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Here are two cases of recurring ovale malaria in Sarawak, Malaysia, that are likely relapses that occurred 1–2 months after successful treatment of the initial imported falciparum malaria with artemisinin-based combined therapy. The patients have no history or recollection of previous malaria episodes. These cases add to the limited evidence on the relapsing nature of Plasmodium ovale, after a febrile episode. In regions where P. ovale is not known to be autochthonous, active follow-up of treated imported malaria patients is highly recommended following their return, particularly to areas nearing or having achieved elimination.
Financial support: Y. L. L. is supported by the Ministry of Education Malaysia (long-term research grant scheme LR002D-2018). G. S. was supported by a grant from the Agence Nationale de la Recherche, France (ANR-17-CE13-0025-01).
Authors’ addresses: Jonathan Wee Kent Liew and Yee Ling Lau, Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, E-mails: jonathanliew@um.edu.my, jon_wkent@hotmail.com, and lauyeeling@um.edu.my. Choo Huck Ooi, Vector Borne Diseases Section, Sarawak Health Department, Ministry of Health Malaysia, Kuching, Malaysia, E-mail: ooi.choo.huck@gmail.com. Georges Snounou, CEA-Université Paris Sud 11-INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA), IDMIT Department, IBFJ, DRF, Fontenay-aux-Roses, France, E-mail: georges.snounou@cea.fr.