Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Garcia HH , Nash TE , Del Brutto OH , 2014. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 13: 1202–1215.
-
2.
Fabiani S , Bruschi F , 2013. Neurocysticercosis in Europe: still a public health concern not only for imported cases. Acta Trop 128: 18–26.
-
3.
Ong S , Talan DA , Moran GJ , Mower W , Newdow M , Tsang VCW , Pinner RW ; EMERGEncy ID NET Study Group , 2002. Neurocysticercosis in radiographically imaged seizure patients in U.S. emergency departments. Emerg Infect Dis 8: 608–613.
-
4.
Fleury A , Carrillo-Mezo R , Flisser A , Sciutto E , Corona T , 2011. Subarachnoid basal neurocysticercosis: a focus on the most severe form of the disease. Expert Rev Anti Infect Ther 9: 123–133.
-
5.
Garcia HH , Gonzalez AE , Gilman RH , 2020. Taenia solium cysticercosis and its impact in neurological disease. Clin Microbiol Rev 33: e00085-19.
-
6.
Bustos JA et al. For the Cysticercosis Working Group in Peru , 2020. Frequency and determinant factors for calcification in neurocysticercosis. Clin Infect Dis ciaa784. Available at: https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciaa784/5859152?redirectedFrom=fulltext.
-
7.
Bruno E , Bartoloni A , Zammarchi L , Strohmeyer M , Bartalesi F , Bustos JA , Santivañez S , García HH , Nicoletti A ; COHEMI Project Study Group , 2013. Epilepsy and neurocysticercosis in Latin America: a systematic review and meta-analysis. PLoS Negl Trop Dis 7: e2480.
-
8.
DeGiorgio CM , Houston I , Oviedo S , Sorvillo F , 2002. Deaths associated with cysticercosis. Report of three cases and review of the literature. Neurosurg Focus 12: e2.
-
9.
Siu-Chang D , 2015. Neurocisticercosis Subaracnoidea Basal, Mortalidad Y Factores Asociados. Lima, Peru: Universidad Peruana Cayetano Heredia. Available at: http://repositorio. upch.edu.pe/handle/upch/4434.
-
10.
Martins-Melo FR , Ramos AN , Cavalcanti MG , Alencar CH , Heukelbach J , 2016. Neurocysticercosis-related mortality in Brazil, 2000–2011: epidemiology of a neglected neurologic cause of death. Acta Trop 153: 128–136.
-
11.
Santo AH , 2007. Cysticercosis-related mortality in the State of São Paulo, Brazil, 1985–2004: a study using multiple causes of death. Cad Saude Publica 23: 2917–2927.
-
12.
Garcia HH , Pretell EJ , Gilman RH , Martinez SM , Moulton LH , Del Brutto OH , Herrera G , Evans CAW , Gonzalez AE , 2004. A trial of antiparasitic treatment to reduce the rate of seizures due to cerebral cysticercosis. N Engl J Med 350: 249–258.
-
13.
Nash TE , Pretell EJ , Lescano AG , Bustos JA , Gilman RH , Gonzalez AE , Garcia HH ; Cysticercosis Working Group in Peru , 2008. Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case-control study. Lancet Neurol 7: 1099–1105.
-
14.
Garcia HH et al. Cysticercosis Working Group in Peru , 2011. Pharmacokinetics of combined treatment with praziquantel and albendazole in neurocysticercosis. Br J Clin Pharmacol 72: 77–84.
-
15.
Callacondo D , Garcia HH , Gonzales I , Escalante D , Nash TE ; Cysticercosis Working Group in Peru , 2012. High frequency of spinal involvement in patients with basal subarachnoid neurocysticercosis. Neurology 78: 1394–1400.
-
16.
Garcia HH et al. Cysticercosis Working Group in Peru , 2014. Efficacy of combined antiparasitic therapy with praziquantel and albendazole for neurocysticercosis: a double-blind, randomised controlled trial. Lancet Infect Dis 14: 687–695.
-
17.
Garcia HH , Gonzales I , Lescano AG , Bustos JA , Pretell EJ , Saavedra H , Nash TE ; Cysticercosis Working Group in Peru , 2014. Enhanced steroid dosing reduces seizures during antiparasitic treatment for cysticercosis and early after. Epilepsia 55: 1452–1459.
-
18.
Garcia HH , Lescano AG , Gonzales I , Bustos JA , Pretell EJ , Horton J , Saavedra H , Gonzalez AE , Gilman RH ; Cysticercosis Working Group in Peru , 2016. Cysticidal efficacy of combined treatment with praziquantel and albendazole for parenchymal brain cysticercosis. Clin Infect Dis 62: 1375–1379.
