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Cysticidal Therapy for Diffuse Parenchymal and Calcific Neurocysticercosis

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  • 1 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India;
  • 2 Department of Neuroradiology, All India Institute of Medical Sciences, New Delhi, India

ABSTRACT

Antiparasitic treatment improves the prognosis for neurocysticercosis (NCC)-induced seizures. However, patients with high lesion loads are typically denied the possible benefit of cysticidal therapy because of fear of complications, and such patients are not represented in clinical trials involving cysticidal therapy. We provide proof of concept for combination treatment with dual antiparasitic therapy and corticosteroids in patients with diffuse lesions, including starry sky patterns, or calcific NCC. The safety and efficacy of treating patients with high lesion loads or calcific NCC should be tested in a randomized controlled trial.

Author Notes

Address correspondence to Venugopalan Y. Vishnu, Department of Neurology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. E-mail: vishnuvy16@yahoo.com

Disclosure: The corresponding author confirms that he had full access to all the data in the study and had final responsibility for the decision to submit for publication. Individual patient data can be accessed through a pertinent request to the corresponding author.

Authors’ addresses: Ayush Agarwal, M. Vasantha Padma Srivastava, Anu Gupta, Roopa Rajan, Biswamohan Mishra, Mamta B. Singh, Rohit Bhatia, and Venugopalan Y. Vishnu, Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, E-mails: ayushthetaurian@gmail.com, vasanthapadma123@gmail.com, doctoranugupta1@gmail.com, roops84@gmail.com, biswamohan26@gmail.com, mbsneuro@gmail.com, rohitbhatia71@yahoo.com, and vishnuvy16@yahoo.com. Ajay Garg, Department of Neuroradiology, All India Institute of Medical Sciences, New Delhi, India, E-mail: drajaygarg@gmail.com.

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