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1.
Whitfield KC et al. 2018. Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Ann N Y Acad Sci 1430: 3–43.
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2.
Nazir M, Lone R, Charoo BA, 2019. Infantile thiamine deficiency: new insights into an old disease. Indian Pediatr 56: 673–681.
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3.
Whitfield KC et al. 2017. High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children. PLoS Negl Trop Dis 11: e0005814.
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4.
Barennes H, Sengkhamyong K, René JP, Phimmasane M, 2015. Beriberi (thiamine deficiency) and high infant mortality in northern Laos. PLoS Negl Trop Dis 9: e0003581.
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5.
Bhat JI et al. 2017. Shoshin beriberi-thiamine responsive pulmonary hypertension in exclusively breastfed infants: a study from northern India. Indian Heart J 69: 24–27.
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6.
Rao SN, Chandak GR, 2010. Cardiac beriberi: often a missed diagnosis. J Trop Pediatr 56: 284–285.
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7.
Saya RP, Baikunje S, Prakash PS, Subramanyam K, Patil V, 2012. Clinical correlates and outcome of shoshin beriberi. N Am J Med Sci 4: 503–506.
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8.
Cerroni MP et al. 2010. Outbreak of beriberi in an Indian population of the upper Amazon region, Roraima State, Brazil, 2008. Am J Trop Med Hyg 83: 1093–1097.
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9.
Imamura T, Kinugawa K, 2015. Shoshin beriberi with low cardiac output and hemodynamic deterioration treated dramatically by thiamine administration. Int Heart J 56: 568–570.
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10.
Coats D et al. 2013. Thiamine pharmacokinetics in Cambodian mothers and their breastfed infants. Am J Clin Nutr 98: 839–844.
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11.
Allen LH, 2012. B vitamins in breast milk: relative importance of maternal status and intake, and effects on infant status and function. Adv Nutr 3: 362–369.
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Case Report: Fulminant Infantile Beriberi: A Report of Six Cases
Madhusudan Samprathi
Madhusudan Samprathi
Rainbow Children’s Hospital, Bannerghatta Road, Bangalore, India
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Faisal Mohammad
Faisal Mohammad
Rainbow Children’s Hospital, Bannerghatta Road, Bangalore, India
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Sridhar M
Sridhar M
Rainbow Children’s Hospital, Bannerghatta Road, Bangalore, India
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Prakash Ramachandra
Prakash Ramachandra
Rainbow Children’s Hospital, Bannerghatta Road, Bangalore, India
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Prakash Vemgal
Prakash Vemgal
Rainbow Children’s Hospital, Bannerghatta Road, Bangalore, India
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Abstract.
Thiamine deficiency disorders are an under-recognized public health problem in low- and middle-income countries. Infantile beriberi, the most important symptom for children, is suspected to significantly contribute to infant mortality and lifelong neurodevelopmental morbidity. Lack of awareness, varied clinical presentation, and lack of a readily available diagnostic marker lead to frequent misdiagnoses. We report six thriving infants who presented with an acute fulminant illness with varied clinical manifestations mimicking common childhood illnesses like pneumonia and sepsis. Four of them presented with the severe cardiovascular form, called Shoshin beriberi, and severe pulmonary arterial hypertension. Empirical intravenous thiamine administered to four of the six infants resulted in dramatic recovery. Awareness of the clinical definition of infantile beriberi and treatment with empirical thiamine can be lifesaving.
Author Notes
Authors’ addresses: Madhusudan Samprathi, Faisal Mohammad, Sridhar M, Prakash Ramachandra, and Prakash Vemgal, Rainbow Children’s Hospital, Bannerghatta Road, Bangalore, India, E-mails: madhu_1511@yahoo.com, faisal20_1897@yahoo.co.in, docsridhara@gmail.com, drprakashr@gmail.com, and pvemgal@hotmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Whitfield KC et al. 2018. Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Ann N Y Acad Sci 1430: 3–43.
-
2.
Nazir M, Lone R, Charoo BA, 2019. Infantile thiamine deficiency: new insights into an old disease. Indian Pediatr 56: 673–681.
-
3.
Whitfield KC et al. 2017. High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children. PLoS Negl Trop Dis 11: e0005814.
-
4.
Barennes H, Sengkhamyong K, René JP, Phimmasane M, 2015. Beriberi (thiamine deficiency) and high infant mortality in northern Laos. PLoS Negl Trop Dis 9: e0003581.
-
5.
Bhat JI et al. 2017. Shoshin beriberi-thiamine responsive pulmonary hypertension in exclusively breastfed infants: a study from northern India. Indian Heart J 69: 24–27.
-
6.
Rao SN, Chandak GR, 2010. Cardiac beriberi: often a missed diagnosis. J Trop Pediatr 56: 284–285.
-
7.
Saya RP, Baikunje S, Prakash PS, Subramanyam K, Patil V, 2012. Clinical correlates and outcome of shoshin beriberi. N Am J Med Sci 4: 503–506.
-
8.
Cerroni MP et al. 2010. Outbreak of beriberi in an Indian population of the upper Amazon region, Roraima State, Brazil, 2008. Am J Trop Med Hyg 83: 1093–1097.
-
9.
Imamura T, Kinugawa K, 2015. Shoshin beriberi with low cardiac output and hemodynamic deterioration treated dramatically by thiamine administration. Int Heart J 56: 568–570.
-
10.
Coats D et al. 2013. Thiamine pharmacokinetics in Cambodian mothers and their breastfed infants. Am J Clin Nutr 98: 839–844.
-
11.
Allen LH, 2012. B vitamins in breast milk: relative importance of maternal status and intake, and effects on infant status and function. Adv Nutr 3: 362–369.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 718 | 89 | 17 |
| Full Text Views | 471 | 215 | 0 |
| PDF Downloads | 297 | 73 | 0 |