-
19.
Arroyo G et al. Cysticercosis Working Group in Peru , 2018. Antibody banding patterns of the enzyme-linked immunoelectrotransfer blot and brain imaging findings in patients with neurocysticercosis. Clin Infect Dis 66: 282–288.
-
20.
Watila MM , Balarabe SA , Ojo O , Keezer MR , Sander JW , 2018. Overall and cause-specific premature mortality in epilepsy: a systematic review. Epilepsy Behav 87: 213–225.
-
21.
Dreier JW , Pedersen CB , Gasse C , Christensen J , 2019. Antiepileptic drugs and suicide: role of prior suicidal behavior and parental psychiatric disorder. Ann Neurol 86: 951–961.
-
22.
Mula M , Sander JW , 2015. Suicide and epilepsy: do antiepileptic drugs increase the risk? Expert Opin Drug Saf 14: 553–558.
-
23.
Scorza FA , Arida RM , de Mendonça PRF , Cavalheiro EA , Leite JP , 2012. Neurocysticercosis: a new trend in SUDEP research? Rev Soc Bras Med Trop 45: 280.
-
24.
Holmes NE , Iles LE , Danks RA , Korman TM , 2010. Neurocysticercosis causing sudden death. Am J Forensic Med Pathol 31: 117–119.
-
25.
Llompart Pou JA , Gené A , Ayestarán JI , Saus C , 2005. Neurocysticercosis presenting as sudden death. Acta Neurochir (Wien) 147: 785–786.
-
26.
Reddy GK , Bollam P , Caldito G , 2012. Ventriculoperitoneal shunt surgery and the risk of shunt infection in patients with hydrocephalus: long-term single institution experience. World Neurosurg 78: 155–163.
-
27.
Nash TE , O’Connell EM , Hammoud DA , Wetzler L , Ware JM , Mahanty S , 2020. Natural history of treated subarachnoid neurocysticercosis. Am J Trop Med Hyg 102: 78–89.
-
28.
Bhattarai R , Budke CM , Carabin H , Proaño JV , Flores-Rivera J , Corona T , Ivanek R , Snowden KF , Flisser A , 2012. Estimating the non-monetary burden of neurocysticercosis in Mexico. PLoS Negl Trop Dis 6: e1521.
-
29.
Bhattarai R , Carabin H , Proaño JV , Flores-Rivera J , Corona T , Flisser A , León-Maldonado L , Budke CM , 2019. The monetary burden of cysticercosis in Mexico. PLoS Negl Trop Dis 13: e0007501.
-
30.
Sorvillo FJ , DeGiorgio C , Waterman SH , 2007. Deaths from cysticercosis, United States. Emerg Infect Dis 13: 230–235.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1180 | 190 | 19 |
| Full Text Views | 422 | 173 | 1 |
| PDF Downloads | 309 | 106 | 0 |
Mortality in Parenchymal and Subarachnoid Neurocysticercosis
Jesus Abanto
Jesus Abanto
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru;
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis Del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis Del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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Daniel Blanco
Daniel Blanco
Unidad de Investigación, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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Herbert Saavedra
Herbert Saavedra
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis Del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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Isidro Gonzales
Isidro Gonzales
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis Del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
Unidad de Investigación, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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Unidad de Investigación, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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Diego Siu
Diego Siu
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru;
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E. Javier Pretell
E. Javier Pretell
Hospital Nacional Alberto Sabogal, Essalud, Callao, Peru
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Javier A. Bustos
Javier A. Bustos
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru;
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis Del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis Del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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Hector H. Garcia
Hector H. Garcia
Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru;
Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis Del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru;
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for the Cysticercosis Working Group in Peru
for the Cysticercosis Working Group in Peru
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Abstract.
