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RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Fraga TR, Isaac L, Barbosa AS, 2016. Complement evasion by pathogenic Leptospira. Front Immunol 21: 623.
-
3.
Smith S, Liu Y-H, Carter A, Kennedy BJ, Dermedgoglou A, Poulgrain SS, Paavola M P, Minto TL, Luc M, Hanson J, 2019. Severe leptospirosis in tropical Australia: optimising intensive care unit management to reduce mortality. PLoS Negl Trop Dis 13: e0007929.
-
4.
Evangelista KV, Coburn J, 2010. Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses. Future Microbiol 5: 1413–1425.
-
5.
Miyahara S, Saito M, Kanemaru T, Villanueva SY, Gloriani NG, Yoshida S, 2014. Destruction of the hepatocyte junction by intercellular invasion of Leptospira causes jaundice in a hamster model of Weil’s disease. Int J Exp Pathol 95: 271–281.
-
6.
Sato H, Coburn J, 2017. Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells. PLoS Negl Trop Dis 27: e0005830.
-
7.
Nicodemo AC, Duarte MI, Alves VA, Takakura CF, Santos RT, Nicodemo EL, 1997. Lung lesions in human leptospirosis: microscopic, immunohistochemical, and ultrastructural features related to thrombocytopenia. Am J Trop Med Hyg 56: 181–187.
-
8.
Del Carlo Bernardi F, Ctenas B, da Silva LF, Nicodemo AC, Saldiva PH, Dolhnikoff M, Mauad T, 2012. Immune receptors and adhesion molecules in human pulmonary leptospirosis. Hum Pathol 43: 1601–1610.
-
9.
Evangelista K, Franco R, Schwab A, Coburn J, 2014. Leptospira interrogans binds to cadherins. PLoS Negl Trop Dis 8: e2672.
-
10.
De Brito T, Silva AMGD, Abreu PAE, 2018. Pathology and pathogenesis of human leptospirosis: a commented review. Rev Inst Med Trop São Paulo 60: e23.
-
11.
Kochi LT, Fernandes LGV, Souza GO, Vasconcellos SA, Heinemann MB, Romero EC, Kirchgatter K, Nascimento ALTO, 2019. The interaction of two novel putative proteins of Leptospira interrogans with E-cadherin, plasminogen and complement components with potential role in bacterial infection. Virulence 10: 734–753.
-
12.
Vieira ML, Fernandes LG, Domingos RF, Oliveira R, Siqueira GH, Souza NM, Teixeira AR, Atzingen MV, Nascimento AL, 2014. Leptospiral extracellular matrix adhesins as mediators of pathogen–host interactions. FEMS Microbiol Lett 352: 129–139.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2159 | 1181 | 505 |
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Pathogenesis of Pulmonary Hemorrhagic Syndrome in Human Leptospirosis
Antonio C. Nicodemo
Antonio C. Nicodemo
Department of Infectious Diseases, University of São Paulo Medical School, São Paulo, Brazil;
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Amaro Nunes Duarte-Neto
Amaro Nunes Duarte-Neto
Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil
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Abstract.
Based on a previous study and by incorporating new knowledge, the goal of our study was to understand more fully the pathogenesis of hemorrhagic pneumonia of severe human leptospirosis, highlighting the onset of capillary lesions by Leptospira itself and/or its antigenic/toxic products acting on the endothelium and binding to cadherins. Both events lead to loss of endothelial integrity, alter permeability, cause rupture, and open intercellular junctions, contributing to the hemorrhagic phenomena associated with severe leptospirosis.
Author Notes
Authors’ addresses: Antonio C. Nicodemo, Department of Infectious Diseases, University of São Paulo Medical School, São Paulo, Brazil, E-mail: ac_nicodemo@uol.com.br. Amaro Nunes Duarte-Neto, Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil, E-mail: amaro.ndneto@hc.fm.usp.br.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Fraga TR, Isaac L, Barbosa AS, 2016. Complement evasion by pathogenic Leptospira. Front Immunol 21: 623.
-
3.
Smith S, Liu Y-H, Carter A, Kennedy BJ, Dermedgoglou A, Poulgrain SS, Paavola M P, Minto TL, Luc M, Hanson J, 2019. Severe leptospirosis in tropical Australia: optimising intensive care unit management to reduce mortality. PLoS Negl Trop Dis 13: e0007929.
-
4.
Evangelista KV, Coburn J, 2010. Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses. Future Microbiol 5: 1413–1425.
-
5.
Miyahara S, Saito M, Kanemaru T, Villanueva SY, Gloriani NG, Yoshida S, 2014. Destruction of the hepatocyte junction by intercellular invasion of Leptospira causes jaundice in a hamster model of Weil’s disease. Int J Exp Pathol 95: 271–281.
-
6.
Sato H, Coburn J, 2017. Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells. PLoS Negl Trop Dis 27: e0005830.
-
7.
Nicodemo AC, Duarte MI, Alves VA, Takakura CF, Santos RT, Nicodemo EL, 1997. Lung lesions in human leptospirosis: microscopic, immunohistochemical, and ultrastructural features related to thrombocytopenia. Am J Trop Med Hyg 56: 181–187.
-
8.
Del Carlo Bernardi F, Ctenas B, da Silva LF, Nicodemo AC, Saldiva PH, Dolhnikoff M, Mauad T, 2012. Immune receptors and adhesion molecules in human pulmonary leptospirosis. Hum Pathol 43: 1601–1610.
-
9.
Evangelista K, Franco R, Schwab A, Coburn J, 2014. Leptospira interrogans binds to cadherins. PLoS Negl Trop Dis 8: e2672.
-
10.
De Brito T, Silva AMGD, Abreu PAE, 2018. Pathology and pathogenesis of human leptospirosis: a commented review. Rev Inst Med Trop São Paulo 60: e23.
-
11.
Kochi LT, Fernandes LGV, Souza GO, Vasconcellos SA, Heinemann MB, Romero EC, Kirchgatter K, Nascimento ALTO, 2019. The interaction of two novel putative proteins of Leptospira interrogans with E-cadherin, plasminogen and complement components with potential role in bacterial infection. Virulence 10: 734–753.
-
12.
Vieira ML, Fernandes LG, Domingos RF, Oliveira R, Siqueira GH, Souza NM, Teixeira AR, Atzingen MV, Nascimento AL, 2014. Leptospiral extracellular matrix adhesins as mediators of pathogen–host interactions. FEMS Microbiol Lett 352: 129–139.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2159 | 1181 | 505 |
| Full Text Views | 664 | 167 | 1 |
| PDF Downloads | 378 | 24 | 0 |