World Health Organization, 2020. Dengue et dengue sévère. Geneva, Switzerland: WHO. Available at: https://www.who.int/fr/news-room/fact-sheets/detail/dengue-and-severe-dengue. Accessed June 1, 2020.
World Health organization, 2009. Dengue Guidelines for Diagnosis, Treatment, Prevention and Control. WHO Library Cataloguing-in-Publication Data. Geneva, Switzerland: WHO. Available at: https://www.who.int/publications/i/item/9789241547871. Accessed December 1, 2018.
Sane S, Saulova A, McLaren R, White H, 2015. A fatal case of primary dengue infection with myocarditis and cerebral oedema. Australas Med J 8: 299–303.
Woon YL, Hor CP, Hussin N, Zakaria A, Goh PP, Cheah WK, 2016. A two-year review on epidemiology and clinical characteristics of dengue deaths in Malaysia, 2013–2014. PLoS Negl Trop Dis 10: e0004575.
Nunes PCG 2018. 30 years of dengue fatal cases in Brazil: a laboratorial-based investigation of 1047 cases. BMC Infect Dis 18: 346.
Sam SS, Omar SFS, Teoh BT, Abd-Jamil J, AbuBakar S, 2013. Review of dengue hemorrhagic fever fatal cases seen among adults: a retrospective study. PLoS Negl Trop Dis 7: e2194.
Li Y 2016. Characterization of the myocarditis during the worst outbreak of dengue infection in China. Medicine (Baltimore) 95: e4051.
Kularatne SAM, Rajapakse MM, Ralapanawa U, Waduge R, Pathirage LPMMK, Rajapakse RPVJ, 2018. Heart and liver are infected in fatal cases of dengue: three PCR based case studies. BMC Infect Dis 18: 681.
Miranda CH, de Carvalho Borges M, Schmidt A, Pazin-Filho A, Rossi MA, Ramos SG, Lopes da Fonseca BA, 2014. A case presentation of a fatal dengue myocarditis showing evidence for dengue virus-induced lesion. Eur Heart J Acute Cardiovasc Care 2: 127–130.
Yacoub S, Wertheim H, Simmons CP, Screaton G, Wills B, 2014. Cardiovascular manifestations of the emerging dengue pandemic. Nat Rev Cardiol 11: 335–345.
Lee IK, Lee WH, Liu JW, Yang KD, 2010. Acute myocarditis in dengue hemorrhagic fever: a case report and review of cardiac complications in dengue-affected patients. Int J Infect Dis 14: e919–e922.
Caforio ALP 2013. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on myocardial and pericardial diseases. Eur Heart J 34: 2636–2648, 2648a–2648d.
Dennert R, Crijns HJ, Heymans S, 2008. Acute viral myocarditis. Eur Heart J 29: 2073–2082.
Weerakoon KG, Kularatne SA, Edussuriya DH, Kodikara SK, Gunatilake LP, Pinto VG, Seneviratne AB, Gunasena S, 2011. Histopathological diagnosis of myocarditis in a dengue outbreak in Sri Lanka, 2009. BMC Res Notes 4: 268.
Alvarez MF, Bolívar-Mejía A, Rodriguez-Morales AJ, Ramirez-Vallejo E, 2017. Cardiovascular involvement and manifestations of systemic Chikungunya virus infection: a systematic review. F1000Res 6: 390.
Tahir H, Daruwalla V, Hayat S, 2015. Myocarditis leading to severe dilated cardiomyopathy in a patient with dengue fever. Case Rep Cardiol 2015: 319312.
McCarthy RE, Boehmer JP, Hruban RH, Hutchins GM, Kasper EK, Hare JM, Baughman KL, 2000. Long-term outcome of fulminant myocarditis as compared with acute (nonfulminant) myocarditis. N Engl J Med 342: 690–695.
Veronese G, Ammirati E, Cipriani M, Frigerio M, 2018. Fulminant myocarditis: characteristics, treatment, and outcomes. Anatol J Cardiol 19: 279–286.