Neurocysticercosis (NCC) is endemic in many parts of the world, carrying significant neurological morbidity that varies according to whether lesions are located inside the cerebral parenchyma or in extraparenchymal spaces. The latter, in particular subarachnoid NCC, is assumed to be more severe, but no controlled studies comparing mortality between types of NCC exist. The aim of this study was to compare all-cause mortality between patients with intraparenchymal NCC and those with subarachnoid NCC. Vital status and sociodemographic characteristics were evaluated in patients with intraparenchymal viable, intraparenchymal calcified, and subarachnoid NCC attending a neurological referral hospital in Lima, Perú. Survival analyses using Kaplan–Meier curves and Cox proportional regression models were carried out to compare mortality rates between groups. From 840 NCC patients followed by a median time of 82.3 months, 42 (5.0%) died, six (1.8%) in the intraparenchymal viable group, four (1.3%) in the calcified group, and 32 (16.6%) in the subarachnoid group (P < 0.001). Older age and lower education were significantly associated with mortality. The age-adjusted hazard ratio for death in the subarachnoid group was 13.6 (95% CI: 5.6–33.0, P < 0.001) compared with the intraparenchymal viable group and 10.7 (95% CI: 3.7–30.8, P < 0.001) when compared with the calcified group. We concluded that subarachnoid disease is associated with a much higher mortality in NCC.
Author Notes
Authors’ addresses: Jesus Abanto and Diego Siu, Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mails: jesus.abanto@upch.pe and diego.siu@upch.pe. Daniel Blanco, Unidad de Investigación, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, E-mail: daniel.blanco.v@upch.pe. Herbert Saavedra, Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, E-mail: hsaavedrapastor@hotmail.com. Isidro Gonzales, Unidad de Investigación, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, and Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, E-mail: isidrogonzalesq@hotmail.com. E. Javier Pretell, Hospital Nacional Alberto Sabogal, Essalud, Callao, Peru, E-mail: ejpretell@hotmail.com. Javier A. Bustos and Hector H. Garcia, Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru, and Centro Básico de Investigación en Exámenes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurológicas, Lima, Peru, E-mails: javier.bustos@jhu.edu and hgarcia1@jhu.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Garcia HH , Nash TE , Del Brutto OH , 2014. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol 13: 1202–1215.
-
2.
Fabiani S , Bruschi F , 2013. Neurocysticercosis in Europe: still a public health concern not only for imported cases. Acta Trop 128: 18–26.
-
3.
Ong S , Talan DA , Moran GJ , Mower W , Newdow M , Tsang VCW , Pinner RW ; EMERGEncy ID NET Study Group , 2002. Neurocysticercosis in radiographically imaged seizure patients in U.S. emergency departments. Emerg Infect Dis 8: 608–613.
-
4.
Fleury A , Carrillo-Mezo R , Flisser A , Sciutto E , Corona T , 2011. Subarachnoid basal neurocysticercosis: a focus on the most severe form of the disease. Expert Rev Anti Infect Ther 9: 123–133.
-
5.
Garcia HH , Gonzalez AE , Gilman RH , 2020. Taenia solium cysticercosis and its impact in neurological disease. Clin Microbiol Rev 33: e00085-19.
-
6.
Bustos JA et al. For the Cysticercosis Working Group in Peru , 2020. Frequency and determinant factors for calcification in neurocysticercosis. Clin Infect Dis ciaa784. Available at: https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciaa784/5859152?redirectedFrom=fulltext.
-
7.
Bruno E , Bartoloni A , Zammarchi L , Strohmeyer M , Bartalesi F , Bustos JA , Santivañez S , García HH , Nicoletti A ; COHEMI Project Study Group , 2013. Epilepsy and neurocysticercosis in Latin America: a systematic review and meta-analysis. PLoS Negl Trop Dis 7: e2480.
-
8.
DeGiorgio CM , Houston I , Oviedo S , Sorvillo F , 2002. Deaths associated with cysticercosis. Report of three cases and review of the literature. Neurosurg Focus 12: e2.
-
9.
Siu-Chang D , 2015. Neurocisticercosis Subaracnoidea Basal, Mortalidad Y Factores Asociados. Lima, Peru: Universidad Peruana Cayetano Heredia. Available at: http://repositorio. upch.edu.pe/handle/upch/4434.
-
10.
Martins-Melo FR , Ramos AN , Cavalcanti MG , Alencar CH , Heukelbach J , 2016. Neurocysticercosis-related mortality in Brazil, 2000–2011: epidemiology of a neglected neurologic cause of death. Acta Trop 153: 128–136.
-
11.
Santo AH , 2007. Cysticercosis-related mortality in the State of São Paulo, Brazil, 1985–2004: a study using multiple causes of death. Cad Saude Publica 23: 2917–2927.
-
12.
Garcia HH , Pretell EJ , Gilman RH , Martinez SM , Moulton LH , Del Brutto OH , Herrera G , Evans CAW , Gonzalez AE , 2004. A trial of antiparasitic treatment to reduce the rate of seizures due to cerebral cysticercosis. N Engl J Med 350: 249–258.
-
13.
