ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Cheesbrough M, 2009. District Laboratory Practice in Tropical Countries, Part 1, 2nd edition. Cambridge, United Kingdom: Cambridge University Press.
-
2.
WHO, 2010. WHO Laboratory Manual for the Examination and Processing of Human Semen, 5th edition. Geneva, Switzerland: World Health Organization.
-
3.
Kayuni SA et al. 2019. How can schistosome circulating antigen assays be best applied for diagnosing male genital schistosomiasis (MGS): an appraisal using exemplar MGS cases from a longitudinal cohort study among fishermen on the south shoreline of Lake Malawi. Parasitology :1–11, doi:http://10.1017/S0031182019000969.
-
4.
Kenguele HM, Adegnika AA, Nkoma AM, Ateba-Ngoa U, Mbong M, Zinsou J, Lell B, Verweij JJ, 2014. Impact of short-time urine freezing on the sensitivity of an established Schistosoma real-time PCR assay. Am J Trop Med Hyg 90: 1153–1155.
-
5.
Colley DG, Bustinduy AL, Secor WE, King CH, 2014. Human schistosomiasis. Lancet 383: 2253–2264.
-
6.
McManus DP, Dunne DW, Sacko M, Utzinger J, Vennervald BJ, Zhou X-N, 2018. Schistosomiasis. Nat Rev Dis Primers 4: 13.
-
7.
WHO, 2018. Schistosomiasis. Available at: http://www.who.int/en/news-room/fact-sheets/detail/schistosomiasis. Accessed December 29, 2018.
-
8.
Madden FC, 1911. Two rare manifestations of bilharziosis. Lancet 178: 754–755.
-
9.
Farrar J, Hotez PJ, Junghanss T, Kang G, Lalloo D, White NJ, 2014. Manson’s Tropical Diseases, Section 10, Chapter 52, 23rd edition. China: Elsevier Health Sciences.
-
10.
Kayuni S, Lampiao F, Makaula P, Juziwelo L, Lacourse EJ, Reinhard-Rupp J, Leutscher PDC, Stothard JR, 2019. A systematic review with epidemiological update of male genital schistosomiasis (MGS): a call for integrated case management across the health system in sub-Saharan Africa. Parasite Epidemiol Control 4: e00077.
-
11.
Gelfand M, Ross CMD, Blair DM, Castle WM, Webber MC, 1970. Schistosomiasis of the male pelvic organs: severity of infection as determined by digestion of tissue and histologic methods in 300 cadavers. Am J Trop Med Hyg 19: 779–784.
-
12.
Leutscher P, Ramarokoto C-E, Reimert C, Feldmeier H, Esterre P, Vennervald BJ, 2000. Community-based study of genital schistosomiasis in men from Madagascar. Lancet 355: 117–118.
-
13.
Vilana R, Corachan M, Gascon J, Valls E, Bru C, 1997. Schistosomiasis of the male genital tract: transrectal sonographic findings. J Urol 158: 1491–1493.
-
14.
Makaula P, Sadalaki JR, Muula AS, Kayuni S, Jemu S, Bloch P, 2014. Schistosomiasis in Malawi: a systematic review. Parasit Vectors 7: 20.
-
15.
Alharbi MH, Condemine C, Christiansen R, LaCourse EJ, Makaula P, Stanton MC, Juziwelo L, Kayuni S, Stothard JR, 2019. Biomphalaria pfeifferi snails and intestinal schistosomiasis, Lake Malawi, Africa, 2017–2018. Emerg Infect Dis 25: 613–615.
-
16.
WHO, 2003. Guidelines for the Management of Sexually Transmitted Infections. Geneva, Switzerland: World Health Organization.
-
17.
Leutscher PDC, Ramarokoto CE, Hoffmann S, Jensen JS, Ramaniraka V, Randrianasolo B, Raharisolo C, Migliani R, Christensen N, 2008. Coexistence of urogenital schistosomiasis and sexually transmitted infection in women and men living in an area where Schistosoma haematobium is endemic. Clin Infect Dis 47: 775–782.
-
18.
Yirenya-Tawiah DR, Ackumey MM, Bosompem KM, 2016. Knowledge and awareness of genital involvement and reproductive health consequences of urogenital schistosomiasis in endemic communities in Ghana: a cross–sectional study. Reprod Health 13: 117.
-
19.
Leutscher PDC, Pedersen M, Raharisolo C, Jensen JS, Hoffmann S, Lisse I, Ostrowski SR, Reimert CM, Mauclere P, Ullum H, 2005. Increased prevalence of leukocytes and elevated cytokine levels in semen from Schistosoma haematobium–infected individuals. J Infect Dis 191: 1639–1647.
-
20.
Stecher CW, Kallestrup P, Kjetland EF, Vennervald B, Petersen E, 2015. Considering treatment of male genital schistosomiasis as a tool for future HIV prevention: a systematic review. Int J Public Health 60: 839–848.
-
21.