Salazar LA, Schreuder CM, Eslava JA, Murcia AS, Forero MJ, Orozco-Levi MA, Echeverría LE, Figueredo AI, 2017. Extracorporeal membrane oxygenation in dengue, malaria, and acute chagas disease. ASAIO J 63: e71–e76.
Ku YH, Yu WL, 2016. Fatal dengue myocarditis despite the use of extracorporeal membrane oxygenation. Case Rep Infect Dis 2016: 5627217.
Vuppali NK, Pandey A, Torkadi R, Sandya P, Nagarajan R, Anil Kumar D, Sudeep V, 2018. Fulminant dengue myocarditis requiring VA ECMO support. Egypt J Crit Care Med 6: 155–156.
Makdisi G, Wang I, 2015. Extra corporeal membrane oxygenation (ECMO) review of a lifesaving technology. J Thorac Dis 7: E166–E176.
Aubron C, Cheng AC, Pilcher D, Leong T, Magrin G, Cooper DJ, Scheinkestel C, Pellegrino V, 2013. Factors associated with outcomes of patients on extracorporeal membrane oxygenation support: a 5-year cohort study. Crit Care 17: R73.
Lum LCS, Goh AYT, Keong Chan PW, El-Amin ALM, Lam SK, 2002. Risk factors for hemorrhage in severe dengue infections. J Pediatr 140: 629–631.
Agence Régionale de Santé de La Réunion, 2020. Communications Relatives à la situation de la dengue à La Réunion. Available at: https://www.lareunion.ars.sante.fr/system/files/2020-03/2020-03-03-CP_Situation-Dengue-2020.pdf. Accessed March 1, 2020.
Santé publique France, 2020. Epidémie de Dengue à la Réunion Forte augmentation du nombre de cas Point de situation au 5 avril 2020. Available at: file:///C:/Users/134455/Downloads/pe_dengue_reunion_140420%20(1).pdf. Accessed April 1, 2020.
European Centre for Disease Prevention and Control, 2019. Rapid Risk Assessment: Dengue Outbreak in Réunion, France, and Associated Risk of Autochthonous Outbreak in the EU/EEA. Available at: https://www.ecdc.europa.eu/en/publications-data/rapid-risk-assessment-dengue-outbreak-reunion-france-and-associated-risk. Accessed June 1, 2019.
Dengue disease is found worldwide and has been spreading exponentially in the past decades. Severe forms affect about 2% of patients, sometimes leading to organ failure. Recent studies have shown that fulminant dengue myocarditis is more common than previously thought, and fatal cases have been reported. The treatment of fulminant dengue myocarditis remains supportive and is very challenging in cases of cardiogenic shock. Here, we describe four cases presenting with fulminant dengue myocarditis treated with extracorporeal membrane oxygenation, among two survived.
Authors’ addresses: Laura Teysseyre, Yael Levy, Amélie Renou, Charles Vidal, and Julien Jabot, Réanimation Polyvalente, Centre Hospitalier Universitaire Félix Guyon, Saint Denis, France, E-mails: laura.teysseyre@gmail.com, l.yael@hotmail.fr, amelie.renou@chu-reunion.fr, charles.vidal@chu-reunion.fr, and julien.jabot@chu-reunion.fr. Mathilde Larghi and Guillaume Biland, Chirurgie Cardio-thoracique, Centre Hospitalier Universitaire Félix Guyon, Saint Denis, France, E-mails: larghi.mathilde@chu-reunion.fr and biland.guillaume@chu-reunion.fr. Nicolas Ledieu, Service de Cardiologie, Centre Hospitalier Universitaire Felix Guyon, Saint Denis, France, E-mail: ledieu.nicolas@chu-reunion.fr. Nicolas Allou and Jérôme Allyn, Réanimation Polyvalente, Centre Hospitalier Universitaire Félix Guyon, Saint Denis, France, and Département d’informatique Clinique, Centre Hospitalier Universitaire Félix Guyon, Saint Denis, France, E-mails: nicolas.allou@hotmail.fr and allyn.jer@gmail.com.