J Trop Med Hyg 92: 7581.

    • Search Google Scholar
    • Export Citation
  • 22.

    Diptyanusa A , Phumratanaprapin W , Phonrat B , Poovorawan K , Hanboonkunupakarn B , Sriboonvorakul N , Thisyakorn U , 2019. Characteristics and associated factors of acute kidney injury among adult dengue patients: a retrospective single-center study. PLoS One 14: e0210360.

    • Search Google Scholar
    • Export Citation
  • 23.

    Poggio ED , Nef PC , Wang X , Greene T , Van Lente F , Dennis VW , Hall PM , 2005. Performance of the Cockcroft-Gault and modification of diet in renal disease equations in estimating GFR in ill hospitalized patients. Am J Kidney Dis 46: 242252.

    • Search Google Scholar
    • Export Citation
  • 24.

    Batte A , Starr MC , Schwaderer AL , Opoka RO , Namazzi R , Phelps Nishiguchi ES , Ssenkusu JM , John CC , Conroy AL , 2020. Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: a prospective cohort study. BMC Nephrol 21: 417.

    • Search Google Scholar
    • Export Citation
  • 25.

    Cho MH , 2020. Pediatric acute kidney injury: focusing on diagnosis and management. Child Kidney Dis 24: 1926.

  • 26.

    Mehra N , Patel A , Abraham G , Reddy YN , Reddy YN , 2012. Acute kidney injury in dengue fever using Acute Kidney Injury Network criteria: incidence and risk factors. Trop Doct 42: 160162.

    • Search Google Scholar
    • Export Citation
  • 27.

    Neeraja M et al. 2014. Unusual and rare manifestations of dengue during a dengue outbreak in a tertiary care hospital in South India. Arch Virol 159: 15671573.

    • Search Google Scholar
    • Export Citation
  • 28.

    Mehta K , Pajai A , Bhurke S , Shirkande A , Bhadade R , D’Souza R , 2018. Acute kidney injury of infectious etiology in monsoon season: a prospective study using acute kidney injury network criteria. Indian J Nephrol 28: 143152.

    • Search Google Scholar
    • Export Citation
  • 29.

    Basu B , Roy B , 2018. Acute renal failure adversely affects survival in pediatric dengue infection. Indian J Crit Care Med 22: 3033.

  • 30.

    Mehta RL , Chertow GM , 2003. Acute renal failure definitions and classification: time for change? J Am Soc Nephrol 14: 21782187.

  • 31.

    Boonpucknavig V , Bhamarapravati N , Boonpucknavig S , Futrakul P , Tanpaichitr P , 1976. Glomerular changes in dengue hemorrhagic fever. Arch Pathol Lab Med 100: 206212.

    • Search Google Scholar
    • Export Citation
  • 32.

    Glassock RJ , 1991. Immune complex-induced glomerular injury in viral diseases: an overview. Kidney Int Suppl 35 (Suppl): 5–7.

  • 33.

    Lombardi R , Yu L , Younes-Ibrahim M , Schor N , Burdmann EA , 2008. Epidemiology of acute kidney injury in Latin America. Semin Nephrol 28: 320329.

    • Search Google Scholar
    • Export Citation
  • 34.

    Futrakul P , Poshyachinda V , Mitrakul C , Kun-Anake C , Boonpucknavig V , Boompucknavig S , Bhamarapravati N , 1973. Renal involvement and reticulo-endothelial-system clearance in dengue hemorrhagic fever. J Med Assoc Thai 56: 3339.

    • Search Google Scholar
    • Export Citation
  • 35.

    Khan NA , Azhar EI , El-Fiky S , Madani HH , Abuljadial MA , Ashshi AM , Turkistani AM , Hamouh EA , 2008. Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia. Acta Trop 105: 3944.

    • Search Google Scholar
    • Export Citation
  • 36.

    Oliveira JF , Burdmann EA , 2015. Dengue-associated acute kidney injury. Clin Kidney J 8: 681685.

  • 37.

    Goonasekera CD , Thenuwara BG , Kumarasiri RP , 2012. Peritoneal dialysis in dengue shock syndrome may be detrimental. J Trop Med 2012: 15.

    • Search Google Scholar
    • Export Citation
  • 38.

    Boonpucknavig V , Soontornniyomkij V , 2003. Pathology of renal diseases in the tropics. Semin Nephrol 23: 88106.

  • 39.

    Vakrani GP , Subramanyam NT , 2017. Acute renal failure in dengue infection. J Clin Diagn Res 11: OC10OC13.

