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Case Report: Two Cases of Recurring Ovale Malaria in Sarawak, Malaysia, after Successful Treatment of Imported Plasmodium falciparum Infection

Jonathan Wee Kent LiewDepartment of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;

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Choo Huck OoiVector Borne Diseases Section, Sarawak Health Department, Kuching, Malaysia;

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Georges SnounouCEA-Université Paris Sud 11-INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA), Infectious Disease Models and Innovative Therapies (IDMIT) Department, Institut de Biologie François Jacob (IBFJ), Direction de la Recherche Fondamentale (DRF), Fontenay-aux-Roses, France

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Yee Ling LauDepartment of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;

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Here are two cases of recurring ovale malaria in Sarawak, Malaysia, that are likely relapses that occurred 1–2 months after successful treatment of the initial imported falciparum malaria with artemisinin-based combined therapy. The patients have no history or recollection of previous malaria episodes. These cases add to the limited evidence on the relapsing nature of Plasmodium ovale, after a febrile episode. In regions where P. ovale is not known to be autochthonous, active follow-up of treated imported malaria patients is highly recommended following their return, particularly to areas nearing or having achieved elimination.

Author Notes

Address correspondence to Yee Ling Lau, Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. E-mail: lauyeeling@um.edu.my

Financial support: Y. L. L. is supported by the Ministry of Education Malaysia (long-term research grant scheme LR002D-2018). G. S. was supported by a grant from the Agence Nationale de la Recherche, France (ANR-17-CE13-0025-01).

Authors’ addresses: Jonathan Wee Kent Liew and Yee Ling Lau, Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, E-mails: jonathanliew@um.edu.my, jon_wkent@hotmail.com, and lauyeeling@um.edu.my. Choo Huck Ooi, Vector Borne Diseases Section, Sarawak Health Department, Ministry of Health Malaysia, Kuching, Malaysia, E-mail: ooi.choo.huck@gmail.com. Georges Snounou, CEA-Université Paris Sud 11-INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA), IDMIT Department, IBFJ, DRF, Fontenay-aux-Roses, France, E-mail: georges.snounou@cea.fr.

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