Nash TE , Pretell EJ , Lescano AG , Bustos JA , Gilman RH , Gonzalez AE , Garcia HH ; Cysticercosis Working Group in Peru , 2008. Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case-control study. Lancet Neurol 7: 1099–1105.
-
14.
Garcia HH et al. Cysticercosis Working Group in Peru , 2011. Pharmacokinetics of combined treatment with praziquantel and albendazole in neurocysticercosis. Br J Clin Pharmacol 72: 77–84.
-
15.
Callacondo D , Garcia HH , Gonzales I , Escalante D , Nash TE ; Cysticercosis Working Group in Peru , 2012. High frequency of spinal involvement in patients with basal subarachnoid neurocysticercosis. Neurology 78: 1394–1400.
-
16.
Garcia HH et al. Cysticercosis Working Group in Peru , 2014. Efficacy of combined antiparasitic therapy with praziquantel and albendazole for neurocysticercosis: a double-blind, randomised controlled trial. Lancet Infect Dis 14: 687–695.
-
17.
Garcia HH , Gonzales I , Lescano AG , Bustos JA , Pretell EJ , Saavedra H , Nash TE ; Cysticercosis Working Group in Peru , 2014. Enhanced steroid dosing reduces seizures during antiparasitic treatment for cysticercosis and early after. Epilepsia 55: 1452–1459.
-
18.
Garcia HH , Lescano AG , Gonzales I , Bustos JA , Pretell EJ , Horton J , Saavedra H , Gonzalez AE , Gilman RH ; Cysticercosis Working Group in Peru , 2016. Cysticidal efficacy of combined treatment with praziquantel and albendazole for parenchymal brain cysticercosis. Clin Infect Dis 62: 1375–1379.
-
19.
Arroyo G et al. Cysticercosis Working Group in Peru , 2018. Antibody banding patterns of the enzyme-linked immunoelectrotransfer blot and brain imaging findings in patients with neurocysticercosis. Clin Infect Dis 66: 282–288.
-
20.
Watila MM , Balarabe SA , Ojo O , Keezer MR , Sander JW , 2018. Overall and cause-specific premature mortality in epilepsy: a systematic review. Epilepsy Behav 87: 213–225.
-
21.
Dreier JW , Pedersen CB , Gasse C , Christensen J , 2019. Antiepileptic drugs and suicide: role of prior suicidal behavior and parental psychiatric disorder. Ann Neurol 86: 951–961.
-
22.
Mula M , Sander JW , 2015. Suicide and epilepsy: do antiepileptic drugs increase the risk? Expert Opin Drug Saf 14: 553–558.
-
23.
Scorza FA , Arida RM , de Mendonça PRF , Cavalheiro EA , Leite JP , 2012. Neurocysticercosis: a new trend in SUDEP research? Rev Soc Bras Med Trop 45: 280.
-
24.
Holmes NE , Iles LE , Danks RA , Korman TM , 2010. Neurocysticercosis causing sudden death. Am J Forensic Med Pathol 31: 117–119.
-
25.
Llompart Pou JA , Gené A , Ayestarán JI , Saus C , 2005. Neurocysticercosis presenting as sudden death. Acta Neurochir (Wien) 147: 785–786.
-
26.
Reddy GK , Bollam P , Caldito G , 2012. Ventriculoperitoneal shunt surgery and the risk of shunt infection in patients with hydrocephalus: long-term single institution experience. World Neurosurg 78: 155–163.
-
27.
Nash TE , O’Connell EM , Hammoud DA , Wetzler L , Ware JM , Mahanty S , 2020. Natural history of treated subarachnoid neurocysticercosis. Am J Trop Med Hyg 102: 78–89.
-
28.
Bhattarai R , Budke CM , Carabin H , Proaño JV , Flores-Rivera J , Corona T , Ivanek R , Snowden KF , Flisser A , 2012. Estimating the non-monetary burden of neurocysticercosis in Mexico. PLoS Negl Trop Dis 6: e1521.
-
29.
Bhattarai R , Carabin H , Proaño JV , Flores-Rivera J , Corona T , Flisser A , León-Maldonado L , Budke CM , 2019. The monetary burden of cysticercosis in Mexico. PLoS Negl Trop Dis 13: e0007501.
-
30.
Sorvillo FJ , DeGiorgio C , Waterman SH , 2007. Deaths from cysticercosis, United States. Emerg Infect Dis 13: 230–235.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1180 | 190 | 19 |
| Full Text Views | 422 | 173 | 1 |
| PDF Downloads | 309 | 106 | 0 |