  • 40.

    Lumpaopong A , Kaewplang P , Watanaveeradej V , Thirakhupt P , Chamnanvanakij S , Srisuwan K , Pongwilairat N , Chulamokha Y , 2010. Electrolyte disturbances and abnormal urine analysis in children with dengue infection. Southeast Asian J Trop Med Public Health 41: 7276.

    • Search Google Scholar
    • Export Citation
  • 41.

    Voets P , Maas R , 2018. Extracellular volume depletion and resultant hypotonic hyponatremia: a novel translational approach. Math Biosci 295: 6266.

    • Search Google Scholar
    • Export Citation
  • 42.

    Miller AS , Wonnacott AC , McBride JW , 2012. Dengue induced syndrome of inappropriate secretion of anti-diuretic hormone. J Clin Case Rep 2: 1000109.

    • Search Google Scholar
    • Export Citation
  • 43.

    Vachvanichsanong P , Thisyakorn U , Thisyakorn C , 2012. Dengue hemorrhagic fever and the kidney. Arch Virol 161: 771778.

  • 44.

    Lizarraga KJ , Nayer A , 2014. Dengue-associated kidney disease. J Nephropathol 3: 5762.

  • 45.

    Lee IK , Huang CH , Huang WC , Chen YC , Tsai CY , Chang K , Chen YH , 2018. Prognostic factors in adult patients with dengue: developing risk scoring models and emphasizing factors associated with death ≤ 7 days after illness onset and ≤ 3 days after presentation. J Clin Med 7: 396.

    • Search Google Scholar
    • Export Citation
  • 46.

    Liu KT , Liu YH , Lin CY , Tsai MJ , Hsu YL , Yen MC , Kuo PL , 2016. Serum neutrophil gelatinase-associated lipocalin and resistin are associated with dengue infection in adults. BMC Infect Dis 16: 441.

    • Search Google Scholar
    • Export Citation
  • 47.

    Kashani K , Cheungpasitporn W , Ronco C , 2017. Biomarkers of acute kidney injury: the pathway from discovery to clinical adoption. Clin Chem Lab Med 55: 10741089.

    • Search Google Scholar
    • Export Citation
  • 48.

    Mallhi TH , Khan AH , Sarriff A , Adnan AS , Khan YH , Jummaat F , 2016. Defining acute kidney injury in dengue viral infection by conventional and novel classification systems (AKIN and RIFLE): a comparative analysis. Postgrad Med J 92: 7886.

    • Search Google Scholar
    • Export Citation
  • 49.

    Patel ML , Himanshu D , Chaudhary SC , Atam V , Sachan R , Misra R , Mohapatra SD , 2019. Clinical characteristic and risk factors of acute kidney injury among dengue viral infections in adults: a retrospective analysis. Indian J Nephrol 29: 1521.

    • Search Google Scholar
    • Export Citation
  • 50.

    Matthys E , Patton MK , Osgood RW , Venkatachalam MA , Stein JH , 1983. Alterations in vascular function and morphology in acute ischemic renal failure. Kidney Int 23: 717724.

    • Search Google Scholar
    • Export Citation
  • 51.

    Metcalfe PD , Leslie JA , Campbell MT , Meldrum DR , Hile KL , Meldrum KK , 2008. Testosterone exacerbates obstructive renal injury by stimulating TNF-alpha production and increasing proapoptotic and profibrotic signaling. Am J Physiol Endocrinol Metab 294: E435E443.

    • Search Google Scholar
    • Export Citation
  • 52.

    Hodeify R , Megyesi J , Tarcsafalvi A , Mustafa HI , Hti Lar Seng NS , Price PM , 2013. Gender differences control the susceptibility to ER stress-induced acute kidney injury. Am J Physiol Renal Physiol 304: F875F882.

    • Search Google Scholar
    • Export Citation
  • 53.

    Sato Y , Yanagita M , 2018. Immune cells and inflammation in AKI to CKD progression. Am J Physiol Renal Physiol 315: F1501F1512.

  • 54.

    Peng J , Li X , Zhang D , Chen JK , Su Y , Smith SB , Dong Z , 2015. Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney Int 87: 137150.

    • Search Google Scholar
    • Export Citation
  • 55.

    Patschan D , Muller GA , 2016. Acute kidney injury in diabetes mellitus. Int J Nephrol 2016: 17.

  • 56.

    Zager RA , 1997. Pathogenetic mechanisms in nephrotoxic acute renal failure. Semin Nephrol 17: 314.

  • 57.