Midzi N, Mduluza T, Mudenge B, Foldager L, Leutscher PDC, 2017. Decrease in seminal HIV-1 RNA load after praziquantel treatment of urogenital schistosomiasis coinfection in HIV-positive men–an observational study. Open Forum Infect Dis 4: ofx199.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1014 | 704 | 229 |
| Full Text Views | 1017 | 14 | 0 |
| PDF Downloads | 337 | 15 | 0 |
Case Report: Highlighting Male Genital Schistosomiasis (MGS) in Fishermen from the Southwestern Shoreline of Lake Malawi, Mangochi District
Sekeleghe A. Kayuni
Sekeleghe A. Kayuni
Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;
MASM Medi Clinics Limited, Medical Society of Malawi (MASM), Blantyre, Malawi;
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MASM Medi Clinics Limited, Medical Society of Malawi (MASM), Blantyre, Malawi;
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E. James LaCourse
E. James LaCourse
Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;
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Peter Makaula
Peter Makaula
Research for Health Environment and Development (RHED), Mangochi, Malawi;
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Fanuel Lampiao
Fanuel Lampiao
Physiology Department, College of Medicine, University of Malawi, Blantyre, Malawi;
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Lazarus Juziwelo
Lazarus Juziwelo
National Schistosomiasis and STH Control Program, Community Health Sciences Unit (CHSU), Ministry of Health, Lilongwe, Malawi;
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Joanna Fawcett
Joanna Fawcett
Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;
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Alexandra Shaw
Alexandra Shaw
Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;
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Mohammad H. Alharbi
Mohammad H. Alharbi
Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;
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Jaco J. Verweij
Jaco J. Verweij
Elisabeth-TweeSteden Hospital Tilburg, Laboratory for Medical Microbiology and Immunology, Tilburg, The Netherlands
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J. Russell Stothard
J. Russell Stothard
Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;
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Urogenital schistosomiasis causes morbidity within the genitalia but is underreported and infrequently examined in men. To draw attention to male genital schistosomiasis (MGS), a longitudinal cohort study was conducted among fishermen along the southwestern shoreline of Lake Malawi. A case series of five participants is presented inclusive of questionnaire interviews, parasitological examinations, ultrasonography, and provision of a standard dose (40 mg/kg) of praziquantel (PZQ) treatment at baseline, 1-, 3-, 6-, and 12-month follow-up time points. Eggs of Schistosoma haematobium were observed in urine or semen across all time points; parasitological diagnostics were bolstered by real-time PCR for Schistosoma DNA in semen and by portable ultrasonography to document putative MGS-associated morbidity. We highlight the importance of developing standard diagnostic tests for MGS and increasing the accessibility of PZQ treatment to men, especially those in at-risk endemic areas.
Author Notes
Financial support: S. A. K. was funded by a PhD scholarship from Commonwealth Scholarship Commission, United Kingdom, which supported the baseline and 1-month follow-up studies. He received an International Travel Fellowship from the British Society for Parasitology to conduct 3- and 6-month follow-up studies and from World Friendship Charity to conduct 12-month follow-up studies. J. F. and A. S. were supported by LSTM Education Department MSc Degree Research Project Module funding. This publication was supported by a grant from the African Research Network for Neglected Tropical Diseases (ARNTD) through United States Agency for International Development (USAID), UK aid from the British people (UK aid) and Coalition for Operational Research on Neglected Tropical Diseases (COR-NTD). Its contents are solely the responsibility of the authors and do not necessarily represent he views of ARNTD, COR-NTD, UK aid or the USAID.
Authors’ addresses: Sekeleghe A. Kayuni, MASM Medi Clinics Limited, Medical Society of Malawi (MASM), Blantyre, Malawi, E-mail: seke.kayuni@lstmed.ac.uk. E. James LaCourse, Joanna Fawcett, Alexandra Shaw, Mohammad H. Alharbi, and J. Russell Stothard, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, E-mails: james.lacourse@lstmed.ac.uk, joanna_fawcett@hotmail.co.uk, alexandrashaw100@gmail.com, mohammad.alharbi@lstmed.ac.uk, and russell.stothard@lstmed.ac.uk. Peter Makaula, Research for Health Environment and Development (RHED), Mangochi, Malawi, E-mail: petmakau@yahoo.co.uk. Fanuel Lampiao, Physiology Department, College of Medicine, University of Malawi, Blantyre, Malawi, E-mail: flampiao@medcol.mw. Lazarus Juziwelo, National Schistosomiasis and STH Control Program, Community Health Sciences Unit, Ministry of Health, Lilongwe, Malawi, E-mail: juziwelol@gmail.com. Jaco J. Verweij, Elisabeth-TweeSteden Hospital Tilburg, Laboratory for Medical Microbiology and Immunology, Tilburg, The Netherlands, E-mail: j.verweij@etz.nl.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Cheesbrough M, 2009. District Laboratory Practice in Tropical Countries, Part 1, 2nd edition. Cambridge, United Kingdom: Cambridge University Press.
-
2.
WHO, 2010. WHO Laboratory Manual for the Examination and Processing of Human Semen, 5th edition. Geneva, Switzerland: World Health Organization.