    Schetz M , Dasta J , Goldstein S , Golper T , 2005. Drug-induced acute kidney injury. Curr Opin Crit Care 11: 555565.

  • 58.

    Naughton CA , 2008. Drug-induced nephrotoxicity. Am Fam Physician 78: 743750.

  • 59.

    Bagshaw SM , 2006. Epidemiology of renal recovery after acute renal failure. Curr Opin Crit Care 12: 544550.

  • 60.

    Hsieh CC , Cia CT , Lee JC , Sung JM , Lee NY , Chen PL , Kuo TH , Chao JY , Ko WC , 2017. A cohort study of adult patients with severe dengue in Taiwanese intensive care units: the elderly and APTT prolongation matter for prognosis. PLoS Negl Trop Dis 11: e0005270.

    • Search Google Scholar
    • Export Citation
  • 61.

    Padyana M , Karanth S , Vaidya S , Gopaldas JA , 2019. Clinical profile and outcome of dengue fever in multidisciplinary intensive care unit of a tertiary level hospital in India. Indian J Crit Care Med 23: 270273.

    • Search Google Scholar
    • Export Citation
  • 62.

    Gurugama P , Jayarajah U , Wanigasuriya K , Wijewickrama A , Perera J , Seneviratne SL , 2018. Renal manifestations of dengue virus infections. J Clin Virol 101: 16.

    • Search Google Scholar
    • Export Citation
  • 63.

    Forni LG , Darmon M , Ostermann M , Oudemans-van Straaten HM , Pettila V , Prowle JR , Schetz M , Joannidis M , 2017. Renal recovery after acute kidney injury. Intensive Care Med 43: 855866.

    • Search Google Scholar
    • Export Citation
  • 64.

    Mallhi TH , Khan AH , Sarriff A , Adnan AS , Khan YH , 2017. Determinants of mortality and prolonged hospital stay among dengue patients attending tertiary care hospital: a cross-sectional retrospective analysis. BMJ Open 7: e016805.

    • Search Google Scholar
    • Export Citation
  • 65.

    Hommel D , Talarmin A , Reynes JM , Hulin A , 1999. Acute renal failure associated with dengue fever in French Guiana. Nephron 83: 183.

  • 66.

    Harty J , 2014. Prevention and management of acute kidney injury. Ulster Med J 83: 149157.

  • 67.

    Lee IK , Liu JW , Yang KD , 2012. Fatal dengue hemorrhagic fever in adults: emphasizing the evolutionary pre-fatal clinical and laboratory manifestations. PLoS Negl Trop Dis 6: e1532.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 914 143 35
Full Text Views 605 440 17
PDF Downloads 436 277 17
 
 
 
 
 
 
 
 
 
 
 

Predictors and Outcomes of Dengue-Associated Acute Kidney Injury

Ajib Diptyanusa Center for Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia;

Search for other papers by Ajib Diptyanusa in
Current site
Google Scholar
PubMed
Close
and
Weerapong Phumratanaprapin Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Search for other papers by Weerapong Phumratanaprapin in
Current site
Google Scholar
PubMed
Close
View More View Less
Restricted access

Abstract.

Dengue viral infections present with a wide clinical spectrum ranging from asymptomatic to severe manifestations with organ involvement. The term “expanded dengue syndrome” has been commonly used to illustrate the unusual or atypical manifestations; acute kidney injury (AKI) is one of the atypical manifestations of this syndrome. The use of heterogeneous criteria to determine the presence of AKI in dengue patients due to the vast diversity in populations led to difficulties in assessing the true incidence of dengue-associated AKI. This review presents a variable, but often high, frequency of dengue-associated AKI among vastly diverse populations with various disease severities. Dengue-associated AKI is not an uncommon complication, and its importance has often been neglected during the management of dengue patients. The risk factors and certain clinical and laboratory findings commonly reported among dengue patients with AKI should be considered to support a timely diagnosis and case management. This review highlights the need for clinicians to be aware of dengue-associated AKI to reduce the morbidity and mortality associated with this common and important tropical disease.

Author Notes

Address correspondence to Weerapong Phumratanaprapin, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok 10400, Thailand. E-mail: weerapong.phu@mahidol.ac.th

Disclosure: The information presented in the article reflects the views of the authors and contributors of the articles.

Authors’ addresses: Ajib Diptyanusa, Center for Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia, E-mail: ajib.diptyanusa@mail.ugm.ac.id. Weerapong Phumratanaprapin, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, E-mail: weerapong.phu@mahidol.ac.th.

Save