-
3.
Kayuni SA et al. 2019. How can schistosome circulating antigen assays be best applied for diagnosing male genital schistosomiasis (MGS): an appraisal using exemplar MGS cases from a longitudinal cohort study among fishermen on the south shoreline of Lake Malawi. Parasitology :1–11, doi:http://10.1017/S0031182019000969.
-
4.
Kenguele HM, Adegnika AA, Nkoma AM, Ateba-Ngoa U, Mbong M, Zinsou J, Lell B, Verweij JJ, 2014. Impact of short-time urine freezing on the sensitivity of an established Schistosoma real-time PCR assay. Am J Trop Med Hyg 90: 1153–1155.
-
5.
Colley DG, Bustinduy AL, Secor WE, King CH, 2014. Human schistosomiasis. Lancet 383: 2253–2264.
-
6.
McManus DP, Dunne DW, Sacko M, Utzinger J, Vennervald BJ, Zhou X-N, 2018. Schistosomiasis. Nat Rev Dis Primers 4: 13.
-
7.
WHO, 2018. Schistosomiasis. Available at: http://www.who.int/en/news-room/fact-sheets/detail/schistosomiasis. Accessed December 29, 2018.
-
8.
Madden FC, 1911. Two rare manifestations of bilharziosis. Lancet 178: 754–755.
-
9.
Farrar J, Hotez PJ, Junghanss T, Kang G, Lalloo D, White NJ, 2014. Manson’s Tropical Diseases, Section 10, Chapter 52, 23rd edition. China: Elsevier Health Sciences.
-
10.
Kayuni S, Lampiao F, Makaula P, Juziwelo L, Lacourse EJ, Reinhard-Rupp J, Leutscher PDC, Stothard JR, 2019. A systematic review with epidemiological update of male genital schistosomiasis (MGS): a call for integrated case management across the health system in sub-Saharan Africa. Parasite Epidemiol Control 4: e00077.
-
11.
Gelfand M, Ross CMD, Blair DM, Castle WM, Webber MC, 1970. Schistosomiasis of the male pelvic organs: severity of infection as determined by digestion of tissue and histologic methods in 300 cadavers. Am J Trop Med Hyg 19: 779–784.
-
12.
Leutscher P, Ramarokoto C-E, Reimert C, Feldmeier H, Esterre P, Vennervald BJ, 2000. Community-based study of genital schistosomiasis in men from Madagascar. Lancet 355: 117–118.
-
13.
Vilana R, Corachan M, Gascon J, Valls E, Bru C, 1997. Schistosomiasis of the male genital tract: transrectal sonographic findings. J Urol 158: 1491–1493.
-
14.
Makaula P, Sadalaki JR, Muula AS, Kayuni S, Jemu S, Bloch P, 2014. Schistosomiasis in Malawi: a systematic review. Parasit Vectors 7: 20.
-
15.
Alharbi MH, Condemine C, Christiansen R, LaCourse EJ, Makaula P, Stanton MC, Juziwelo L, Kayuni S, Stothard JR, 2019. Biomphalaria pfeifferi snails and intestinal schistosomiasis, Lake Malawi, Africa, 2017–2018. Emerg Infect Dis 25: 613–615.
-
16.
WHO, 2003. Guidelines for the Management of Sexually Transmitted Infections. Geneva, Switzerland: World Health Organization.
-
17.
Leutscher PDC, Ramarokoto CE, Hoffmann S, Jensen JS, Ramaniraka V, Randrianasolo B, Raharisolo C, Migliani R, Christensen N, 2008. Coexistence of urogenital schistosomiasis and sexually transmitted infection in women and men living in an area where Schistosoma haematobium is endemic. Clin Infect Dis 47: 775–782.
-
18.
Yirenya-Tawiah DR, Ackumey MM, Bosompem KM, 2016. Knowledge and awareness of genital involvement and reproductive health consequences of urogenital schistosomiasis in endemic communities in Ghana: a cross–sectional study. Reprod Health 13: 117.
-
19.
Leutscher PDC, Pedersen M, Raharisolo C, Jensen JS, Hoffmann S, Lisse I, Ostrowski SR, Reimert CM, Mauclere P, Ullum H, 2005. Increased prevalence of leukocytes and elevated cytokine levels in semen from Schistosoma haematobium–infected individuals. J Infect Dis 191: 1639–1647.
-
20.
Stecher CW, Kallestrup P, Kjetland EF, Vennervald B, Petersen E, 2015. Considering treatment of male genital schistosomiasis as a tool for future HIV prevention: a systematic review. Int J Public Health 60: 839–848.
-
21.
Midzi N, Mduluza T, Mudenge B, Foldager L, Leutscher PDC, 2017. Decrease in seminal HIV-1 RNA load after praziquantel treatment of urogenital schistosomiasis coinfection in HIV-positive men–an observational study. Open Forum Infect Dis 4: ofx199.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1014 | 704 | 229 |
| Full Text Views | 1017 | 14 | 0 |
| PDF Downloads | 337 | 15 | 0 |